Research Topics
| N ProudfootSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
The spanish connection: transcription and mRNA processing get even closerManuel Ares
Department of Molecular Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA
Cell 120:163-6. 2005....- Gene silencing CUTs both waysNick Proudfoot
Sir William Dunn School of Pathology, South Parks Rd, OX1 3RE, University of Oxford, Oxford, UK
Cell 131:649-51. 2007..In this issue, Camblong et al. (2007) demonstrate in the budding yeast that antisense transcripts, if stabilized by exosome impairment, are able to mediate gene silencing via the recruitment of histone deacetylases... - Terminating transcription in yeast: whether to be a 'nerd' or a 'rat'Ana G Rondon
Nat Struct Mol Biol 15:775-6. 2008 
Yeast Sen1 helicase protects the genome from transcription-associated instabilityHannah E Mischo
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Mol Cell 41:21-32. 2011..Based on these findings, we propose that R loop formation is a frequent event during transcription and a key function of Sen1 is to prevent their accumulation and associated genome instability...- Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent terminationKonstantina Skourti-Stathaki
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK
Mol Cell 42:794-805. 2011..This affords 3' transcript degradation and consequent Pol II termination. In effect, R-loops formed over G-rich pause sites, followed by their resolution by senataxin, are key steps in the termination process... - Fail-safe transcriptional termination for protein-coding genes in S. cerevisiaeAna G Rondon
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Mol Cell 36:88-98. 2009..We propose that these alternative Pol II termination pathways serve the dual function of avoiding transcription interference and promoting rapid removal of aberrant transcripts... - Molecular dissection of mammalian RNA polymerase II transcriptional terminationSteven West
Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, UK
Mol Cell 29:600-10. 2008.... - Transcription-dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signalsKelly J Perkins
Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford OX1 3RE, UK
Mol Cell 29:56-68. 2008..Overall, we demonstrate that both ongoing transcription and pre-mRNA processing are essential for gene loop formation, and predict that these structures represent a defining feature of active gene transcription... - Transcriptional termination enhances protein expression in human cellsSteven West
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX13RE, UK
Mol Cell 33:354-64. 2009..We establish that termination of Pol II increases the efficiency of pre-mRNA processing that is completed posttranscriptionally. As such, transcripts escape from nuclear surveillance... - Connecting transcription to messenger RNA processingN Proudfoot
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK OX1 3RE
Trends Biochem Sci 25:290-3. 2000..The processing of mRNA is therefore orchestrated to act on the nascent RNA as soon as it emerges from the polymerase complex... - Ending the message: poly(A) signals then and nowNick J Proudfoot
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
Genes Dev 25:1770-82. 2011.... - Integrating mRNA processing with transcriptionNick J Proudfoot
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
Cell 108:501-12. 2002..The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout transcriptional elongation and termination... - Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sitesSteven West
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nature 432:522-5. 2004..Degradation of the downstream cleavage product by Xrn2 results in transcriptional termination, as envisaged in the torpedo model... - Pause sites promote transcriptional termination of mammalian RNA polymerase IINatalia Gromak
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
Mol Cell Biol 26:3986-96. 2006..Taken together, we provide new insights into the mechanism of pause site-mediated termination and establish a general role for the 5'-->3' exonuclease Xrn2 in Pol II termination... - Gene loops juxtapose promoters and terminators in yeastSue Mei Tan-Wong
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, UK
Nat Genet 36:1014-8. 2004..They also predict a previously unknown structural dimension to gene regulation, in which both ends of the transcription unit are defined before and during the transcription cycle... - Transcriptional termination factors for RNA polymerase II in yeastA Aranda
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
Mol Cell 7:1003-11. 2001..Deletion of res2 in both fission and budding yeast results in a defect in 3' end formation. This raises the possibility that RNAP II transcriptional termination may in some situations be integrated with cell cycle events... - Strong polyadenylation and weak pausing combine to cause efficient termination of transcription in the human Ggamma-globin geneKathryn E Plant
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
Mol Cell Biol 25:3276-85. 2005..Instead we find evidence that the 3' flank of the Ggamma-globin gene contains multiple weak pause elements which, combined with the strong polyA signal the gene possesses, are likely to cause gradual termination across the 3' flank... - U1 snRNA associates with TFIIH and regulates transcriptional initiationKon Yew Kwek
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nat Struct Biol 9:800-5. 2002..Our results suggest that U1 snRNA functions in regulating transcription by RNA Polymerase II in addition to its role in RNA processing... - Primary microRNA transcripts are processed co-transcriptionallyMariangela Morlando
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nat Struct Mol Biol 15:902-9. 2008.... - Budding yeast RNA polymerases I and II employ parallel mechanisms of transcriptional terminationJunya Kawauchi
Sir William Dunn School of Pathology, Oxford OX1 3RE, United Kingdom
Genes Dev 22:1082-92. 2008.... - Exon tethering in transcription by RNA polymerase IIMichael J Dye
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
Mol Cell 21:849-59. 2006..This observation suggests that for some genes a continuous intron transcript is not required for pre-mRNA splicing in vivo... - Promoter proximal splice sites enhance transcriptionAndre Furger
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
Genes Dev 16:2792-9. 2002..This further establishes that mRNA processing and transcription are tightly coupled mechanisms... - Autocatalytic RNA cleavage in the human beta-globin pre-mRNA promotes transcription terminationAlexandre Teixeira
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nature 432:526-30. 2004.... - Transcriptional collision between convergent genes in budding yeastElizabeth M Prescott
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
Proc Natl Acad Sci U S A 99:8796-801. 2002..These data reinforce the necessity of separating adjacent RNA polymerase II transcription units by efficient termination signals... - Transcriptional termination sequences in the mouse serum albumin geneSteven West
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
RNA 12:655-65. 2006..Many transcripts from this region are cleaved cotranscriptionally, implying that such cleavage of pre-mRNA may be a more general feature of transcriptional termination... - RNA polymerase I in yeast transcribes dynamic nucleosomal rDNAHannah S Jones
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nat Struct Mol Biol 14:123-30. 2007..We suggest that Pol I transcription, like that of Pol II, may be modulated by specific chromatin structures... - Transcriptional termination by RNA polymerase I requires the small subunit Rpa12pElizabeth M Prescott
Sir William Dunn School of Pathology, South Parks Road, Oxford OX1 3RE, United Kingdom
Proc Natl Acad Sci U S A 101:6068-73. 2004..The homology of Rpa12p to the small subunit Rpb9p of Pol II and Rpc11p of Pol III, both implicated in transcriptional termination, points to a common termination mechanism for all three classes of RNA polymerase... 
Cohesin complex promotes transcriptional termination between convergent genes in S. pombeMonika Gullerova
Sir William Dunn School of Pathology, University of Oxford, South Parks Rd, Oxford OX1 3RE, UK
Cell 132:983-95. 2008..Our results uncover a hitherto unanticipated role for cohesin and further suggest a widespread role for the selective formation of dsRNA, heterochromatin, and subsequent cohesin recruitment in regulated transcriptional termination...- Dawdling polymerases allow introns time to spliceNick J Proudfoot
Nat Struct Biol 10:876-8. 2003 - Nuclear roadblocks for mRNA exportAna G Rondon
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
Cell 135:207-8. 2008..The THO complex and Sub2 RNA helicase have been shown to function in both transcription and mRNA processing. Rougemaille et al. (2008) now uncover evidence that THO/Sub2 coordinates mRNA processing and nuclear export...