P M Preshaw

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Current concepts in periodontal pathogenesis
    Philip M Preshaw
    School of Dental Sciences, University of Newcastle upon Tyne, UK
    Dent Update 31:570-2, 574-8. 2004
  2. ncbi request reprint A pilot study of treatment of periodontal-endodontic lesions
    Sotirios V Vakalis
    Int Dent J 55:313-8. 2005
  3. ncbi request reprint Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis. A review
    Philip M Preshaw
    School of Dental Sciences, University of Newcastle upon Tyne, UK
    J Clin Periodontol 31:697-707. 2004
  4. ncbi request reprint Subantimicrobial dose doxycycline in the treatment of recurrent oral aphthous ulceration: a pilot study
    Philip M Preshaw
    Newcastle University School of Dental Sciences, Newcastle, UK
    J Oral Pathol Med 36:236-40. 2007
  5. ncbi request reprint Subantimicrobial dose doxycycline enhances the efficacy of scaling and root planing in chronic periodontitis: a multicenter trial
    Philip M Preshaw
    Department of Periodontology, Newcastle University School of Dental Sciences, Newcastle, UK
    J Periodontol 75:1068-76. 2004
  6. ncbi request reprint Periodontal maintenance in a specialist periodontal clinic and in general dental practice
    Philip M Preshaw
    School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK
    J Clin Periodontol 32:280-6. 2005
  7. ncbi request reprint Systemic antibiotics in the management of chronic periodontitis
    Philip M Preshaw
    School of Dental Sciences, University of Newcastle upon Tyne
    Eur J Prosthodont Restor Dent 12:63-9. 2004
  8. ncbi request reprint Modified-release subantimicrobial dose doxycycline enhances scaling and root planing in subjects with periodontal disease
    Philip M Preshaw
    Department of Periodontology, School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, U K
    J Periodontol 79:440-52. 2008
  9. doi request reprint How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis?
    Philip M Preshaw
    School of Dental Sciences and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Clin Periodontol 38:60-84. 2011
  10. ncbi request reprint Geriatric dentistry education in European dental schools
    P M Preshaw
    School of Dental Sciences, University of Newcastle upon Tyne, Newcastle, UK
    Eur J Dent Educ 9:73-7. 2005

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Current concepts in periodontal pathogenesis
    Philip M Preshaw
    School of Dental Sciences, University of Newcastle upon Tyne, UK
    Dent Update 31:570-2, 574-8. 2004
    ..The purpose of this paper is to review current thinking in periodontics with special reference to periodontal epidemiology, microbiology, and pathogenesis...
  2. ncbi request reprint A pilot study of treatment of periodontal-endodontic lesions
    Sotirios V Vakalis
    Int Dent J 55:313-8. 2005
    ..A pilot study to evaluate a standardised treatment protocol for combined periodontal-endodontic lesions (involving staged endodontic and periodontal treatment)...
  3. ncbi request reprint Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis. A review
    Philip M Preshaw
    School of Dental Sciences, University of Newcastle upon Tyne, UK
    J Clin Periodontol 31:697-707. 2004
    ..Research supports that downregulation of MMPs by SDD confers benefit to patients with periodontitis...
  4. ncbi request reprint Subantimicrobial dose doxycycline in the treatment of recurrent oral aphthous ulceration: a pilot study
    Philip M Preshaw
    Newcastle University School of Dental Sciences, Newcastle, UK
    J Oral Pathol Med 36:236-40. 2007
    ..The aim of this pilot study was to evaluate the role of subantimicrobial dose doxycycline (SDD - 20 mg doxycycline twice daily) in the management of patients with ROAU...
  5. ncbi request reprint Subantimicrobial dose doxycycline enhances the efficacy of scaling and root planing in chronic periodontitis: a multicenter trial
    Philip M Preshaw
    Department of Periodontology, Newcastle University School of Dental Sciences, Newcastle, UK
    J Periodontol 75:1068-76. 2004
    ..The aim of this study was to further assess the role of SDD as an adjunct to scaling and root planing (SRP) in the treatment of CP...
  6. ncbi request reprint Periodontal maintenance in a specialist periodontal clinic and in general dental practice
    Philip M Preshaw
    School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, UK
    J Clin Periodontol 32:280-6. 2005
    ..To monitor the efficacy of periodontal maintenance whether conducted in a specialist periodontology clinic or in the practice of the referring general dentist...
