Research Topics
Genomes and Genes | Chris P PontingSummaryAffiliation: University of Oxford Country: UK Publications
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Publications
Evolutionary conservation and selection of human disease gene orthologs in the rat and mouse genomesHui Huang
Department of Bioinformatics, Genome Therapeutics Corporation, Waltham, MA 02453, USA
Genome Biol 5:R47. 2004..Here, we investigate whether human disease genes differ significantly from their rodent orthologs with respect to their overall levels of conservation and their rates of evolutionary change...
The natural history of protein domainsChris P Ponting
Department of Human Anatomy and Genetics, University of Oxford, MRC Functional Genetics Unit, South Parks Road, Oxford OX1 3QX, UK
Annu Rev Biophys Biomol Struct 31:45-71. 2002..These parallels illustrate how the concept of domains can be applied to provide insights into evolutionary biology...- Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders?C P Ponting
MRC Functional Genetics Unit, University of Oxford, Department of Human Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK
Hum Mol Genet 10:1853-8. 2001..The hypothesis that aberrant ferric reductase activities are involved in the progression of neurodegenerative diseases should open up new avenues of research, and possibly therapy, for these devastating diseases... - The genomic landscape shaped by selection on transposable elements across 18 mouse strainsChristoffer Nellåker
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Genome Biol 13:R45. 2012..Despite their high prevalence, the different genomic and gene properties controlling whether TEs are preferentially purged from, or are retained by, genetic drift or positive selection in mammalian genomes remain poorly defined... - Genome assembly quality: assessment and improvement using the neutral indel modelStephen Meader
Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Genome Res 20:675-84. 2010..Our approach contributes a new fine-scale quality metric for assemblies that should facilitate development of improved genome sequencing and assembly strategies... - Variable strength of translational selection among 12 Drosophila speciesAndreas Heger
MRC Functional Genetics Unit, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Genetics 177:1337-48. 2007..The strength of translational selection was predicted to have varied between species largely according to their phylogeny, with the D. melanogaster group species exhibiting the strongest degree of selection... - OPTIC: orthologous and paralogous transcripts in cladesAndreas Heger
Department of Physiology, Anatomy and Genetics, MRC Functional Genetics Unit, University of Oxford, Le Gros Clark Building, Oxford OX1 3QX, UK
Nucleic Acids Res 36:D267-70. 2008..Gene predictions, multiple alignments and phylogenetic trees are freely available to browse and download from http://genserv.anat.ox.ac.uk/clades. Further genomes and clades will be added in the future... - Catalogues of mammalian long noncoding RNAs: modest conservation and incompletenessAna C Marques
MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, Oxford OX1 3QX, UK
Genome Biol 10:R124. 2009..This apparent difference may account for the surprisingly small fraction (11%) of transcripts that are represented in both catalogues. Here we sought to resolve the reported discrepancy between the evolutionary rates for these two sets... - A transcriptomic atlas of mouse neocortical layersT Grant Belgard
MRC Functional Genomics Unit, University of Oxford, Oxford OX1 3QX, UK
Neuron 71:605-16. 2011.... - The long and the short of RNA mapsJasmina Ponjavic
MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, UK
Bioessays 29:1077-80. 2007..These results suggest that a proportion of these RNAs might have roles in the cis-regulation of neighbouring protein-coding genes' expression... - Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion eventsEitan E Winter
Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
BMC Evol Biol 5:54. 2005.... - Massive turnover of functional sequence in human and other mammalian genomesStephen Meader
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Genome Res 20:1335-43. 2010..This suggests that, rather than genome size or protein-coding gene complement, it is the number of functional bases that might best mirror our naïve preconceptions of organismal complexity... - Comparative evolutionary genomics of androgen-binding protein genesRichard D Emes
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Genome Res 14:1516-29. 2004..We propose a role for ABPalpha/beta/gamma proteins as pheromones, or in modulating odorant detection. This would account for the extraordinary adaptive evolution of these genes, and surrounding genomic regions, in murid rodents... - Long noncoding RNA genes: conservation of sequence and brain expression among diverse amniotesRebecca A Chodroff
Department of Physiology, Anatomy, and Genetics, Le Gros Clark Building South Parks Road, University of Oxford, Oxford OX1 3QX, UK
Genome Biol 11:R72. 2010..This dearth of information is partially attributable to a lack of established non-protein-coding RNA (ncRNA) orthologs among birds and mammals within sequence and expression databases... - Meisetz and the birth of the KRAB motifZoë Birtle
Department of Physiology, Anatomy and Genetics, MRC Functional Genetics Unit, University of Oxford South Parks Road, Oxford OX1 3QX, UK
Bioinformatics 22:2841-5. 2006..Finally, we present evidence that KRAB motifs derive from a novel family of KRI (KRAB Interior) motifs that were present in the last common ancestor of animals, plants and fungi... - Hotspots of mutation and breakage in dog and human chromosomesCaleb Webber
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Genome Res 15:1787-97. 2005..Rather, we propose that high G+C sequences are found preferentially within dog subtelomeres as a direct consequence of chromosomal fission occurring more frequently within regions elevated in G+C... - Evolution and comparative genomics of odorant- and pheromone-associated genes in rodentsRichard D Emes
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
Genome Res 14:591-602. 2004..We predict that these contribute to physicochemical and functional diversity within pheromone-receptor interaction sites... 
