David J Price

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Evidence that descending cortical axons are essential for thalamocortical axons to cross the pallial-subpallial boundary in the embryonic forebrain
    Yijing Chen
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e33105. 2012
  2. pmc The importance of combinatorial gene expression in early Mammalian thalamic patterning and thalamocortical axonal guidance
    David J Price
    Centre for Integrative Physiology, University of Edinburgh Edinburgh, UK
    Front Neurosci 6:37. 2012
  3. ncbi request reprint The development of cortical connections
    David J Price
    Centre for Integrative Physiology, Hugh Robson Building, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Eur J Neurosci 23:910-20. 2006
  4. ncbi request reprint Lipids make smooth brains gyrate
    David J Price
    Genes and Development Group, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, UK
    Trends Neurosci 27:362-4. 2004
  5. pmc The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice
    Martine Manuel
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 137:487-97. 2010
  6. doi request reprint Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein
    Tian Yu
    Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, Edinburgh, United Kingdom
    J Comp Neurol 512:613-27. 2009
  7. pmc The transcription factor Foxg1 regulates telencephalic progenitor proliferation cell autonomously, in part by controlling Pax6 expression levels
    Martine N Manuel
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Neural Dev 6:9. 2011
  8. doi request reprint Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development
    Christopher D Conway
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 31:1955-70. 2011
  9. pmc Pax6 controls cerebral cortical cell number by regulating exit from the cell cycle and specifies cortical cell identity by a cell autonomous mechanism
    Jane C Quinn
    Genes and Development Group, Department of Biomedical Sciences, Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK
    Dev Biol 302:50-65. 2007
  10. pmc Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization
    Martine Manuel
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh, UK
    Development 134:545-55. 2007

Collaborators

Detail Information

Publications62

  1. pmc Evidence that descending cortical axons are essential for thalamocortical axons to cross the pallial-subpallial boundary in the embryonic forebrain
    Yijing Chen
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e33105. 2012
    ..These results support the hypothesis that thalamic axons grow from subpallium to cortex guided by cortical efferents, with stimulation from diffusible cortical growth-promoting factors...
  2. pmc The importance of combinatorial gene expression in early Mammalian thalamic patterning and thalamocortical axonal guidance
    David J Price
    Centre for Integrative Physiology, University of Edinburgh Edinburgh, UK
    Front Neurosci 6:37. 2012
    ..We stress the importance of the combinatorial actions of multiple genes for the development of the numerous specific identities and functions of cells in this exquisitely complex system and their orderly innervation of the cortex...
  3. ncbi request reprint The development of cortical connections
    David J Price
    Centre for Integrative Physiology, Hugh Robson Building, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Eur J Neurosci 23:910-20. 2006
    ....
  4. ncbi request reprint Lipids make smooth brains gyrate
    David J Price
    Genes and Development Group, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, UK
    Trends Neurosci 27:362-4. 2004
    ..A recent study suggests that the regulation of cortical size might involve phospholipids, by showing that their addition to cultured embryonic mouse cortices increases cortical size and induces folds resembling gyri...
  5. pmc The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice
    Martine Manuel
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 137:487-97. 2010
    ..These findings indicate that, in addition to regulating the production of ventralising signals, Foxg1 acts cell-autonomously in the telencephalon to ensure that cells develop the competence to adopt ventral identities...
  6. doi request reprint Analysis of early ventral telencephalic defects in mice lacking functional Gli3 protein
    Tian Yu
    Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, Edinburgh, United Kingdom
    J Comp Neurol 512:613-27. 2009
    ....
  7. pmc The transcription factor Foxg1 regulates telencephalic progenitor proliferation cell autonomously, in part by controlling Pax6 expression levels
    Martine N Manuel
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Neural Dev 6:9. 2011
    ..We analysed Foxg1+/+↔Foxg1-/- chimeras, in which mutant telencephalic cells have the potential to interact with, and to have any cell non-autonomous defects rescued by, normal wild-type cells...
  8. doi request reprint Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development
    Christopher D Conway
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 31:1955-70. 2011
    ..At the corpus callosum we find that Hs6st1 has Slit-independent functions and our data indicate additional roles in FGF signaling...