  7. ncbi request reprint Systemic antibiotics in the management of chronic periodontitis
    Philip M Preshaw
    School of Dental Sciences, University of Newcastle upon Tyne
    Eur J Prosthodont Restor Dent 12:63-9. 2004
    ..Drawing definitive conclusions is difficult, but given the lack of reliable data available, systemic antibiotics cannot be indicated as adjuncts in the treatment of chronic periodontitis...
  8. ncbi request reprint Modified-release subantimicrobial dose doxycycline enhances scaling and root planing in subjects with periodontal disease
    Philip M Preshaw
    Department of Periodontology, School of Dental Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, U K
    J Periodontol 79:440-52. 2008
    ..The aim of this study was to investigate the efficacy of SDD-40 when used as an adjunct to SRP for the treatment of periodontitis...
  9. doi request reprint How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis?
    Philip M Preshaw
    School of Dental Sciences and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Clin Periodontol 38:60-84. 2011
    ..To review current knowledge on cytokine interactions and the cytokine-mediated links between innate and adaptive immunity that are relevant to the pathophysiology of periodontitis...
  10. ncbi request reprint Geriatric dentistry education in European dental schools
    P M Preshaw
    School of Dental Sciences, University of Newcastle upon Tyne, Newcastle, UK
    Eur J Dent Educ 9:73-7. 2005
    ..It is of concern that geriatric dentistry was not taught at all in 7% of schools. No data are available concerning whether or not geriatric dentistry is taught in the 58% non-responding schools...
  11. doi request reprint Association of removable partial denture use with oral and systemic health
    P M Preshaw
    School of Dental Sciences, Newcastle University, UK
    J Dent 39:711-9. 2011
    ..This narrative literature review aims to consider the impact of removable partial dentures (RPDs) on oral and systemic health...
  12. ncbi request reprint Prostaglandin E2 concentrations in gingival crevicular fluid: observations in untreated chronic periodontitis
    Philip M Preshaw
    Department of Restorative Dentistry, The Dental School, Newcastle upon Tyne, UK
    J Clin Periodontol 29:15-20. 2002
    ....
  13. pmc Periodontitis and diabetes: a two-way relationship
    P M Preshaw
    School of Dental Sciences and Institute of Cellular Medicine, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4BW, UK
    Diabetologia 55:21-31. 2012
    ..Treatment of periodontitis is associated with HbA(1c) reductions of approximately 0.4%. Oral and periodontal health should be promoted as integral components of diabetes management...
  14. ncbi request reprint Adjunctive subantimicrobial dose doxycycline in smokers and non-smokers with chronic periodontitis
    Philip M Preshaw
    School of Dental Sciences, Newcastle University, UK
    J Clin Periodontol 32:610-6. 2005
    ..The aim of this study was to retrospectively evaluate the role of SDD as an adjunct to scaling and root planing (SRP) in the treatment of smokers and non-smokers with CP...
  15. ncbi request reprint The effect of quitting smoking on chronic periodontitis
    P M Preshaw
    School of Dental Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Clin Periodontol 32:869-79. 2005
    ..To evaluate longitudinally the effect of smoking cessation on clinical and radiographic outcomes following non-surgical treatment in smokers with chronic periodontitis...
  16. ncbi request reprint Outcomes of non-surgical periodontal treatment by dental hygienists in training: impact of site- and patient-level factors
    P M Preshaw
    School of Dental Sciences and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Int J Dent Hyg 11:273-9. 2013
    ..To investigate the site- and patient-level factors that impact on the response to non-surgical periodontal therapy in patients with chronic periodontitis...
  17. ncbi request reprint Effects of ketorolac tromethamine mouthrinse (0.1%) on crevicular fluid prostaglandin E2 concentrations in untreated chronic periodontitis
    P M Preshaw
    University of Newcastle upon Tyne, UK
    J Periodontol 69:777-83. 1998
    ....
  18. ncbi request reprint Smoking cessation advice for patients with chronic periodontitis
    H A Nasry
    School of Dental Sciences, University of Newcastle upon Tyne
    Br Dent J 200:272-5; discussion 265. 2006
    ..There are limited data on the utility of dental professionals in providing smoking cessation counselling in the UK...
  19. ncbi request reprint The crossover design to evaluate the efficacy of plaque removal in tooth-brushing studies
    G I McCracken
    School of Dental Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Clin Periodontol 32:1157-62. 2005
    ..To evaluate the crossover clinical trial design to assess plaque removal efficacy of the Sonicare Elite...
