Ann Prentice

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi What are the dietary requirements for calcium and vitamin D?
    A Prentice
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Calcif Tissue Int 70:83-8. 2002
  2. pmc Unexpected long-term effects of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake: a follow-up study
    Landing M A Jarjou
    Medical Research Council Keneba, Keneba, The Gambia
    Am J Clin Nutr 98:723-30. 2013
  3. pmc Bone mineral changes after lactation in Gambian women accustomed to a low calcium intake
    Y Sawo
    MRC Keneba, West Kiang, The Gambia
    Eur J Clin Nutr 67:1142-6. 2013
  4. doi Nutritional rickets around the world
    Ann Prentice
    MRC Human Nutrition Research, Cambridge, United Kingdom
    J Steroid Biochem Mol Biol 136:201-6. 2013
  5. pmc The effect of prepubertal calcium carbonate supplementation on the age of peak height velocity in Gambian adolescents
    Ann Prentice
    Medical Research Council Human Nutrition Research, Cambridge, United Kingdom
    Am J Clin Nutr 96:1042-50. 2012
  6. pmc MAVIDOS Maternal Vitamin D Osteoporosis Study: study protocol for a randomized controlled trial. The MAVIDOS Study Group
    Nicholas C Harvey
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Trials 13:13. 2012
  7. pmc Mining the depths: metabolic insights into mineral nutrition
    Ann Prentice
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge CB1 9NL and MRC Keneba, The Gambia
    Proc Nutr Soc 66:512-21. 2007
  8. ncbi The relative contribution of diet and genotype to bone development
    A Prentice
    MRC Human Nutrition Research, Cambridge, UK
    Proc Nutr Soc 60:45-52. 2001
  9. ncbi Calcium supplementation increases stature and bone mineral mass of 16- to 18-year-old boys
    Ann Prentice
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, United Kingdom
    J Clin Endocrinol Metab 90:3153-61. 2005
  10. doi FGF23 is elevated in Gambian children with rickets
    Ann Prentice
    MRC Keneba, The Gambia
    Bone 42:788-97. 2008

Collaborators

Detail Information

Publications100

  1. ncbi What are the dietary requirements for calcium and vitamin D?
    A Prentice
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Calcif Tissue Int 70:83-8. 2002
    ..In addition, they reflect uncertainties about the relationship between vitamin D status and health outcomes...
  2. pmc Unexpected long-term effects of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake: a follow-up study
    Landing M A Jarjou
    Medical Research Council Keneba, Keneba, The Gambia
    Am J Clin Nutr 98:723-30. 2013
    ..Calcium supplementation of pregnant Gambian women with a low calcium intake results in lower maternal bone mineral content in the subsequent lactation...
  3. pmc Bone mineral changes after lactation in Gambian women accustomed to a low calcium intake
    Y Sawo
    MRC Keneba, West Kiang, The Gambia
    Eur J Clin Nutr 67:1142-6. 2013
    ..The aim of this study was to examine whether these effects are reversed after lactation...
  4. doi Nutritional rickets around the world
    Ann Prentice
    MRC Human Nutrition Research, Cambridge, United Kingdom
    J Steroid Biochem Mol Biol 136:201-6. 2013
    ..Continuing studies of the etiology of nutritional rickets will provide evidence to underpin guidelines for the prevention and treatment of rickets world-wide. This article is part of a Special Issue entitled 'Vitamin D Workshop'...
  5. pmc The effect of prepubertal calcium carbonate supplementation on the age of peak height velocity in Gambian adolescents
    Ann Prentice
    Medical Research Council Human Nutrition Research, Cambridge, United Kingdom
    Am J Clin Nutr 96:1042-50. 2012
    ..Such an effect might be particularly marked in populations in whom low calcium intake, stunting, and delayed puberty are common...
  6. pmc MAVIDOS Maternal Vitamin D Osteoporosis Study: study protocol for a randomized controlled trial. The MAVIDOS Study Group
    Nicholas C Harvey
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Trials 13:13. 2012
    ..MAVIDOS is a randomised, double-blind, placebo-controlled trial (ISRCTN82927713, registered 2008 Apr 11), funded by Arthritis Research UK, MRC, Bupa Foundation and NIHR...
  7. pmc Mining the depths: metabolic insights into mineral nutrition
    Ann Prentice
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge CB1 9NL and MRC Keneba, The Gambia
    Proc Nutr Soc 66:512-21. 2007
    ..The contributions of Dr Widdowson to the early understanding of mineral nutrition are reviewed and the latest scientific findings in this rapidly-expanding field of research are presented...
