Siobhan Quenby

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi request reprint Recurrent miscarriage: a defect in nature's quality control?
    Siobhan Quenby
    Department of Obstetrics and Gynaecology, Department of Immunology, University of Liverpool, Liverpool L69 3BX, UK
    Hum Reprod 17:1959-63. 2002
  2. pmc Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium
    Ai Wei Tang
    School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool Women s Hospital, Crown Street, Liverpool, L8 7SS, UK
    Trials 10:102. 2009
  3. ncbi request reprint Successful pregnancy outcome following 19 consecutive miscarriages: case report
    Siobhan Quenby
    Departments of Obstetrics and Gynaecology and Immunology, University of Liverpool, Liverpool L69 3BX, UK
    Hum Reprod 18:2562-4. 2003
  4. ncbi request reprint Trophoblast invasion
    Sheba Anin Anin
    Department of Obstetrics and Gynaecology, University of Liverpool, UK
    Hum Fertil (Camb) 7:169-74. 2004
  5. ncbi request reprint Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage
    Siobhan Quenby
    School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool, United Kingdom
    Fertil Steril 84:980-4. 2005
  6. ncbi request reprint Different types of recurrent miscarriage are associated with varying patterns of adhesion molecule expression in endometrium
    Siobhan Quenby
    School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool, UK
    Reprod Biomed Online 14:224-34. 2007
  7. doi request reprint A feasibility trial of screening women with idiopathic recurrent miscarriage for high uterine natural killer cell density and randomizing to prednisolone or placebo when pregnant
    Ai Wei Tang
    Department for Women s and Children s Health, Institute of Translational Medicine, University of Liverpool, Liverpool L8 7SS, UK
    Hum Reprod 28:1743-52. 2013
  8. ncbi request reprint Uterine natural killer cells, implantation failure and recurrent miscarriage
    Siobhan Quenby
    School of Reproductive and Developmental Medicine, University of Liverpool, First Floor, Liverpool Women s Hospital, Crown Street, Liverpool L8 7SS, UK
    Reprod Biomed Online 13:24-8. 2006
  9. doi request reprint A rapid, reliable method for uNK cell density estimation
    Josephine A Drury
    Department of Women s and Children s Health, University of Liverpool, UK
    J Reprod Immunol 97:183-5. 2013
  10. pmc Poor spontaneous and oxytocin-stimulated contractility in human myometrium from postdates pregnancies
    Sarah Arrowsmith
    Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 7:e36787. 2012

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Recurrent miscarriage: a defect in nature's quality control?
    Siobhan Quenby
    Department of Obstetrics and Gynaecology, Department of Immunology, University of Liverpool, Liverpool L69 3BX, UK
    Hum Reprod 17:1959-63. 2002
    ..Further research is needed to understand the mechanisms of maternal tract-embryo interaction and move towards improved management of recurrent pregnancy loss...
  2. pmc Prednisolone Trial: Study protocol for a randomised controlled trial of prednisolone for women with idiopathic recurrent miscarriage and raised levels of uterine natural killer (uNK) cells in the endometrium
    Ai Wei Tang
    School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool Women s Hospital, Crown Street, Liverpool, L8 7SS, UK
    Trials 10:102. 2009
    ..We have shown that prednisolone reduces the number of uNK cells in the endometrium. The question remains as to whether reducing the number of uNK cells improves pregnancy outcome...
  3. ncbi request reprint Successful pregnancy outcome following 19 consecutive miscarriages: case report
    Siobhan Quenby
    Departments of Obstetrics and Gynaecology and Immunology, University of Liverpool, Liverpool L69 3BX, UK
    Hum Reprod 18:2562-4. 2003
    ..This case report describes a patient in whom an excessive number of uterine NK cells were found. She received preconceptual prednisolone and delivered a live baby. This is a novel observation of untested significance...
  4. ncbi request reprint Trophoblast invasion
    Sheba Anin Anin
    Department of Obstetrics and Gynaecology, University of Liverpool, UK
    Hum Fertil (Camb) 7:169-74. 2004
    ..Each of these functions has multiple overlapping control systems so that trophoblast invasion is a finely controlled balance of competing mechanisms...
  5. ncbi request reprint Prednisolone reduces preconceptual endometrial natural killer cells in women with recurrent miscarriage
    Siobhan Quenby
    School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool, United Kingdom
    Fertil Steril 84:980-4. 2005
    ..To test the hypothesis that high numbers of uterine natural killer (uNK) cells in the endometrium of women with recurrent miscarriage (RM) could be reduced with prednisolone...
  6. ncbi request reprint Different types of recurrent miscarriage are associated with varying patterns of adhesion molecule expression in endometrium
    Siobhan Quenby
    School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool, UK
    Reprod Biomed Online 14:224-34. 2007
    ..Different endometrial integrin distribution was found in women suffering different types of recurrent pregnancy loss. It is postulated that impairment of the implantation barrier contributes to recurrent fetal loss...
  7. doi request reprint A feasibility trial of screening women with idiopathic recurrent miscarriage for high uterine natural killer cell density and randomizing to prednisolone or placebo when pregnant
    Ai Wei Tang
    Department for Women s and Children s Health, Institute of Translational Medicine, University of Liverpool, Liverpool L8 7SS, UK
    Hum Reprod 28:1743-52. 2013
    ..Is it feasible to screen women with idiopathic recurrent miscarriage (RM) for high uterine natural killer (uNK) cell density and then randomize them to prednisolone or placebo when pregnant?..