  9. pmc Pax6 controls cerebral cortical cell number by regulating exit from the cell cycle and specifies cortical cell identity by a cell autonomous mechanism
    Jane C Quinn
    Genes and Development Group, Department of Biomedical Sciences, Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, UK
    Dev Biol 302:50-65. 2007
    ....
  10. pmc Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization
    Martine Manuel
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh, UK
    Development 134:545-55. 2007
    ..These findings indicate that Pax6 levels are stabilized by autoregulation, that the proliferation of cortical progenitors is sensitive to altered Pax6 levels and that cortical arealization is not...
  11. pmc Abnormal positioning of diencephalic cell types in neocortical tissue in the dorsal telencephalon of mice lacking functional Gli3
    Vassiliki Fotaki
    Genes and Development Group, Biomedical Sciences, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:9282-92. 2006
    ..We propose that Gli3 is indispensable for formation of an intact telencephalic-diencephalic boundary and for preventing the abnormal positioning of diencephalic cells in the dorsal telencephalon...
  12. doi request reprint Loss of Wnt8b has no overt effect on hippocampus development but leads to altered Wnt gene expression levels in dorsomedial telencephalon
    Vassiliki Fotaki
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, United Kingdom
    Dev Dyn 239:284-96. 2010
    ..Thus, loss of Wnt8b does not give rise to an overt morphological phenotype, but does affect expression levels of other Wnts in developing forebrain...
  13. ncbi request reprint Foxg1 is required for specification of ventral telencephalon and region-specific regulation of dorsal telencephalic precursor proliferation and apoptosis
    Ben Martynoga
    Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
    Dev Biol 283:113-27. 2005
    ....
  14. pmc Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
    Martine Manuel
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 8:59. 2008
    ..Here, we examined the consequences of over-expression for the eye and its axonal connections...
  15. ncbi request reprint Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm
    Thomas Pratt
    Genes and Development Group, Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:6911-23. 2006
    ....
  16. pmc Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice
    T Ian Simpson
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    Neural Dev 4:19. 2009
    ..Its functions in these cells are unknown...
  17. ncbi request reprint Pax6 regulates regional development and neuronal migration in the cerebral cortex
    Ana Talamillo
    Comparative and Developmental Genetics Section, MRC Human Genetic Unit, Western General Hospital, Edinburgh, UK
    Dev Biol 255:151-63. 2003
    ....
  18. pmc Penetrance of eye defects in mice heterozygous for mutation of Gli3 is enhanced by heterozygous mutation of Pax6
    Paulette A Zaki
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    BMC Dev Biol 6:46. 2006
    ..Here we examined whether eye development, which is abnormal in mice lacking functional Gli3, is defective in Gli3+/- mice...
  19. pmc Pax6 exerts regional control of cortical progenitor proliferation via direct repression of Cdk6 and hypophosphorylation of pRb
    Da Mi
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    Neuron 78:269-84. 2013
    ..Our results indicate that Pax6's modulation of cortical progenitor cell cycles is regional and direct...
  20. pmc Evaluation of the mouse TgTP6.3 tauGFP transgene as a lineage marker in chimeras
    Gillian E MacKay
    Division of Reproductive and Developmental Sciences, University of Edinburgh, UK
    J Anat 206:79-92. 2005
    ..3(+/-) cells fulfils the main criteria of a good lineage marker for many tissues. It provides a useful lineage marker, which should be particularly suitable for axons, blood vessels and pre-implantation embryos...
  21. pmc Newly identified patterns of Pax2 expression in the developing mouse forebrain
    Vassiliki Fotaki
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, School of Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    BMC Dev Biol 8:79. 2008
    ..5, and become part of the eminentia thalami by E11.5. The discovery of this previously undescribed cell population prompted us to examine Pax2 protein expression in the developing mouse forebrain in more detail...
  22. pmc Novel lines of Pax6-/- embryonic stem cells exhibit reduced neurogenic capacity without loss of viability
    Jane C Quinn
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    BMC Neurosci 11:26. 2010
    ..Recently, mouse ES cell lines lacking the neurogenic transcription factor Pax6 were reported; neurons derived from these Pax6-/- ES cells died rapidly after neuronal differentiation in vitro...
  23. doi request reprint Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activity
    Natasha M Tian
    Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 135:4081-9. 2008
    ....
