R Polosa

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. ncbi request reprint Adenosine receptors: promising targets for the development of novel therapeutics and diagnostics for asthma
    Cristina Russo
    Dipartimento di Medicina Interna e Specialistica, Ascoli Tomaselli Hospitals, University of Catania, Via Passo Gravina 187, 95125 Catania, Italy
    Fundam Clin Pharmacol 20:9-19. 2006
  2. doi request reprint Treatment strategies for allergy and asthma
    Stephen T Holgate
    IIR Division, F Level, South Block, Southampton General Hospital, Southampton, SO16 6YD, UK
    Nat Rev Immunol 8:218-30. 2008
  3. ncbi request reprint Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease
    R Polosa
    Dept of Internal and Specialist Medicine, University of Catania, Ascoli Tomaselli Hospitals, Italy
    Eur Respir J 20:488-96. 2002
  4. pmc Greater risk of incident asthma cases in adults with allergic rhinitis and effect of allergen immunotherapy: a retrospective cohort study
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
    Respir Res 6:153. 2005
  5. ncbi request reprint Effect of immunotherapy on asthma progression, BHR and sputum eosinophils in allergic rhinitis
    R Polosa
    Istituto di Malattie Apparato Respiratorio, University of Catania, Catania, Italy
    Allergy 59:1224-8. 2004
  6. doi request reprint The presence of anticardiolipin antibodies in adults may be influenced by infections in infancy
    C J Edwards
    Department of Rheumatology, Southampton General Hospital, Tremona Road, Southampton, UK
    QJM 101:41-7. 2008
  7. doi request reprint The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial
    J B Morjaria
    Infection, Inflammation and Repair Division, Southampton University Hospitals Trust, Southampton, UK
    Thorax 63:584-91. 2008
  8. ncbi request reprint Particulate air pollution from motor vehicles: a putative proallergic hazard?
    R Polosa
    University of Southampton, Southampton, United Kingdom
    Can Respir J 6:436-41. 1999
  9. ncbi request reprint Interleukin-5 production by human airway epithelial cells
    S Salvi
    Department of Medicine, University of Southampton, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 20:984-91. 1999
  10. pmc Finding better therapeutic targets for patients with asthma: adenosine receptors?
    R Polosa
    Dipartimento di Medicina Interna e Specialistica, Institute of Internal Medicine and Clinical Immunology, S Marta Hospital, University of Catania, Catania, Italy
    Br J Pharmacol 155:441-3. 2008

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Adenosine receptors: promising targets for the development of novel therapeutics and diagnostics for asthma
    Cristina Russo
    Dipartimento di Medicina Interna e Specialistica, Ascoli Tomaselli Hospitals, University of Catania, Via Passo Gravina 187, 95125 Catania, Italy
    Fundam Clin Pharmacol 20:9-19. 2006
    ..In addition, because adenosine exerts its multiple biological activities by interacting with four adenosine receptor subtypes, selective activation or blockade of these receptors may lead to the development of novel therapies for asthma...
  2. doi request reprint Treatment strategies for allergy and asthma
    Stephen T Holgate
    IIR Division, F Level, South Block, Southampton General Hospital, Southampton, SO16 6YD, UK
    Nat Rev Immunol 8:218-30. 2008
    ....
  3. ncbi request reprint Adenosine-receptor subtypes: their relevance to adenosine-mediated responses in asthma and chronic obstructive pulmonary disease
    R Polosa
    Dept of Internal and Specialist Medicine, University of Catania, Ascoli Tomaselli Hospitals, Italy
    Eur Respir J 20:488-96. 2002
    ..The recent characterisation of the A2B receptors indicates the human lung mast cell as one of the most strategic cellular targets...
  4. pmc Greater risk of incident asthma cases in adults with allergic rhinitis and effect of allergen immunotherapy: a retrospective cohort study
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
    Respir Res 6:153. 2005
    ..Moreover, treatment with allergen immunotherapy lowers the risk of the development of new asthma cases in adults with allergic rhinitis...
  5. ncbi request reprint Effect of immunotherapy on asthma progression, BHR and sputum eosinophils in allergic rhinitis
    R Polosa
    Istituto di Malattie Apparato Respiratorio, University of Catania, Catania, Italy
    Allergy 59:1224-8. 2004
    ..Specific immunotherapy (SIT) reduces symptom in subjects with allergic rhinitis, but the mechanisms are not clear...
