Diane Proudfoot

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi Acetylated low-density lipoprotein stimulates human vascular smooth muscle cell calcification by promoting osteoblastic differentiation and inhibiting phagocytosis
    D Proudfoot
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Circulation 106:3044-50. 2002
  2. ncbi Calcification of human vascular cells in vitro is correlated with high levels of matrix Gla protein and low levels of osteopontin expression
    D Proudfoot
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, England
    Arterioscler Thromb Vasc Biol 18:379-88. 1998
  3. ncbi Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies
    D Proudfoot
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Circ Res 87:1055-62. 2000
  4. ncbi The role of apoptosis in the initiation of vascular calcification
    D Proudfoot
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Level 6, ACCI Building, Hills Road, Cambridge CB2 2QQ, UK
    Z Kardiol 90:43-6. 2001
  5. ncbi Molecular mechanisms mediating vascular calcification: role of matrix Gla protein
    Diane Proudfoot
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Hospital ACCI, Level 6, Cambridge, UK
    Nephrology (Carlton) 11:455-61. 2006
  6. ncbi Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization
    Alexandra E Ewence
    Division of Cardiovascular Medicine, University of Cambridge, ACCI Building, Level 6, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Circ Res 103:e28-34. 2008
  7. ncbi Mineral surface in calcified plaque is like that of bone: further evidence for regulated mineralization
    Melinda J Duer
    Department of Chemistry, University of Cambridge, Cambridge, UK
    Arterioscler Thromb Vasc Biol 28:2030-4. 2008
  8. ncbi Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells
    John D Davies
    Department of Medicine, University of Cambridge, ACCI, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, United Kingdom
    J Biol Chem 280:3911-9. 2005
  9. ncbi Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD
    Joanne L Reynolds
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Soc Nephrol 15:2857-67. 2004
  10. doi Human vascular smooth muscle cell culture
    Diane Proudfoot
    Department of Medicine, University of Cambridge, Cambridge, UK
    Methods Mol Biol 806:251-63. 2012

Collaborators

Detail Information

Publications10

  1. ncbi Acetylated low-density lipoprotein stimulates human vascular smooth muscle cell calcification by promoting osteoblastic differentiation and inhibiting phagocytosis
    D Proudfoot
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Circulation 106:3044-50. 2002
    ..We therefore tested the hypothesis that lipid components in atherosclerotic lesions influenced VSMC phenotype and calcification using an in vitro model of calcification...
  2. ncbi Calcification of human vascular cells in vitro is correlated with high levels of matrix Gla protein and low levels of osteopontin expression
    D Proudfoot
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, England
    Arterioscler Thromb Vasc Biol 18:379-88. 1998
    ..These studies reveal that human VSMCs are capable of inducing calcification and that MGP may have a role in human vascular calcification...
  3. ncbi Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodies
    D Proudfoot
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Circ Res 87:1055-62. 2000
    ..These observations provide evidence that apoptosis precedes VSMC calcification and that apoptotic bodies derived from VSMCs may act as nucleating structures for calcium crystal formation...
  4. ncbi The role of apoptosis in the initiation of vascular calcification
    D Proudfoot
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Level 6, ACCI Building, Hills Road, Cambridge CB2 2QQ, UK
    Z Kardiol 90:43-6. 2001
    ..These observations suggest that apoptosis is involved in the development of VSMC calcification and that VSMC-derived ABs have similarities with matrix vesicles...
  5. ncbi Molecular mechanisms mediating vascular calcification: role of matrix Gla protein
    Diane Proudfoot
    Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke s Hospital ACCI, Level 6, Cambridge, UK
    Nephrology (Carlton) 11:455-61. 2006
    ..Therefore, strategies aimed at increasing its expression and activity may be beneficial in tipping the balance in favour of inhibition of calcification in CKD...
  6. ncbi Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization
    Alexandra E Ewence
    Division of Cardiovascular Medicine, University of Cambridge, ACCI Building, Level 6, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Circ Res 103:e28-34. 2008
    ....
  7. ncbi Mineral surface in calcified plaque is like that of bone: further evidence for regulated mineralization
    Melinda J Duer
    Department of Chemistry, University of Cambridge, Cambridge, UK
    Arterioscler Thromb Vasc Biol 28:2030-4. 2008
    ..This study was undertaken to compare the poorly understood interface in mineralized plaque with that of bone, which is considerably better characterized...
  8. ncbi Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells
    John D Davies
    Department of Medicine, University of Cambridge, ACCI, Box 110, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, United Kingdom
    J Biol Chem 280:3911-9. 2005
    ..Moreover, the development of an adipogenic phenotype in VSMC is consistent with their known phenotypic plasticity and may contribute to their dysfunction in atherosclerotic plaques and, thus, impinge on plaque growth and stability...
  9. ncbi Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD
    Joanne L Reynolds
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Soc Nephrol 15:2857-67. 2004
    ..These vesicles contain mineralization inhibitors derived from VSMC and serum, and perturbation of the production or function of these inhibitors would lead to accelerated vascular calcification...
  10. doi Human vascular smooth muscle cell culture
    Diane Proudfoot
    Department of Medicine, University of Cambridge, Cambridge, UK
    Methods Mol Biol 806:251-63. 2012
    ..Overall, these procedures enable the investigator to undertake a diverse array of experimental assays on cultured VSMCs...