  24. ncbi request reprint Disruption of early events in thalamocortical tract formation in mice lacking the transcription factors Pax6 or Foxg1
    Thomas Pratt
    Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 22:8523-31. 2002
    ....
  25. ncbi request reprint The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse
    Thomas Pratt
    Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
    Development 131:3773-84. 2004
    ....
  26. pmc Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex
    Uladzislau Ivaniutsin
    Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK
    Neural Dev 4:3. 2009
    ..We examined the consequences of loss of Apc function for the early development of the cerebral cortex...
  27. ncbi request reprint Pax6 regulates cell adhesion during cortical development
    David A Tyas
    Genes and Development Group, Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Cereb Cortex 13:612-9. 2003
    ..These new data support the hypothesis that Pax6 exerts a cell-autonomous effect on the adhesiveness of cortical cells...
  28. doi request reprint Wnt/β-catenin signaling is disrupted in the extra-toes (Gli3(Xt/Xt) ) mutant from early stages of forebrain development, concomitant with anterior neural plate patterning defects
    Vassiliki Fotaki
    Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Comp Neurol 519:1640-57. 2011
    ..Our data reveal that Gli3 is required at the neural plate stage to regulate Wnt expression and Wnt/β-catenin signaling in the presumptive forebrain and confirm its previously proposed role in patterning the anterior neural plate...
  29. pmc Functional conservation of Pax6 regulatory elements in humans and mice demonstrated with a novel transgenic reporter mouse
    David A Tyas
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 6:21. 2006
    ..The sequence of the Pax6/PAX6 protein is identical in mice and humans and previous studies have shown structural conservation of the gene's regulatory regions...
  30. doi request reprint Gli3 is required autonomously for dorsal telencephalic cells to adopt appropriate fates during embryonic forebrain development
    Jane C Quinn
    Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Dev Biol 327:204-15. 2009
    ..We propose that an important cell autonomous action of Gli3 is to regulate the competence of dorsal telencephalic cells, preventing cells near to its boundaries expressing regulatory factors normally restricted to adjacent tissues...
  31. pmc Loss of Gli3 enhances the viability of embryonic telencephalic cells in vitro
    Paulette A Zaki
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    Eur J Neurosci 22:1547-51. 2005
    ..Gli3(Xt/Xt) cells are also more sensitive to released factors present in conditioned media. These data suggest that Gli3 plays both cell-autonomous and cell-nonautonomous roles in mediating telencephalic cell viability...
  32. pmc Foxg1 is required to limit the formation of ciliary margin tissue and Wnt/β-catenin signalling in the developing nasal retina of the mouse
    Vassiliki Fotaki
    University of Edinburgh, Centre for Integrative Physiology, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Dev Biol 380:299-313. 2013
    ..Our results reveal a new role of Foxg1 in limiting CM development in the nasal peripheral retina and add a new molecular player in the developmental network involved in CM specification...
  33. pmc The expression and activity of β-catenin in the thalamus and its projections to the cerebral cortex in the mouse embryo
    Thomas Pratt
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, Scotland, UK
    BMC Neurosci 13:20. 2012
    ..In this study we tested whether β-catenin is likely to play a role in thalamocortical connectivity by examining its expression and activity in developing thalamic neurons and their axons...
  34. pmc The generation of superficial cortical layers is regulated by levels of the transcription factor Pax6
    Petrina A Georgala
    Centre for Integrative Physiology, School of Biomedical Sciences, Genes and Development Group, The University of Edinburgh, Edinburgh, UK
    Cereb Cortex 21:81-94. 2011
    ..Our analyses suggest that correct levels of Pax6 are essential for normal production of superficial layers of the cortex...
  35. doi request reprint The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence
    Dario Magnani
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    J Neurosci 30:13883-94. 2010
    ..We conclude that correct Gli3 levels are particularly important for the LGE's growth, patterning, and development of axon guidance capabilities...
  36. pmc Analysis of axon guidance defects at the optic chiasm in heparan sulphate sulphotransferase compound mutant mice
    Christopher D Conway
    Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh, UK
    J Anat 219:734-42. 2011
    ..We also found that expression of the Hs6st1 isoform Hs6st3 overlaps with that of Hs6st1 in the developing visual system, suggesting that some Hs6st activity remains present in this region of Hs6st1(-/-) mutant embryos...
