R J Pleass

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi request reprint Opinion: antibody-based therapies for malaria
    Richard J Pleass
    Institute of Genetics, School of Biology, University of Nottingham, Nottingham, NG7 2UH, UK
    Nat Rev Microbiol 3:893-9. 2005
  2. ncbi request reprint Escherichia coli do not express Fc-receptors for human immunoglobulin G (IgG)
    Ashfaq Ghumra
    Institute of Genetics, School of Biology, University of Nottingham NG7 2UH, UK
    Mol Immunol 44:2144-6. 2007
  3. pmc When is a malaria immune complex not an immune complex?
    R J Pleass
    Institute of Genetics, Queen s Medical Centre, Nottingham, UK
    Parasite Immunol 31:61-3. 2009
  4. ncbi request reprint Novel antimalarial antibodies highlight the importance of the antibody Fc region in mediating protection
    Richard J Pleass
    School of Biology, University Park, Nottingham, NG7 2RD, United Kingdom
    Blood 102:4424-30. 2003
  5. pmc B-cells get the T-cells but antibodies get the worms
    Richard J Pleass
    Institute of Genetics, and Parasite Biology and Immunogenetics Research Group, Queen s Medical Centre, University of Nottingham, NG7 2UH, UK
    Trends Parasitol 25:443-6. 2009
  6. doi request reprint Do Escherichia coli express Fc-receptors for immunoglobulin?
    Richard J Pleass
    Institute of Genetics, School of Biology, Queen s Medical School, University of Nottingham, NG7 2UH Nottingham, United Kingdom
    Mol Immunol 46:2439-40. 2009
  7. ncbi request reprint Piggybacking schistosome invasion: similarities are only skin deep
    Richard J Pleass
    Institute of Genetics, Queens Medical Centre, Nottingham NG7 2UH, UK
    Trends Parasitol 24:153-6. 2008
  8. pmc Platelet power: sticky problems for sticky parasites?
    Richard J Pleass
    Institute of Genetics, School of Biology, University of Nottingham, NG7 2UH, UK
    Trends Parasitol 25:296-9. 2009
  9. pmc Fc-receptors and immunity to malaria: from models to vaccines
    R J Pleass
    Institute of Genetics, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Parasite Immunol 31:529-38. 2009
  10. ncbi request reprint Heterogeneous interspecific interactions in a host-parasite system
    J A Jackson
    School of Biology, University of Nottingham, Nottingham NG7 2RD, UK
    Int J Parasitol 36:1341-9. 2006

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Opinion: antibody-based therapies for malaria
    Richard J Pleass
    Institute of Genetics, School of Biology, University of Nottingham, Nottingham, NG7 2UH, UK
    Nat Rev Microbiol 3:893-9. 2005
    ..In this article, we discuss the possible therapeutic uses of antibodies in the treatment and prevention of malaria...
  2. ncbi request reprint Escherichia coli do not express Fc-receptors for human immunoglobulin G (IgG)
    Ashfaq Ghumra
    Institute of Genetics, School of Biology, University of Nottingham NG7 2UH, UK
    Mol Immunol 44:2144-6. 2007
    ..Here we use mono-specific recombinant antibodies to develop a novel assay for Ig binding non reliant on traditional polyclonal antibodies, allowing us to demonstrate the unequivocal absence of Fc binding proteins from E. coli...
  3. pmc When is a malaria immune complex not an immune complex?
    R J Pleass
    Institute of Genetics, Queen s Medical Centre, Nottingham, UK
    Parasite Immunol 31:61-3. 2009
    ..However, researchers should be aware of potential pitfalls to current assays aimed at measuring plasma ICs and correlating these to deposition in tissues...
  4. ncbi request reprint Novel antimalarial antibodies highlight the importance of the antibody Fc region in mediating protection
    Richard J Pleass
    School of Biology, University Park, Nottingham, NG7 2RD, United Kingdom
    Blood 102:4424-30. 2003
    ..Such antibodies may serve as prototype therapeutic agents, and as useful tools in the development of in vitro neutralization assays with Plasmodium parasites...
  5. pmc B-cells get the T-cells but antibodies get the worms
    Richard J Pleass
    Institute of Genetics, and Parasite Biology and Immunogenetics Research Group, Queen s Medical Centre, University of Nottingham, NG7 2UH, UK
    Trends Parasitol 25:443-6. 2009
    ..Here we discuss recent technological advances in humanizing animal models at the level of both Abs and their Fc-receptors, that might provide some answers...
  6. doi request reprint Do Escherichia coli express Fc-receptors for immunoglobulin?
    Richard J Pleass
    Institute of Genetics, School of Biology, Queen s Medical School, University of Nottingham, NG7 2UH Nottingham, United Kingdom
    Mol Immunol 46:2439-40. 2009
    ....
  7. ncbi request reprint Piggybacking schistosome invasion: similarities are only skin deep
    Richard J Pleass
    Institute of Genetics, Queens Medical Centre, Nottingham NG7 2UH, UK
    Trends Parasitol 24:153-6. 2008
    ..The advent of transgenic schistosomes is explored in relation to the biology of these important molecules...
  8. pmc Platelet power: sticky problems for sticky parasites?
    Richard J Pleass
    Institute of Genetics, School of Biology, University of Nottingham, NG7 2UH, UK
    Trends Parasitol 25:296-9. 2009
    ..suggests that they are also involved in innate protection during the early stages of infection. Here, we discuss the implications of their important findings in the context of immunity to malaria...