  6. doi request reprint The presence of anticardiolipin antibodies in adults may be influenced by infections in infancy
    C J Edwards
    Department of Rheumatology, Southampton General Hospital, Tremona Road, Southampton, UK
    QJM 101:41-7. 2008
    ..We measured anticardiolipin antibodies (aCL) in a general population with well-defined early lives to see whether fetal and infant growth and infections were associated with aCL positivity in adult life...
  7. doi request reprint The role of a soluble TNFalpha receptor fusion protein (etanercept) in corticosteroid refractory asthma: a double blind, randomised, placebo controlled trial
    J B Morjaria
    Infection, Inflammation and Repair Division, Southampton University Hospitals Trust, Southampton, UK
    Thorax 63:584-91. 2008
    ..Tumour necrosis factor alpha (TNFalpha) is a cytokine recognised as a therapeutic target in chronic inflammatory diseases...
  8. ncbi request reprint Particulate air pollution from motor vehicles: a putative proallergic hazard?
    R Polosa
    University of Southampton, Southampton, United Kingdom
    Can Respir J 6:436-41. 1999
    ..Legislators should consider pollutants emitted from motor vehicle exhausts as a potential pro-allergic hazard, before making important changes in environmental policy...
  9. ncbi request reprint Interleukin-5 production by human airway epithelial cells
    S Salvi
    Department of Medicine, University of Southampton, Southampton, United Kingdom
    Am J Respir Cell Mol Biol 20:984-91. 1999
    ....
  10. pmc Finding better therapeutic targets for patients with asthma: adenosine receptors?
    R Polosa
    Dipartimento di Medicina Interna e Specialistica, Institute of Internal Medicine and Clinical Immunology, S Marta Hospital, University of Catania, Catania, Italy
    Br J Pharmacol 155:441-3. 2008
    ..Important conclusions can be drawn about the function of adenosine receptors in human asthma and approaches to these important targets with novel therapeutic agents...
  11. ncbi request reprint Effect of salbutamol on nasal symptoms and mast cell degranulation induced by adenosine 5' monophosphate nasal challenge
    C Russo
    Dipartimento di Medicina Interna e Specialistica, University of Catania, Via Passo Gravina 187, 95125 Catania, Italy
    Clin Exp Allergy 35:1192-6. 2005
    ..In addition to its well-known functional agonism at the level of beta(2) adrenergic receptors on airways smooth muscle cells, salbutamol appears to have additional protective effects, possibly through an inhibition of mast cell activation...
  12. ncbi request reprint Electronic cigarette: a possible substitute for cigarette dependence
    P Caponnetto
    Centro per Ia Prevenzione e Cura del Tabagismo CPCT, Azienda Ospedaliero Universitaria Policlinico V Emanuele, Universita di Catania, Catania, Italy
    Monaldi Arch Chest Dis 79:12-9. 2013
    ....
  13. ncbi request reprint An overview of chronic severe asthma
    R Polosa
    Department of Internal Medicine, University of Catania, Catania, Italy
    Intern Med J 38:190-8. 2008
    ..In this review, a diagnostic and therapeutic overview of CSA is provided for the benefit of those who have a specific interest in this problematic condition...
  14. pmc Evolving concepts on the value of adenosine hyperresponsiveness in asthma and chronic obstructive pulmonary disease
    R Polosa
    Dipartimento di Medicina Interna e Specialistica, Ospedale Tomaselli, Universita di Catania, 95125 Catania, Italy
    Thorax 57:649-54. 2002
    ....
  15. ncbi request reprint Monitoring of seasonal variability in bronchial hyper-responsiveness and sputum cell counts in non-asthmatic subjects with rhinitis and effect of specific immunotherapy
    R Polosa
    Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
    Clin Exp Allergy 33:873-81. 2003
    ..The clinical efficacy of Parietaria SIT was exclusively associated with attenuation in seasonal worsening of PC15 AMP, suggesting that AMP may be useful in monitoring changes in allergic inflammation of the airways...
  16. ncbi request reprint The role of endogenous and exogenous AMP in asthma and chronic obstructive pulmonary disease
    Maarten van den Berge
    Department of Pulmonology, University Hospital Groningen, The Netherlands
    J Allergy Clin Immunol 114:737-46. 2004
    ..The aim of this article was to review the literature assessing AMP's value in asthma and chronic obstructive pulmonary disease...
