Bettina Platt

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. doi request reprint FDG-PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease
    Bettina Platt
    School of Medical Sciences, Institute of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Biochem Soc Trans 39:874-80. 2011
  2. pmc Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1
    Bettina Platt
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 6:e27068. 2011
  3. ncbi request reprint Paired-pulse depression in the superficial layers of the guinea-pig superior colliculus
    B Platt
    Department of Biomedical Sciences, IMS, Aberdeen University, Foresterhill, UK
    Brain Res 777:131-9. 1997
  4. ncbi request reprint Differential toxicity of novel aluminium compounds in hippocampal culture
    Bettina Platt
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland, UK
    Neurotoxicology 28:576-86. 2007
  5. ncbi request reprint Cannabinoids: mechanisms and therapeutic applications in the CNS
    Alison J Drysdale
    Department of Biomedical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK
    Curr Med Chem 10:2719-32. 2003
  6. ncbi request reprint Aluminium toxicity in the rat brain: histochemical and immunocytochemical evidence
    B Platt
    Biomedical Sciences, Aberdeen University, Scotland, Aberdeen, UK
    Brain Res Bull 55:257-67. 2001
  7. doi request reprint The cholinergic system, EEG and sleep
    Bettina Platt
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Behav Brain Res 221:499-504. 2011
  8. ncbi request reprint GABA-induced long-term potentiation in the guinea-pig superior colliculus
    B Platt
    Department of Biomedical Sciences, IMS, Aberdeen University, Foresterhill, UK
    Neuropharmacology 37:1111-22. 1998
  9. ncbi request reprint Experimental approaches to assess metallotoxicity and ageing in models of Alzheimer's disease
    Bettina Platt
    School of Medical Sciences, University of Aberdeen, Scotland, UK
    J Alzheimers Dis 10:203-13. 2006
  10. ncbi request reprint Modulation of hippocampal calcium signalling and plasticity by serine/threonine protein phosphatases
    David J Koss
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    J Neurochem 102:1009-23. 2007