  20. ncbi request reprint Progression and treatment of chronic adult periodontitis
    P M Preshaw
    University of Newcastle upon Tyne, UK
    J Periodontol 70:1209-20. 1999
    ..The periodontal status of 41 medically healthy adults with untreated chronic periodontitis was monitored before and after scaling and root planing (SRP)...
  21. ncbi request reprint Crevicular fluid prostaglandin E2 levels in periodontitis-resistant and periodontitis-susceptible adults
    P A Heasman
    The Dental School, University of Newcastle upon Tyne, UK
    J Clin Periodontol 25:1003-7. 1998
    ..In the CAPD cohort, there were no differences in GCF-PGE2 concentrations between subgroups of smokers (n=13), ex-smokers (n=11) and non smokers (n=11). In the PDR cohort, 19/20 subjects were non-smokers...
  22. doi request reprint Do patients with aggressive periodontitis have evidence of diabetes? A pilot study
    R C Davies
    School of Dental Sciences and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Periodontal Res 46:663-72. 2011
    ..This pilot study aimed to investigate whether patients with aggressive periodontitis (not previously diagnosed with diabetes) have evidence of diabetes and have altered serum levels of inflammatory mediators, lipids and adipokines...
  23. ncbi request reprint The effect of smoking on periodontal treatment response: a review of clinical evidence
    L Heasman
    School of Dental Sciences, University of Newcastle upon Tyne, UK
    J Clin Periodontol 33:241-53. 2006
    ..Smoking has been identified as a significant risk factor for periodontal diseases and is regarded as being responsible for incomplete or delayed healing in patients following treatment...
  24. ncbi request reprint Measuring plaque in clinical trials: index or weight?
    G I McCracken
    School of Dental Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Clin Periodontol 33:172-6. 2006
    ..To explore the possibility of using plaque weight rather than plaque index as a more objective, clinical outcome measure in periodontal clinical trials...
  25. ncbi request reprint Smoking cessation as a dental intervention--views of the profession
    F Stacey
    School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, NE2 4BW, UK
    Br Dent J 201:109-13; discussion 99. 2006
    ..To undertake a questionnaire-based survey to determine the attitudes and activities of dental professionals in primary care in the Northern Deanery of the UK in relation to providing smoking cessation advice...
  26. ncbi request reprint VIP inhibits P. gingivalis LPS-induced IL-18 and IL-18BPa in monocytes
    N Foster
    Oral Microbiology and Host Responses Group, Oral Biology, School of Dental Sciences, University of Newcastle upon Tyne, UK
    J Dent Res 86:883-7. 2007
    ..VIP (10(-8)M) inhibited both IL-18 and IL-18Bpa secretion by stimulated monocytes. We conclude that IL-18 and IL-18BPa secretion by monocytes is part of the immune response to Pg, and that VIP can inhibit this process...
  27. ncbi request reprint Antibiotics in the treatment of periodontitis
    Philip M Preshaw
    School of Dental Sciences, Department of Periodontology, University of Newcastle upon Tyne
    Dent Update 31:448-50, 453-4, 456. 2004
    ..Systemic antibiotics are not indicated in the vast majority of periodontal conditions encountered in general dental practice...
  28. ncbi request reprint Effect of smoking on crevicular polymorphonuclear neutrophil function in periodontally healthy subjects
    A Güntsch
    Department of Restorative Dentistry, School of Dental Sciences, Friedrich Schiller University Jena, Germany
    J Periodontal Res 41:184-8. 2006
    ..Smoking, as probably the most important environmental risk factor for periodontitis, has been shown to adversely affect many neutrophil functions...
  29. ncbi request reprint Pivotal advance: vasoactive intestinal peptide inhibits up-regulation of human monocyte TLR2 and TLR4 by LPS and differentiation of monocytes to macrophages
    N Foster
    Oral Microbiology and Host Responses Group, Oral Biology, School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
    J Leukoc Biol 81:893-903. 2007
    ..gingivalis and E. coli, VIP inhibited the action of both of these LPS types on monocytes. The mechanism of action of VIP on monocyte differentiation may be via inhibition of the transcription factor PU.1...
  30. pmc Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide
    H E Barksby
    Periodontal Immunobiology Research Group, School of Dental Sciences, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Clin Exp Immunol 156:479-87. 2009
    ..We conclude that differences in signalling pathways activated by TLR-2 and TLR-4 ligands lead to differential innate immune responses which may be important in polymicrobial diseases such as periodontal disease...
