Nigel J Pyne

Summary

Affiliation: University of Strathclyde
Country: UK

Publications

  1. ncbi Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer
    Nigel J Pyne
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Cancer Cell 23:5-7. 2013
  2. ncbi Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK Electronic address
    Biochim Biophys Acta 1831:228-38. 2013
  3. ncbi Sphingosine 1-phosphate signalling in cancer
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK
    Biochem Soc Trans 40:94-100. 2012
  4. ncbi Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms: out of the shadow?
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK
    Trends Pharmacol Sci 32:443-50. 2011
  5. ncbi Sphingosine 1-phosphate and cancer
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Nat Rev Cancer 10:489-503. 2010
  6. ncbi Receptor tyrosine kinase-GPCR signal complexes
    N J Pyne
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow G4 0NR, Scotland, U K
    Biochem Soc Trans 31:1220-5. 2003
  7. ncbi c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells
    Catherine M Waters
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow G4 ONR, UK
    Cell Signal 17:263-77. 2005
  8. ncbi FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
    Francesca Tonelli
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, UK
    Cell Signal 22:1536-42. 2010
  9. ncbi Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b
    Keng Gat Lim
    Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, UK
    Int J Biochem Cell Biol 44:1457-64. 2012
  10. ncbi Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1
    Catherine M Waters
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Glasgow, UK
    FASEB J 20:509-11. 2006

