Sarah M Puddicombe

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium
    Sarah M Puddicombe
    The Brooke Laboratory, Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 28:61-8. 2003
  2. ncbi request reprint Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis
    Fabio Bucchieri
    School of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 27:179-85. 2002
  3. ncbi request reprint Beta-catenin/T-cell factor-mediated transcription is modulated by cell density in human bronchial epithelial cells
    Mark D Steel
    The Brooke Laboratories, School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Biochem Cell Biol 37:1281-95. 2005
  4. ncbi request reprint Characterization of ciliated bronchial epithelium 1, a ciliated cell-associated gene induced during mucociliary differentiation
    Hajime Yoshisue
    Infection, Inflammation, and Repair Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 31:491-500. 2004
  5. ncbi request reprint Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells
    James L Lordan
    School of Medicine, Respiratory Cell and Molecular Biology Division, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 169:407-14. 2002
  6. doi request reprint Defective epithelial barrier function in asthma
    Chang Xiao
    Synairgen Research Ltd, Southampton General Hospital, Southampton, United Kingdom
    J Allergy Clin Immunol 128:549-56.e1-12. 2011
  7. ncbi request reprint Airway remodeling in asthma: new insights
    Donna E Davies
    Brooke Laboratories, Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    J Allergy Clin Immunol 111:215-25; quiz 226. 2003
  8. ncbi request reprint Kinetic analysis of the interleukin-13 receptor complex
    Allison Lynn Andrews
    Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, 97 Tremona Rd, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Biol Chem 277:46073-8. 2002
  9. doi request reprint Tumor necrosis factor alpha (TNF-α) autoregulates its expression and induces adhesion molecule expression in asthma
    Suresh K Babu
    The Brooke Laboratories, Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
    Clin Immunol 140:18-25. 2011
  10. ncbi request reprint Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects
    Riccardo Polosa
    School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, United Kingdom
    J Allergy Clin Immunol 109:75-81. 2002

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium
    Sarah M Puddicombe
    The Brooke Laboratory, Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 28:61-8. 2003
    ..We conclude that p21(waf) overexpression in asthma influences cell proliferation and survival. This may cause abnormal repair responses that contribute to airway inflammation and remodeling...
  2. ncbi request reprint Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis
    Fabio Bucchieri
    School of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 27:179-85. 2002
    ..This susceptibility may contribute to the rising trends in asthma associated with air pollution and diets low in antioxidants...
  3. ncbi request reprint Beta-catenin/T-cell factor-mediated transcription is modulated by cell density in human bronchial epithelial cells
    Mark D Steel
    The Brooke Laboratories, School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Biochem Cell Biol 37:1281-95. 2005
    ..Recognising that many chronic inflammatory disorders of the airways involve epithelial damage and repair, altered Wnt signalling might contribute to disease pathogenesis or progression...
  4. ncbi request reprint Characterization of ciliated bronchial epithelium 1, a ciliated cell-associated gene induced during mucociliary differentiation
    Hajime Yoshisue
    Infection, Inflammation, and Repair Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 31:491-500. 2004
    ..Regulated expression during differentiation and the subcellular localization of CBE1 suggest that it may play an important role in the differentiation and/or function of ciliated cells in human airways...
  5. ncbi request reprint Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells
    James L Lordan
    School of Medicine, Respiratory Cell and Molecular Biology Division, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 169:407-14. 2002
    ....
  6. doi request reprint Defective epithelial barrier function in asthma
    Chang Xiao
    Synairgen Research Ltd, Southampton General Hospital, Southampton, United Kingdom
    J Allergy Clin Immunol 128:549-56.e1-12. 2011
    ..The bronchial epithelium forms the interface with the external environment and is pivotally involved in controlling tissue homeostasis through provision of a physical barrier controlled by tight junction (TJ) complexes...
  7. ncbi request reprint Airway remodeling in asthma: new insights
    Donna E Davies
    Brooke Laboratories, Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    J Allergy Clin Immunol 111:215-25; quiz 226. 2003
    ....
  8. ncbi request reprint Kinetic analysis of the interleukin-13 receptor complex
    Allison Lynn Andrews
    Infection, Inflammation and Repair Division, School of Medicine, University of Southampton, 97 Tremona Rd, Southampton General Hospital, Southampton SO16 6YD, United Kingdom
    J Biol Chem 277:46073-8. 2002
    ....
  9. doi request reprint Tumor necrosis factor alpha (TNF-α) autoregulates its expression and induces adhesion molecule expression in asthma
    Suresh K Babu
    The Brooke Laboratories, Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton General Hospital, Southampton, SO16 6YD, UK
    Clin Immunol 140:18-25. 2011
    ..03) and this was reduced in the presence of CDP-870. So, allergen exposure up-regulates TNF-α expression in asthma and down-stream targets, including adhesion molecules that contribute to airway inflammation...
  10. ncbi request reprint Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects
    Riccardo Polosa
    School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, United Kingdom
    J Allergy Clin Immunol 109:75-81. 2002
    ..The c-erbB family of receptor tyrosine kinases act in a combinatorial fashion to regulate cell behavior. Disturbances in this system have been associated with neoplastic and inflammatory diseases...