N Proudfoot

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint The spanish connection: transcription and mRNA processing get even closer
    Manuel Ares
    Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Cell 120:163-6. 2005
  2. ncbi request reprint Gene silencing CUTs both ways
    Nick Proudfoot
    Sir William Dunn School of Pathology, South Parks Rd, OX1 3RE, University of Oxford, Oxford, UK
    Cell 131:649-51. 2007
  3. doi request reprint Terminating transcription in yeast: whether to be a 'nerd' or a 'rat'
    Ana G Rondon
    Nat Struct Mol Biol 15:775-6. 2008
  4. pmc Definition of RNA polymerase II CoTC terminator elements in the human genome
    Takayuki Nojima
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE Oxford, UK
    Cell Rep 3:1080-92. 2013
  5. pmc Yeast Sen1 helicase protects the genome from transcription-associated instability
    Hannah E Mischo
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Mol Cell 41:21-32. 2011
  6. pmc Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination
    Konstantina Skourti-Stathaki
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Mol Cell 42:794-805. 2011
  7. pmc Fail-safe transcriptional termination for protein-coding genes in S. cerevisiae
    Ana G Rondon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Mol Cell 36:88-98. 2009
  8. pmc Transcription-dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signals
    Kelly J Perkins
    Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford OX1 3RE, UK
    Mol Cell 29:56-68. 2008
  9. pmc Molecular dissection of mammalian RNA polymerase II transcriptional termination
    Steven West
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Mol Cell 29:600-10. 2008
  10. pmc Transcriptional termination enhances protein expression in human cells
    Steven West
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX13RE, UK
    Mol Cell 33:354-64. 2009

Collaborators

  • Jane Mellor
  • Nicholas A Kent
  • Monika Gullerova
  • Antonin Morillon
  • Hiroshi Kimura
  • Manuel Ares
  • Kelly J Perkins
  • Steven West
  • Ana G Rondon
  • Natalia Gromak
  • Michael J Dye
  • Hannah E Mischo
  • Junya Kawauchi
  • Elizabeth M Prescott
  • Hannah S Jones
  • Takayuki Nojima
  • Konstantina Skourti-Stathaki
  • Justin M O'Sullivan
  • Mariangela Morlando
  • Andre Furger
  • Priscilla Braglia
  • Shona Murphy
  • Claudia M Alen
  • Kathryn E Plant
  • Alexandre Teixeira
  • Benjamin Thomas
  • Alexandre Akoulitchev
  • Kon Yew Kwek
  • Martin Dienstbier
  • A Aranda
  • Pawel Grzechnik
  • Wu Wei
  • Andres Aguilera
  • Lars Steinmetz
  • Belén Gómez-González
  • Irene Bozzoni
  • Francesca Pagano
  • Hannah Mischo
  • Monica Ballarino
  • Ana Rondon
  • Kenneth Zaret
  • Celina Lafaille
  • Barbara Lee
  • Aroul Ramadass
  • Igor Martianov
  • Abdessamad Tahiri-Alaoui
  • Yvonne N Osheim
  • Joel Coles
  • Steve West
  • William James
  • Mick Dye
  • Ronald H Reeder
  • Judith G Roan
  • Ann L Beyer
  • Sue Mei Tan-Wong
  • Barbara A Lee
  • William O'Gorman
  • Alexandra Binnie