Separating derived from ancestral features of mouse and human genomesChris P Ponting
Department of Physiology, MRC Functional Genomics Unit, University of Oxford, Oxford OX1 3QX, UK
Biochem Soc Trans 37:734-9. 2009..Nevertheless, many such genes may be under little or no selection...- Wrangling for microRNAs provokes much crosstalkAna C Marques
MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, Oxford, UK
Genome Biol 12:132. 2011..Levels of transcripts sharing microRNA response elements are co-regulated. These RNA-RNA interactions imply that combinations of microRNAs modulate cell-specific transcript networks... - Structure and evolutionary history of DISC1Luis Sanchez-Pulido
Department of Physiology, Anatomy and Genetics, MRC Functional Genomics Unit, University of Oxford, South Parks Road, Oxford, UK
Hum Mol Genet 20:R175-81. 2011..One common missense variant in DISC1 (L607F) lies within the second DISC1 UVR-like domain. These observations should assist in delineating the functional regions of the DISC1 protein... - Occurrence and consequences of coding sequence insertions and deletions in Mammalian genomesMartin S Taylor
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
Genome Res 14:555-66. 2004..There is a specific enrichment of CpG dinucleotides in close proximity to insertion events, and both insertions and deletions are more common in higher G+C content sequences... - Evolutionary rate analyses of orthologs and paralogs from 12 Drosophila genomesAndreas Heger
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Genome Res 17:1837-49. 2007..Duplications were significantly more frequent among trypsin-like proteases and DM8 putative lipid-binding domain proteins... - Structure-function mapping of BbCRASP-1, the key complement factor H and FHL-1 binding protein of Borrelia burgdorferiFrank S Cordes
Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Int J Med Microbiol 296:177-84. 2006..This work demonstrates that pathogens interact with complement regulators in ways that are distinct from the mechanisms used by the host and are thus obvious targets for drug design... - Reduced purifying selection prevails over positive selection in human copy number variant evolutionDuc Quang Nguyen
MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, Oxford OX1 3QX, United Kingdom
Genome Res 18:1711-23. 2008..In contrast, SD sequences that appear fixed in the human population lie more frequently within low G+C sequence. These findings provide an overarching view of how CNVs arise and segregate in the human population... - Bias of selection on human copy-number variantsDuc-Quang Nguyen
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
PLoS Genet 2:e20. 2006..It thus appears that CNV differences among mouse strains do not provide an appropriate model for large-scale sequence variations in the human population... - An analysis of the gene complement of a marsupial, Monodelphis domestica: evolution of lineage-specific genes and giant chromosomesLeo Goodstadt
MRC Functional Genetics Unit, University of Oxford, Department of Physiology, Oxford, UK
Genome Res 17:969-81. 2007..In particular, we propose that the higher G+C content of the Monodelphis X chromosome is a direct consequence of its small size relative to the giant autosomes... - Nprl3 is required for normal development of the cardiovascular systemMonika S Kowalczyk
MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, UK
Mamm Genome 23:404-15. 2012..NPRL3 is a candidate gene for harbouring mutations in individuals with developmental abnormalities of the cardiovascular system... - Genome-wide identification of human functional DNA using a neutral indel modelGerton Lunter
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
PLoS Comput Biol 2:e5. 2006..The ability to identify elements under heterogeneous selection enables, for the first time, the genome-wide investigation of positive selection on functional elements other than protein-coding genes... - A novel domain suggests a ciliary function for ASPM, a brain size determining geneChris P Ponting
MRC Functional Genetics Unit, University of Oxford, Department of Human Anatomy and Genetics South Parks Road, Oxford OX1 3QX, UK
Bioinformatics 22:1031-5. 2006..ASPM's rapid evolution may thus reflect selective pressures on ciliary function, rather than pressures on mitosis during neurogenesis... - Signatures of adaptive evolution within human non-coding sequenceChris P Ponting
MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Hum Mol Genet 15:R170-5. 2006..Illuminating the functions of this adaptive dark matter will lead to a better understanding of the sequence changes that have shaped the innovative biology of our species... - Elevated rates of protein secretion, evolution, and disease among tissue-specific genesEitan E Winter
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
Genome Res 14:54-61. 2004..These findings illuminate major selective pressures that have shaped the gene repertoires expressed in different mammalian tissues... - THoR: a tool for domain discovery and curation of multiple alignmentsNicholas J Dickens