Collaborators

Detail Information

Publications48

  1. ncbi Sphingosine 1-phosphate is a missing link between chronic inflammation and colon cancer
    Nigel J Pyne
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Cancer Cell 23:5-7. 2013
    ..This appears critical for progression from chronic inflammation to colon cancer...
  2. ncbi Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK Electronic address
    Biochim Biophys Acta 1831:228-38. 2013
    ..Thus, LPA- and S1P-directed therapeutics may not be too far from the clinic. This article is part of a Special Issue entitled Advances in Lysophospholipid Research...
  3. ncbi Sphingosine 1-phosphate signalling in cancer
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK
    Biochem Soc Trans 40:94-100. 2012
    ..Finally, we describe how S1P receptor-modulating agents abrogate S1P receptor-receptor tyrosine kinase interactions, with potential to inhibit growth-factor-dependent cancer progression...
  4. ncbi Receptor tyrosine kinase-G-protein-coupled receptor signalling platforms: out of the shadow?
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow, G4 0RE, UK
    Trends Pharmacol Sci 32:443-50. 2011
    ..In this paper, we provide an opinion of the biology and unusual pharmacology of RTK-GPCR signalling platforms and make comparisons with a more traditional model of crosstalk between RTKs and GPCRs...
  5. ncbi Sphingosine 1-phosphate and cancer
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Nat Rev Cancer 10:489-503. 2010
    ..This Review summarizes current research findings and examines the potential for new therapeutics designed to alter S1P signalling and function in cancer...
  6. ncbi Receptor tyrosine kinase-GPCR signal complexes
    N J Pyne
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow G4 0NR, Scotland, U K
    Biochem Soc Trans 31:1220-5. 2003
    ..NGF induces recruitment of the LPA(1) receptor to the nucleus (delivery might be Trk A-dependent), whereupon the LPA(1) receptor may govern gene expression via novel nuclear signalling processes...
  7. ncbi c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells
    Catherine M Waters
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow G4 ONR, UK
    Cell Signal 17:263-77. 2005
    ..These findings provide important information concerning the molecular organisation of novel receptor tyrosine kinase (RTK)-GPCR signal relays in mammalian cells...
  8. ncbi FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells
    Francesca Tonelli
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, UK
    Cell Signal 22:1536-42. 2010
    ....
  9. ncbi Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b
    Keng Gat Lim
    Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, UK
    Int J Biochem Cell Biol 44:1457-64. 2012
    ..Therefore, our proposed 'see-saw' model might be usefully employed in the design of sphingosine kinase inhibitors to promote apoptosis of chemotherapeutic resistant cancer cells...
  10. ncbi Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1
    Catherine M Waters
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Glasgow, UK
    FASEB J 20:509-11. 2006
    ..The data obtained with SB649146 also suggest that the constitutively active endogenous S1P1 receptor enhances PDGF-induced cell migration...
  11. ncbi Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells
    Alayna Rodgers
    Cell Biology Group, SIPBS, University of Strathclyde, Glasgow G4 0NR, United Kingdom
    Stem Cells Dev 18:1319-30. 2009
    ....
  12. ncbi Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells
    Jaclyn S Long
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, United Kingdom
    Mol Cell Biol 30:3827-41. 2010
    ..This is correlated with improved prognosis in patients who have a low HER1-3/SK1 expression ratio in their ER(+) breast cancer tumors compared to patients that have a high HER1-3/SK1 expression ratio...
  13. ncbi Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules
    Susan Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, UK
    Cancer Res 71:6576-82. 2011
    ..Herein, we provide a perspective about these recent developments and highlight the importance of translating basic pharmacologic and biochemical findings on sphingosine kinase into new drug discovery programs for treatment of cancer...
  14. ncbi Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells
    Jaclyn S Long
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Science, Univesity of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland, United Kingdom
    J Biol Chem 285:35957-66. 2010
    ..The linkage of S1P with an oncogene suggests that S1P and specifically S1P(4) may have an important role in breast cancer progression...
  15. ncbi Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
    Susan Pyne
    Cell Biology Group, SIPBS, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, Scotland, UK
    Cell Signal 21:14-21. 2009
    ..Finally, we survey the function of S1P in relation to disease, where the major challenge is to dissect the role of intracellular versus extracellular actions of S1P in terms of association with defined diseased phenotypes...
  16. ncbi Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells
    Catherine M Waters
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, UK
    Biochem J 398:55-62. 2006
    ..These findings demonstrate that trafficking of LPA1 to the nucleus is influenced by cell-matrix interactions and that nuclear LPA1 may be involved in regulating intranuclear protein phosphorylation and signalling...
  17. ncbi Nerve growth factor signaling involves interaction between the Trk A receptor and lysophosphatidate receptor 1 systems: nuclear translocation of the lysophosphatidate receptor 1 and Trk A receptors in pheochromocytoma 12 cells