Detail Information

Publications31

  1. ncbi request reprint The spanish connection: transcription and mRNA processing get even closer
    Manuel Ares
    Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
    Cell 120:163-6. 2005
    ....
  2. ncbi request reprint Gene silencing CUTs both ways
    Nick Proudfoot
    Sir William Dunn School of Pathology, South Parks Rd, OX1 3RE, University of Oxford, Oxford, UK
    Cell 131:649-51. 2007
    ..In this issue, Camblong et al. (2007) demonstrate in the budding yeast that antisense transcripts, if stabilized by exosome impairment, are able to mediate gene silencing via the recruitment of histone deacetylases...
  3. doi request reprint Terminating transcription in yeast: whether to be a 'nerd' or a 'rat'
    Ana G Rondon
    Nat Struct Mol Biol 15:775-6. 2008
  4. pmc Definition of RNA polymerase II CoTC terminator elements in the human genome
    Takayuki Nojima
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE Oxford, UK
    Cell Rep 3:1080-92. 2013
    ..The results of this analysis pave the way for the full understanding of Pol II termination pathways and their roles in gene expression...
  5. pmc Yeast Sen1 helicase protects the genome from transcription-associated instability
    Hannah E Mischo
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Mol Cell 41:21-32. 2011
    ..Based on these findings, we propose that R loop formation is a frequent event during transcription and a key function of Sen1 is to prevent their accumulation and associated genome instability...
  6. pmc Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination
    Konstantina Skourti-Stathaki
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
    Mol Cell 42:794-805. 2011
    ..This affords 3' transcript degradation and consequent Pol II termination. In effect, R-loops formed over G-rich pause sites, followed by their resolution by senataxin, are key steps in the termination process...
  7. pmc Fail-safe transcriptional termination for protein-coding genes in S. cerevisiae
    Ana G Rondon
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Mol Cell 36:88-98. 2009
    ..We propose that these alternative Pol II termination pathways serve the dual function of avoiding transcription interference and promoting rapid removal of aberrant transcripts...
  8. pmc Transcription-dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signals
    Kelly J Perkins
    Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford OX1 3RE, UK
    Mol Cell 29:56-68. 2008
    ..Overall, we demonstrate that both ongoing transcription and pre-mRNA processing are essential for gene loop formation, and predict that these structures represent a defining feature of active gene transcription...
  9. pmc Molecular dissection of mammalian RNA polymerase II transcriptional termination
    Steven West
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
    Mol Cell 29:600-10. 2008
    ....
  10. pmc Transcriptional termination enhances protein expression in human cells
    Steven West
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX13RE, UK
    Mol Cell 33:354-64. 2009
    ..We establish that termination of Pol II increases the efficiency of pre-mRNA processing that is completed posttranscriptionally. As such, transcripts escape from nuclear surveillance...
  11. pmc Ending the message: poly(A) signals then and now
    Nick J Proudfoot
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Genes Dev 25:1770-82. 2011
    ....
  12. ncbi request reprint Connecting transcription to messenger RNA processing
    N Proudfoot
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK OX1 3RE
    Trends Biochem Sci 25:290-3. 2000
    ..The processing of mRNA is therefore orchestrated to act on the nascent RNA as soon as it emerges from the polymerase complex...
  13. ncbi request reprint Integrating mRNA processing with transcription
    Nick J Proudfoot
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Cell 108:501-12. 2002
    ..The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout transcriptional elongation and termination...
  14. pmc Pause sites promote transcriptional termination of mammalian RNA polymerase II
    Natalia Gromak
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Mol Cell Biol 26:3986-96. 2006
    ..Taken together, we provide new insights into the mechanism of pause site-mediated termination and establish a general role for the 5'-->3' exonuclease Xrn2 in Pol II termination...
  15. ncbi request reprint Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites
    Steven West
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 432:522-5. 2004
    ..Degradation of the downstream cleavage product by Xrn2 results in transcriptional termination, as envisaged in the torpedo model...
  16. ncbi request reprint Gene loops juxtapose promoters and terminators in yeast
    Justin M O'Sullivan
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
    Nat Genet 36:1014-8. 2004