MRC Functional Genetics Unit, University of Oxford, Department of Human Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK
Genome Biol 4:R52. 2003..THoR has been benchmarked for accuracy using the SMART and pufferfish genome databases... - The functional repertoires of metazoan genomesChris P Ponting
MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, UK
Nat Rev Genet 9:689-98. 2008..Yet it is here, encoded in lineage-specific and functional sequence, that we expect physiological differences between species to be most concentrated... - Accurate estimation of gene evolutionary rates using XRATE, with an application to transmembrane proteinsAndreas Heger
Department of Physiology, Anatomy and Genetics, MRC Functional Genomics Unit, University of Oxford, Oxford, UK
Mol Biol Evol 26:1715-21. 2009..Less stringent purifying selection is thus a general property of the extracellular milieu, rather than being specific to only soluble and secreted proteins... - Functionality or transcriptional noise? Evidence for selection within long noncoding RNAsJasmina Ponjavic
MRC Functional Genetics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Genome Res 17:556-65. 2007..2%). These macroRNAs, taken together, thus possess the imprint of purifying selection, thereby indicating their functionality. Our findings should now provide an incentive for the experimental investigation of these macroRNAs' functions... - Insights into the evolution of Darwin's finches from comparative analysis of the Geospiza magnirostris genome sequenceChris M Rands
Department of Physiology, Anatomy, and Genetics, MRC Functional Genomics Unit, University of Oxford, Oxford, OX1 3PT, UK
BMC Genomics 14:95. 2013..Here we report evolutionary analyses of genome of the large ground finch, Geospiza magnirostris... - Novel domains and orthologues of eukaryotic transcription elongation factorsChris P Ponting
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Nucleic Acids Res 30:3643-52. 2002..These findings imply that much of the transcription elongation machinery of eukaryotes has been acquired subsequent to their divergence from prokaryotes... - Rapid turnover of functional sequence in human and other genomesChris P Ponting
Medical Research Council Functional Genomics Unit, Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Annu Rev Genomics Hum Genet 12:275-99. 2011..In contrast to the slow rate at which protein-coding sequence changes, functional noncoding sequence appears to change or be turned over at rapid rates in mammals... - Transcribed dark matter: meaning or myth?Chris P Ponting
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK
Hum Mol Genet 19:R162-8. 2010..These issues will only be resolved upon the demonstration, or otherwise, that organismal or cellular phenotypes frequently result when non-coding RNA loci are disrupted... - Vitamin K epoxide reductase: homology, active site and catalytic mechanismLeo Goodstadt
MRC Functional Genetics Unit, University of Oxford, Department of Human Anatomy and Genetics, South Parks Road, Oxford, OX1 3QX, UK
Trends Biochem Sci 29:289-92. 2004..These might reduce disulfide bonds of VKORC1-like enzymes as a prerequisite for their catalytic activities... - Evolution and functions of long noncoding RNAsChris P Ponting
MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford, OX1 3QX, UK
Cell 136:629-41. 2009..quot; Here, we review the evolution of lncRNAs and their roles in transcriptional regulation, epigenetic gene regulation, and disease... - The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylaseThomas Gerken
Chemistry Research Laboratory and Oxford Centre for Integrative Systems Biology, University of Oxford, 12 Mansfield Road, Oxford, Oxon OX1 3TA, UK
Science 318:1469-72. 2007..Studies can now be directed toward determining the physiologically relevant FTO substrate and how nucleic acid methylation status is linked to increased fat mass... - What fraction of the human genome is functional?Chris P Ponting
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
Genome Res 21:1769-76. 2011..Experimental investigations focusing on lineage-specific, noncoding, and functional sequence are now essential if we are to appreciate the complete functional repertoire of the human genome... - What are the genomic drivers of the rapid evolution of PRDM9?Chris P Ponting
Medical Research Council Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK
Trends Genet 27:165-71. 2011.... - Cdc45: the missing RecJ ortholog in eukaryotes?Luis Sanchez-Pulido
Department of Physiology, Anatomy and Genetics, MRC Functional Genomics Unit, University of Oxford, Oxford OX1 3QX, UK
Bioinformatics 27:1885-8. 2011..The likely orthology between Cdc45 and RecJ reveals new lines of enquiry into DNA replication mechanisms in eukaryotes... - Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebratesHannah K Long
Department of Biochemistry, University of Oxford, Oxford, United Kingdom Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom
