Research Topics
Species | Christopher G ProudSummaryAffiliation: University of Southampton Country: UK Publications
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Publications
mTORC1 signalling and mRNA translationChristopher G Proud
School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
Biochem Soc Trans 37:227-31. 2009..However, there are still important gaps in our understanding of the actions of mTORC1 and the relative contributions that different targets of mTORC1 make to the activation of protein synthesis remain to be established...
A new link in the chain from amino acids to mTORC1 activationChris G Proud
Centre for Biological Sciences, Life Sciences Building B85, University of Southampton, Southampton SO17 1BJ, UK
Mol Cell 44:7-8. 2011..A recent study reveals that the scaffold protein p62 plays a role in linking nutritional cues (amino acids) to the activation of mammalian target of rapamycin complex 1 (mTORC1), a protein kinase that controls cell size and proliferation...- Dynamic balancing: DEPTOR tips the scalesChristopher G Proud
School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
J Mol Cell Biol 1:61-3. 2009..A recent study identifies a new partner and regulator of mTOR, which can alter the balance of signaling downstream of mTOR and appears to be important in certain cancers, such as multiple myelomas... - mTOR Signalling in Health and DiseaseChristopher G Proud
School of Biological Sciences, Life Sciences Building, University of Southampton, Southampton SO17 1BJ, UK
Biochem Soc Trans 39:431-6. 2011.... - Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesisYilin Huo
Centre for Biological Sciences, University of Southampton, UK
Biochem J 444:141-51. 2012..Lastly, a SILAC-based approach revealed that, although rapamycin and mTOR-KIs have little effect on general protein stability, they stabilize proteins encoded by 5'-TOP mRNAs... - Roles of the mammalian target of rapamycin, mTOR, in controlling ribosome biogenesis and protein synthesisValentina Iadevaia
School of Biological Sciences, Life Sciences Building, Highfield Campus, University of Southampton, Southampton SO17 1BJ, UK
Biochem Soc Trans 40:168-72. 2012..We found that mTORC1 also regulates the processing of the precursors of rRNA. mTORC1 thus co-ordinates several steps in ribosome biogenesis... - Evaluation of mTOR-regulated mRNA translationValentina Iadevaia
School of Biological Sciences, University of Southampton, Southampton, UK
Methods Mol Biol 821:171-85. 2012..A method for the separation of polysomes from non-polysomal mRNAs is described... 
mTOR signaling regulates the processing of pre-rRNA in human cellsValentina Iadevaia
School of Biological Sciences, University of Southampton, SO17 1BJ, UK
Nucleic Acids Res 40:2527-39. 2012..These data show that mTORC1 is located in nucleoli where it acts to regulate events involved in ribosome biogenesis including the maturation of rRNA molecules...- mTOR's role in ageing: protein synthesis or autophagy?Sarah L Hands
School of Biological Sciences, University of Southampton, Southampton, Boldrewood Campus, Basset Crescent East, SO16 7PX, UK
Aging (Albany NY) 1:586-97. 2009..In this article we discuss the relative importance of both these processes in ageing, identify how TOR regulates translation and autophagy and speculate on links between the TOR signaling network and ageing pathways... - Severity of Vanishing White Matter disease does not correlate with deficits in eIF2B activity or the integrity of eIF2B complexesAuthors Rui Liu
Department of Biochemistry, School of Life Sciences, Fudan University, 220 Handan Road, Liren Building 106, Shanghai 200433, PR China School of Biological Sciences, Life Sciences Building, University of Southampton, Southampton, SO17 1BJ, UK Department of Biochemistry and Molecular Biology, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada
Hum Mutat . 2011..2011 Wiley-Liss, Inc... - Identification of residues that underpin interactions within the eukaryotic initiation factor (eIF2) 2B complexXuemin Wang
Centre for Biological Sciences, Life Sciences Building, University of Southampton, Southampton SO17 1BJ, United Kingdom
J Biol Chem 287:8263-74. 2012..Lastly, our data show that eIF2Bγ promotes the expression of eIF2Bε, providing a mechanism for achieving correct stoichiometry of these eIF2B subunits in the cell... - mTORC1 signaling: what we still don't knowXuemin Wang
School of Biological Sciences, Life Sciences Building, University of Southampton, UK
J Mol Cell Biol 3:206-20. 2011.... - Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesisYilin Huo
School of Biological Sciences, University of Southampton, Southampton SO17 1BJ, UK
Biochem Soc Trans 39:446-50. 2011..Synthesis of proteins encoded by 'non-TOP' mRNAs was less inhibited by mTOR kinase inhibitors and especially by rapamycin. The implications of our findings are discussed... - Nutrient control of TORC1, a cell-cycle regulatorXuemin Wang
School of Biological Sciences, University of Southampton, Southampton, UK
Trends Cell Biol 19:260-7. 2009..mTORC1 is known to control the G1/S transition of the cell cycle: new data show that (m)TORC1 also controls G2/M progression in yeast and mammals, albeit in contrasting ways...