Research Topics
Genomes and Genes | C PontingSummaryAffiliation: University of Oxford Country: UK Publications
| Collaborators
|
Detail Information
Publications
beta-propeller repeats and a PDZ domain in the tricorn protease: predicted self-compartmentalisation and C-terminal polypeptide-binding strategies of substrate selectionC P Ponting
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
FEMS Microbiol Lett 179:447-51. 1999..acidophilum proteasome, whereas the beta-propeller domains serve to exclude large substrates from the tricorn protease active site in a similar manner to that previously indicated for prolyl oligopeptidase...
Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?C P Ponting
University of Oxford, Fibrinolysis Research Unit, United Kingdom
Protein Sci 5:2353-7. 1996....- P100, a transcriptional coactivator, is a human homologue of staphylococcal nucleaseC P Ponting
Fibrinolysis Research Unit, University of Oxford, United Kingdom
Protein Sci 6:459-63. 1997..Conservation of Asp-19 and Asp-83 among these homologues suggests a re-evaluation of the roles of these residues in Ca(2+)-binding and/or catalysis... - Evidence for PDZ domains in bacteria, yeast, and plantsC P Ponting
Fibrinolysis Research Unit, University of Oxford, United Kingdom
Protein Sci 6:464-8. 1997..The known affinity of Escherichia coli tsp for C-terminal polypeptides is proposed to be mediated by its PDZ-like domain, in a similar manner to the binding of C-terminal polypeptides by animal PDZ domains... - Tudor domains in proteins that interact with RNAC P Ponting
Fibrinolysis Research Unit, University of Oxford, UK OX1 3RH
Trends Biochem Sci 22:51-2. 1997 - SPRY domains in ryanodine receptors (Ca(2+)-release channels)C Ponting
Fibrinolysis Research Unit, University of Oxford, UK
Trends Biochem Sci 22:193-4. 1997 - Regulation of chromatin structure by site-specific histone H3 methyltransferasesS Rea
Research Institute of Molecular Pathology, The Vienna Biocenter, Austria
Nature 406:593-9. 2000..Our data reveal a functional interdependence of site-specific H3 tail modifications and suggest a dynamic mechanism for the regulation of higher-order chromatin... - Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function predictionC P Ponting
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Biochem J 351:527-35. 2000..This finding hints at the mechanism by which Ire1p may sense extended unfolded proteins at the expense of compact folded molecules... - Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complexS E Newey
Department of Human Anatomy and Genetics, University of Oxford, UK
Curr Biol 10:1295-8. 2000..This is likely to have important consequences for the recruitment of specific signalling molecules to the DPC and ultimately for its function... - JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2betaP M Clissold
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, OX1 3QX, Oxford, UK
Trends Biochem Sci 26:7-9. 2001..JmjC domains are predicted to be metalloenzymes that adopt the cupin fold, and are candidates for enzymes that regulate chromatin remodelling... - Sialidase-like Asp-boxes: sequence-similar structures within different protein foldsR R Copley
EMBL, Heidelberg 69012, Germany
Protein Sci 10:285-92. 2001.... - On the evolution of protein folds: are similar motifs in different protein folds the result of convergence, insertion, or relics of an ancient peptide world?A N Lupas
Bioinformatics, GlaxoSmithKline, UP1345, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426 0989, USA
J Struct Biol 134:191-203. 2001..Subsequently, and perhaps concomitantly with the evolution of higher fidelity DNA replication and repair systems, single polypeptide domains arose from the fusion of ADSs genes. Thus modern protein domains may have a polyphyletic origin... - Mutations in the fukutin-related protein gene (FKRP) cause a form of congenital muscular dystrophy with secondary laminin alpha2 deficiency and abnormal glycosylation of alpha-dystroglycanM Brockington
The Dubowitz Neuromuscular Centre, Department of Paediatrics, Imperial College School of Medicine, Hammersmith Hospital Campus, London, United Kindom
Am J Hum Genet 69:1198-209. 2001..We suggest these abnormalities of alpha-dystroglycan are caused by its defective glycosylation and are integral to the pathology seen in MDC1C... - Phospholipase Czeta, the trigger of egg activation in mammals, is present in a non-mammalian speciesK Coward
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Reproduction 130:157-63. 2005..Our findings suggest that PLCzeta may have a universal role in triggering egg activation in vertebrates... - A beta-propeller domain within TolBC P Ponting
Mol Microbiol 31:739-40. 1999 - Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complexK Talbot