  8. ncbi The relative contribution of diet and genotype to bone development
    A Prentice
    MRC Human Nutrition Research, Cambridge, UK
    Proc Nutr Soc 60:45-52. 2001
    ..Optimisation of nutrition and lifestyle remains an attractive strategy for the reduction of fracture risk, but more research is required to fully define optimal dietary requirements...
  9. ncbi Calcium supplementation increases stature and bone mineral mass of 16- to 18-year-old boys
    Ann Prentice
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, United Kingdom
    J Clin Endocrinol Metab 90:3153-61. 2005
    ..Follow-up studies will determine whether this reflects a change in the tempo of growth or an effect on skeletal size that persists into adulthood...
  10. doi FGF23 is elevated in Gambian children with rickets
    Ann Prentice
    MRC Keneba, The Gambia
    Bone 42:788-97. 2008
    ....
  11. doi Vitamin D deficiency: a global perspective
    Ann Prentice
    The Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom and Medical Research Council Keneba, Keneba, The Gambia
    Nutr Rev 66:S153-64. 2008
    ..There is an urgent need for action to address the global burden of rickets and osteomalacia...
  12. ncbi Diet, nutrition and the prevention of osteoporosis
    A Prentice
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Public Health Nutr 7:227-43. 2004
    ..To review the evidence on diet and nutrition relating to osteoporosis and provide recommendations for preventing osteoporosis, in particular, osteopototic fracture...
  13. pmc Nutrition and bone growth and development
    Ann Prentice
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge CB1 9NL, UK
    Proc Nutr Soc 65:348-60. 2006
    ....
  14. ncbi Nutrition and health of the elderly: osteoporosis
    A Prentice
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    J Nutr Health Aging 6:282-6. 2002
    ....
  15. ncbi Calcium in pregnancy and lactation
    A Prentice
    MRC Human Nutrition Research, Downhams Lane, Milton Road, Cambridge CB4 1XJ, United Kingdom
    Annu Rev Nutr 20:249-72. 2000
    ..However, more research is required to define whether a low calcium intake prior to or during pregnancy can have deleterious effects on reproductive and lactational performance, and on the long-term health of the mother and child...
  16. ncbi Maternal calcium metabolism and bone mineral status
    A Prentice
    MRC Human Nutrition Research, Cambridge, United Kingdom, and MRC Keneba, The Gambia
    Am J Clin Nutr 71:1312S-6S. 2000
    ..Calcium nutrition may influence the health of the pregnant woman, her breast-milk calcium concentration, and the bone mineralization and blood pressure of her infant, but these possibilities require formal testing...
  17. ncbi Vitamin D across the lifecycle: physiology and biomarkers
    Ann Prentice
    Medical Research Council Human Nutrition Research, Cambridge, United Kingdom
    Am J Clin Nutr 88:500S-506S. 2008
    ..However, evidence using the biomarkers currently available shows that frank vitamin D deficiency is a major public health problem in many parts of the world that requires urgent attention...
  18. ncbi Randomized, placebo-controlled, calcium supplementation study in pregnant Gambian women: effects on breast-milk calcium concentrations and infant birth weight, growth, and bone mineral accretion in the first year of life
    Landing M A Jarjou
    Medical Research Council Keneba, Keneba, The Gambia
    Am J Clin Nutr 83:657-66. 2006
    ..A low maternal calcium supply in pregnancy may limit fetal mineral accretion and breast-milk calcium concentrations and thereby affect infant growth and bone mineral accretion...
  19. ncbi Effect of a calcium and exercise intervention on the bone mineral status of 16-18-y-old adolescent girls
    Samantha J Stear
    MRC Human Nutrition Research, Cambridge, United Kingdom
    Am J Clin Nutr 77:985-92. 2003
    ..Osteoporosis may be prevented or delayed by maximizing peak bone mass through diet modification and physical activity during adolescence...
  20. pmc Effect of calcium supplementation in pregnancy on maternal bone outcomes in women with a low calcium intake
    Landing M A Jarjou
    Medical Research Council Keneba, Keneba, The Gambia
    Am J Clin Nutr 92:450-7. 2010
    ..Mobilization of maternal bone mineral partly supplies calcium for fetal and neonatal bone growth and development...
  21. ncbi Bone mineral contents and plasma osteocalcin concentrations of Gambian children 12 and 24 mo after the withdrawal of a calcium supplement
    Bakary Dibba
    MRC Keneba, The Gambia
    Am J Clin Nutr 76:681-6. 2002
    ....
