N Purandare

..The authors investigated the effect of cerebral emboli on cognitive and functional decline in both Alzheimer's disease and vascular dementia patients over a 2-year period...

..The study aims to quantify the population impact of prescribing cholinesterase inhibitors to slow the cognitive decline in Alzheimer's disease (AD), and to compare with the benefit of treating hypertension to prevent the onset of AD...

..Dementia, Alzheimer's disease and vascular dementia being two main causes, is major and growing health problem. Vascular risk factors are thought to be involved in the causation of both dementias...

..SCE may represent a potentially treatable target to slow and possibly prevent dementia, both AD and VaD...

..Knowledge of suicide in people with dementia is limited to small case series...

..Mental illness and cognitive impairment are risk factors for poor dental health...

..Spontaneous cerebral emboli (SCE) are frequent in Alzheimer's disease (AD) and vascular dementia (VaD). We investigated the effect of SCE on the rates of cognitive and functional decline in AD and VaD...

..The aim of this study was to examine knowledge of dementia in South Asian older people, as compared with Caucasian older people...

..To examine the association between the angiotensin-converting enzyme (ACE) deletion/insertion (D/I) polymorphism and white matter hyperintensities (WMHs) in patients with dementia...

..The vascular depression hypothesis and our recent findings of increased frequency of spontaneous cerebral emboli in dementia suggest that such emboli may be involved in the causation of depressive symptoms in dementia...

..We reviewed the potential role of paradoxical embolization in AD...

..The implementation of the original NICE (2001) guidance that made these drugs available in the UK was not examined in this review process, and was the objective of this study...

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..Facilitating activities that are enjoyed by both patients with dementia and spouses may be an alternative intervention strategy to reduce carer burden...

..In addition, there is a significant negative correlation between SCE and DWMH in VaD, which supports the hypothesis that VaD may be the result of ischaemic injury, predominantly reflecting embolic aetiology...

..CONCLUSION: Depressive symptoms occur in AD when co-existing depression is ruled out. Their recognition has implications for the diagnosis of major depression in these patients...

..Asymptomatic spontaneous cerebral emboli (SCE) are common in dementia and are associated with cognitive decline in dementia. The significance of their presence in older people is unknown...

..To determine whether musculoskeletal pain was associated with impaired sexual function in a population sample of middle-aged and older men...

..This study therefore aimed to explore coping in older patients with psychosis...

..80 to 3.07) and 1.67 (0.81 to 3.41). CONCLUSION: Spontaneous cerebral emboli were significantly associated with both Alzheimer's disease and vascular dementia. They may represent a potentially preventable or treatable cause of dementia...

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..Patients, their carers, and clinicians deserve to be optimistic in a field which often attracts therapeutic nihilism...

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..To examine whether asymptomatic spontaneous cerebral emboli (SCE) predicts subsequent depression in older people...

..Although there is a plethora of published research on the topic, results have been inconsistent with different studies reporting positive, negative or no effects of sex hormones on various aspects of mental agility...

..Further double blind prospective studies are needed to understand natural progression of personality changes in AD and to validate the findings of this study...

..44, was highest in the 60-69 years age class, progressively decreasing either side of this age group. APOE epsilon4 allele therefore has its maximum impact between onset ages of between 60 and 70 years...

..To assess perceived need and adequacy of service provision by old age psychiatrists (OAPs) to older people living in care homes in the UK...

..To investigate whether orofacial tardive dyskinesia (OTD) is associated with frontal lobe dysfunction and whether either are related to the coping abilities independent of psychiatric symptoms in older people with psychotic disorders...

..Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function. We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men...

..The aim of the study was to investigate whether possession of the epsilon4 allelic form of the apolipoprotein E (APOE) gene increases the risk of developing vascular dementia (VaD)...