  17. ncbi request reprint Adenosine receptors as promising therapeutic targets for drug development in chronic airway inflammation
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, Ascoli Tomaselli Hospitals University of Catania, Via Passo Gravina 187, 95125 Catania, Italy
    Curr Drug Targets 7:699-706. 2006
    ....
  18. ncbi request reprint The mechanisms, diagnosis, and management of severe asthma in adults
    Stephen T Holgate
    AIR Division, Level D Centre Block, Southampton General Hospital, Southampton, UK
    Lancet 368:780-93. 2006
    ....
  19. doi request reprint Cigarette smoking is associated with a greater risk of incident asthma in allergic rhinitis
    Riccardo Polosa
    Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
    J Allergy Clin Immunol 121:1428-34. 2008
    ..Sensitization to allergen has been shown to be one of the strongest determinants of incident asthma, but little is known about the effects of cigarette smoking among individuals with allergic rhinitis...
  20. ncbi request reprint Tumor necrosis factor alpha in refractory asthma
    Chiara Oliveri
    N Engl J Med 354:2074-5; author reply 2074-5. 2006
  21. ncbi request reprint Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects
    Riccardo Polosa
    School of Medicine, Division of Respiratory Cell and Molecular Biology, Southampton General Hospital, Southampton, United Kingdom
    J Allergy Clin Immunol 109:75-81. 2002
    ..The c-erbB family of receptor tyrosine kinases act in a combinatorial fashion to regulate cell behavior. Disturbances in this system have been associated with neoplastic and inflammatory diseases...
  22. ncbi request reprint Study of infliximab treatment in asthma
    Christopher J Edwards
    Am J Respir Crit Care Med 175:196; author reply 196-7. 2007
  23. ncbi request reprint New and emerging infectious diseases
    Lucia Spicuzza
    Dipartimento di Medicina Interna e Medicina Specialistica, Sezione Malattie Respiratorie, Universita di Catania, Italy
    Allergy Asthma Proc 28:28-34. 2007
    ..As for SARS, the World Health Organization has adopted a global action plan to control avian influenza among chickens and ducks and at the same time to limit the threat of a human flu pandemic...
  24. doi request reprint Endothelial-coagulative activation during chronic obstructive pulmonary disease exacerbations
    Riccardo Polosa
    Haematologica 93:1275-6. 2008
  25. ncbi request reprint Adenosine monophosphate challenge and monitoring of airway response to antiinflammatory therapy
    Riccardo Polosa
    Am J Respir Crit Care Med 165:1336; author reply 1336. 2002
  26. ncbi request reprint Beclomethasone dipropionate attenuates airways hyperresponsiveness to neurokinin A and histamine in asthma
    Gaetano Prosperini
    Dipartimento di Medicina Interna e Specialistica, Sezione di Malattie Respiratorie, Universita di Catania, Via Passo Gravina 187, 95125 Catania, Italy
    Respir Med 100:1006-12. 2006
    ..However, little is known about the possibility that treatment with ICS might cause additional protection on BHR to inhaled tachykinins such as neurokinin A (NKA)...
  27. ncbi request reprint Adenosine signalling in airways
    Massimo Caruso
    Dipartimento di Medicina Interna e Specialistica, Ascoli Tomaselli Hospitals University of Catania, Via Passo Gravina, 187, 95125 Catania, Italy
    Curr Opin Pharmacol 6:251-6. 2006
    ..It is likely that therapies interfering with adenosine signalling in the airways will offer a considerable advance in the management of asthma and COPD...
  28. ncbi request reprint Anti-TNF-alpha and Th1 cytokine-directed therapies for the treatment of asthma
    Mario Cazzola
    Department of Respiratory Medicine, Unit of Pneumology and Allergology and Centre of Respiratory Clinical Pharmacology, Antonio Cardarelli Hospital, Napoli, Italy
    Curr Opin Allergy Clin Immunol 6:43-50. 2006
    ..This article examines recent work about the role of TNF-alpha and of selected Th1-related cytokines in asthma with particular emphasis on the therapeutic potential of blocking the biological activity of these mediators...
  29. ncbi request reprint Adenosine in the airways: implications and applications
    Lucia Spicuzza
    Dipartimento di Medicina Interna e Medicina Specialistica Sezione Malattie Respiratorie Università di Catania, Italy
    Eur J Pharmacol 533:77-88. 2006
    ....