  22. ncbi Changes in bone mineral status and bone size during pregnancy and the influences of body weight and calcium intake
    Hanna Olausson
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Am J Clin Nutr 88:1032-9. 2008
    ..Calcium may be mobilized from the maternal skeleton during pregnancy, which may be influenced by several factors...
  23. pmc Randomized, placebo-controlled, calcium supplementation trial in pregnant Gambian women accustomed to a low calcium intake: effects on maternal blood pressure and infant growth
    Gail R Goldberg
    Medical Research Council Human Nutrition Research, Cambridge, United Kingdom
    Am J Clin Nutr 98:972-82. 2013
    ..Studies have suggested that calcium supplementation of women receiving low-calcium diets significantly reduces risk of pregnancy hypertension...
  24. pmc Abundant sunshine and vitamin D deficiency
    Inez Schoenmakers
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Br J Nutr 99:1171-3. 2008
  25. ncbi An investigation of ethnic differences in bone mineral, hip axis length, calcium metabolism and bone turnover between West African and Caucasian adults living in the United Kingdom
    B Dibba
    Medical Research Council Dunn Nutrition Unit, Cambridge, UK
    Ann Hum Biol 26:229-42. 1999
    ..This study revealed few ethnic differences that could account for the disparity in osteoporotic fracture rates between Africans and Caucasians, with the possible exception of anatomical differences in the hip...
  26. pmc Ethnic differences in parathyroid hormone secretion and mineral metabolism in response to oral phosphate administration
    Liya Yan
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Bone 45:238-45. 2009
    ....
  27. doi Birth weight predicts bone size in young adulthood at cortical sites in men and trabecular sites in women from The Gambia
    Stephanie de Bono
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Bone 46:1316-21. 2010
    ..Current weight was a positive predictor of BMC and aBMD in both sexes. This suggests that pre-natal factors affecting fetal growth may influence adult bone strength independently of post-natal factors...
  28. doi Calcium economy in human pregnancy and lactation
    Hanna Olausson
    MRC Human Nutrition Research, The Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Nutr Res Rev 25:40-67. 2012
    ....
  29. pmc Iron status and fibroblast growth factor-23 in Gambian children
    Vickie Braithwaite
    Medical Research Council MRC Human Nutrition Research, Cambridge, UK
    Bone 50:1351-6. 2012
    ..This study provides support for the contention that iron may be involved in FGF23 metabolic pathways...
  30. ncbi Fruit and vegetable intakes and bone mineral status: a cross sectional study in 5 age and sex cohorts
    Celia J Prynne
    Elsie Widdowson Laboratory, MRC Human Nutrition Research, Cambridge, United Kingdom
    Am J Clin Nutr 83:1420-8. 2006
    ..Evidence is increasing for positive effects of fruit and vegetable intakes on bone health. However, most of the studies to date were conducted in adults, and few reports included adolescents...
  31. pmc Plasma appearance and disappearance of an oral dose of 25-hydroxyvitamin D2 in healthy adults
    Kerry S Jones
    MRC Keneba, MRC Unit, PO Box 273, Banjul, The Gambia
    Br J Nutr 107:1128-37. 2012
    ..The present study provides data on the plasma response to oral 25(OH)D2 that will underpin and contribute to the further development of studies to investigate 25(OH)D half-life...
  32. ncbi Effect of apolipoprotein E genotype on vitamin K status in healthy older adults from China and the UK
    Liya Yan
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL, UK
    Br J Nutr 94:956-61. 2005
    ..1 (27.2) %, P=0.02; 49.6 (19.9) %, P=0.01 respectively) but not in Cambridge. This study demonstrates that a superior vitamin K status is associated with the apoE4 genotype in healthy older individuals from China and the UK...
  33. ncbi Dependence of blood indices of selenium and mercury on estimated fish intake in a national survey of British adults
    Christopher J Bates
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Public Health Nutr 10:508-17. 2007
    ..Contributions of fish and other foods to variance of selenium and mercury status were studied in British adults...
  34. ncbi Effect of calcium supplementation on bone mineral accretion in gambian children accustomed to a low-calcium diet
    B Dibba
    MRC Keneba, The Gambia, and MRC Human Nutrition Research (formerly MRC Dunn Nutritional Laboratory, Cambridge, United Kingdom
    Am J Clin Nutr 71:544-9. 2000
    ..Further studies are needed to determine whether an increased calcium intake has long-term benefits in Gambian children...
  35. ncbi North-south differences in some indices of Vitamin B6 nutritional status in older British people
    K D Pentieva
    MRC Human Nutrition Research, Cambridge, UK
    Int J Vitam Nutr Res 69:371-7. 1999
    ..This may have important implications for disease-risk geographical gradients in the UK...
