C Ponting

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint beta-propeller repeats and a PDZ domain in the tricorn protease: predicted self-compartmentalisation and C-terminal polypeptide-binding strategies of substrate selection
    C P Ponting
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    FEMS Microbiol Lett 179:447-51. 1999
  2. pmc Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?
    C P Ponting
    University of Oxford, Fibrinolysis Research Unit, United Kingdom
    Protein Sci 5:2353-7. 1996
  3. pmc P100, a transcriptional coactivator, is a human homologue of staphylococcal nuclease
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, United Kingdom
    Protein Sci 6:459-63. 1997
  4. pmc Evidence for PDZ domains in bacteria, yeast, and plants
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, United Kingdom
    Protein Sci 6:464-8. 1997
  5. ncbi request reprint Tudor domains in proteins that interact with RNA
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, UK OX1 3RH
    Trends Biochem Sci 22:51-2. 1997
  6. ncbi request reprint SPRY domains in ryanodine receptors (Ca(2+)-release channels)
    C Ponting
    Fibrinolysis Research Unit, University of Oxford, UK
    Trends Biochem Sci 22:193-4. 1997
  7. ncbi request reprint Regulation of chromatin structure by site-specific histone H3 methyltransferases
    S Rea
    Research Institute of Molecular Pathology, The Vienna Biocenter, Austria
    Nature 406:593-9. 2000
  8. pmc Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction
    C P Ponting
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Biochem J 351:527-35. 2000
  9. ncbi request reprint Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex
    S E Newey
    Department of Human Anatomy and Genetics, University of Oxford, UK
    Curr Biol 10:1295-8. 2000
  10. ncbi request reprint JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta
    P M Clissold
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, OX1 3QX, Oxford, UK
    Trends Biochem Sci 26:7-9. 2001

