Desmond G Powe

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc DACH1: Its Role as a Classifier of Long Term Good Prognosis in Luminal Breast Cancer
    Desmond G Powe
    The John Van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, United Kingdom Department of Cellular Pathology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
    PLoS ONE 9:e84428. 2014
  2. pmc FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis
    Somaia Elbauomy Elsheikh
    Department of Histopathology, School of Molecular Medical Sciences, Queen s Medical Centre, Nottingham University Hospitals Trust and University of Nottingham, Nottingham, UK
    Breast Cancer Res 9:R23. 2007
  3. pmc Luminal and basal-like breast cancer cells show increased migration induced by hypoxia, mediated by an autocrine mechanism
    Melanie J Voss
    Institute of Immunology, ZBAF, Witten Herdecke University, Stockumer Str, 10, 58448 Witten, Germany
    BMC Cancer 11:158. 2011
  4. pmc Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplification
    Desmond G Powe
    Department of Cellular Pathology, Queen s Medical Centre, Nottingham University Hospitals NHS Trust, Derby Road, Nottingham NG7 2UH, UK
    Breast Cancer Res 11:R90. 2009
  5. doi request reprint 'Entopy': local allergy paradigm
    D G Powe
    Division of Histopathology, Queen s Medical Centre, Nottingham University Hospitals Trust, Nottingham, UK
    Clin Exp Allergy 40:987-97. 2010
  6. doi request reprint Mucosal thickening in allergic and idiopathic rhinitis mucosa and its probable mechanism
    Desmond G Powe
    Department of Histopathology and Surgical Science, Queen s Medical Centre, Nottingham University Hospitals Trust, Nottingham, England
    Ann Allergy Asthma Immunol 103:14-9. 2009
  7. ncbi request reprint Local mucosal immunoglobulin E production: does allergy exist in non-allergic rhinitis?
    D G Powe
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, Nottingham, UK
    Clin Exp Allergy 36:1367-72. 2006
  8. doi request reprint Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study
    D G Powe
    Department of Cellular Pathology, Queen s Medical Centre, Nottingham University Hospitals Trust and School of Molecular Medical Sciences, University of Nottingham, Nottingham NG7 2UH, UK
    Breast Cancer Res Treat 130:457-63. 2011
  9. pmc Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival
    Desmond G Powe
    Department of Cellular Pathology, Queen s Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK
    Oncotarget 1:628-38. 2010
  10. doi request reprint Evidence for the involvement of free light chain immunoglobulins in allergic and nonallergic rhinitis
    Desmond G Powe
    Department of Histopathology, Surgical and Medical Sciences, Queen s Medical Centre, Nottingham University Hospitals Trust, Nottingham NG7 2UH, United Kingdom
    J Allergy Clin Immunol 125:139-45.e1-3. 2010

Collaborators

Detail Information

Publications55

  1. pmc DACH1: Its Role as a Classifier of Long Term Good Prognosis in Luminal Breast Cancer
    Desmond G Powe
    The John Van Geest Cancer Research Centre, Nottingham Trent University, Nottingham, United Kingdom Department of Cellular Pathology, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom
    PLoS ONE 9:e84428. 2014
    ..In this study, we have used an artificial neural network (ANN) approach to identify DACH1 as a candidate luminal marker and its role in predicting clinical outcome in breast cancer is assessed...
  2. pmc FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysis
    Somaia Elbauomy Elsheikh
    Department of Histopathology, School of Molecular Medical Sciences, Queen s Medical Centre, Nottingham University Hospitals Trust and University of Nottingham, Nottingham, UK
    Breast Cancer Res 9:R23. 2007
    ..Recent studies have demonstrated that specific FGFR1 amplification correlates with gene expression and that FGFR1 activity is required for the survival of a FGFR1 amplified breast cancer cell line...
  3. pmc Luminal and basal-like breast cancer cells show increased migration induced by hypoxia, mediated by an autocrine mechanism
    Melanie J Voss
    Institute of Immunology, ZBAF, Witten Herdecke University, Stockumer Str, 10, 58448 Witten, Germany
    BMC Cancer 11:158. 2011
    ..The effect of hypoxia on tumor cell migration was assessed in selected luminal, post-EMT and basal-like breast carcinoma cell lines...
