Karen E Porter

Summary

Affiliation: University of Leeds
Country: UK

Publications

  1. doi request reprint The vascular smooth muscle cell: a therapeutic target in Type 2 diabetes?
    Karen E Porter
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS2 9JT, UK
    Clin Sci (Lond) 125:167-82. 2013
  2. ncbi request reprint Cardiac fibroblasts: at the heart of myocardial remodeling
    Karen E Porter
    Multidisciplinary Cardiovascular Research Centre MCRC, Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS29JT, UK
    Pharmacol Ther 123:255-78. 2009
  3. pmc Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers
    Alex Cheong
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds LS2 9JT, UK
    Cardiovasc Res 89:282-9. 2011
  4. ncbi request reprint Simvastatin inhibits TNFalpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms
    Neil A Turner
    Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK
    J Mol Cell Cardiol 43:168-76. 2007
  5. pmc Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands
    Mohamed S Amer
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Br J Pharmacol 168:1445-55. 2013
  6. doi request reprint Peroxisome proliferator-activated receptor gamma-independent effects of thiazolidinediones on human cardiac myofibroblast function
    Romana S Mughal
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    Clin Exp Pharmacol Physiol 36:478-86. 2009
  7. ncbi request reprint Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones
    Neil A Turner
    Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS2 9JT, UK
    Cardiovasc Res 76:81-90. 2007
  8. doi request reprint Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts
    Neil A Turner
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health, and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom
    Am J Physiol Heart Circ Physiol 297:H1117-27. 2009
  9. pmc Nanomolar potency and selectivity of a Ca²⁺ release-activated Ca²⁺ channel inhibitor against store-operated Ca²⁺ entry and migration of vascular smooth muscle cells
    Jing Li
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Br J Pharmacol 164:382-93. 2011
  10. ncbi request reprint Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion
    Neil A Turner
    Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    J Cardiovasc Pharmacol 50:458-61. 2007

Collaborators

Detail Information

Publications50

  1. doi request reprint The vascular smooth muscle cell: a therapeutic target in Type 2 diabetes?
    Karen E Porter
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS2 9JT, UK
    Clin Sci (Lond) 125:167-82. 2013
    ..Current research in this area will be discussed...
  2. ncbi request reprint Cardiac fibroblasts: at the heart of myocardial remodeling
    Karen E Porter
    Multidisciplinary Cardiovascular Research Centre MCRC, Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS29JT, UK
    Pharmacol Ther 123:255-78. 2009
    ..We also review the evidence suggesting that certain cardiovascular drugs can reduce myocardial remodeling specifically via modulatory effects on cardiac fibroblasts...
  3. pmc Potent suppression of vascular smooth muscle cell migration and human neointimal hyperplasia by KV1.3 channel blockers
    Alex Cheong
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds LS2 9JT, UK
    Cardiovasc Res 89:282-9. 2011
    ..The aim of the study was to determine the potential for K(V)1 potassium channel blockers as inhibitors of human neoinitimal hyperplasia...
  4. ncbi request reprint Simvastatin inhibits TNFalpha-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms
    Neil A Turner
    Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK
    J Mol Cell Cardiol 43:168-76. 2007
    ....
  5. pmc Inhibition of endothelial cell Ca²⁺ entry and transient receptor potential channels by Sigma-1 receptor ligands
    Mohamed S Amer
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Br J Pharmacol 168:1445-55. 2013
    ..This study investigated Sig1R and its ligands in relation to endogenous calcium events of endothelial cells and transient receptor potential (TRP) channels...
  6. doi request reprint Peroxisome proliferator-activated receptor gamma-independent effects of thiazolidinediones on human cardiac myofibroblast function
    Romana S Mughal
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    Clin Exp Pharmacol Physiol 36:478-86. 2009
    ..Although TZDs do not inhibit CMF invasion, their antiproliferative activity may contribute to the ability of this class of drugs to modulate adverse myocardial remodelling...