elife 2:e00348. 2013..Together these findings demonstrate an ancient logic for NMI usage at gene promoters and reveal an unprecedented level of epigenetic conservation across vertebrate evolution. http://dx.doi.org/10.7554/eLife.00348.001... - Brain, know thy transcriptome, know thyselfChris P Ponting
MRC Functional Genomics Unit, University of Oxford, Department of Physiology, Anatomy, and Genetics, Oxford OX1 3PT, UK
Neuron 75:543-5. 2012..The data provide an initial opportunity for linking genomic and brain differences among these primate species... - A common ancestry for BAP1 and Uch37 regulatorsLuis Sanchez-Pulido
MRC Functional Genomics Unit, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
Bioinformatics 28:1953-6. 2012..Our analysis demonstrates a common ancestry for BAP1 and Uch37 regulators in PR-DUB, INO80 chromatin remodelling and proteosome complexes... - Genes and homologyCaleb Webber
MRC Functional Genetics Unit, University of Oxford, Department of Human Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK
Curr Biol 14:R332-3. 2004 - TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing domains?Eitan Winter
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK OX1 3QX
Trends Biochem Sci 27:381-3. 2002..The identification of these homologues has potential implications for our understanding of ceramide synthesis, lipid regulation and protein translocation in the endoplasmic reticulum... - Comparison of the genomes of human and mouse lays the foundation of genome zoologyRichard D Emes
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Hum Mol Genet 12:701-9. 2003..We predict that the availability of numerous animal genomes will give rise to a new field of genome zoology in which differences in animal physiology and ethology are illuminated by the study of genomic sequence variations... - Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function predictionC P Ponting
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Biochem J 351:527-35. 2000..This finding hints at the mechanism by which Ire1p may sense extended unfolded proteins at the expense of compact folded molecules... - SMART: identification and annotation of domains from signalling and extracellular protein sequencesC P Ponting
University of Oxford, Fibrinolysis Research Unit, The Old Observatory, South Parks Road, Oxford OX1 3RH, UK
Nucleic Acids Res 27:229-32. 1999..In addition, each domain is annotated extensively with respect to cellular localisation, species distribution, functional class, tertiary structure and functionally important residues... - Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complexS E Newey
Department of Human Anatomy and Genetics, University of Oxford, UK
Curr Biol 10:1295-8. 2000..This is likely to have important consequences for the recruitment of specific signalling molecules to the DPC and ultimately for its function... - Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) geneJ D Vargas
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Mech Dev 117:289-92. 2002..The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development... - Sequence variation and disease in the wake of the draft human genomeL Goodstadt
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Hum Mol Genet 10:2209-14. 2001..Ultimately, the success of genome sequencing and functional genomics will be measured not by the quantity and accuracy of raw data generated, but how rapidly they can be harnessed to span the divide between genotype and phenotype... - Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolutionC P Ponting
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
Genome Res 11:1996-2008. 2001..These findings demonstrate how completely sequenced genomes can be exploited to further understand the relationships between molecular structure, function, and evolution... - Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complexK Talbot
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Hum Mol Genet 7:2149-56. 1998..In addition to a possible role for this protein as a pro-apoptotic factor, SMN and its related protein share significant similarities in sequence and cellular function... - Genome cartography through domain annotationC P Ponting
MRC Functional Genetics Unit, University of Oxford, Department of Human Anatomy and Genetics, South Parks Road, Oxford OX13QX, UK
Genome Biol 2:Comment 2006. 2001..To account for the great diversity of domain contexts and an unexpected paucity of ortholog conservation, we must categorize the coding regions of completely sequenced genomes into domain families, as well as protein families... - Issues in predicting protein function from sequenceC P Ponting
Department of Human Anatomy and Genetics, University of Oxford, UK
Brief Bioinform 2:19-29. 2001..Pitfalls in database searching methods arising from amino acid compositional bias and database size effects are also discussed... - JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2betaP M Clissold
