Price H, MacLean L, Marrison J, O Toole P, Smith D. Validation of a new method for immobilising kinetoplastid parasites for live cell imaging. Mol Biochem Parasitol. 2010;169:66-9 pubmed publisher
..This allows reproducible live cell imaging of these highly motile organisms, thus enabling a full complement of advanced microscopic techniques to be utilised to better understand these pathogenic species. ..
Price H, Peltan A, Stark M, Smith D. The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei. Mol Biochem Parasitol. 2010;173:123-31 pubmed
..Our data indicate that Arl2 has a fundamentally conserved role in trypanosome microtubule biogenesis that correlates with -tubulin acetylation. ..
Price H, GÃ¼ther M, Ferguson M, Smith D. Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects. Mol Biochem Parasitol. 2010;169:55-8 pubmed publisher
..Critically we show that following NMT knockdown, T. brucei bloodstream form cells are unable to establish an infection in a mouse model, therefore providing further validation of this enzyme as a target for drug development. ..