Research Topics
Genomes and Genes
| Thomas PrattSummaryAffiliation: University of Edinburgh Country: UK Publications
| Collaborators
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Detail Information
Publications
Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidanceMartine Manuel
Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
BMC Dev Biol 8:59. 2008..Here, we examined the consequences of over-expression for the eye and its axonal connections...- The expression and activity of β-catenin in the thalamus and its projections to the cerebral cortex in the mouse embryoThomas Pratt
Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, Scotland, UK
BMC Neurosci 13:20. 2012..In this study we tested whether β-catenin is likely to play a role in thalamocortical connectivity by examining its expression and activity in developing thalamic neurons and their axons... 
Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasmThomas Pratt
Genes and Development Group, Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
J Neurosci 26:6911-23. 2006....- The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouseThomas Pratt
Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
Development 131:3773-84. 2004.... - Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic miceT Ian Simpson
Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
Neural Dev 4:19. 2009..Its functions in these cells are unknown... 
Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure developmentChristopher D Conway
Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
J Neurosci 31:1955-70. 2011..At the corpus callosum we find that Hs6st1 has Slit-independent functions and our data indicate additional roles in FGF signaling...- Evidence that descending cortical axons are essential for thalamocortical axons to cross the pallial-subpallial boundary in the embryonic forebrainYijing Chen
Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
PLoS ONE 7:e33105. 2012..These results support the hypothesis that thalamic axons grow from subpallium to cortex guided by cortical efferents, with stimulation from diffusible cortical growth-promoting factors... - Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activityNatasha M Tian
Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
Development 135:4081-9. 2008.... - Disruption of early events in thalamocortical tract formation in mice lacking the transcription factors Pax6 or Foxg1Thomas Pratt
Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
J Neurosci 22:8523-31. 2002.... - Analysis of axon guidance defects at the optic chiasm in heparan sulphate sulphotransferase compound mutant miceChristopher D Conway
Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh, UK
J Anat 219:734-42. 2011..We also found that expression of the Hs6st1 isoform Hs6st3 overlaps with that of Hs6st1 in the developing visual system, suggesting that some Hs6st activity remains present in this region of Hs6st1(-/-) mutant embryos... - Evaluation of the mouse TgTP6.3 tauGFP transgene as a lineage marker in chimerasGillian E MacKay
Division of Reproductive and Developmental Sciences, University of Edinburgh, UK
J Anat 206:79-92. 2005..3(+/-) cells fulfils the main criteria of a good lineage marker for many tissues. It provides a useful lineage marker, which should be particularly suitable for axons, blood vessels and pre-implantation embryos... - Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealizationMartine Manuel
Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh, UK
Development 134:545-55. 2007..These findings indicate that Pax6 levels are stabilized by autoregulation, that the proliferation of cortical progenitors is sensitive to altered Pax6 levels and that cortical arealization is not... - Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortexUladzislau Ivaniutsin
Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK
Neural Dev 4:3. 2009..We examined the consequences of loss of Apc function for the early development of the cerebral cortex... - Specific modification of heparan sulphate is required for normal cerebral cortical developmentDavid McLaughlin
Division of Biomedical Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
Mech Dev 120:1481-8. 2003.... - Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalonTomasz Jan Nowakowski
Developmental Biology Laboratory, Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
PLoS ONE 6:e23013. 2011..Together, our data suggest novel roles for micro RNAs during early development of progenitor cells in the embryonic telencephalon... - The motility of glioblastoma tumour cells is modulated by intracellular cofilin expression in a concentration-dependent mannerCelestial T Yap
Genes and Development Group, School of Biomedical and Clinical Laboratory Sciences, College of Medicine, University of Edinburgh, Scotland, United Kingdom
Cell Motil Cytoskeleton 60:153-65. 2005..We conclude that overexpression of cofilin enhances the motility of glioblastoma tumour cells in a concentration-dependent fashion, which is likely to contribute to their invasiveness... - Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nervesFelipe A Court
Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH9 1QH, UK
Nature 431:191-5. 2004..We propose that microtubule-based transport in the longitudinal bands of Cajal permits internodal Schwann cells to lengthen in response to axonal growth, thus ensuring rapid nerve impulse transmission... - MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brainTomasz Jan Nowakowski
Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
Proc Natl Acad Sci U S A 110:7056-61. 2013..Acute miR-92b loss of function had opposite effects. These findings indicate that miR-92b limits the production of intermediate cortical progenitors... - Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2(-/-) as well as Slit1(-/-)Slit2(-/-) embryosMatthew Down
Institute for Adaptive and Neural Computation, University of Edinburgh, Edinburgh, UK
BMC Neurosci 14:9. 2013..Here we used steerable-filters to quantify key properties of the population of axons at the chiasm in wild-type, Slit1(-/-), Slit2(-/-) and Slit1(-/-)Slit2(-/-) embryos... - The importance of combinatorial gene expression in early Mammalian thalamic patterning and thalamocortical axonal guidanceDavid J Price
Centre for Integrative Physiology, University of Edinburgh Edinburgh, UK
Front Neurosci 6:37. 2012..We stress the importance of the combinatorial actions of multiple genes for the development of the numerous specific identities and functions of cells in this exquisitely complex system and their orderly innervation of the cortex...