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
Hum Mol Genet 7:2149-56. 1998..In addition to a possible role for this protein as a pro-apoptotic factor, SMN and its related protein share significant similarities in sequence and cellular function... - PDZ domains: targeting signalling molecules to sub-membranous sitesC P Ponting
University of Oxford, Fibrinolysis Research Unit, UK
Bioessays 19:469-79. 1997..Recently, the crystal structures of PDZ domains, with and without ligand, have been determined. These demonstrate the mode of ligand-binding and the structural bases for sequence conservation among diverse PDZ domains... - Missense mutation clustering in the survival motor neuron gene: a role for a conserved tyrosine and glycine rich region of the protein in RNA metabolism?K Talbot
University of Oxford, Department of Biochemistry, UK
Hum Mol Genet 6:497-500. 1997..We have identified apparent orthologues of SMN in Caenorhabditis elegans and Schizosaccharomyces pombe. These sequences retain the highly conserved Y-G motif and provide additional support for a role of SMN in mRNA metabolism... - The crystal structure of the catalytic domain of human urokinase-type plasminogen activatorG Spraggon
Laboratory of Molecular Biophysics, Oxford, UK
Structure 3:681-91. 1995..Solution of the structure of the u-PA serine protease was undertaken to provide such data... - Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductasesJ D Vargas
Department of Human Anatomy and Genetics, University of Oxford, OX1 3QX Oxford, UK
Biochim Biophys Acta 1651:116-23. 2003..Moreover, we demonstrate the presence of mouse sdr2 in the choroid plexus and in the ependymal cells lining the four ventricles, through in situ hybridization analysis... - Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) geneJ D Vargas
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Mech Dev 117:289-92. 2002..The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development... - A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migrationR D Emes
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Hum Mol Genet 10:2813-20. 2001..Uncharacterized LisH motif-containing proteins represent candidates for other diseases associated with aberrant microtubule dynamics and defects of cell migration, nucleokinesis or chromosome segregation... - Sequence variation and disease in the wake of the draft human genomeL Goodstadt
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Hum Mol Genet 10:2209-14. 2001..Ultimately, the success of genome sequencing and functional genomics will be measured not by the quantity and accuracy of raw data generated, but how rapidly they can be harnessed to span the divide between genotype and phenotype... - SAM as a protein interaction domain involved in developmental regulationJ Schultz
EMBL, Heidelberg, Germany
Protein Sci 6:249-53. 1997..A conserved tyrosine in the SAM sequences of the EPH related RPTKs is likely to mediate cell-cell initiated signal transduction via the binding of SH2 containing proteins to phosphotyrosine... - Protein repeats: structures, functions, and evolutionM A Andrade
European Molecular Biology Laboratory, Meyerhofstr. 1, Heidelberg, 69012, Germany
J Struct Biol 134:117-31. 2001.... - The kyphoscoliosis (ky) mouse is deficient in hypertrophic responses and is caused by a mutation in a novel muscle-specific proteinG Blanco
MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, Oxon OX11 ORD, UK
Hum Mol Genet 10:9-16. 2001..The ky transcript encodes a novel protein that is detected only in skeletal muscle and heart. The identification of the ky gene will allow detailed analysis of the impact of primary myopathy on idiopathic scoliosis in mice and man... - Homologues of 26S proteasome subunits are regulators of transcription and translationL Aravind
Department of Biology BSBW, Texas A and M University, College Station 77843, USA
Protein Sci 7:1250-4. 1998..The presence of homologous, and sometimes identical, proteins in contrasting functional contexts suggests that the large multisubunit complexes of the 26S proteasome, eIF3 and TFIIH perform overlapping cellular roles... - Syncoilin, a novel member of the intermediate filament superfamily that interacts with alpha-dystrobrevin in skeletal muscleS E Newey
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom
J Biol Chem 276:6645-55. 2001.... - SAM: a novel motif in yeast sterile and Drosophila polyhomeotic proteinsC P Ponting
Fibrinolysis Research Unit, University of Oxford, Old Observatory, United Kingdom
Protein Sci 4:1928-30. 1995..Its appearance in byr2 and STE11, which are MEK kinases, and in proteins containing pleckstrain homology, src homology 3, and discs-large homologous region domains, suggests possible participation in signal transduction pathways...