Collaborators

Detail Information

Publications29

  1. ncbi request reprint beta-propeller repeats and a PDZ domain in the tricorn protease: predicted self-compartmentalisation and C-terminal polypeptide-binding strategies of substrate selection
    C P Ponting
    National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA
    FEMS Microbiol Lett 179:447-51. 1999
    ..acidophilum proteasome, whereas the beta-propeller domains serve to exclude large substrates from the tricorn protease active site in a similar manner to that previously indicated for prolyl oligopeptidase...
  2. pmc Novel domains in NADPH oxidase subunits, sorting nexins, and PtdIns 3-kinases: binding partners of SH3 domains?
    C P Ponting
    University of Oxford, Fibrinolysis Research Unit, United Kingdom
    Protein Sci 5:2353-7. 1996
    ....
  3. pmc P100, a transcriptional coactivator, is a human homologue of staphylococcal nuclease
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, United Kingdom
    Protein Sci 6:459-63. 1997
    ..Conservation of Asp-19 and Asp-83 among these homologues suggests a re-evaluation of the roles of these residues in Ca(2+)-binding and/or catalysis...
  4. pmc Evidence for PDZ domains in bacteria, yeast, and plants
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, United Kingdom
    Protein Sci 6:464-8. 1997
    ..The known affinity of Escherichia coli tsp for C-terminal polypeptides is proposed to be mediated by its PDZ-like domain, in a similar manner to the binding of C-terminal polypeptides by animal PDZ domains...
  5. ncbi request reprint Tudor domains in proteins that interact with RNA
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, UK OX1 3RH
    Trends Biochem Sci 22:51-2. 1997
  6. ncbi request reprint SPRY domains in ryanodine receptors (Ca(2+)-release channels)
    C Ponting
    Fibrinolysis Research Unit, University of Oxford, UK
    Trends Biochem Sci 22:193-4. 1997
  7. ncbi request reprint Regulation of chromatin structure by site-specific histone H3 methyltransferases
    S Rea
    Research Institute of Molecular Pathology, The Vienna Biocenter, Austria
    Nature 406:593-9. 2000
    ..Our data reveal a functional interdependence of site-specific H3 tail modifications and suggest a dynamic mechanism for the regulation of higher-order chromatin...
  8. pmc Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction
    C P Ponting
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Biochem J 351:527-35. 2000
    ..This finding hints at the mechanism by which Ire1p may sense extended unfolded proteins at the expense of compact folded molecules...
  9. ncbi request reprint Alternative splicing of dystrobrevin regulates the stoichiometry of syntrophin binding to the dystrophin protein complex
    S E Newey
    Department of Human Anatomy and Genetics, University of Oxford, UK
    Curr Biol 10:1295-8. 2000
    ..This is likely to have important consequences for the recruitment of specific signalling molecules to the DPC and ultimately for its function...
  10. ncbi request reprint JmjC: cupin metalloenzyme-like domains in jumonji, hairless and phospholipase A2beta
    P M Clissold
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, OX1 3QX, Oxford, UK
    Trends Biochem Sci 26:7-9. 2001
    ..JmjC domains are predicted to be metalloenzymes that adopt the cupin fold, and are candidates for enzymes that regulate chromatin remodelling...
  11. pmc Sialidase-like Asp-boxes: sequence-similar structures within different protein folds
    R R Copley
    EMBL, Heidelberg 69012, Germany
    Protein Sci 10:285-92. 2001
    ....
  12. ncbi request reprint On the evolution of protein folds: are similar motifs in different protein folds the result of convergence, insertion, or relics of an ancient peptide world?
    A N Lupas
    Bioinformatics, GlaxoSmithKline, UP1345, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426 0989, USA
    J Struct Biol 134:191-203. 2001
    ..Subsequently, and perhaps concomitantly with the evolution of higher fidelity DNA replication and repair systems, single polypeptide domains arose from the fusion of ADSs genes. Thus modern protein domains may have a polyphyletic origin...
  13. pmc Mutations in the fukutin-related protein gene (FKRP) cause a form of congenital muscular dystrophy with secondary laminin alpha2 deficiency and abnormal glycosylation of alpha-dystroglycan
    M Brockington
    The Dubowitz Neuromuscular Centre, Department of Paediatrics, Imperial College School of Medicine, Hammersmith Hospital Campus, London, United Kindom
    Am J Hum Genet 69:1198-209. 2001
    ..We suggest these abnormalities of alpha-dystroglycan are caused by its defective glycosylation and are integral to the pathology seen in MDC1C...
  14. ncbi request reprint Phospholipase Czeta, the trigger of egg activation in mammals, is present in a non-mammalian species
    K Coward
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Reproduction 130:157-63. 2005
    ..Our findings suggest that PLCzeta may have a universal role in triggering egg activation in vertebrates...
  15. ncbi request reprint A beta-propeller domain within TolB
    C P Ponting
    Mol Microbiol 31:739-40. 1999
  16. ncbi request reprint Characterization of a gene encoding survival motor neuron (SMN)-related protein, a constituent of the spliceosome complex
    K Talbot
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Hum Mol Genet 7:2149-56. 1998
