J A Powell

..The aims were to review relevant guidelines and to collate and analyse views of clinical trialists on the role of payments and other factors that motivated clinicians to join clinical trials...

..Internet-based interventions to assist in diabetes management have the potential to provide patients with the information and support they need to become effective self-managers...

..Major benefits to patient care could ensue given sufficient development of the care-research interface via electronic records...

..abstract:..

..They rated peer interaction as the most desirable and the most useful of the features available. Using an Internet-based clinic to support the self-management of diabetes is feasible and acceptable to patients...

..Most households in the United Kingdom have Internet access, and health-related Internet use is increasing. The National Health Service (NHS) Direct website is the major UK provider of online health information...

..Problems related more to misuse of the internet rather than concerns over inaccuracy. Such qualitative work is important in an emerging research area to understand internet use better...

..A qualitative study was therefore undertaken to explore these issues for mental health service users...

..A major use of the of the internet is for health information-seeking. There has been little research into its use in relation to mental health...

..A larger study of representative samples of patients in both primary and secondary care settings is needed to further investigate issues of data sharing and consent...

..Treatment effects were found to vary with caregiver characteristics such as ethnic groups, formal support and baseline burden. Further evaluation is needed in robust trials with good follow-up...

..There is a lack of qualitative research that explores how citizens are actually using the Internet for health care...

..As Internet use grows, health interventions are increasingly being delivered online. Pioneering researchers are using the networking potential of the Internet, and several of them have evaluated these interventions...

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..All five patients were positive about the Virtual Clinic. A user-centred approach to developing an Internet intervention is important to ensure that it will meet patients' needs and that they will be enthusiastic about using it...

..To compile and evaluate the evidence on the effects on health and social outcomes of computer based peer to peer communities and electronic self support groups, used by people to discuss health related issues remotely...

..The quality of consumer health information on the World Wide Web is an important issue for medicine, but to date no systematic and comprehensive synthesis of the methods and evidence has been performed...

..Gene expression analysis suggests differential expression of isoforms of tau in regions in the brain. CONCLUSIONS; Frontotemporal dementia can result from gene mutations that alter splicing and expression of tau...

..They also need to consider issues of equity, which have not been addressed in research to date...

..In addition, homozygous or hemizygous carriers of the 5-HT2C Ser allele were 12 times more likely to have major depressive illness than homozygous or hemizygous carriers of the 5-HT2C Cys allele...

..Levels of linkage disequilibrium were generally low across the CHAT locus but two of the coding variants, D7N and A120T, proved to be in complete linkage disequilibrium...

..9-6.7) compared to those with ID/II genotype (odds ratio 0.7, 95% CI 0.4-1.2). This interaction was particularly strong for decline in verbal memory and was not apparently mediated by vascular risk factors measured at baseline...

..Internet-based depression communities provide a forum for individuals to communicate and share information and ideas. There has been little research into the health status and other characteristics of users of these communities...