Kenneth E S Poole

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. doi request reprint Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture
    Jon Power
    Bone Research Division, Department of Medicine, University of Cambridge, Cambridge, UK
    J Bone Miner Res 25:1867-76. 2010
  2. ncbi request reprint Rapid long-term bone loss following stroke in a man with osteoporosis and atherosclerosis
    Kenneth E S Poole
    MRC Bone Research Group, Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Level 5, Box 157, Cambridge, CB2 2QQ, UK
    Osteoporos Int 16:302-5. 2005
  3. ncbi request reprint Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
    Kenneth E S Poole
    MRC Bone Research Group, Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    FASEB J 19:1842-4. 2005
  4. ncbi request reprint Reduced vitamin D in acute stroke
    Kenneth E S Poole
    Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Stroke 37:243-5. 2006
  5. pmc Bone structure and remodelling in stroke patients: early effects of zoledronate
    Kenneth E S Poole
    Division of Bone Research, Department of Medicine, University of Cambridge, Box 157, Addenbrooke s Hospital, Cambridge, England, CB2 2QQ, UK
    Bone 44:629-33. 2009
  6. pmc Cortical thickness mapping to identify focal osteoporosis in patients with hip fracture
    Kenneth E S Poole
    Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
    PLoS ONE 7:e38466. 2012
  7. ncbi request reprint A single infusion of zoledronate prevents bone loss after stroke
    Kenneth E S Poole
    Division of Bone Research, Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, England, UK
    Stroke 38:1519-25. 2007
  8. ncbi request reprint Changing structure of the femoral neck across the adult female lifespan
    Kenneth E S Poole
    Department of Medicine, University of Cambridge, Box 157, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    J Bone Miner Res 25:482-91. 2010
  9. ncbi request reprint Parathyroid hormone - a bone anabolic and catabolic agent
    Kenneth E S Poole
    Division of Bone Research, Department of Medicine, Level 5, University of Cambridge, Addenbrooke s Hospital Box 157, Cambridge CB2 2QQ, UK
    Curr Opin Pharmacol 5:612-7. 2005
  10. ncbi request reprint Falls, fractures, and osteoporosis after stroke: time to think about protection?
    Kenneth E S Poole
    Department of Stroke Medicine, Addenbrooke s Hospital, Cambridge, UK
    Stroke 33:1432-6. 2002

Detail Information

Publications13

  1. doi request reprint Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture
    Jon Power
    Bone Research Division, Department of Medicine, University of Cambridge, Cambridge, UK
    J Bone Miner Res 25:1867-76. 2010
    ..In FNF, full osteonal closure is postponed, with increased porosity, in part because the proportion of osteocytes expressing sclerostin increases sharply with osteonal maturation...
  2. ncbi request reprint Rapid long-term bone loss following stroke in a man with osteoporosis and atherosclerosis
    Kenneth E S Poole
    MRC Bone Research Group, Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Level 5, Box 157, Cambridge, CB2 2QQ, UK
    Osteoporos Int 16:302-5. 2005
    ..There was also an unexpected decline in vertebral BMD after the stroke. This is the first report of the accelerated effect of hemiplegia on bone loss in an already osteoporotic skeleton...
  3. ncbi request reprint Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
    Kenneth E S Poole
    MRC Bone Research Group, Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    FASEB J 19:1842-4. 2005
    ..In doing so, sclerostin may act as a key inhibitory signal governing skeletal microarchitecture...
  4. ncbi request reprint Reduced vitamin D in acute stroke
    Kenneth E S Poole
    Department of Medicine, Addenbrooke s Hospital, Cambridge, UK
    Stroke 37:243-5. 2006
    ..Vitamin D deficiency is well documented in long-term stroke survivors and is associated with post-stroke hip fractures. Less is known regarding levels in acute stroke...
  5. pmc Bone structure and remodelling in stroke patients: early effects of zoledronate
    Kenneth E S Poole
    Division of Bone Research, Department of Medicine, University of Cambridge, Box 157, Addenbrooke s Hospital, Cambridge, England, CB2 2QQ, UK
    Bone 44:629-33. 2009
    ..Participants from the trial also volunteered for trans-iliac bone biopsy, to assess the early effects of stroke and zoledronate on iliac bone remodelling...
  6. pmc Cortical thickness mapping to identify focal osteoporosis in patients with hip fracture
    Kenneth E S Poole
    Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom
    PLoS ONE 7:e38466. 2012
    ..By analysing ordinary clinical CT scans using a novel cortical thickness mapping technique, we discovered patches of markedly thinner bone at fracture-prone regions in the femurs of women with acute hip fracture compared with controls...
  7. ncbi request reprint A single infusion of zoledronate prevents bone loss after stroke
    Kenneth E S Poole
    Division of Bone Research, Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, England, UK
    Stroke 38:1519-25. 2007
    ..This proof-of-concept study evaluated the efficacy of a single infusion of zoledronate, an intravenous bisphosphonate, in preserving hip bone density after stroke...
  8. ncbi request reprint Changing structure of the femoral neck across the adult female lifespan
    Kenneth E S Poole
    Department of Medicine, University of Cambridge, Box 157, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    J Bone Miner Res 25:482-91. 2010
    ..It remains to be determined whether this MDCT technique can provide better prediction of hip fracture than conventional clinical dual X-ray absorptiometry (DXA)...
  9. ncbi request reprint Parathyroid hormone - a bone anabolic and catabolic agent
    Kenneth E S Poole
    Division of Bone Research, Department of Medicine, Level 5, University of Cambridge, Addenbrooke s Hospital Box 157, Cambridge CB2 2QQ, UK
    Curr Opin Pharmacol 5:612-7. 2005
    ..Microarray analysis has also delineated many genes and pathways regulated by intermittent and continuous PTH in osteoblasts and whole bones...
  10. ncbi request reprint Falls, fractures, and osteoporosis after stroke: time to think about protection?
    Kenneth E S Poole
    Department of Stroke Medicine, Addenbrooke s Hospital, Cambridge, UK
    Stroke 33:1432-6. 2002
    ..Stroke patients may also have motor, sensory, and visual/perceptual deficits that predispose them to falls. These factors result in an early but sustained increase in hip fractures after stroke...
  11. pmc Targeted regeneration of bone in the osteoporotic human femur
    Kenneth E S Poole
    Department of Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 6:e16190. 2011
    ..Applying these methods to the proximal femurs of osteoporotic women, we discover targeted and apparently synergistic effects of pharmaceutical osteoporosis therapy and habitual mechanical load in enhancing bone thickness...
  12. ncbi request reprint Yearly zoledronic acid in postmenopausal osteoporosis
    Kenneth E S Poole
    N Engl J Med 357:711-2; author reply 714-5. 2007
  13. pmc Osteoporosis and its management
    Kenneth E S Poole
    Addenbrooke s Hospital, Cambridge CB2 2QQ
    BMJ 333:1251-6. 2006