  8. ncbi request reprint Uterine natural killer cells, implantation failure and recurrent miscarriage
    Siobhan Quenby
    School of Reproductive and Developmental Medicine, University of Liverpool, First Floor, Liverpool Women s Hospital, Crown Street, Liverpool L8 7SS, UK
    Reprod Biomed Online 13:24-8. 2006
    ....
  9. doi request reprint A rapid, reliable method for uNK cell density estimation
    Josephine A Drury
    Department of Women s and Children s Health, University of Liverpool, UK
    J Reprod Immunol 97:183-5. 2013
    ..92) centred around the line of equality, with no systematic differences observed in Bland Altman plots. The area measurement was significantly faster and thus is a useful screening method...
  10. pmc Poor spontaneous and oxytocin-stimulated contractility in human myometrium from postdates pregnancies
    Sarah Arrowsmith
    Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 7:e36787. 2012
    ..We show that postdates pregnancy is associated with poor myometrial activity and suggest that this may contribute to increased myometrial quiescence and hence, prolonged gestation...
  11. doi request reprint Endometrial cell counts in recurrent miscarriage: a comparison of counting methods
    Josephine A Drury
    Department of Women s and Children s Health, University of Liverpool, Liverpool, UK
    Histopathology 59:1156-62. 2011
    ..The aim of this study was to compare cell counting manually with two computer-aided methods based on a public domain software package, ImageJ...
  12. doi request reprint Expression and distribution of Na, K-ATPase isoforms in the human uterus
    Rachel V Floyd
    Department of Physiology, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Reprod Sci 17:366-76. 2010
    ..In pregnancy, there was a switch in isoform expression, resulting in increased beta3 and decreased FXYD2 at the protein and messenger RNA (mRNA) levels. Na, K-ATPase isoform alterations may modulate uterine contractility during labor...
  13. doi request reprint Uterine natural killer cells and angiogenesis in recurrent reproductive failure
    Siobhan Quenby
    School of Reproductive and Developmental Medicine, University of Liverpool, First Floor, Liverpool Women s Hospital, Crown Street, Liverpool L8 7SS, UK
    Hum Reprod 24:45-54. 2009
    ..We tested the hypothesis that increased uNK cells in preimplantation endometrium are associated with altered angiogenesis...
  14. ncbi request reprint Antiphospholipid antibodies prevent extravillous trophoblast differentiation
    Siobhan Quenby
    Department of Obstetrics and Gynaecology, Liverpool Women s Hospital, University of Liverpool, Liverpool, United Kingdom
    Fertil Steril 83:691-8. 2005
    ..We investigated the hypothesis that antiphospholipid antibodies (aPL) have a detrimental effect on human extravillous trophoblast (EVT) differentiation into giant multinucleated cells "in vitro."..
  15. doi request reprint Recent thoughts on management and prevention of recurrent early pregnancy loss
    Ai Wei Tang
    School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool, UK
    Curr Opin Obstet Gynecol 22:446-51. 2010
    ..To provide an overview of the latest views and evidence available to clinicians managing couples with recurrent early pregnancy loss (RPL)...
  16. doi request reprint A short review of twin pregnancy and how oxytocin receptor expression may differ in multiple pregnancy
    Peter Turton
    Department of Physiology, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L693BX, UK
    Eur J Obstet Gynecol Reprod Biol 144:S40-4. 2009
    ..New hypotheses based on increased experimental work are called for. Such information may throw light on specific mechanisms leading to the increased incidence of pre-term delivery in twins...
  17. doi request reprint Intravenous fluids for reducing the duration of labour in low risk nulliparous women
    Feroza Dawood
    Liverpool Women s NHS Foundation Trust, Liverpool, UK
    Cochrane Database Syst Rev 6:CD007715. 2013
    ..Furthermore, excessive volumes of intravenous fluids may pose risks to both the mother and her newborn and different fluids are associated with different risks...
  18. ncbi request reprint Genetic polymorphisms on the factor V gene in women with recurrent miscarriage and acquired APCR
    Feroza Dawood
    Department of Reproductive and Developmental Health, Liverpool Women s Hospital, University of Liverpool, Crown Street, Liverpool L8 7SS, UK
    Hum Reprod 22:2546-53. 2007
    ..The objective of this study was to determine whether other polymorphisms exist on the parts of the gene encoding the B domain of the factor V in women with acquired APCR and RM...
  19. ncbi request reprint Effects of low-molecular-weight and unfractionated heparin on trophoblast function
    Siobhan Quenby
    Department of Obstetrics and Gynaecology, University of Liverpool, Liverpool, United Kingdom
    Obstet Gynecol 104:354-61. 2004
    ..We investigated the effect of these drugs on in vitro models of human extravillous trophoblast motility and differentiation...
  20. ncbi request reprint Contractility and calcium signaling of human myometrium are profoundly affected by cholesterol manipulation: implications for labor?
    - Jie Zhang
    University of Liverpool, Liverpool, UK
    Reprod Sci 14:456-66. 2007
    ..Cholesterol may contribute to uterine quiescence but could cause difficulties in labor in obese/dyslipidemic women, consistent with their increased cesarean delivery rates...
  21. ncbi request reprint Acquired activated protein C resistance may be a risk factor for recurrent fetal loss
    Feroza Dawood
    Fertil Steril 80:649-50. 2003