  4. pmc Investigating AP-2 and YY1 protein expression as a cause of high HER2 gene transcription in breast cancers with discordant HER2 gene amplification
    Desmond G Powe
    Department of Cellular Pathology, Queen s Medical Centre, Nottingham University Hospitals NHS Trust, Derby Road, Nottingham NG7 2UH, UK
    Breast Cancer Res 11:R90. 2009
    ....
  5. doi request reprint 'Entopy': local allergy paradigm
    D G Powe
    Division of Histopathology, Queen s Medical Centre, Nottingham University Hospitals Trust, Nottingham, UK
    Clin Exp Allergy 40:987-97. 2010
    ..This review is intended to provide an improved understanding of the mechanisms and causes of local mucosal hypersensitivity...
  6. doi request reprint Mucosal thickening in allergic and idiopathic rhinitis mucosa and its probable mechanism
    Desmond G Powe
    Department of Histopathology and Surgical Science, Queen s Medical Centre, Nottingham University Hospitals Trust, Nottingham, England
    Ann Allergy Asthma Immunol 103:14-9. 2009
    ..Rhinitis is a prevalent condition characterized by nasal mucosal irritation. Conflicting studies suggest that the mucosa of patients with allergic and nonallergic rhinitis undergoes thickening...
  7. ncbi request reprint Local mucosal immunoglobulin E production: does allergy exist in non-allergic rhinitis?
    D G Powe
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, Nottingham, UK
    Clin Exp Allergy 36:1367-72. 2006
    ..Furthermore, successful therapeutic regimens used in the treatment of non-allergic rhinitis will be examined as these could provide an insight into the underlying pathophysiology of this common but poorly understood disease...
  8. doi request reprint Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study
    D G Powe
    Department of Cellular Pathology, Queen s Medical Centre, Nottingham University Hospitals Trust and School of Molecular Medical Sciences, University of Nottingham, Nottingham NG7 2UH, UK
    Breast Cancer Res Treat 130:457-63. 2011
    ..These findings suggest a possible role for targeted therapy using adrenoceptor antagonists...
  9. pmc Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival
    Desmond G Powe
    Department of Cellular Pathology, Queen s Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, NG7 2UH, UK
    Oncotarget 1:628-38. 2010
    ..A larger epidemiological study leading to randomised clinical trials is needed for breast and other cancer types including colon, prostate and ovary...
  10. doi request reprint Evidence for the involvement of free light chain immunoglobulins in allergic and nonallergic rhinitis
    Desmond G Powe
    Department of Histopathology, Surgical and Medical Sciences, Queen s Medical Centre, Nottingham University Hospitals Trust, Nottingham NG7 2UH, United Kingdom
    J Allergy Clin Immunol 125:139-45.e1-3. 2010
    ..Recent murine studies suggest the existence of an IgE-independent hypersensitivity response involving antigen-induced mast cell activation, mediated by immunoglobulin free light chains (FLCs)...
  11. ncbi request reprint Evidence for an inflammatory pathophysiology in idiopathic rhinitis
    D G Powe
    Division of Pathology, Department of Clinical Laboratory Sciences, University Hospital Queen s Medical Centre, Nottingham, UK
    Clin Exp Allergy 31:864-72. 2001
    ..In contrast, allergic rhinitis has a Th2 type inflammatory pathology mediated by IgE and mast cells...
  12. doi request reprint Targeted therapies: Using β-blockers to inhibit breast cancer progression
    Desmond G Powe
    Department of Cellular Pathology, Queen s Medical Centre, Nottingham University Hospitals NHS Trust, Derby Road, Nottingham, UK
    Nat Rev Clin Oncol 8:511-2. 2011
    ..Should we be skeptical about these controversial findings?..
  13. doi request reprint The prognostic significance of PELP1 expression in invasive breast cancer with emphasis on the ER-positive luminal-like subtype
    Hany Onsy Habashy
    Department of Histopathology, School of Molecular Medical Sciences, Nottingham University Hospitals NHS Trust, University of Nottingham, Hucknall Road, Nottingham, UK
    Breast Cancer Res Treat 120:603-12. 2010
    ..PELP1 appears to have a potential application in assessing the clinical outcome of patients with ER-positive breast cancer...