    Noreen Akhtar Moughal
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow G4 ONR, UK
    Cell Signal 16:127-36. 2004
    ..Taken together, these findings suggest that NGF and LPA exert cross-talk regulation both at the level of p42/p44 MAPK signaling and in the nuclear translocation of LPA(1) and Trk A receptors...
  18. ncbi The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor
    Jaclyn S Long
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Prostaglandins Other Lipid Mediat 80:74-80. 2006
    ..These findings resolve an important issue regarding the functional role of the S1P(1) receptor in regulating MEF migration and suggest an important role within the context of PDGFbeta receptor-S1P(1) receptor complex signaling...
  19. ncbi Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells
    Noreen A Moughal
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Glasgow, UK
    J Neurochem 98:1920-9. 2006
    ..These findings suggest a novel role for the constitutively active LPA(1) receptor in regulating NGF-induced neuronal differentiation...
  20. ncbi Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer
    Jan Ohotski
    Cell Biology Group, SIPBS, University of Strathclyde, Glasgow, United Kingdom
    Int J Cancer 132:605-16. 2013
    ..These findings identify potential novel biomarker associations, which might serve as new targets for drug intervention designed to improve treatment of estrogen receptor-positive breast cancer...
  21. ncbi Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools
    Jaclyn Long
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Biochem J 391:25-32. 2005
    ..Taken together, these data are consistent with an important role for LPP2 and LPP3 in regulating an intracellular pool of PA and S1P respectively, that may govern the apoptotic status of the cell upon serum deprivation...
  22. ncbi FTY720 analogues as sphingosine kinase 1 inhibitors: enzyme inhibition kinetics, allosterism, proteasomal degradation, and actin rearrangement in MCF-7 breast cancer cells
    Keng G Lim
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland, United Kingdom
    J Biol Chem 286:18633-40. 2011
    ..These findings are discussed in relation to the anticancer properties of SK1 inhibitors...
  23. ncbi Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration
    Jaclyn S Long
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK
    Biochem J 394:495-500. 2006
    ..Therefore the physiological changes in the expression levels of LPP1 might represent a heterologous desensitization mechanism for attenuating PKC-mediated signalling and regulation of cell migration...
  24. ncbi The effect of RGS12 on PDGFbeta receptor signalling to p42/p44 mitogen activated protein kinase in mammalian cells
    Balwinder S Sambi
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, UK
    Cell Signal 18:971-81. 2006
    ..These findings suggest that RGS12 via its PDZ/PTB domain N-terminus may regulate trafficking of the PDGFbeta receptor in ASM cells...
  25. ncbi The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells
    David G Watson
    Cell Biology Group and Pharmaceutical Analysis and Metabolomics Research Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK
    Cell Signal 25:1011-7. 2013
    ..We conclude that SK1 functions to increase the stability of c-Myc and suppresses Ap3A formation, which might maintain the Warburg effect and cell survival, while SK2 exhibits a non-overlapping function...
  26. ncbi (R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells
    Keng Gat Lim
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, UK
    Cell Signal 23:1590-5. 2011
    ..These findings demonstrate that SK2 functions as a pro-survival protein and is involved in promoting actin rearrangement into membrane ruffles/lamellipodia in response to S1P in MCF-7 breast cancer cells...
  27. ncbi The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells
    Maqsood Ahmad
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, UK
    Prostaglandins Other Lipid Mediat 79:278-86. 2006
    ..Therefore, we have demonstrated for the first time that hypoxia can lead to marked changes in the expression of genes involved in S1P production and may modify post S1P receptor signal transduction pathways...
  28. ncbi Experimental systems for studying the role of G-protein-coupled receptors in receptor tyrosine kinase signal transduction
    Nigel J Pyne
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Glasgow, Scotland
    Methods Enzymol 390:451-75. 2004
    ..This article highlights experimental approaches used to investigate this novel mechanism of cross-talk between receptor tyrosine kinases and GPCRs...
  29. ncbi The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor
    Kah Fei Wan
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 ONR, Scotland, United Kingdom
    J Biol Chem 278:18658-63. 2003
    ....
  30. ncbi Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells
    Nigel J Pyne
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow G4 0NR, UK
    Adv Enzyme Regul 47:271-80. 2007
  31. ncbi Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells
    Catherine Waters
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, Scotland, United Kingdom
    J Biol Chem 278:6282-90. 2003
    ....
  32. ncbi The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells
    Carolyn Loveridge
    Cell Biology Group, Univesity of Strathclyde, Glasgow G4 0RE, United Kingdom
    J Biol Chem 285:38841-52. 2010
    ....
  33. ncbi The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia
    Robert A McDonald
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4 0NR, Scotland, UK
    Br J Pharmacol 159:543-53. 2010
    ..Here, we evaluate the effect of d-erythro-N,N-dimethylsphingosine (DMS), a sphingosine kinase (SK) inhibitor, on VSMC proliferation, apoptosis and neointimal formation...