  9. pmc Fc-receptors and immunity to malaria: from models to vaccines
    R J Pleass
    Institute of Genetics, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Parasite Immunol 31:529-38. 2009
    ..Therefore, to develop the most efficacious vaccines it will be necessary to fully understand which Abs and Fc-receptors (FcRs) are best engaged for a positive outcome...
  10. ncbi request reprint Heterogeneous interspecific interactions in a host-parasite system
    J A Jackson
    School of Biology, University of Nottingham, Nottingham NG7 2RD, UK
    Int J Parasitol 36:1341-9. 2006
    ..We emphasise that such local (within-host) context-dependent processes are likely to be a fundamental determinant of population dynamics in multi-species parasite assemblages...
  11. pmc Functional effects of CCL3L1 copy number
    D Carpenter
    Centre for Genetics and Genomics and School of Biology, University of Nottingham, Nottingham, UK
    Genes Immun 13:374-9. 2012
    ..The data also provide evidence that expression of CCL3 predominates in both protein and mRNA, and therefore the observed variation of CCL3 is potentially more important biologically than that of CNV of CCL3L1...
  12. ncbi request reprint Characterization of immunoglobulin binding by schistosomes
    R S McIntosh
    Institute of Genetics, School of Biology, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2RD, UK
    Parasite Immunol 28:407-19. 2006
    ..Given their apparent low affinity, we postulate hydrogen bonding between reactive residues in a hydrophobic patch at the bottom of the Cgamma3 domain and negatively charged Glu or Asp amino acids in paramyosin...
  13. doi request reprint The secretory tailpiece isoform of IgE is not associated with allergy
    A Aslam
    School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    Allergy 63:942-3. 2008
  14. ncbi request reprint IgA is a more potent inducer of NADPH oxidase activation and degranulation in blood eosinophils than IgE
    Richard J Pleass
    Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, United Kingdom
    Mol Immunol 44:1401-8. 2007
    ....
  15. ncbi request reprint Antibody- and Fc-receptor-based therapeutics for malaria
    Jianguo Shi
    Institute of Genetics, School of Biology, University of Nottingham NG7 2RD, UK
    Clin Sci (Lond) 110:11-9. 2006
    ..These Abs also aid investigation of immune mechanisms operating to control the disease and are valuable tools in developing neutralization assays for vaccine design. This review explores how this might be achieved...
  16. pmc The importance of human FcgammaRI in mediating protection to malaria
    Richard S McIntosh
    Institute of Genetics, Queen s Medical Centre, University of Nottingham, United Kingdom
    PLoS Pathog 3:e72. 2007
    ..This important finding documents the capacity of FcgammaRI to mediate potent antimalaria immunity and supports the development of FcgammaRI-directed therapy for human malaria...
  17. ncbi request reprint Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions
    Akhmed Aslam
    Institute of Genetics, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Mol Immunol 45:567-74. 2008
    ..Indeed, the finding may raise new possibilities for treatment of IgE-mediated allergic reactions mediated through Fcepsilon-receptors...
  18. ncbi request reprint Structural requirements for the interaction of human IgA with the human polymeric Ig receptor
    Melanie J Lewis
    Division of Pathology and Neurosciences, University of Dundee Medical School, Ninewells Hospital, Dundee, United Kingdom
    J Immunol 175:6694-701. 2005
    ..This directed mutagenesis approach has thus identified motifs lying principally across the upper surface of the Calpha3 domain (i.e., that closest to Calpha2) critical for human pIgR binding and transcytosis...
  19. pmc Cloning and characterization of equine CD89 and identification of the CD89 gene in chimpanzees and rhesus macaques
    H Craig Morton
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, Rikshospitalet, University Hospital, Oslo, Norway
    Immunology 115:74-84. 2005
    ..The identification and characterization of CD89 in different species will contribute to a greater understanding of the biological role of IgA and CD89 in mucosal and systemic immunity throughout evolution...
  20. pmc Identification of residues in the Cmu4 domain of polymeric IgM essential for interaction with Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)
    Ashfaq Ghumra
    Institute of Genetics, Queens Medical Centre, University of Nottingham, Nottingham, England, United Kingdom
    J Immunol 181:1988-2000. 2008
    ..We have therefore shown that PfEMP1 is an Fc-binding protein of malaria parasites specific for polymeric human IgM, and that it shows functional similarities with Fc-binding proteins from pathogenic bacteria...
  21. ncbi request reprint Bifunctional nanotube scaffolds for diverse ligands are purified simply from Escherichia coli strains coexpressing two functionalized flagellar genes
    Richard D Woods
    Institute of Genetics, School of Biology, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Nano Lett 7:1809-16. 2007
    ..Tobacco Etch Virus (TEV) protease site-containing FliCs were cleaved by the cognate protease without filament disintegration, potentiating their use as removable nanolithography masks to deposit attached ligands by protease cleavage...
  22. ncbi request reprint Characterization of the ligand binding site of the bovine IgA Fc receptor (bFc alpha R)
    H Craig Morton
    Laboratory for Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    J Biol Chem 279:54018-22. 2004
    ..We show that, in common with CD89, Tyr-35 in the B-C loop is essential for IgA binding. However, in contrast to earlier observations on CD89, mutation of residues in the F-G loop did not significantly inhibit IgA binding...
  23. pmc Limited role of charge matching in the interaction of human immunoglobulin A with the immunoglobulin A Fc receptor (Fc alpha RI) CD89
    Richard J Pleass
    Department of Molecular and Cellular Pathology, University of Dundee Medical School, Dundee, UK
    Immunology 109:331-5. 2003
    ..Moreover, the lack of effect of mutations in residues adjacent to those previously implicated in binding, reaffirms the importance of the interdomain loops in Fc alpha RI binding...