  36. ncbi Relationship between cigarette smoking and nutrient intakes and blood status indices of older people living in the UK: further analysis of data from the National Diet and Nutrition Survey of people aged 65 years and over, 1994/95
    C M Walmsley
    MRC Human Nutrition Research, Cambridge, UK
    Public Health Nutr 2:199-208. 1999
    ..CONCLUSION: Older people who smoke cigarettes are at increased risk of suboptimal antioxidant and other micronutrient intakes and status, but the lower intakes found in cigarette smokers only partly explain their reduced blood indices...
  37. pmc Follow-up study of Gambian children with rickets-like bone deformities and elevated plasma FGF23: possible aetiological factors
    Vickie Braithwaite
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Bone 50:218-25. 2012
    ..This study provided evidence in support of the calcium deficiency hypothesis leading to urinary phosphate wasting and rickets and identified glomerular filtration rate and iron status as possible modulators of FGF23 metabolic pathways...
  38. ncbi Can osteoporosis be prevented with dietary strategies during adolescence?
    Fiona Ginty
    MRC Human Nutrition Research, Fulbourn Road, Cambridge CB1 9NL, UK
    Br J Nutr 92:5-6. 2004
  39. pmc Evidence for a downward secular trend in age of menarche in a rural Gambian population
    Sarah Prentice
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Ann Hum Biol 37:717-21. 2010
    ..65 years of age per decade (p < 0.00001). There was no evidence for a change in the rate of decline over the two decades studied. These results probably reflect ongoing socio-economic development within the region...
  40. ncbi Parathyroid hormone and rates of bone formation are raised in perimenopausal rural Gambian women
    Terence J Aspray
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Bone 36:710-20. 2005
    ..We postulate that high endogenous PTH concentrations may be beneficial to bone health in Gambian women, removing fatigue damage and improving bone quality...
  41. ncbi Intake and sources of phylloquinone (vitamin K(1)) in 4-year-old British children: comparison between 1950 and the 1990s
    C J Prynne
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Public Health Nutr 8:171-80. 2005
    ....
  42. ncbi Influence of birth weight and early diet on peripheral bone in premenopausal Cambridge women: a pQCT study
    M A Laskey
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge CB1 9NL
    J Musculoskelet Neuronal Interact 7:83. 2007
  43. ncbi Ethnic differences in osteocalcin gamma-carboxylation, plasma phylloquinone (vitamin K1) and apolipoprotein E genotype
    S R Beavan
    MRC Human Nutrition Research formerly MRC Dunn Nutritional Laboratory, Elsie Widdowson Laboratory, Cambridge, UK
    Eur J Clin Nutr 59:72-81. 2005
    ..To investigate plasma osteocalcin gamma-carboxylation and its relationship to plasma phylloquinone concentration and apolipoprotein E (apoE) genotype in women from three ethnic groups with differing osteoporotic fracture risk...
  44. ncbi Vitamin D: seasonal and regional differences in preschool children in Great Britain
    P S Davies
    Medical Research Council Human Nutrition Research, Cambridge, UK
    Eur J Clin Nutr 53:195-8. 1999
    ..Supplements are needed in the winter, to achieve satisfactory vitamin D status and minimise the risk of rickets and of poor bone health, especially in high-risk groups...
  45. doi Milk intake, calcium and vitamin D in pregnancy and lactation: effects on maternal, fetal and infant bone in low- and high-income countries
    Ann Prentice
    MRC Human Nutrition Research, Cambridge, UK, and MRC Keneba, Keneba, The Gambia
    Nestle Nutr Workshop Ser Pediatr Program 67:1-15. 2011
    ....
  46. ncbi Comparison of narrow-angle fan-beam and pencil-beam densitometers: in vivo and phantom study of the effect of bone density, scan mode, and tissue depth on spine measurements
    M Ann Laskey
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge CB1 9NL, UK
    J Clin Densitom 7:341-8. 2004
    ..In vivo studies confirmed the in vitro findings and demonstrated that even when the appropriate scan mode was selected, the BMC, BMD, and T-scores were significantly higher on the Prodigy than MD...
  47. ncbi Correlates of plasma homocysteine, cysteine and cysteinyl-glycine in respondents in the British National Diet and Nutrition Survey of young people aged 4-18 years, and a comparison with the survey of people aged 65 years and over
    C J Bates
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Br J Nutr 87:71-9. 2002
    ..We conclude that disease-risk indices, like tHcy and perhaps cysteine, if established during early life, may be modulated by diet and lifestyle, thereby providing an opportunity for public health intervention...