  31. ncbi request reprint Experimental gingivitis in women using oral contraceptives
    P M Preshaw
    University of Newcastle upon Tyne, The Dental School, UK
    J Dent Res 80:2011-5. 2001
    ..05). PI, GI, and GCF volume did not vary in control quadrants over the course of the study (P > 0.05). Analysis of these data suggests that current OC formulations do not affect the inflammatory response of the gingiva to dental plaque...
  32. ncbi request reprint Attitudes regarding specialist referrals in periodontics
    G Sharpe
    Department of Restorative Dentistry, School of Dental Sciences, University of Newcastle, Framlington Place, Newcastle upon Tyne, UK
    Br Dent J 202:E11; discussion 218-9. 2007
    ..To examine the attitudes of dental practitioners towards specialist periodontal referral in the North East of England...
  33. doi request reprint Investigation and quantification of key periodontal pathogens in patients with type 2 diabetes
    C A Field
    School of Dental Sciences, Newcastle University, Newcastle, UK
    J Periodontal Res 47:470-8. 2012
    ..The aim of the present study was to detect quantitative differences in selected periodontopathogens in the subgingival plaque of diabetic patients using TaqMan quantitative PCR...
  34. ncbi request reprint A double-blind, crossover study of Biotène Oralbalance and BioXtra systems as salivary substitutes in patients with post-radiotherapy xerostomia
    S A Shahdad
    Restorative Dentistry, Newcastle Dental Hospital, Newcastle upon Tyne, UK
    Eur J Cancer Care (Engl) 14:319-26. 2005
    ..05). In conclusion, both treatments were effective in alleviating the symptoms of post-radiotherapy xerostomia, although BX achieved superiority in some of the outcomes assessed compared with OB...
  35. ncbi request reprint Cardiovascular diseases and periodontology
    R A Seymour
    Department of Restorative Dentistry, The Dental School, University of Newcastle, Framlington Place, Newcastle upon Tyne NE2 4BW, UK
    J Clin Periodontol 30:279-92. 2003
    ..The various diseases and their treatments can have an impact upon the periodontium and the delivery of periodontal care...
  36. ncbi request reprint Oral health and heart disease
    Robin A Seymour
    Department of Restorative Dentistry, The Dental School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4BW
    Prim Dent Care 9:125-31. 2002
    ..A brief synopsis of the epidemiological studies to date and their outcomes is shown in Table 1...
  37. pmc The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders
    H E Barksby
    Oral Microbiology and Host Responses Group, Oral Biology, School of Dental Sciences, Newcastle University, UK
    Clin Exp Immunol 149:217-25. 2007
    ..g. anti-IL-18 antibodies). This review highlights the emerging data on these novel IL-1 cytokines and assesses their possible role in the pathogenesis and therapy of destructive inflammatory disorders such as RA and periodontitis...
  38. ncbi request reprint VIP Inhibits Porphyromonas gingivalis LPS-induced immune responses in human monocytes
    N Foster
    Oral Microbiology and Host Responses Group, School of Dental Sciences, University of Newcastle upon Tyne, NE2 4BW, UK
    J Dent Res 84:999-1004. 2005
    ..This is the first report to show the potential of VIP as an immunomodulator of Pg-stimulated inflammatory pathways in human monocytes...
  39. ncbi request reprint Change in cardiovascular risk status after dental clearance
    J S Ellis
    School of Dental Sciences, University of Newcastle upon Tyne, Framlington Place, UK
    Br Dent J 202:543-4. 2007
    ..CRP levels have also been shown to decrease following periodontal therapy. CRP is a reliable marker of the acute phase reaction to infections and/or inflammation and is a powerful predictor of future coronary events...
  40. ncbi request reprint Efficacy of plaque removal of the Sonicare Elite versus the Sonicare Advance from hard-to-reach sites
    G I McCracken
    School of Dental Sciences, University of Newcastle upon Tyne, UK
    J Clin Periodontol 31:1007-11. 2004
    ..To compare the Sonicare Elite with the Sonicare Advance in terms of the reduction in supragingival plaque in the posterior, hard-to-reach areas of the mouth...
  41. ncbi request reprint Cross-susceptibility between periodontal disease and type 2 diabetes mellitus: an immunobiological perspective
    Philip M Preshaw
    Periodontology, School of Dental Sciences, Newcastle University, Newcastle, UK
    Periodontol 2000 45:138-57. 2007
  42. doi request reprint Patients' experiences of the impact of periodontal disease
    Louise K O'Dowd
    Restorative Department, Newcastle Dental Hospital, Newcastle upon Tyne, UK
    J Clin Periodontol 37:334-9. 2010
    ..To examine critically patients' experiences of the impact of periodontal disease on their daily lives...