  7. ncbi request reprint Mechanism of TNFalpha-induced IL-1alpha, IL-1beta and IL-6 expression in human cardiac fibroblasts: effects of statins and thiazolidinediones
    Neil A Turner
    Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS2 9JT, UK
    Cardiovasc Res 76:81-90. 2007
    ..The present study examined the mechanisms by which TNFalpha stimulates expression of pro-inflammatory cytokines in cultured human cardiac fibroblasts and determined the effects of statin or TZD treatment...
  8. doi request reprint Interleukin-1alpha stimulates proinflammatory cytokine expression in human cardiac myofibroblasts
    Neil A Turner
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health, and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom
    Am J Physiol Heart Circ Physiol 297:H1117-27. 2009
    ..In conclusion, IL-1alpha stimulates human CMF to express IL-1beta, TNF-alpha, and IL-6 via specific signaling pathways, responses that are unaffected by IL-10 exposure...
  9. pmc Nanomolar potency and selectivity of a Ca²⁺ release-activated Ca²⁺ channel inhibitor against store-operated Ca²⁺ entry and migration of vascular smooth muscle cells
    Jing Li
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Br J Pharmacol 164:382-93. 2011
    ..The aim was to advance the understanding of Orai proteins and identify a specific inhibitor of the associated calcium entry mechanism in vascular smooth muscle cells (VSMCs)...
  10. ncbi request reprint Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion
    Neil A Turner
    Academic Unit of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    J Cardiovasc Pharmacol 50:458-61. 2007
    ..Our data provide strong evidence that individual statins possess differential pleiotropic effects on SV-SMC function. This may be of clinical relevance in the selection of individual statins for the treatment of CABG patients...
  11. doi request reprint Inherent differences in morphology, proliferation, and migration in saphenous vein smooth muscle cells cultured from nondiabetic and Type 2 diabetic patients
    Haifa A Madi
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, United Kingdom
    Am J Physiol Cell Physiol 297:C1307-17. 2009
    ..In conclusion, SV-SMC from T2DM patients differ from nondiabetic SV-SMC in that they exhibit a rhomboid phenotype and are more migratory, but less proliferative, in response to serum...
  12. doi request reprint Interleukin-1 has opposing effects on connective tissue growth factor and tenascin-C expression in human cardiac fibroblasts
    Azhar Maqbool
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds LS2 9JT, UK
    Matrix Biol 32:208-14. 2013
    ..In conclusion, IL-1α reduced CCN2 expression and increased TNC expression in human CF. These observations are of potential value for understanding how inflammation and ECM regulation are linked at the level of the CF...
  13. pmc TRPC1 transcript variants, inefficient nonsense-mediated decay and low up-frameshift-1 in vascular smooth muscle cells
    Alexandra M Dedman
    Multidisciplinary Cardiovascular Research Centre, Institute of Membrane and Systems Biology, Faculty of Biological Sciences, Mount Preston Street, University of Leeds, Leeds, LS2 9JT, UK
    BMC Mol Biol 12:30. 2011
    ..The initial aim of this study was to investigate variation in TRPC1-encoding gene transcripts...
  14. doi request reprint MMP-3 (5A/6A) polymorphism does not influence human smooth muscle cell invasion
    Azhar Maqbool
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    J Surg Res 175:343-9. 2012
    ..The aim of this study was to determine whether the MMP-3 5A/6A polymorphism directly influences endogenous MMP-3 expression levels and, consequently, cell invasion, in SV-derived SMC cultured from patients with different genotypes...
  15. doi request reprint The -1562C/T MMP-9 promoter polymorphism does not predict MMP-9 expression levels or invasive capacity in saphenous vein smooth muscle cells cultured from different patients
    Azhar Maqbool
    Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
    Atherosclerosis 207:458-65. 2009
    ..Our data challenge the functional nature of the -1562C/T polymorphism and its capacity to modulate MMP-9 expression levels and SV-SMC invasion, and hence susceptibility to vascular pathologies in vivo...
  16. pmc Chronic hypoxia inhibits MMP-2 activation and cellular invasion in human cardiac myofibroblasts
    Kirsten Riches
    Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds LS2 9JT, UK
    J Mol Cell Cardiol 47:391-9. 2009
    ..Regulation of these MMPs remains an attractive target for therapeutic intervention...