  48. ncbi Do appendicular bone measurements reflect changes in the axial skeleton?: the use of dual-energy X-ray absorptiometry and ultrasound measurements during lactation
    M Ann Laskey
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, CB1 9NL, UK
    J Clin Densitom 7:296-301. 2004
    ..7, p < 0.01; spine: 3.3%, SE = 1.3, p < 0.03). The similarity of DXA calcaneal changes to spine changes indicates that DXA calcaneal measurements could be a useful alternative tool when it is difficult to monitor BMC at axial sites...
  49. ncbi PASSCLAIM - Bone health and osteoporosis
    Ann Prentice
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Eur J Nutr 42:I28-49. 2003
    ..The EC Concerted Action PASSCLAIM aims to produce a generic tool for assessing the scientific support for health-related claims for foods and food components...
  50. ncbi Vitamin K status of older individuals in northern China is superior to that of older individuals in the UK
    Liya Yan
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Br J Nutr 92:939-45. 2004
    ..11); P=0.0003) and Cambridge subjects (coefficient -0.17 (SE 0.07); P=0.02). The present study demonstrates that older individuals in northern China have a better vitamin K status compared with their British counterparts in Cambridge, UK...
  51. ncbi Energy and nutrient dietary reference values for children in Europe: methodological approaches and current nutritional recommendations
    Ann Prentice
    MRC Medical Research Council, Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Br J Nutr 92:S83-146. 2004
    ....
  52. ncbi Determination of phylloquinone (vitamin K1) in plasma and serum by HPLC with fluorescence detection
    Laura Y Wang
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Clin Chim Acta 347:199-207. 2004
    ..Good agreement was obtained, with y=1.06x-0.09, R2=0.99. Validation also included linearity of response, absence of interference and confirmation of vitamin K1 peak purity...
  53. ncbi Bone mineralization and turnover in preterm infants at 8-12 years of age: the effect of early diet
    M S Fewtrell
    MRC Human Nutrition Research (formerly Dunn Nutritional Laboratory, Cambridge, United Kingdom
    J Bone Miner Res 14:810-20. 1999
    ..However, poor nutrition during the neonatal period may result in higher bone formation rates during childhood...
  54. doi Interrelation of parathyroid hormone and vitamin D metabolites in adolescents from the UK and The Gambia
    I Schoenmakers
    MRC Human Nutrition Research, Cambridge CB1 9NL, UK
    J Steroid Biochem Mol Biol 121:217-20. 2010
    ..The more uniform prediction of PTH by the 1,25VD:25VD ratio may be because this better reflects the extent to which PTH-induced 1,25VD production can be met by VD supply. Further validation is needed...
  55. ncbi Bone changes after 3 mo of lactation: influence of calcium intake, breast-milk output, and vitamin D-receptor genotype
    M A Laskey
    MRC Dunn Nutrition Centre, Cambridge, United Kingdom
    Am J Clin Nutr 67:685-92. 1998
    ..001). This finding suggests that the marked bone mineral changes observed in breast-feeding mothers represented a physiologic response to lactation that was independent of dietary calcium supply...
  56. ncbi Intake and sources of phylloquinone (vitamin K1): variation with socio-demographic and lifestyle factors in a national sample of British elderly people
    C W Thane
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Br J Nutr 87:605-13. 2002
    ..Dietary supplements contributed less than 0.5 % of phylloquinone intake. Participants living in northern England or in Scotland, in particular, derived less phylloquinone from vegetables than those living in southern England...
  57. ncbi Plasma phylloquinone (vitamin K1) concentration and its relationship to intake in a national sample of British elderly people
    C W Thane
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Br J Nutr 87:615-22. 2002
    ..The possibility of concurrent low fat-soluble vitamin status in elderly populations may be a cause for concern...
  58. ncbi Selenium status and associated factors in a British National Diet and Nutrition Survey: young people aged 4-18 y
    C J Bates
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Eur J Clin Nutr 56:873-81. 2002
    ..Assessment of selenium status to provide normative reference values, and investigation of associated socio-demographic factors, in a national sample of British young people aged 4-18 y...
  59. ncbi Biochemical markers of calcium and bone metabolism during 18 months of lactation in Gambian women accustomed to a low calcium intake and in those consuming a calcium supplement
    A Prentice
    Medical Research Council Dunn Nutrition Unit, Cambridge, United Kingdom
    J Clin Endocrinol Metab 83:1059-66. 1998
    ..015). These data demonstrate that lactation-associated changes in calcium and bone metabolism are physiological and are independent of dietary calcium supply in women with very low calcium intakes...