  30. ncbi request reprint Research applications and implications of adenosine in diseased airways
    Lucia Spicuzza
    Dipartimento di Medicina Interna e Specialistica, Ospedale Tomaselli, Universita di Catania, Via Passo Gravina, 187, 95125 Catania, Italy
    Trends Pharmacol Sci 24:409-13. 2003
    ....
  31. ncbi request reprint [Malignant pleural mesothelioma in housewives in the province of Catania]
    Lidia Proietti
    Sezione di Medicina del Lavoro, Dipartimento di Medicina Interna e Patologie Sistemiche, Universita, Catania
    Recenti Prog Med 95:365-8. 2004
    ..Therefore, further studies in a more large number of subjects are necessary to determine whether one or all of these hypothetic pathogenetic mechanisms are more significant for the develop of PMM...
  32. ncbi request reprint Heparin attenuates symptoms and mast cell degranulation induced by AMP nasal provocation
    Dewan Zeng
    Department of Drug Research and Pharmacological Sciences, CV Therapeutics, Inc, Palo Alto, Italy
    J Allergy Clin Immunol 114:316-20. 2004
    ..Previous studies have shown that inhaled heparin attenuated the airway responses to allergen, exercise, and AMP bronchial provocation, possibly through an inhibition of mast cell activation...
  33. ncbi request reprint A randomized, controlled study of specific immunotherapy in monosensitized subjects with seasonal rhinitis: effect on bronchial hyperresponsiveness, sputum inflammatory markers and development of asthma symptoms
    Nunzio Crimi
    Istituto di Malattie dell Apparato Respiratorio, Universita degli Studi di Catania
    Ann Ital Med Int 19:98-108. 2004
    ..Moreover, Parietaria-SIT appears to prevent the natural progression of allergic rhinitis to asthma, suggesting that SIT should be considered earlier in the management of this condition...
  34. ncbi request reprint Rapid effect of inhaled fluticasone on airway responsiveness to AMP: research implications
    Gaetano Prosperini
    J Allergy Clin Immunol 111:1416; author reply 1416-7. 2003
  35. ncbi request reprint Monitoring the adjustment of antiasthma medications with adenosine monophosphate bronchoprovocation
    Lidia Proietti
    Chest 126:1384-5; author reply 1385. 2004
  36. ncbi request reprint Mast cell degranulation after endobronchial adenosine challenge
    Daniela Lauretta
    J Allergy Clin Immunol 115:1097-8; author reply 1098-9. 2005
  37. ncbi request reprint TNF-alpha as a promising therapeutic target in chronic asthma: a lesson from rheumatoid arthritis
    Cristina Russo
    Dipartimento di Medicina Interna e Specialistica, Ascoli Tomaselli Hospitals, University of Catania, Italy
    Clin Sci (Lond) 109:135-42. 2005
    ....
  38. ncbi request reprint The role of adenosine as a novel bronchoprovocant in asthma
    Lucia Spicuzza
    Department of Internal and Specialist Medicine, University of Catania, Italy
    Curr Opin Allergy Clin Immunol 3:65-9. 2003
    ..Here the authors review the most recent development in this area of rapidly evolving clinical research, focusing on the putative role of adenosine as a useful bronchoprovocant in asthma...
  39. ncbi request reprint Changes in sputum counts and airway hyperresponsiveness after budesonide: monitoring anti-inflammatory response on the basis of surrogate markers of airway inflammation
    Gaetano Prosperini
    Dipartimento di Medicina Interna e Specialistica, University of Catania, Catania, Italy
    J Allergy Clin Immunol 110:855-61. 2002
    ..In addition, detailed longitudinal assessment of changes in airway response with inhaled GCSs has never been carried out...
  40. ncbi request reprint Study of infliximab treatment in smokers with COPD: what next?
    Cristina Russo
    Am J Respir Crit Care Med 172:1607-8; author reply 1608. 2005
  41. ncbi request reprint Can immunotherapy prevent progression to asthma in allergic individuals?
    Riccardo Polosa
    J Allergy Clin Immunol 110:672-3; author reply 273. 2002
  42. ncbi request reprint Critical appraisal of antileukotriene use in asthma management
    Riccardo Polosa
    Department of Internal and Specialist Medicine, Ascoli Tomaselli Hospitals, University of Catania, Italy
    Curr Opin Pulm Med 13:24-30. 2007
    ..In the present article the clinical applications of this class of drugs have been critically reviewed based on recent evidence...