  43. ncbi request reprint Cytokine gene polymorphism and immunoregulation in periodontal disease
    John J Taylor
    Oral Microbiology and Host Responses Group, School of Dental Sciences, University of Newcastle upon Tyne, UK
    Periodontol 2000 35:158-82. 2004
  44. ncbi request reprint Compromised periodontal status in an urban Sri Lankan population with type 2 diabetes
    Philip M Preshaw
    School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK
    J Clin Periodontol 37:165-71. 2010
    ..To determine the prevalence of periodontitis in an urban population of Sri Lankans with type 2 diabetes (T2DM) and to compare the data with those from a population of adults without diabetes...
  45. ncbi request reprint Comparison of two topical treatments for dentine sensitivity
    Konstantina Merika
    School of Dental Sciences, University of Newcastle upon Tyne
    Eur J Prosthodont Restor Dent 14:38-41. 2006
    ..05). The treatments had similar efficacy and both can be considered effective therapies for treating dentine sensitivity...
  46. ncbi request reprint Long-term treatment with sub-antimicrobial dose doxycycline has no antibacterial effect on intestinal flora
    Clay Walker
    Periodontal Disease Research Clinics, University of Florida, Gainesville, FL 32610, USA
    J Clin Periodontol 32:1163-9. 2005
    ..The purpose of this study was to determine if a 9-month regimen of sub-antimicrobial doxycycline (20 mg, bid) had an effect on either the intestinal or the vaginal microflora...
  47. ncbi request reprint Adjunctive subantimicrobial dose doxycycline in the management of institutionalised geriatric patients with chronic periodontitis
    Abdel R Mohammad
    College of Dentistry, Ohio State University, Columbus, OH 43210, USA
    Gerodontology 22:37-43. 2005
    ....
  48. ncbi request reprint Current status of predoctoral geriatric education in U.S. dental schools
    Abdel R Mohammad
    Ohio State University College of Dentistry, Section of Geriatrics, 305 West 12th Ave, 193, P O Box 182357, Columbus, OH 43218 2357, USA
    J Dent Educ 67:509-14. 2003
    ..Although didactic teaching of geriatric dentistry has increased markedly in the last two decades, clinical experience, both intramurally and extramurally, did not keep pace...
  49. ncbi request reprint An investigation of the relationship between systemic bone density and clinical periodontal status in post-menopausal Asian-American women
    Abdel R Mohammad
    Geriatric Dental Program, The Ohio State University, College of Dentistry, 305 W 12th Avenue, Columbus, OH 43210, USA
    Int Dent J 53:121-5. 2003
    ..The relationship between osteoporosis and periodontal disease is not understood. The aim of this study was to examine the association between bone mineral density (BMD) and periodontal status in a population of Asian-American women...
  50. ncbi request reprint Clinical and microbiological efficacy of chlorine dioxide in the management of chronic atrophic candidiasis: an open study
    Abdel R Mohammad
    The Ohio State University College of Dentistry, Section of Primary Care, Postle Hall Office 3058, 305 West 12th Avenue, Columbus, OH 43210, USA
    Int Dent J 54:154-8. 2004
    ..To assess the clinical and microbiological efficacy of chlorine dioxide (ClO2) as a topical antiseptic for the treatment of chronic atrophic candidiasis in geriatric patients...
  51. doi request reprint The use of a linear oscillating device in periodontal treatment: a review
    Arndt Guentsch
    Department of Conservative Dentistry, University Hospital of Jena, Friedrich Schiller University, Jena, Germany
    J Clin Periodontol 35:514-24. 2008
    ..The aim of this paper is to review the existing literature regarding the Vector method...
  52. ncbi request reprint Periodontitis: a complication of type 2 diabetes in Sri Lankans
    Nimali T De Silva
    Diabetes Res Clin Pract 74:209-10. 2006
  53. ncbi request reprint Management of xerostomia in older patients : a randomised controlled trial evaluating the efficacy of a new oral lubricant solution
    Stephane Mouly
    Department of Internal Medicine, Lariboisiere Hospital, Paris, France
    Drugs Aging 24:957-65. 2007
    ..Xerostomia is a subjective sensation of mouth dryness that may frequently occur in older patients...