  60. ncbi Relationship between methylmalonic acid, homocysteine, vitamin B12 intake and status and socio-economic indices, in a subset of participants in the British National Diet and Nutrition Survey of people aged 65 y and over
    C J Bates
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Eur J Clin Nutr 57:349-57. 2003
    ..Assessment of functional vitamin B(12) status in a subset of the respondents in the British National Diet and Nutrition Survey of people aged 65 y and over...
  61. ncbi Risk factors for poor iron status in British toddlers: further analysis of data from the National Diet and Nutrition Survey of children aged 1.5-4.5 years
    C W Thane
    MRC Human Nutrition Research, Cambridge, UK
    Public Health Nutr 3:433-40. 2000
    ..To examine risk factors for poor iron status in British toddlers...
  62. ncbi Relationship between alcohol and nutrient intakes and blood status indices of older people living in the UK: further analysis of data from the National Diet and Nutrition Survey of people aged 65 years and over, 1994/5
    C M Walmsley
    MRC Dunn Nutrition Unit, Cambridge, UK
    Public Health Nutr 1:157-67. 1998
    ..To examine the relationships between alcohol consumption and a range of nutrient intakes and blood status indices in older people...
  63. ncbi Vitamin D status and parathyroid hormone concentrations in Chinese women and men from north-east of the People's Republic of China
    L Yan
    Medical Research Council Human Nutrition Research, Cambridge, UK
    Eur J Clin Nutr 54:68-72. 2000
    ....
  64. ncbi Epidemiological study of hip fracture in Shenyang, People's Republic of China
    L Yan
    Department of Preventive Medicine, Shenyang Medical College, People s Republic of China
    Bone 24:151-5. 1999
    ....
  65. ncbi An appraisal of vitamin B6 status indices and associated confounders, in young people aged 4-18 years and in people aged 65 years and over, in two national British surveys
    C J Bates
    MRC Human Nutrition Research, Cambridge, UK
    Public Health Nutr 2:529-35. 1999
    ..To compare vitamin B6 status indices with each other and with potential confounding factors, in the datasets from two national British surveys and associated studies...
  66. ncbi Micronutrients: highlights and research challenges from the 1994-5 National Diet and Nutrition Survey of people aged 65 years and over
    C J Bates
    MRC Human Nutrition Research, Cambridge, UK
    Br J Nutr 82:7-15. 1999
    ..The answers to these questions will help to define the characteristics of nutritional risk for older people in Britain, and to clarify future needs for education and intervention...
  67. ncbi Bone mineral changes during and after lactation
    M A Laskey
    MRC Human Nutrition Research, Cambridge, United Kingdom
    Obstet Gynecol 94:608-15. 1999
    ..To assess bone mineral changes during and after lactation...
  68. ncbi Gender differences in food and nutrient intakes and status indices from the National Diet and Nutrition Survey of people aged 65 years and over
    C J Bates
    MRC Human Nutrition Research, Cambridge, UK
    Eur J Clin Nutr 53:694-9. 1999
    ....
  69. ncbi Use of medicines by older people in a large British national survey, and their relation to vitamin status indices
    C J Bates
    MRC Human Nutrition Research, Cambridge, UK
    Public Health Nutr 2:15-22. 1999
    ..To describe the extent of use of medicines by older people living in Britain, and to explore relationships with vitamin status indices...
  70. ncbi Plasma pyridoxal phosphate and pyridoxic acid and their relationship to plasma homocysteine in a representative sample of British men and women aged 65 years and over
    C J Bates
    MRC Human Nutrition Research, Cambridge, UK
    Br J Nutr 81:191-201. 1999
    ..Since poor vitamin B6 status may have health implications, e.g. for immune function, cognition, and for essential intermediary metabolic pathways in older people, it needs to be investigated as a possible public health problem...
  71. ncbi Older people in China and the United Kingdom differ in the relationships among parathyroid hormone, vitamin D, and bone mineral status
    L Yan
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Bone 33:620-7. 2003
    ..2 (0.08), P = 0.02]. These data suggest that although PTH increases when 25OH-D decreases, and Chinese people have a higher PTH for a given 25OH-D, older Chinese adults may be more resistant than Britons to the effects of PTH on bone...
  72. ncbi Risk factors for low iron intake and poor iron status in a national sample of British young people aged 4-18 years
    C W Thane
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, CB1 9NL, UK
    Public Health Nutr 6:485-96. 2003
    ..To examine the prevalence and dietary, sociodemographic and lifestyle risk factors of low iron intake and poor iron status in British young people...