  34. ncbi The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division
    Laura Gillies
    Cell Biology Group, SIPBS, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, UK
    Cell Signal 21:675-84. 2009
    ..We therefore propose that the centrosomal S1P(5) receptor might function as an intracellular target of S1P linked to regulation of mitosis...
  35. ncbi Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival
    Keng Gat Lim
    Cell Biology and Pharmaceutical Sciences Groups, Strathclyde Institute of Pharmacy and Biomedical Science, University of Strathclyde, Glasgow, UK
    Br J Pharmacol 166:1605-16. 2012
    ..We have assessed the effect of the anti-cancer agent, resveratrol and its dimers (ampelopsin A and balanocarpol) on sphingosine kinase 1 activity and on survival of MCF-7 breast cancer cells...
  36. ncbi The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction
    Catherine Waters
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 ONR, Scotland, UK
    Semin Cell Dev Biol 15:309-23. 2004
    ..This review highlights this novel mechanism of cross talk between receptor tyrosine kinases and GPCRs, which is distinct from growth factor receptor transactivation by GPCRs...
  37. ncbi Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination
    Nigel J Pyne
    Cell Biology Group, SIPBS, University of Strathclyde, 27 Taylor Street, Glasgow, G4 0NR, Scotland, UK
    Biochim Biophys Acta 1781:467-76. 2008
    ....
  38. ncbi The sphingosine kinase inhibitor 2-(p-hyroxyanilino)-4-(p-chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress-dependent mechanism
    Francesca Tonelli
    Cell Biology and Pharmaceutical Analysis and Metabolomics Groups, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Br J Pharmacol 168:1497-505. 2013
    ..Therefore, we investigated the effect of sphingosine kinase inhibitors on androgen receptor expression...
  39. ncbi Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function
    Jaclyn S Long
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, Scotland, UK
    Biochem J 411:371-7. 2008
    ....
  40. ncbi Translational aspects of sphingosine 1-phosphate biology
    Susan Pyne
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK
    Trends Mol Med 17:463-72. 2011
    ..This review describes fundamental aspects of S1P biology with an emphasis on the translational potential of intervention therapeutics...
  41. ncbi Sphingosine 1-phosphate receptors and sphingosine kinase 1: novel biomarkers for clinical prognosis in breast, prostate, and hematological cancers
    Susan Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde Glasgow, UK
    Front Oncol 2:168. 2012
    ..These findings suggest that S1P, in addition to being a biomarker of clinical prognosis, might also be a new therapeutic target for intervention in cancer...
  42. ncbi An assessment of the role of the inhibitory gamma subunit of the retinal cyclic GMP phosphodiesterase and its effect on the p42/p44 mitogen-activated protein kinase pathway in animal and cellular models of pulmonary hypertension
    Fiona Murray
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 ONR, Scotland
    Br J Pharmacol 138:1313-9. 2003
    ..Future studies will focus on strategies designed to knockout rod PDEgamma to assess whether this rescues rats from chronic hypoxic-dependent changes in arterial remodelling and PHT...
  43. ncbi Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors
    Susan Pyne
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Scotland, Glasgow, UK
    Biochim Biophys Acta 1582:121-31. 2002
    ..This tethered receptor complex enables coincident integrative signalling to p42/p44 MAPK. This is compared with a sequential model in which PDGF promotes S1P release, which in turn acts on S1P(1) to promote Rac signalling...
  44. ncbi Cyclic AMP signaling in pancreatic islets
    Brian Furman
    Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow G4ONR, Scotland, UK
    Adv Exp Med Biol 654:281-304. 2010
    ..This chapter discusses the formation, destruction and actions of cAMP in the islets with particular emphasis on the beta-cell...
  45. ncbi The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism
    Abdullah A Y Gibriel
    Strathclyde Institute of Pharmacy and Biomedical Sciences SIPBS, University of Strathclyde, Glasgow, G4 0NR, Scotland, UK
    Gene 515:155-8. 2013
    ..The aim of the present study is to probe the potential association between previously-reported GARP2 mutations and retinitis pigmentosa (RP) using Scottish RP patients and controls...
  46. ncbi New perspectives on the role of sphingosine 1-phosphate in cancer
    Susan Pyne
    Cell Biology Group, SIPBS, University of Strathclyde, 161 Cathedral St, Glasgow, UK
    Handb Exp Pharmacol 216:55-71. 2013
    ..The potential of this S1P-dependent pathophysiology as a therapeutic target for the treatment of cancer is also discussed...
  47. ncbi Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1)
    Mhairi J Frame
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, Scotland, UK
    Eur J Biochem 270:962-70. 2003
    ..From this, we can predict that a caspase-3-mediated cleavage of the [778]DQGD[781] motif would result in removal of the C-terminal tail containing Q807 and F810, which are potentially important amino acids required for substrate binding...
  48. ncbi Selectivity and specificity of sphingosine 1-phosphate receptor ligands: "off-targets" or complex pharmacology?
    Nigel J Pyne
    Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde Glasgow, UK
    Front Pharmacol 2:26. 2011
    ..Here we highlight the complex pharmacology of S1P receptors, which along with "inside-out" signaling might provide an alternative explanation for "off-target" effects...