  14. doi request reprint PIK3CA expression in invasive breast cancer: a biomarker of poor prognosis
    Mohammed A Aleskandarany
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Clifton Boulevard, Nottingham NG7 2UH, UK
    Breast Cancer Res Treat 122:45-53. 2010
    ..Thus, targeting of PIK3CA using specific inhibitors could potentially be beneficial, particularly for patients with more aggressive poorly differentiated tumors, irrespective of their molecular subtype...
  15. doi request reprint Morphologic and molecular evolutionary pathways of low nuclear grade invasive breast cancers and their putative precursor lesions: further evidence to support the concept of low nuclear grade breast neoplasia family
    Tarek M A Abdel-Fatah
    Division of Pathology, School of Molecular Medical Sciences and Nottingham University Hospitals Trust, University of Nottingham, Nottingham, UK
    Am J Surg Pathol 32:513-23. 2008
    ..Our findings support the concept that progression of LNGBC to HNGBC (basal-like or HER2+) phenotype is an unlikely biologic phenomenon...
  16. doi request reprint Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen
    Hany Onsy Habashy
    Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK
    Breast Cancer Res Treat 119:283-93. 2010
    ..CD71 appears to be a candidate marker of a subgroup of ER+/luminal-like breast cancer characterised by poor outcome and resistance to tamoxifen...
  17. doi request reprint Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast
    Andrew R Green
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham and Nottingham University Hospitals NHS Trust, Queen s Medical Centre, Nottingham, UK NG7 2UH
    Breast Cancer Res Treat 113:59-66. 2009
    ..The aim of this study is to assess the expression of these genes in LCIS and compare them with normal breast, using CDH1 as a control, in order to evaluate their role as TSGs...
  18. doi request reprint Triple-negative breast cancer: distinguishing between basal and nonbasal subtypes
    Emad A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, United Kingdom
    Clin Cancer Res 15:2302-10. 2009
    ..It is widely perceived that BLBC and TN tumors are synonymous and BLBC can be defined using a TN definition without the need for the expression of basal markers...
  19. ncbi request reprint Invasive lobular carcinoma of the breast: response to hormonal therapy and outcomes
    Emad A Rakha
    Department of Histopathology, School of Molecular Medical Sciences, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UK
    Eur J Cancer 44:73-83. 2008
    ..It is less common than invasive ductal carcinoma (IDC) and few large studies have addressed its biologic characteristics and behaviour with respect to long-term clinical outcome and response to adjuvant therapy...
  20. doi request reprint RERG (Ras-like, oestrogen-regulated, growth-inhibitor) expression in breast cancer: a marker of ER-positive luminal-like subtype
    Hany Onsy Habashy
    Department of Pathology, School of Molecular Medical Sciences, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UK
    Breast Cancer Res Treat 128:315-26. 2011
    ..In conclusion, we used novel bioinformatics methods to identify candidate genes to characterise ER+ luminal-like breast cancer. RERG gene is a key marker of the luminal BC class and can be used to separate distinct prognostic subgroups...
  21. doi request reprint Proposal for a modified grading system based on mitotic index and Bcl2 provides objective determination of clinical outcome for patients with breast cancer
    Tarek M A Abdel-Fatah
    Division of Pathology, School of Molecular Medical Sciences and Nottingham University Hospitals Trust, University of Nottingham, Nottingham, UK
    J Pathol 222:388-99. 2010
    ....
  22. doi request reprint CTEN (C-terminal tensin-like), a novel oncogene overexpressed in invasive breast carcinoma of poor prognosis
    Abdulkader Albasri
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Breast Cancer Res Treat 126:47-54. 2011
    ..In conclusion, our results demonstrated the oncogenetic role of increased CTEN expression and its association with poor prognostic parameters. These data could help in prognostic assessment in BC patients...
  23. doi request reprint Forkhead-box A1 (FOXA1) expression in breast cancer and its prognostic significance
    Hany Onsy Habashy
    Department of Histopathology, School of Molecular Medical Sciences, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, UK
    Eur J Cancer 44:1541-51. 2008
    ....
  24. doi request reprint Quantitative RT-PCR analysis of estrogen receptor gene expression in laser microdissected prostate cancer tissue
    Thomas J Walton
    The John Van Geest Cancer Research Centre, School of Biomedical and Natural Sciences, Nottingham Trent University, Clifton Campus, Clifton Lane, Nottingham, United Kingdom
    Prostate 69:810-9. 2009
    ....
