Thomas Pratt

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
    Martine Manuel
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 8:59. 2008
  2. pmc The expression and activity of β-catenin in the thalamus and its projections to the cerebral cortex in the mouse embryo
    Thomas Pratt
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, Scotland, UK
    BMC Neurosci 13:20. 2012
  3. ncbi request reprint The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse
    Thomas Pratt
    Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
    Development 131:3773-84. 2004
  4. ncbi request reprint Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm
    Thomas Pratt
    Genes and Development Group, Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:6911-23. 2006
  5. pmc Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice
    T Ian Simpson
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    Neural Dev 4:19. 2009
  6. doi request reprint Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development
    Christopher D Conway
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 31:1955-70. 2011
  7. pmc Evidence that descending cortical axons are essential for thalamocortical axons to cross the pallial-subpallial boundary in the embryonic forebrain
    Yijing Chen
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e33105. 2012
  8. doi request reprint Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activity
    Natasha M Tian
    Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 135:4081-9. 2008
  9. ncbi request reprint Disruption of early events in thalamocortical tract formation in mice lacking the transcription factors Pax6 or Foxg1
    Thomas Pratt
    Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 22:8523-31. 2002
  10. pmc Loss of functional Dicer in mouse radial glia cell-autonomously prolongs cortical neurogenesis
    Tomasz Jan Nowakowski
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK Electronic address
    Dev Biol 382:530-7. 2013