  73. ncbi Gamma-tocopherol as a possible marker for nutrition-related risk: results from four National Diet and Nutrition Surveys in Britain
    C J Bates
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Br J Nutr 92:137-50. 2004
    ..Although the mechanisms underlying these relationships are obscure, the gamma-tocopherol:alpha-tocopherol ratio may reveal poor dietary choices, status predictors and a propensity for obesity in later life, especially in women...
  74. ncbi Nutrient intakes; biochemical and risk indices associated with Type 2 diabetes and glycosylated haemoglobin, in the British National Diet and Nutrition Survey of people aged 65 years and over
    C J Bates
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Diabet Med 21:677-84. 2004
    ..To characterize nutritional differences between survey participants diagnosed with Type 2 diabetes; those without diabetes, and those with "undiagnosed diabetes" based on glycosylated haemoglobin (HbA(1c))...
  75. ncbi Dietary acid-base balance and intake of bone-related nutrients in Cambridge teenagers
    C J Prynne
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Eur J Clin Nutr 58:1462-71. 2004
    ..To evaluate the diet of 16-18-y-old boys and girls with particular reference to intakes of nutrients believed to affect bone health and dietary acid-base balance...
  76. ncbi Does hip strength analysis explain the lower incidence of hip fracture in the People's Republic of China?
    L Yan
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Bone 34:584-8. 2004
    ..The short HAL and NL of the population, however, could be an independent factor contributing to the low incidence of hip fracture...
  77. ncbi Zinc and vitamin A intake and status in a national sample of British young people aged 4-18 y
    C W Thane
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, UK
    Eur J Clin Nutr 58:363-75. 2004
    ..To examine zinc and vitamin A intake and status and associated dietary, socio-demographic, lifestyle and physiological factors in British young people...
  78. ncbi Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis
    M L Hull
    Reproductive Molecular Research Group, Department of Pathology Tennis Court Road, Cambridge CB2 1QP, UK
    Hum Reprod 20:350-8. 2005
    ..We hypothesized that COX-2 inhibition would reduce the size and number of ectopic human endometrial lesions in a nude mouse model of endometriosis...
  79. ncbi Blood indices of selenium and mercury, and their correlations with fish intake, in young people living in Britain
    C J Bates
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Br J Nutr 96:523-31. 2006
    ..Hg intakes need to be monitored, especially in women of child-bearing age, to ensure that Food Standards Agency guidelines are met...
  80. ncbi The effect of RU486 on the gene expression profile in an endometrial explant model
    R D Catalano
    Reproductive Molecular Research Group, Department of Pathology, University of Cambridge, Cambridge, UK
    Mol Hum Reprod 9:465-73. 2003
    ..Genes whose expression is controlled by these pathways are likely to be involved in the mechanism by which steroids render the endometrium receptive to the implanting embryo...
  81. ncbi Impact of calcium supplementation in the preceding pregnancy on the human milk calcium concentration of Gambian women
    L M A Jarjou
    MRC Keneba, The Gambia and MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge CB1 9NL, UK
    Adv Exp Med Biol 554:347-9. 2004
  82. ncbi Age- and gender-related differences in bone mineral status and biochemical markers of bone metabolism in Northern Chinese men and women
    L Yan
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Bone 30:412-5. 2002
    ..The pronounced low bone mineral status in older women may be associated with increased bone turnover, which was not observed in older men...
  83. ncbi In a population study, can parathyroid hormone aid the definition of adequate vitamin D status? A study of people aged 65 years and over from the British National Diet and Nutrition Survey
    C J Bates
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, CB1 9NL, Cambridge, UK
    Osteoporos Int 14:152-9. 2003
    ..In people living in institutions such as nursing homes, who are less likely to be exposed to sunlight throughout the year, plasma 25OHD levels were lower throughout the year...
  84. ncbi Nutritional characteristics of people with impaired mental capacity from a nationally representative survey of British people aged 65 years and over
    C J Bates
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge CB1 9NL, UK
    J Nutr Health Aging 8:240-4. 2004
    ..Mentally impaired older people are frequently excluded from population surveys for practical reasons; thus their nutritional characteristics are poorly delineated...
  85. ncbi Influence of birth weight on peripheral bone in young Gambian adults: a pQCT study
    S de Bono
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge
    J Musculoskelet Neuronal Interact 7:82. 2007
  86. ncbi Positive, site-specific associations between bone mineral status, fitness, and time spent at high-impact activities in 16- to 18-year-old boys
    F Ginty
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, CB1 9NL, United Kingdom
    Bone 36:101-10. 2005
    ..These findings indicate that participation of male adolescents in a range of high-impact activities for 1 h or more a day is associated with greater bone size and mineral content, especially at the hip...