  25. doi request reprint Growth fraction as a predictor of response to chemotherapy in node-negative breast cancer
    Mohammed A Aleskandarany
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, United Kingdom
    Int J Cancer 126:1761-9. 2010
    ..Patients with a high growth fraction appear to be ideal candidates for adjuvant chemotherapy while those with low growth fraction are less likely to benefit and are prone to the potential serious side effects of adjuvant chemotherapy...
  26. doi request reprint MIB1/Ki-67 labelling index can classify grade 2 breast cancer into two clinically distinct subgroups
    Mohammed A Aleskandarany
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    Breast Cancer Res Treat 127:591-9. 2011
    ....
  27. doi request reprint The biological, clinical and prognostic implications of p53 transcriptional pathways in breast cancers
    Tarek M Abdel-Fatah
    Division of Pathology, School of Molecular Medical Sciences, Nottingham University Hospitals NHS Trust, UK
    J Pathol 220:419-34. 2010
    ....
  28. doi request reprint FOXO3a nuclear localisation is associated with good prognosis in luminal-like breast cancer
    Hany Onsy Habashy
    School of Molecular Medical Sciences, University of Nottingham, Nottingham, NG7 2UH, UK
    Breast Cancer Res Treat 129:11-21. 2011
    ..In conclusion, our results demonstrate the biological and prognostic role of FOXO3a protein expression and its subcellular localisation in ER-positive/luminal-like BC possibly through its involvement in controlling cell proliferation...
  29. doi request reprint EpCAM expression is an indicator of recurrence in basal-like breast cancer
    Ayodeji J Agboola
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Breast Cancer Res Treat 133:575-82. 2012
    ..97, P = 0.005) and MFS (LR 4.01, P = 0.045). EpCAM may play a role in breast cancer progression and its expression is associated with poor patient outcome in basal-like breast cancer, independent of other prognostic factors...
  30. pmc Histological grading of breast cancer on needle core biopsy: the role of immunohistochemical assessment of proliferation
    T ng Chang Kwok
    Department of Pathology and School Molecular Medical Sciences, Nottingham University Hospital, Hucknall Road, Nottingham, UK
    Histopathology 57:212-9. 2010
    ..35 and 0.65). A major cause of the discrepancy is underestimation of mitoses in the NCB specimen. The aim was to determine the best method of assessing proliferation on NCB...
  31. doi request reprint Clinicopathologic and molecular significance of phospho-Akt expression in early invasive breast cancer
    Mohammed A Aleskandarany
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    Breast Cancer Res Treat 127:407-16. 2011
    ..These findings may help development more adequate therapeutic regimens for specific subgroups of this key cancer pathway...
  32. doi request reprint The expression of ERalpha, ERbeta and PR in lobular carcinoma in situ of the breast determined using laser microdissection and real-time PCR
    Andrew R Green
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK
    Histopathology 54:419-27. 2009
    ..To determine the status of oestrogen receptor (ER) subtypes (ERalpha and ERbeta) in lobular carcinoma in situ (LCIS) of the breast...
  33. doi request reprint A quantifier-based fuzzy classification system for breast cancer patients
    Daniele Soria
    School of Computer Science, Advanced Data Analysis Centre, University of Nottingham, Jubilee Campus, Wollaton Road, Nottingham NG8 1BB, UK
    Artif Intell Med 58:175-84. 2013
    ..The objective of this study was to investigate the use of fuzzy methodologies to create an easy to interpret set of classification rules, capable of placing the large majority of patients into one of the specified groups...
  34. doi request reprint A review of the biological and clinical characteristics of luminal-like oestrogen receptor-positive breast cancer
    Hany O Habashy
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, UK
    Histopathology 60:854-63. 2012
    ..In this review, we explore the concept and definitions of the luminal-like class of breast carcinoma and their contribution to our understanding of their molecular features, clinical significance and therapeutic implications...
  35. doi request reprint An evaluation of the clinical significance of FOXP3+ infiltrating cells in human breast cancer
    Sahar M A Mahmoud
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Breast Cancer Res Treat 127:99-108. 2011
    ..We therefore conclude that FOXP3(+) infiltrating cells do not have a dominant role in breast cancer prognosis and suggest that other inflammatory cell subsets may be more critical variables...