Collaborators

Detail Information

Publications23

  1. pmc Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance
    Martine Manuel
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    BMC Dev Biol 8:59. 2008
    ..Here, we examined the consequences of over-expression for the eye and its axonal connections...
  2. pmc The expression and activity of β-catenin in the thalamus and its projections to the cerebral cortex in the mouse embryo
    Thomas Pratt
    Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, Scotland, UK
    BMC Neurosci 13:20. 2012
    ..In this study we tested whether β-catenin is likely to play a role in thalamocortical connectivity by examining its expression and activity in developing thalamic neurons and their axons...
  3. ncbi request reprint The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse
    Thomas Pratt
    Genes and Development Group, Biomedical Sciences, George Square, The University of Edinburgh, Edinburgh EH8 9XD, UK
    Development 131:3773-84. 2004
    ....
  4. ncbi request reprint Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm
    Thomas Pratt
    Genes and Development Group, Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 26:6911-23. 2006
    ....
  5. pmc Normal ventral telencephalic expression of Pax6 is required for normal development of thalamocortical axons in embryonic mice
    T Ian Simpson
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh, EH8 9XD, UK
    Neural Dev 4:19. 2009
    ..Its functions in these cells are unknown...
  6. doi request reprint Heparan sulfate sugar modifications mediate the functions of slits and other factors needed for mouse forebrain commissure development
    Christopher D Conway
    Genes and Development Group, Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 31:1955-70. 2011
    ..At the corpus callosum we find that Hs6st1 has Slit-independent functions and our data indicate additional roles in FGF signaling...
  7. pmc Evidence that descending cortical axons are essential for thalamocortical axons to cross the pallial-subpallial boundary in the embryonic forebrain
    Yijing Chen
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 7:e33105. 2012
    ..These results support the hypothesis that thalamic axons grow from subpallium to cortex guided by cortical efferents, with stimulation from diffusible cortical growth-promoting factors...
  8. doi request reprint Foxg1 regulates retinal axon pathfinding by repressing an ipsilateral program in nasal retina and by causing optic chiasm cells to exert a net axonal growth-promoting activity
    Natasha M Tian
    Centre for Integrative Physiology, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Development 135:4081-9. 2008
    ....
  9. ncbi request reprint Disruption of early events in thalamocortical tract formation in mice lacking the transcription factors Pax6 or Foxg1
    Thomas Pratt
    Biomedical Sciences, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 22:8523-31. 2002
    ....
  10. pmc Loss of functional Dicer in mouse radial glia cell-autonomously prolongs cortical neurogenesis
    Tomasz Jan Nowakowski
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK Electronic address
    Dev Biol 382:530-7. 2013
    ..Our findings suggest a role for Dicer-dependent processes in limiting the timespan of cortical neurogenesis. ..
  11. pmc Evaluation of the mouse TgTP6.3 tauGFP transgene as a lineage marker in chimeras
    Gillian E MacKay
    Division of Reproductive and Developmental Sciences, University of Edinburgh, UK
    J Anat 206:79-92. 2005
    ..3(+/-) cells fulfils the main criteria of a good lineage marker for many tissues. It provides a useful lineage marker, which should be particularly suitable for axons, blood vessels and pre-implantation embryos...
  12. pmc Analysis of axon guidance defects at the optic chiasm in heparan sulphate sulphotransferase compound mutant mice
    Christopher D Conway
    Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, George Square, Edinburgh, UK
    J Anat 219:734-42. 2011
    ..We also found that expression of the Hs6st1 isoform Hs6st3 overlaps with that of Hs6st1 in the developing visual system, suggesting that some Hs6st activity remains present in this region of Hs6st1(-/-) mutant embryos...
  13. pmc Foxg1 is required to limit the formation of ciliary margin tissue and Wnt/β-catenin signalling in the developing nasal retina of the mouse
    Vassiliki Fotaki
    University of Edinburgh, Centre for Integrative Physiology, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Dev Biol 380:299-313. 2013
    ..Our results reveal a new role of Foxg1 in limiting CM development in the nasal peripheral retina and add a new molecular player in the developmental network involved in CM specification...
  14. pmc Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2(-/-) as well as Slit1(-/-)Slit2(-/-) embryos
    Matthew Down
    Institute for Adaptive and Neural Computation, University of Edinburgh, Edinburgh, UK
    BMC Neurosci 14:9. 2013
    ..Here we used steerable-filters to quantify key properties of the population of axons at the chiasm in wild-type, Slit1(-/-), Slit2(-/-) and Slit1(-/-)Slit2(-/-) embryos...
  15. pmc Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization
    Martine Manuel
    Genes and Development Group, Centres for Integrative Physiology and Neuroscience Research, Hugh Robson Building, George Square, University of Edinburgh, Edinburgh, UK
    Development 134:545-55. 2007
    ..These findings indicate that Pax6 levels are stabilized by autoregulation, that the proliferation of cortical progenitors is sensitive to altered Pax6 levels and that cortical arealization is not...
  16. pmc MicroRNA-92b regulates the development of intermediate cortical progenitors in embryonic mouse brain
    Tomasz Jan Nowakowski
    Centre for Integrative Physiology, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom
    Proc Natl Acad Sci U S A 110:7056-61. 2013
    ..Acute miR-92b loss of function had opposite effects. These findings indicate that miR-92b limits the production of intermediate cortical progenitors...
  17. pmc Adenomatous polyposis coli is required for early events in the normal growth and differentiation of the developing cerebral cortex
    Uladzislau Ivaniutsin
    Genes and Development Group, Centre for Integrative Physiology, School of Biomedical Sciences, The University of Edinburgh, Edinburgh, UK
    Neural Dev 4:3. 2009
    ..We examined the consequences of loss of Apc function for the early development of the cerebral cortex...
  18. ncbi request reprint Specific modification of heparan sulphate is required for normal cerebral cortical development
    David McLaughlin
    Division of Biomedical Sciences, The University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Mech Dev 120:1481-8. 2003
    ....
  19. doi request reprint Heparan sulfotransferases hs6st1 and hs2st keep erk in check for mouse corpus callosum development
    James M Clegg
    Centre for Integrative Physiology, The University of Edinburgh, Edinburgh EH8 9XD, United Kingdom, Centre for Glycobiology, Institute of Integrative Biology, University of Liverpool, Liverpool L69 7ZB, United Kingdom, and Department of Craniofacial Development and Stem Cell Biology, King s College London, London SE5 9RW, United Kingdom
    J Neurosci 34:2389-401. 2014
    ..Overall, our data fit a model in which Hs2st and Hs6st1 normally generate conditions conducive to CC development by generating an HS-containing environment that keeps Erk signaling in check. ..
  20. pmc Functional dicer is necessary for appropriate specification of radial glia during early development of mouse telencephalon
    Tomasz Jan Nowakowski
    Developmental Biology Laboratory, Centre for Integrative Physiology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS ONE 6:e23013. 2011
    ..Together, our data suggest novel roles for micro RNAs during early development of progenitor cells in the embryonic telencephalon...
  21. ncbi request reprint Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nerves
    Felipe A Court
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH9 1QH, UK
    Nature 431:191-5. 2004
    ..We propose that microtubule-based transport in the longitudinal bands of Cajal permits internodal Schwann cells to lengthen in response to axonal growth, thus ensuring rapid nerve impulse transmission...
  22. ncbi request reprint The motility of glioblastoma tumour cells is modulated by intracellular cofilin expression in a concentration-dependent manner
    Celestial T Yap
    Genes and Development Group, School of Biomedical and Clinical Laboratory Sciences, College of Medicine, University of Edinburgh, Scotland, United Kingdom
    Cell Motil Cytoskeleton 60:153-65. 2005
    ..We conclude that overexpression of cofilin enhances the motility of glioblastoma tumour cells in a concentration-dependent fashion, which is likely to contribute to their invasiveness...
  23. pmc The importance of combinatorial gene expression in early Mammalian thalamic patterning and thalamocortical axonal guidance
    David J Price
    Centre for Integrative Physiology, University of Edinburgh Edinburgh, UK
    Front Neurosci 6:37. 2012
    ..We stress the importance of the combinatorial actions of multiple genes for the development of the numerous specific identities and functions of cells in this exquisitely complex system and their orderly innervation of the cortex...