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, OX1 3QX, Oxford, UK
Trends Biochem Sci 26:7-9. 2001..JmjC domains are predicted to be metalloenzymes that adopt the cupin fold, and are candidates for enzymes that regulate chromatin remodelling... - Identification of distant homologues of fibroblast growth factors suggests a common ancestor for all beta-trefoil proteinsC P Ponting
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, Oxford, UK
J Mol Biol 302:1041-7. 2000..The combined analysis of structure and sequence databases for detecting significant similarities is suggested as a highly sensitive approach to determining the common ancestry of extremely divergent homologues... - Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductasesJ D Vargas
Department of Human Anatomy and Genetics, University of Oxford, OX1 3QX Oxford, UK
Biochim Biophys Acta 1651:116-23. 2003..Moreover, we demonstrate the presence of mouse sdr2 in the choroid plexus and in the ependymal cells lining the four ventricles, through in situ hybridization analysis... - Phospholipase Czeta, the trigger of egg activation in mammals, is present in a non-mammalian speciesK Coward
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Reproduction 130:157-63. 2005..Our findings suggest that PLCzeta may have a universal role in triggering egg activation in vertebrates... - Diverse spatial, temporal, and sexual expression of recently duplicated androgen-binding protein genes in Mus musculusChristina M Laukaitis
Department of Biological Sciences, Butler University, 4600 Sunset Ave, Indianapolis, Indiana 46208, USA
BMC Evol Biol 5:40. 2005..This makes ABP an appropriate model system with which to investigate how recent adaptive evolution of paralogous genes results in functional innovation (neofunctionalization)... - A SNP map of the rat genome generated from cDNA sequencesHeike Zimdahl
Max-Delbruck-Center for Molecular Medicine (MDC, Robert-Rossle-Str. 10, 13092 Berlin-Buch, Germany
Science 303:807. 2004 - Recent improvements to the SMART domain-based sequence annotation resourceIvica Letunic
EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany
Nucleic Acids Res 30:242-4. 2002..SMART output can now be easily included in users' documents. A SMART mirror has been created at http://smart.ox.ac.uk... - Phylogenetic reconstruction of orthology, paralogy, and conserved synteny for dog and humanLeo Goodstadt
Medical Research Council Functional Genetics Unit, University of Oxford, Department of Physiology, Anatomy, and Genetics, Oxford, United Kingdom
PLoS Comput Biol 2:e133. 2006..PhyOP will be particularly useful in predicting orthology for mammalian genomes that have been incompletely sequenced, and for large families of rapidly duplicating genes... - Genome sequence of the Brown Norway rat yields insights into mammalian evolutionRichard A Gibbs
Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, MS BCM226, One Baylor Plaza, Houston, Texas 77030, USA <http://www.hgsc.bcm.tmc.edu
Nature 428:493-521. 2004.... - Evolutionary biology: human brain gene wins genome raceChris P Ponting
Nature 443:149-50. 2006 - Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolutionLadeana W Hillier
Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
Nature 432:695-716. 2004..The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture... - InterPro, progress and status in 2005Nicola J Mulder
EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Nucleic Acids Res 33:D201-5. 2005..The database is available for text- and sequence-based searches via a webserver (http://www.ebi.ac.uk/interpro), and for download by anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro)... - Genome sequence, comparative analysis and haplotype structure of the domestic dogKerstin Lindblad-Toh
Broad Institute of Harvard and MIT, 320 Charles Street, Cambridge, Massachusetts 02141, USA
Nature 438:803-19. 2005..The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health... - SMART 4.0: towards genomic data integrationIvica Letunic
EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany
Nucleic Acids Res 32:D142-4. 2004..Other improvements include the ability to query SMART by Gene Ontology terms, improved structure database searching and batch retrieval of multiple entries... - Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequencesTarjei S Mikkelsen
Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 447:167-77. 2007..A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation... - Rapid bursts of androgen-binding protein (Abp) gene duplication occurred independently in diverse mammalsChristina M Laukaitis
Department of Medical Genetics, University of Washington, Seattle, USA and Division of Human Biology, Fred Hutchinson CancerResearch Center, Seattle, USA
BMC Evol Biol 8:46. 2008..Questions arise from imperfections in the initial mouse genome assembly and a dearth of information about the gene family structure in other rodents and mammals... - Comparison of mouse and human genomes followed by experimental verification yields an estimated 1,019 additional genesRoderic Guigo