  36. doi request reprint Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer
    Sahar M A Mahmoud
    School of Molecular Medical Sciences and School of Community Health Sciences, University of Nottingham, Nottingham, United Kingdom
    J Clin Oncol 29:1949-55. 2011
    ..These results suggest that tumor-infiltrating CD8(+) T lymphocytes have antitumor activity as judged by their favorable effect on patients' survival and could potentially be exploited in the treatment of breast cancer...
  37. doi request reprint The oestrogen receptor coactivator CARM1 has an oncogenic effect and is associated with poor prognosis in breast cancer
    Hany Onsy Habashy
    Department of Histopathology, Nottingham City Hospital, School of Molecular Medical Sciences, The University of Nottingham and Nottingham University Hospitals NHS Trust, Hucknall Road, Nottingham, NG5 1PB, UK
    Breast Cancer Res Treat 140:307-16. 2013
    ..CARM1 could be a potential marker of luminal class subclassification and for target therapy, particularly in the ER-positive luminal-like subgroup. ..
  38. ncbi request reprint Biologic and clinical characteristics of breast cancer with single hormone receptor positive phenotype
    Emad A Rakha
    Department of Histopathology and Surgery, School of Molecular Medical Sciences, Nottingham University Hospitals National Health Service Trust and University of Nottingham, Nottingham, United Kingdom
    J Clin Oncol 25:4772-8. 2007
    ..It is usually easier to decide treatment strategies in cases of double-positive/-negative phenotypes than in single-positive tumors...
  39. ncbi request reprint The prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome
    Andrew R Green
    Division of Pathology, School of Molecular Medical Sciences, Nottingham University Hospitals NHS and University of Nottingham, Nottingham, UK
    Breast Cancer Res Treat 110:427-37. 2008
    ..The aims were to identify whether their expression was related to patient outcome, their relationships to known prognostic factors and to provide a basis for further research into the mechanistic significance of such associations...
  40. doi request reprint Understanding the HER family in breast cancer: interaction with ligands, dimerization and treatments
    Fabrício F T Barros
    School of Molecular Medical Sciences, University of Nottingham, Nottingham, NG7 2UH, UK
    Histopathology 56:560-72. 2010
    ..The study of interaction between receptors/ligands will characterize specifically their signalling pathway and understand which strategy to acquire...
  41. pmc Comparative transcriptional profiling of the limbal epithelial crypt demonstrates its putative stem cell niche characteristics
    Bina B Kulkarni
    Division of Ophthalmology and Visual Sciences, Eye and ENT Building Queen s Medical Centre, Derby Road, Nottingham, UK
    BMC Genomics 11:526. 2010
    ..The purpose of this microarray study was to characterise the transcriptional profile of the LEC and compare with other ocular surface epithelial regions to support our hypothesis that LEC preferentially harbours stem cells (SC)...
  42. ncbi request reprint High frequency of coexistence of columnar cell lesions, lobular neoplasia, and low grade ductal carcinoma in situ with invasive tubular carcinoma and invasive lobular carcinoma
    Tarek M A Abdel-Fatah
    Division of Pathology, School of Molecular Medical Sciences, University of Nottingham, Nottingham, London, UK
    Am J Surg Pathol 31:417-26. 2007
    ..Molecular studies are being performed to substantiate the hypothesis that tubular and lobular carcinomas have direct evolutionary links to CCLs and flat epithelial atypia...
  43. doi request reprint MicroRNA involvement in the pathogenesis and management of breast cancer
    S M Khoshnaw
    Department of Histopathology, School of Molecular Medical Sciences, University of Nottingham and Nottingham University Hospitals Trust, Nottingham, UK
    J Clin Pathol 62:422-8. 2009
    ....
  44. doi request reprint Optimised laser microdissection of the human ocular surface epithelial regions for microarray studies
    Bina B Kulkarni
    Division of Ophthalmology and Visual Sciences, B Floor, Eye and ENT Building, Queen s Medical Centre, Derby Road, Nottingham, UK
    BMC Ophthalmol 13:62. 2013
    ..0 ST arrays...