  17. pmc Constitutively active TRPC channels of adipocytes confer a mechanism for sensing dietary fatty acids and regulating adiponectin
    Piruthivi Sukumar
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, UK
    Circ Res 111:191-200. 2012
    ..An important factor produced by adipocytes is adiponectin, which confers myocardial protection, insulin-sensitization, and antiatherosclerotic effects...
  18. ncbi request reprint Endothelin-1 is an essential co-factor for beta2-adrenergic receptor-induced proliferation of human cardiac fibroblasts
    Neil A Turner
    Institute for Cardiovascular Research, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    FEBS Lett 576:156-60. 2004
    ..Furthermore, despite activation of the MAP kinase pathway, ET-1 treatment did not stimulate CF proliferation. Therefore, the role of ET-1 in this process is that of an essential co-factor acting independently of beta2-AR stimulation...
  19. doi request reprint Human cardiac fibroblasts express ICAM-1, E-selectin and CXC chemokines in response to proinflammatory cytokine stimulation
    Neil A Turner
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Int J Biochem Cell Biol 43:1450-8. 2011
    ....
  20. pmc Robotic multiwell planar patch-clamp for native and primary mammalian cells
    Carol J Milligan
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, Garstang Building, University of Leeds, Leeds LS29JT, UK
    Nat Protoc 4:244-55. 2009
    ..Recording from 48 chambers usually takes 1-6 h depending on the experimental design and yields 16-33 cell recordings...
  21. ncbi request reprint Simvastatin inhibits MMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels
    Neil A Turner
    Institute for Cardiovascular Research, University of Leeds, Leeds, UK
    FASEB J 19:804-6. 2005
    ....
  22. pmc Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone
    Yasser Majeed
    Multidisciplinary Cardiovascular Research Centre, University of Leeds, Leeds, UK
    Cell Calcium 51:1-11. 2012
    ....
  23. ncbi request reprint Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA
    Karen E Porter
    Institute for Cardiovascular Research, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    Cardiovasc Res 61:745-55. 2004
    ..Although statins are known to reduce myocyte hypertrophy, their effect on cardiac fibroblast proliferation is unknown. The purpose of this study was to investigate the effects of simvastatin on human atrial myofibroblast proliferation...
  24. ncbi request reprint Tumor necrosis factor alpha induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin
    Karen E Porter
    Institute for Cardiovascular Research, Academic Unit for Cardiovascular Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    Cardiovasc Res 64:507-15. 2004
    ..This study investigated the effect of TNFalpha on human cardiac myofibroblast proliferation, invasion and MMP-9 secretion, and determined whether these properties were modulated by simvastatin...
  25. pmc p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblasts
    John K Sinfield
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds, UK
    Biochem Biophys Res Commun 430:419-24. 2013
    ..In conclusion, human CF express the α, γ and δ subtypes of p38 MAPK, and the α subtype is important for IL-1α-induced IL-6 and MMP-3 expression in this cell type...
  26. pmc Modulatory effect of interleukin-1α on expression of structural matrix proteins, MMPs and TIMPs in human cardiac myofibroblasts: role of p38 MAP kinase
    Neil A Turner
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    Matrix Biol 29:613-20. 2010
    ..In summary, IL-1α induces a distinct pattern of ECM protein and protease expression in human CMF, in part regulated by distinct p38 MAPK subtypes, affirming the key role of IL-1α and CMF in post-infarction cardiac remodeling...
  27. ncbi request reprint Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421
    Daniel W Lambert
    School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U K
    Clin Sci (Lond) 127:243-9. 2014
    ....
  28. pmc Exploring smooth muscle phenotype and function in a bioreactor model of abdominal aortic aneurysm
    Kirsten Riches
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    J Transl Med 11:208. 2013
    ....
  29. pmc Apolipoprotein(a) acts as a chemorepellent to human vascular smooth muscle cells via integrin αVβ3 and RhoA/ROCK-mediated mechanisms
    Kirsten Riches
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    Int J Biochem Cell Biol 45:1776-83. 2013
    ..Circulating levels of Lp(a) are resistant to lipid-lowering strategies and hence a greater understanding of the mechanisms underlying its functional effects on SMC may provide alternative therapeutic targets. ..