  37. pmc Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2(-/-) as well as Slit1(-/-)Slit2(-/-) embryos
    Matthew Down
    Institute for Adaptive and Neural Computation, University of Edinburgh, Edinburgh, UK
    BMC Neurosci 14:9. 2013
    ..Here we used steerable-filters to quantify key properties of the population of axons at the chiasm in wild-type, Slit1(-/-), Slit2(-/-) and Slit1(-/-)Slit2(-/-) embryos...
  38. ncbi request reprint The role of neurotrophin receptors in female germ-cell survival in mouse and human
    Norah Spears
    Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 130:5481-91. 2003
    ..The results indicate that signalling through TrkB is an important component of the mechanism that regulates the early survival of female germ cells...
  39. pmc Positive autoregulation of the transcription factor Pax6 in response to increased levels of either of its major isoforms, Pax6 or Pax6(5a), in cultured cells
    Jeni Pinson
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    BMC Dev Biol 6:25. 2006
    ..We tested the effects of overexpressing either one or other isoform on endogenous Pax6 expression levels in Neuro2A and NIH3T3 cells...
  40. pmc Identification of genomic regions regulating Pax6 expression in embryonic forebrain using YAC reporter transgenic mouse lines
    Da Mi
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 8:e80208. 2013
    ....
  41. pmc Regulation of the Pax6 : Pax6(5a) mRNA ratio in the developing mammalian brain
    Jeni Pinson
    Biomedical Sciences, Hugh Robson Building, University of Edinburgh, George Square, Edinburgh, EH8 9XD, UK
    BMC Dev Biol 5:13. 2005
    ..Crucially, however, no previous study has determined whether the ratio between Pax6 and Pax6(5a) transcripts alters during mammalian neurogenesis in vivo...
  42. ncbi request reprint Specific modification of heparan sulphate is required for normal cerebral cortical development
    David McLaughlin
    Division of Biomedical Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Mech Dev 120:1481-8. 2003
    ....
  43. pmc Heparan sulfotransferases Hs6st1 and Hs2st keep Erk in check for mouse corpus callosum development
    James M Clegg
    Centre for Integrative Physiology, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom, Centre for Glycobiology, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom, and Department of Craniofacial Development and Stem Cell Biology, King s College London, London SE5 9RW, United Kingdom
    J Neurosci 34:2389-401. 2014
    ..Overall, our data fit a model in which Hs2st and Hs6st1 normally generate conditions conducive to CC development by generating an HS-containing environment that keeps Erk signaling in check. ..
  44. pmc MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brain
    Tomasz Jan Nowakowski
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    Proc Natl Acad Sci U S A 110:7056-61. 2013
    ..Acute miR-92b loss of function had opposite effects. These findings indicate that miR-92b limits the production of intermediate cortical progenitors...
  45. doi request reprint The role of Pax6 in forebrain development
    Petrina A Georgala
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH89XD, United Kingdom
    Dev Neurobiol 71:690-709. 2011
    ..Such studies should also help generate an increasingly coherent understanding of how this pleiotropic transcription factor becomes involved in so many facets of neural development...
  46. ncbi request reprint Mouse models of telencephalic development
    Paulette A Zaki
    Genes and Development Group, Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, EH8 9XD, Edinburgh, UK
    Curr Opin Genet Dev 13:423-37. 2003
    ..Different parts of the telencephalon express different combinations of transcription factors that control processes including proliferation, cell fate determination and migration in order to create the unique phenotype of each region...
  47. ncbi request reprint Pax6; a pleiotropic player in development
    T Ian Simpson
    Genes and Development Research Group, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Bioessays 24:1041-51. 2002
    ..Extrapolation to developmental transcription factors in general suggests that variation in the nature of individual factors is likely to contribute to the emergence of differences between tissues...
  48. ncbi request reprint Etr-r3/mNapor, encoding an ELAV-type RNA binding protein, is expressed in differentiating cells in the developing rodent forebrain
    Teresa E Levers
    Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Mech Dev 112:191-3. 2002
    ..In contrast, Etr-r3/mNapor is expressed by very few cells in proliferative regions, where cell death rates are highest...