  45. doi request reprint Idiopathic rhinitis
    Paul Burns
    Department of Otorhinolaryngology, Queen s Medical Centre, Nottingham, UK
    Curr Opin Otolaryngol Head Neck Surg 20:1-8. 2012
    ..A diagnosis of idiopathic rhinitis can only be used when all other causes have been excluded and this review tries to clarify whom this term should be applied to, and the reasons why...
  46. doi request reprint Reduction of TLR2 gene expression in allergic and nonallergic rhinitis
    Lewis J Vanhinsbergh
    Division of Pathology, Queen s Medical Centre, Nottingham University Hospitals Trust, Nottingham, England
    Ann Allergy Asthma Immunol 99:509-16. 2007
    ..Increased human beta-defensin (HBD) 4 expression is associated with infection...
  47. doi request reprint The proteins FABP7 and OATP2 are associated with the basal phenotype and patient outcome in human breast cancer
    H Zhang
    Division of Pathology, School of Molecular Medical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    Breast Cancer Res Treat 121:41-51. 2010
    ..We have identified a novel subgroup of basal tumours showing FABP7 expression that have significantly better clinical outcome. Further studies analysing the role of FABP7 are therefore warranted...
  48. ncbi request reprint Mucosal T-cell phenotypes in persistent atopic and nonatopic rhinitis show an association with mast cells
    D G Powe
    School of Medical Molecular Science, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Allergy 59:204-12. 2004
    ..Previously, T cell subsets have not been characterized in this subselection of nonallergic subjects and furthermore, their relationship to mast cell and basophil effector cells remain unidentified...
  49. ncbi request reprint Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation
    E A Rakha
    Department of Histopathology, Nottingham City Hospital NHS Trust and University of Nottingham, UK
    J Pathol 208:495-506. 2006
    ..The basal rather than the myoepithelial phenotype has the strongest relationship with patient outcome...
  50. ncbi request reprint Autoanti-IgE antibodies in patients with allergic and idiopathic rhinitis
    A S Carney
    Department of Otolaryngology Head and Neck Surgery, Queen s Medical Centre, Nottingham, UK
    Clin Otolaryngol Allied Sci 26:298-301. 2001
    ..001). Although patients with idiopathic rhinitis may exhibit clinical and pathological features of allergy, they do not show raised levels of anti-IgE in their serum...
  51. pmc Laminin and collagen IV subunit distribution in normal and neoplastic tissues of colorectum and breast
    R E Hewitt
    Department of Histopathology, University of Nottingham Medical School, Queen s Medical Centre, UK
    Br J Cancer 75:221-9. 1997
    ..Within carcinomas, vascular BM staining for beta 2(lam) was clearly weaker than in normal tissues, which may reflect incomplete maturation of these vessels...
  52. pmc Evidence for a weak angiogenic response to human colorectal cancers
    A J Pritchard
    Department of Histopathology, University of Nottingham Medical School, Queen s Medical Centre, UK
    Br J Cancer 71:1081-6. 1995
    ..4 times higher than the mean value for normal mucosa. These findings suggest that colorectal cancers may elicit a relatively weak angiogenic response, consistent with their exceptionally slow growth rate...
  53. pmc De-regulation of the sonic hedgehog pathway in the InsGas mouse model of gastric carcinogenesis
    M el-Zaatari
    Division of Pre Clinical Oncology, University of Nottingham, Nottingham, UK
    Br J Cancer 96:1855-61. 2007
    ....
  54. ncbi request reprint Atypical nasal challenges in patients with idiopathic rhinitis: more evidence for the existence of allergy in the absence of atopy?
    A S Carney
    Department of Otolaryngology Head and Neck Surgery, Flinder s Medical Centre, Bedford Park, Adelaide, SA, Australia
    Clin Exp Allergy 32:1436-40. 2002
    ..This study compares detailed nasal challenge results obtained from patients with idiopathic rhinitis to those of atopic and normal controls...
  55. ncbi request reprint 'Entopy': localized mucosal allergic disease in the absence of systemic responses for atopy
    D G Powe
    Department of Clinical Laboratory Sciences, Erasmus University, Dr Molewaterplein 50, Rotterdam, The Netherlands
    Clin Exp Allergy 33:1374-9. 2003
    ..In contrast, idiopathic rhinitis (IR) subjects with similar histological nasal mucosal features differ in being defined as non-allergic because they have negative atopic responses...