    ..They also predict a previously unknown structural dimension to gene regulation, in which both ends of the transcription unit are defined before and during the transcription cycle...
  17. ncbi request reprint Transcriptional termination factors for RNA polymerase II in yeast
    A Aranda
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Mol Cell 7:1003-11. 2001
    ..Deletion of res2 in both fission and budding yeast results in a defect in 3' end formation. This raises the possibility that RNAP II transcriptional termination may in some situations be integrated with cell cycle events...
  18. ncbi request reprint Primary microRNA transcripts are processed co-transcriptionally
    Mariangela Morlando
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Struct Mol Biol 15:902-9. 2008
    ....
  19. ncbi request reprint U1 snRNA associates with TFIIH and regulates transcriptional initiation
    Kon Yew Kwek
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Struct Biol 9:800-5. 2002
    ..Our results suggest that U1 snRNA functions in regulating transcription by RNA Polymerase II in addition to its role in RNA processing...
  20. pmc Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional termination
    Junya Kawauchi
    Sir William Dunn School of Pathology, Oxford OX1 3RE, United Kingdom
    Genes Dev 22:1082-92. 2008
    ....
  21. ncbi request reprint Exon tethering in transcription by RNA polymerase II
    Michael J Dye
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Mol Cell 21:849-59. 2006
    ..This observation suggests that for some genes a continuous intron transcript is not required for pre-mRNA splicing in vivo...
  22. pmc Strong polyadenylation and weak pausing combine to cause efficient termination of transcription in the human Ggamma-globin gene
    Kathryn E Plant
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Mol Cell Biol 25:3276-85. 2005
    ..Instead we find evidence that the 3' flank of the Ggamma-globin gene contains multiple weak pause elements which, combined with the strong polyA signal the gene possesses, are likely to cause gradual termination across the 3' flank...
  23. pmc Promoter proximal splice sites enhance transcription
    Andre Furger
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Genes Dev 16:2792-9. 2002
    ..This further establishes that mRNA processing and transcription are tightly coupled mechanisms...
  24. pmc Transcriptional collision between convergent genes in budding yeast
    Elizabeth M Prescott
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 99:8796-801. 2002
    ..These data reinforce the necessity of separating adjacent RNA polymerase II transcription units by efficient termination signals...
  25. doi request reprint Cohesin complex promotes transcriptional termination between convergent genes in S. pombe
    Monika Gullerova
    Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford OX1 3RE, UK
    Cell 132:983-95. 2008
    ..Our results uncover a hitherto unanticipated role for cohesin and further suggest a widespread role for the selective formation of dsRNA, heterochromatin, and subsequent cohesin recruitment in regulated transcriptional termination...
  26. pmc Transcriptional termination by RNA polymerase I requires the small subunit Rpa12p
    Elizabeth M Prescott
    Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, United Kingdom
    Proc Natl Acad Sci U S A 101:6068-73. 2004
    ..The homology of Rpa12p to the small subunit Rpb9p of Pol II and Rpc11p of Pol III, both implicated in transcriptional termination, points to a common termination mechanism for all three classes of RNA polymerase...
  27. ncbi request reprint RNA polymerase I in yeast transcribes dynamic nucleosomal rDNA
    Hannah S Jones
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nat Struct Mol Biol 14:123-30. 2007
    ..We suggest that Pol I transcription, like that of Pol II, may be modulated by specific chromatin structures...
  28. pmc Transcriptional termination sequences in the mouse serum albumin gene
    Steven West
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    RNA 12:655-65. 2006
    ..Many transcripts from this region are cleaved cotranscriptionally, implying that such cleavage of pre-mRNA may be a more general feature of transcriptional termination...
  29. ncbi request reprint Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription termination
    Alexandre Teixeira
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Nature 432:526-30. 2004
    ....
  30. ncbi request reprint Dawdling polymerases allow introns time to splice
    Nick J Proudfoot
    Nat Struct Biol 10:876-8. 2003
  31. doi request reprint Nuclear roadblocks for mRNA export
    Ana G Rondon
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Cell 135:207-8. 2008
    ..The THO complex and Sub2 RNA helicase have been shown to function in both transcription and mRNA processing. Rougemaille et al. (2008) now uncover evidence that THO/Sub2 coordinates mRNA processing and nuclear export...