  30. doi request reprint Functional angiotensin-converting enzyme 2 is expressed in human cardiac myofibroblasts
    Jodie L Guy
    Institute of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK
    Exp Physiol 93:579-88. 2008
    ....
  31. doi request reprint Statins and myocardial remodelling: cell and molecular pathways
    Karen E Porter
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre, University of Leeds, Clarendon Way, Leeds, UK
    Expert Rev Mol Med 13:e22. 2011
    ..The prospects for future therapies and ongoing clinical trials are also summarised...
  32. pmc TRPC5 channel sensitivities to antioxidants and hydroxylated stilbenes
    Jacqueline Naylor
    Multidisciplinary Cardiovascular Research Centre, Institute of Membrane and Systems Biology, Faculty of Biological Sciences, and Faculty of Medicine and Health, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 286:5078-86. 2011
    ....
  33. doi request reprint Divergent effects of 17-β-estradiol on human vascular smooth muscle and endothelial cell function diminishes TNF-α-induced neointima formation
    Rungrat Nintasen
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Leeds LS2 9JT, UK
    Biochem Biophys Res Commun 420:828-33. 2012
    ..E2 exerted distinct cell-type and function-specific modulation, the mechanisms underlying which are worthy of further detailed study...
  34. ncbi request reprint Selective gene silencing of either MMP-2 or MMP-9 inhibits invasion of human saphenous vein smooth muscle cells
    Neil A Turner
    Institute for Cardiovascular Research, School of Medicine, Worsley Building, University of Leeds, Leeds LS2 9JT, UK
    Atherosclerosis 193:36-43. 2007
    ..Specific manipulation of either MMP-2 or MMP-9 may therefore provide a valuable strategy for prevention of SV graft stenosis in man...
  35. ncbi request reprint Cellular and molecular mechanisms of endothelial dysfunction in diabetes
    Anna C Roberts
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK
    Diab Vasc Dis Res 10:472-82. 2013
    ..Through understanding the underlying mechanisms, novel targets for future therapies to restore endothelial homeostasis and 'drive' a reparative cellular phenotype are explored. ..
  36. ncbi request reprint Type 2 diabetes impairs venous, but not arterial smooth muscle cell function: possible role of differential RhoA activity
    Kirsten Riches
    Division of Cardiovascular and Diabetes Research, Leeds Institute of Genetics, Health and Therapeutics LIGHT, University of Leeds, Leeds, UK Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
    Cardiovasc Revasc Med 15:141-8. 2014
    ..Smooth muscle cells (SMC) play a pivotal role in graft integration; we therefore examined the phenotype and proliferative function of IMA- and SV-SMC isolated from non-diabetic (ND) patients or those diagnosed with T2DM...
  37. pmc TRPC channel activation by extracellular thioredoxin
    Shang Zhong Xu
    Institute of Membrane and Systems Biology, Garstang Building, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    Nature 451:69-72. 2008
    ..The data indicate the presence of a previously unrecognized ion-channel activation mechanism that couples extracellular thioredoxin to cell function...
  38. pmc A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility
    Shang Zhong Xu
    Institute of Membrane and Systems Biology, University of Leeds, Leeds, LS2 9JT, UK
    Circ Res 98:1381-9. 2006
    ..The extracellular effect appears to have a primary role in S1P-evoked cell motility. The data suggest S1P sensing by TRPC5 calcium channel is a mechanism contributing to vascular smooth muscle adaptation...
  39. pmc Orai1 and CRAC channel dependence of VEGF-activated Ca2+ entry and endothelial tube formation
    Jing Li
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    Circ Res 108:1190-8. 2011
    ..Orai1 and the associated calcium release-activated calcium (CRAC) channel were discovered in the immune system. Existence also in endothelial cells has been suggested, but the relevance to endothelial biology is mostly unknown...
  40. doi request reprint Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts
    Neil A Turner
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
    IUBMB Life 64:143-50. 2012
    ..This review summarizes current knowledge on the identity and regulation of MMPs expressed by CF and discusses future directions for reducing adverse myocardial remodeling by modulating the expression and/or activity of CF-derived MMPs...