    ..In addition to a possible role for this protein as a pro-apoptotic factor, SMN and its related protein share significant similarities in sequence and cellular function...
  17. ncbi request reprint PDZ domains: targeting signalling molecules to sub-membranous sites
    C P Ponting
    University of Oxford, Fibrinolysis Research Unit, UK
    Bioessays 19:469-79. 1997
    ..Recently, the crystal structures of PDZ domains, with and without ligand, have been determined. These demonstrate the mode of ligand-binding and the structural bases for sequence conservation among diverse PDZ domains...
  18. ncbi request reprint Missense mutation clustering in the survival motor neuron gene: a role for a conserved tyrosine and glycine rich region of the protein in RNA metabolism?
    K Talbot
    University of Oxford, Department of Biochemistry, UK
    Hum Mol Genet 6:497-500. 1997
    ..We have identified apparent orthologues of SMN in Caenorhabditis elegans and Schizosaccharomyces pombe. These sequences retain the highly conserved Y-G motif and provide additional support for a role of SMN in mRNA metabolism...
  19. ncbi request reprint The crystal structure of the catalytic domain of human urokinase-type plasminogen activator
    G Spraggon
    Laboratory of Molecular Biophysics, Oxford, UK
    Structure 3:681-91. 1995
    ..Solution of the structure of the u-PA serine protease was undertaken to provide such data...
  20. ncbi request reprint Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases
    J D Vargas
    Department of Human Anatomy and Genetics, University of Oxford, OX1 3QX Oxford, UK
    Biochim Biophys Acta 1651:116-23. 2003
    ..Moreover, we demonstrate the presence of mouse sdr2 in the choroid plexus and in the ependymal cells lining the four ventricles, through in situ hybridization analysis...
  21. ncbi request reprint Cloning and developmental expression analysis of ltd-1, the Caenorhabditis elegans homologue of the mouse kyphoscoliosis (ky) gene
    J D Vargas
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Mech Dev 117:289-92. 2002
    ..The LTD-1::GFP construct is expressed in developing hypodermal cells from the twofold stage embryo through adulthood. These data define the ltd-1 gene as a novel marker for C. elegans epithelial cell development...
  22. ncbi request reprint A new sequence motif linking lissencephaly, Treacher Collins and oral-facial-digital type 1 syndromes, microtubule dynamics and cell migration
    R D Emes
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Hum Mol Genet 10:2813-20. 2001
    ..Uncharacterized LisH motif-containing proteins represent candidates for other diseases associated with aberrant microtubule dynamics and defects of cell migration, nucleokinesis or chromosome segregation...
  23. ncbi request reprint Sequence variation and disease in the wake of the draft human genome
    L Goodstadt
    MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Hum Mol Genet 10:2209-14. 2001
    ..Ultimately, the success of genome sequencing and functional genomics will be measured not by the quantity and accuracy of raw data generated, but how rapidly they can be harnessed to span the divide between genotype and phenotype...
  24. pmc SAM as a protein interaction domain involved in developmental regulation
    J Schultz
    EMBL, Heidelberg, Germany
    Protein Sci 6:249-53. 1997
    ..A conserved tyrosine in the SAM sequences of the EPH related RPTKs is likely to mediate cell-cell initiated signal transduction via the binding of SH2 containing proteins to phosphotyrosine...
  25. ncbi request reprint Protein repeats: structures, functions, and evolution
    M A Andrade
    European Molecular Biology Laboratory, Meyerhofstr. 1, Heidelberg, 69012, Germany
    J Struct Biol 134:117-31. 2001
    ....
  26. ncbi request reprint The kyphoscoliosis (ky) mouse is deficient in hypertrophic responses and is caused by a mutation in a novel muscle-specific protein
    G Blanco
    MRC Mammalian Genetics Unit and UK Mouse Genome Centre, Harwell, Oxon OX11 ORD, UK
    Hum Mol Genet 10:9-16. 2001
    ..The ky transcript encodes a novel protein that is detected only in skeletal muscle and heart. The identification of the ky gene will allow detailed analysis of the impact of primary myopathy on idiopathic scoliosis in mice and man...
  27. pmc Homologues of 26S proteasome subunits are regulators of transcription and translation
    L Aravind
    Department of Biology BSBW, Texas A and M University, College Station 77843, USA
    Protein Sci 7:1250-4. 1998
    ..The presence of homologous, and sometimes identical, proteins in contrasting functional contexts suggests that the large multisubunit complexes of the 26S proteasome, eIF3 and TFIIH perform overlapping cellular roles...
  28. ncbi request reprint Syncoilin, a novel member of the intermediate filament superfamily that interacts with alpha-dystrobrevin in skeletal muscle
    S E Newey
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, United Kingdom
    J Biol Chem 276:6645-55. 2001
    ....
  29. pmc SAM: a novel motif in yeast sterile and Drosophila polyhomeotic proteins
    C P Ponting
    Fibrinolysis Research Unit, University of Oxford, Old Observatory, United Kingdom
    Protein Sci 4:1928-30. 1995
    ..Its appearance in byr2 and STE11, which are MEK kinases, and in proteins containing pleckstrain homology, src homology 3, and discs-large homologous region domains, suggests possible participation in signal transduction pathways...