Research Group in Biomedical Informatics, , E08003 Barcelona, Catalonia, Spain
Proc Natl Acad Sci U S A 100:1140-5. 2003..This is likely to constitute a significant fraction of the previously unknown, multiexon mammalian genes... - Initial sequencing and comparative analysis of the mouse genomeRobert H Waterston
Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
Nature 420:520-62. 2002.... - Evolution of genes and genomes on the Drosophila phylogenyAndrew G Clark
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
Nature 450:203-18. 2007..These may prove to underlie differences in the ecology and behaviour of these diverse species... - Sequence analysis of multidomain proteins: past perspectives and future directionsRichard R Copley
Adv Protein Chem 61:75-98. 2002 - Genome analysis of the platypus reveals unique signatures of evolutionWesley C Warren
Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
Nature 453:175-83. 2008..Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation... - A genetic variation map for chicken with 2.8 million single-nucleotide polymorphismsGane Ka-Shu Wong
Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, Beijing 101300, China
Nature 432:717-22. 2004..In fact, most of the SNPs originated before domestication, and there is little evidence of selective sweeps for adaptive alleles on length scales greater than 100 kilobases... - Sexual selection and the adaptive evolution of mammalian ejaculate proteinsSteven A Ramm
Mammalian Behaviour and Evolution Group, Faculty of Veterinary Science, University of Liverpool, Liverpool, United Kingdom
Mol Biol Evol 25:207-19. 2008.... - The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domainsSebastian Maurer-Stroh
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria
Trends Biochem Sci 28:69-74. 2003..In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'... - GIFT domains: linking eukaryotic intraflagellar transport and glycosylation to bacterial glidingScott Beatson
Microbial Genomics Group, Institute for Biomedical Research, Division of Immunity and Infection, Medical School, University of Birmingham, Birmingham, UK B15 2TT
Trends Biochem Sci 29:396-9. 2004..A distant evolutionary relationship to periplasmic-binding proteins hints that GIFT domains might possess oligosaccharide-binding functions... - Predicting protein cellular localization using a domain projection methodRichard Mott
Wellcome Trust Centre for Human Genetics, Oxford OX3 7BN, United Kingdom
Genome Res 12:1168-74. 2002..This method is complementary to approaches that use amino-acid composition or identify sorting sequences; these methods may be combined to further enhance prediction accuracy... - Defensins and the convergent evolution of platypus and reptile venom genesCamilla M Whittington
Faculty of Veterinary Science, University of Sydney, Sydney, New South Wales 2006, Australia
Genome Res 18:986-94. 2008..Convergent evolution has repeatedly selected genes coding for proteins containing specific structural motifs as templates for venom molecules... - EMSY links the BRCA2 pathway to sporadic breast and ovarian cancerLuke Hughes-Davies
Cancer Research UK Wellcome Trust Institute and Department of Pathology, Tennis Court Road, Cambridge CB2 1QR, United Kingdom
Cell 115:523-35. 2003..The remarkable clinical overlap between sporadic EMSY amplification and familial BRCA2 deletion implicates a BRCA2 pathway in sporadic breast and ovarian cancer... - The InterPro Database, 2003 brings increased coverage and new featuresNicola J Mulder
EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
Nucleic Acids Res 31:315-8. 2003..The database is available via a webserver (http://www.ebi.ac.uk/interpro) and anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro)... - Structural and mechanistic insights into ras association domains of phospholipase C epsilonTom D Bunney
Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Laboratories, The Institute of Cancer Research, Fulham Road, London SW3 6JB, United Kingdom
Mol Cell 21:495-507. 2006..Studies of PLCepsilon regulation suggest that, in a cellular context, the RA2 domain, in a mode specific to PLCepsilon, has a role in membrane targeting with further regulatory impact on PLC activity... - Systematic identification of novel protein domain families associated with nuclear functionsTobias Doerks
European Molecular Biology Laboratory, 69114 Heidelberg, Germany
Genome Res 12:47-56. 2002.... - InterPro: an integrated documentation resource for protein families, domains and functional sitesNicola J Mulder
EMBL Outstation, European Bioinformatics Institute, Hinxton, Cambridge, UK
Brief Bioinform 3:225-35. 2002..Each InterPro entry lists all the matches against SWISS-PROT and TrEMBL (2,141,621 InterPro hits from 586,124 SWISS-PROT and TrEMBL protein sequences). The database is freely accessible for text- and sequence-based searches... - Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteinsNicholas J Dickens
Curr Biol 12:R197-9. 2002