  41. doi request reprint Hypoxic remodelling of Ca(2+) signalling in proliferating human arterial smooth muscle
    Parvinder K Aley
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds, Level 10, Worsley Building, Leeds, LS2 9JT, UK
    Mol Cell Biochem 318:101-8. 2008
    ..Our data provide novel observations of the remodelling of Ca(2+) homeostasis by CH in IMASM cells which may contribute to their superior patency as coronary bypass grafts...
  42. doi request reprint Modulation of Ca(2+) signalling in human vascular endothelial cells by hydrogen sulfide
    Claudia C Bauer
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute for Genetics Health and Therapeutics, University of Leeds, Clarendon Way, Leeds LS2 9JT, UK
    Atherosclerosis 209:374-80. 2010
    ..Our data indicate that H(2)S can modulate endothelial [Ca(2+)](i) via multiple mechanisms, and such effects are likely to contribute to this gasotransmitter's beneficial actions...
  43. ncbi request reprint Investigating inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors
    Bryony Sedgwick
    Division of Cardiovascular and Diabetes Research, School of Medicine, University of Leeds, Leeds, UK
    Cardiovasc Pathol 23:204-10. 2014
    ..As cardiac fibroblasts (CFs) are key effectors of myocardial remodeling, we investigated whether inherent phenotypic differences exist in CF derived from T2DM donors compared with cells from nondiabetic (ND) donors...
  44. ncbi request reprint Chronic beta2-adrenergic receptor stimulation increases proliferation of human cardiac fibroblasts via an autocrine mechanism
    Neil A Turner
    Integrated Molecular Cardiology Group, Institute for Cardiovascular Research, Worsley Building, University of Leeds, UK
    Cardiovasc Res 57:784-92. 2003
    ..The aim of this study was to determine whether chronic beta-adrenergic receptor (beta-AR) stimulation induces proliferation of human cardiac fibroblasts and to investigate the mechanism(s) involved...
  45. ncbi request reprint Downregulated REST transcription factor is a switch enabling critical potassium channel expression and cell proliferation
    Alex Cheong
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    Mol Cell 20:45-52. 2005
    ..1. Here, we show REST plays a previously unrecognized role as a switch regulating potassium channel expression and consequently the phenotype of vascular smooth muscle cells and human vascular disease...
  46. pmc Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis
    Adil Rajwani
    Division of Cardiovascular and Diabetes Research, MultidisciplinaryCardiovascular Research Centre, University of Leeds, Leeds, U K
    Diabetes 61:915-24. 2012
    ....
  47. pmc Function and fate of myofibroblasts after myocardial infarction
    Neil A Turner
    Division of Cardiovascular and Diabetes Research, and Multidisciplinary Cardiovascular Research Centre, School of Medicine, University of Leeds, Leeds LS2 9JT, UK
    Fibrogenesis Tissue Repair 6:5. 2013
    ....
  48. pmc Lipoprotein(a): Cellular Effects and Molecular Mechanisms
    Kirsten Riches
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds LS2 9JT, UK
    Cholesterol 2012:923289. 2012
    ..This paper will summarise the role of Lp(a) in modulating cell behaviour in all aspects of the vascular system including platelets, monocytes, SMC, and EC...
  49. ncbi request reprint Regulation of myocardial matrix metalloproteinase expression and activity by cardiac fibroblasts
    Neil A Turner
    Division of Cardiovascular Medicine, Leeds Institute of Genetics, Health and Therapeutics LIGHT and Multidisciplinary Cardiovascular Research Centre MCRC, University of Leeds, Leeds, UK
    IUBMB Life 64:spcone. 2012
    ..2012 IUBMB IUBMB Life, 2012...
  50. ncbi request reprint Use of in vitro organ cultures of human saphenous vein as a model for intimal proliferation
    Karen E Porter
    Integrated Molecular Cardiology Group, Institute for Cardiovascular Research, University of Leeds, Leeds, UK
    Methods Mol Biol 206:199-214. 2002