  87. pmc Vitamin D supplementation in older people (VDOP): Study protocol for a randomised controlled intervention trial with monthly oral dosing with 12,000 IU, 24,000 IU or 48,000 IU of vitamin Dā‚ƒ
    Inez Schoenmakers
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Trials 14:299. 2013
    ..VDOP is funded by Arthritis Research UK, supported through Newcastle University and MRC Human Nutrition Research and sponsored by the Newcastle upon Tyne Hospitals NHS Foundation Trust.a..
  88. pmc Novel SLC34A3 mutation causing hereditary hypophosphataemic rickets with hypercalciuria in a Gambian family
    Vickie Braithwaite
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Bone 53:216-20. 2013
    ..To our knowledge, this study reports the first cases of HHRH in Africa and describes a novel causal mutation within the SLC34A3 gene...
  89. pmc Evidence for enhanced characterization of cortical bone using novel pQCT shape software
    Margaret Ann Laskey
    Nutrition and Bone Health, MRC Human Nutrition Research, Cambridge, UK
    J Clin Densitom 13:247-55. 2010
    ..Significant differences remained after adjusting for age, height, and weight. In conclusion, shape-sensitive software enhanced the characterization of tibiae in 2 contrasting groups of women...
  90. pmc Quantitative determination of vitamin D metabolites in plasma using UHPLC-MS/MS
    Shujing Ding
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, CB1 9NL, UK
    Anal Bioanal Chem 398:779-89. 2010
    ..All comparisons with conventional methods showed excellent correlations (r(2)ā€‰=ā€‰0.9738) for DEQAS samples, demonstrating the high degree of comparability of the new UHPLC-MS/MS technique to existing methods...
  91. ncbi Selenium status and its correlates in a British national diet and nutrition survey: people aged 65 years and over
    Christopher J Bates
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    J Trace Elem Med Biol 16:1-8. 2002
    ..Whole-blood glutathione peroxidase generally did not share these relationships, was only very weakly correlated with plasma Se, and appeared to be less useful as a status indicator in this population group...
  92. ncbi Micronutrients and the bone mineral content of the mother, fetus and newborn
    Ann Prentice
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, UK, CB1 9NL
    J Nutr 133:1693S-1699S. 2003
    ..Until more studies have been conducted, a precautionary case can be made for targeted supplementation of pregnant women who have very low intakes of calcium or who are at risk of vitamin D deficiency...
  93. pmc FGF23 is correlated with iron status but not with inflammation and decreases after iron supplementation: a supplementation study
    Vickie Braithwaite
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge CB1 9NL, United Kingdom
    Int J Pediatr Endocrinol 2012:27. 2012
    ..abstract:..
  94. doi Can uterine artery embolisation affect endometrial perfusion and function
    R Manchanda
    Department of Obstetrics and Gynaecology, Addenbrooke s Hospital, Cambridge, UK
    J Obstet Gynaecol 28:246-8. 2008
  95. ncbi Challenges in harmonizing energy and nutrient recommendations in Europe
    Mirjana Pavlovic
    Department of Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Belgrade, Serbia
    Ann Nutr Metab 51:108-14. 2007
    ..The symposium hosted by FENS provided a forum to exchange views and to consider the steps that will be needed if harmonization is to be realized in the future. A summary of the presentations and conclusions is presented here...
  96. ncbi Case-control study of breast milk calcium in mothers of children with and without nutritional rickets
    Tom D Thacher
    Department of Family Medicine, Jos University Teaching Hospital, Nigeria
    Acta Paediatr 95:826-32. 2006
    ....
  97. ncbi UK Food Standards Agency Optimal Nutrition Status Workshop: environmental factors that affect bone health throughout life
    Lynn Burns
    Food Standards Agency, Aviation House 125 Kingsway, London WC2 6NH, UK
    Br J Nutr 89:835-40. 2003
    ..Other lifestyle factors were also discussed, particularly the effect of physical activity and possible gene-nutrient interactions affecting bone health...
  98. pmc Nutrition and bone health projects funded by the UK Food Standards Agency: have they helped to inform public health policy?
    Margaret Ashwell
    Ashwell Associates Europe Ltd, Ashwell, Hertfordshire SG7 5PZ and Oxford Brookes University, Oxford OX3 0BP, UK
    Br J Nutr 99:198-205. 2008
    ..The major research gap identified was the need to investigate vitamin D status to define deficiency, insufficiency and depletion across age and ethnic groups in relation to bone health...
  99. ncbi The fallacy of using percentage body fat as a measure of adiposity
    Tim J Cole
    Am J Clin Nutr 87:1959; author reply 1959-60. 2008