  49. ncbi request reprint Selecting cells to make cerebral cortex
    Yijing Chen
    Centres for Integrative Physiology and Neuroscience Research, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    J Biosci 33:1-3. 2008
  50. ncbi request reprint Regulation of cell survival in the developing thalamus: an in vitro analysis
    Pundit Asavaritikrai
    Genes and Development Research Group, Biomedical Sciences, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Exp Neurol 181:39-46. 2003
    ..This culture model may provide a means of investigating the mechanisms of thalamic cell survival during development...
  51. ncbi request reprint Why cavefish are blind
    Natasha M M L Tian
    Genes and Development Group, Centre for Integrative Physiology, Edinburgh, UK
    Bioessays 27:235-8. 2005
    ....
  52. ncbi request reprint Role of Pax6 in forebrain regionalization
    Martine Manuel
    Genes and Development Group, University of Edinburgh, Hugh Robson Building, George Square, UK
    Brain Res Bull 66:387-93. 2005
    ..While the ancestral function of Pax6 may have been to specify a structure sensitive to light, it has been co-opted into the regulation of a broader range of processes in development of the vertebrate nervous system...
  53. pmc Gli3 controls corpus callosum formation by positioning midline guideposts during telencephalic patterning
    Dario Magnani
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, UK
    Cereb Cortex 24:186-98. 2014
    ..Hence, Gli3 controlled restriction of Fgf and Wnt/β-catenin signaling and of Slit2 expression is crucial for positioning midline guideposts and callosal development. ..
  54. ncbi request reprint Layer-specific thalamocortical innervation in organotypic cultures is prevented by substances that alter neural activity
    Gillian Anderson
    Genes and Development Group, Biomedical Sciences Section, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, UK
    Eur J Neurosci 16:345-9. 2002
    ....
  55. ncbi request reprint Interactions between TrkB signaling and serotonin excess in the developing murine somatosensory cortex: a role in tangential and radial organization of thalamocortical axons
    Tania Vitalis
    Department of Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 22:4987-5000. 2002
    ....
  56. ncbi request reprint Pax6 is required to regulate the cell cycle and the rate of progression from symmetrical to asymmetrical division in mammalian cortical progenitors
    Guillermo Estivill-Torrus
    Department of Biomedical Sciences, University of Edinburgh Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 129:455-66. 2002
    ....
  57. ncbi request reprint The motility of glioblastoma tumour cells is modulated by intracellular cofilin expression in a concentration-dependent manner
    Celestial T Yap
    Genes and Development Group, School of Biomedical and Clinical Laboratory Sciences, College of Medicine, University of Edinburgh, Scotland, United Kingdom
    Cell Motil Cytoskeleton 60:153-65. 2005
    ..We conclude that overexpression of cofilin enhances the motility of glioblastoma tumour cells in a concentration-dependent fashion, which is likely to contribute to their invasiveness...
  58. ncbi request reprint Widespread tangential dispersion and extensive cell death during early neurogenesis in the mouse neocortex
    Alison L Wilkie
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, UK
    Dev Biol 267:109-18. 2004
    ..We observe a dramatic and rapid decline in the number of labelled clones after E13.5, indicating that there is extensive cell death at this time...
  59. ncbi request reprint Identification and characterization of a novel transcript down-regulated in Dlx1/Dlx2 and up-regulated in Pax6 mutant telencephalon
    Andrea Faedo
    Stem Cell Research Institute, DIBIT, H S Raffaele, Via Olgettina 58, 20132 Milan, Italy
    Dev Dyn 231:614-20. 2004
    ..5 and in the dorsal, lateral, and ventral pallium at embryonic day 14.5...
  60. pmc Comparative aspects of cerebral cortical development
    Zoltan Molnar
    Department of Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Eur J Neurosci 23:921-34. 2006
    ..Comparative and genetic aspects of cortical development both reveal the workings of evolution...
  61. pmc Long-range downstream enhancers are essential for Pax6 expression
    Dirk A Kleinjan
    MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Dev Biol 299:563-81. 2006
    ..Finally, direct comparison of a single-copy line with the floxed DRR before and after Cre-mediated deletion demonstrates unequivocally the essential role of these long-range control elements for PAX6 expression...
  62. ncbi request reprint Exuberance in the development of cortical networks
    Giorgio M Innocenti
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, S 17177 Stockholm
    Nat Rev Neurosci 6:955-65. 2005
    ....