Collaborators

Detail Information

Publications50

  1. doi request reprint FDG-PET imaging, EEG and sleep phenotypes as translational biomarkers for research in Alzheimer's disease
    Bettina Platt
    School of Medical Sciences, Institute of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Biochem Soc Trans 39:874-80. 2011
    ..The present paper reviews the results obtained so far in rodent AD models, and summarizes advantages and disadvantages of such procedures...
  2. pmc Abnormal cognition, sleep, EEG and brain metabolism in a novel knock-in Alzheimer mouse, PLB1
    Bettina Platt
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Aberdeen, United Kingdom
    PLoS ONE 6:e27068. 2011
    ..PLB1(Triple) mice progress from a mild (MCI-like) state to a more comprehensive AD-relevant phenotype, which are accessible using translational tools such as wireless EEG and microPET/CT...
  3. ncbi request reprint Paired-pulse depression in the superficial layers of the guinea-pig superior colliculus
    B Platt
    Department of Biomedical Sciences, IMS, Aberdeen University, Foresterhill, UK
    Brain Res 777:131-9. 1997
    ..Here, PPD may be crucially involved in setting the threshold for novel vs. background stimulation, since the SC is known to trigger orienting responses towards novel sensory stimuli...
  4. ncbi request reprint Differential toxicity of novel aluminium compounds in hippocampal culture
    Bettina Platt
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland, UK
    Neurotoxicology 28:576-86. 2007
    ..Since the Al(III) compounds introduced here are assumed to form in vivo, our data raise further awareness for the toxicity of Al(III) in general, and for the importance of Al speciation and cell type specific actions in its toxicity...
  5. ncbi request reprint Cannabinoids: mechanisms and therapeutic applications in the CNS
    Alison J Drysdale
    Department of Biomedical Sciences, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK
    Curr Med Chem 10:2719-32. 2003
    ....
  6. ncbi request reprint Aluminium toxicity in the rat brain: histochemical and immunocytochemical evidence
    B Platt
    Biomedical Sciences, Aberdeen University, Scotland, Aberdeen, UK
    Brain Res Bull 55:257-67. 2001
    ....
  7. doi request reprint The cholinergic system, EEG and sleep
    Bettina Platt
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Behav Brain Res 221:499-504. 2011
    ..With novel technologies and computational tools now becoming available, advanced mechanistic insights may be gained and new avenues explored for diagnostics and therapeutics...
  8. ncbi request reprint GABA-induced long-term potentiation in the guinea-pig superior colliculus
    B Platt
    Department of Biomedical Sciences, IMS, Aberdeen University, Foresterhill, UK
    Neuropharmacology 37:1111-22. 1998
    ....
  9. ncbi request reprint Experimental approaches to assess metallotoxicity and ageing in models of Alzheimer's disease
    Bettina Platt
    School of Medical Sciences, University of Aberdeen, Scotland, UK
    J Alzheimers Dis 10:203-13. 2006
    ....
  10. ncbi request reprint Modulation of hippocampal calcium signalling and plasticity by serine/threonine protein phosphatases
    David J Koss
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    J Neurochem 102:1009-23. 2007
    ..This study highlights novel signalling effects of prolonged inhibition of protein phosphatases and suggests reduced post-synaptic signalling as a major mechanism for basal synaptic transmission and long-term potentiation impairments...
  11. pmc WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction
    Lianne Robinson
    School of Medical Sciences, College of Life Science and Medicine, University of Aberdeen, Foresterhill, Aberdeen, UK
    Behav Brain Res 208:584-92. 2010
    ..Collectively, these data suggest that in this spatial reference memory task WIN-2 causes a reduction in cholinergic activation, possibly through a non-CB(1)-like mechanism, which affects long-term but not short-term spatial memory...
  12. doi request reprint Intracellular Ca2+ stores modulate SOCCs and NMDA receptors via tyrosine kinases in rat hippocampal neurons
    David J Koss
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Cell Calcium 46:39-48. 2009
    ..This study provides first evidence for tyrosine based phospho-regulation of SOCCs and NMDA signalling in neurons...
  13. doi request reprint Age-dependent changes in hippocampal synaptic transmission and plasticity in the PLB1Triple Alzheimer mouse
    David J Koss
    School of Medical Sciences College of Life Sciences and Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Cell Mol Life Sci 70:2585-601. 2013
    ....
  14. doi request reprint Culturing conditions determine neuronal and glial excitability
    Sandra Stoppelkamp
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland, UK
    J Neurosci Methods 194:132-8. 2010
    ..Especially for investigations of toxicity and neuroprotection mixed cultures may be more physiologically relevant over isolated cultures as they comprise aspects of mutual influences between glia and neurones...
  15. ncbi request reprint The seed extract of Cassia obtusifolia offers neuroprotection to mouse hippocampal cultures
    Benjamin D Drever
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Aberdeen, Scotland, UK
    J Pharmacol Sci 107:380-92. 2008
    ..2 pg/ml). Collectively, these results are important for the therapeutic use of COE in the treatment of neurodegenerative disorders...
  16. ncbi request reprint Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia
    Duncan Ryan
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Neurosci Lett 408:236-41. 2006
    ....
  17. doi request reprint Cannabidiol targets mitochondria to regulate intracellular Ca2+ levels
    Duncan Ryan
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom
    J Neurosci 29:2053-63. 2009
    ..Thus, under pathological conditions involving mitochondrial dysfunction and Ca(2+) dysregulation, CBD may prove beneficial in preventing apoptotic signaling via a restoration of Ca(2+) homeostasis...
  18. doi request reprint Bi-directional alterations of LTP after acute homocysteine exposure
    Louisa A Christie
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD Scotland, UK
    Behav Brain Res 205:559-63. 2009
    ..By comparison, NMDA unidirectionally reduced LTP, whereas l-cysteine led to facilitated LTP. Such HCY-induced alterations in neuronal communication may contribute to cognitive failure in dementia...
  19. ncbi request reprint Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue
    Duncan Ryan
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD Scotland, UK
    Eur J Neurosci 25:2093-102. 2007
    ..Our data highlight the interaction between exogenous and endogenous cannabinoid signalling, and provide evidence for the presence of an additional pharmacological target, sensitive to endocannabinoids and to AM281...
  20. doi request reprint In vitro modelling of Alzheimer's disease: degeneration and cell death induced by viral delivery of amyloid and tau
    Sandra Stoppelkamp
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD Scotland, UK
    Exp Neurol 229:226-37. 2011
    ..Overall, these cellular models offer advantages for mechanistic studies and target identification in AD and related disorders...
  21. pmc Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice
    Gernot Riedel
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    Br J Pharmacol 156:1154-66. 2009
    ..Cannabinoid receptors have proven an efficient target to suppress hunger and weight gain by their pharmacological inactivation...
  22. ncbi request reprint Memantine acts as a cholinergic stimulant in the mouse hippocampus
    Benjamin D Drever
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD Scotland, UK
    J Alzheimers Dis 12:319-33. 2007
    ..These interactions with the cholinergic system are likely to contribute to memantine's therapeutic potential...
  23. ncbi request reprint Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats
    Lianne Robinson
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Psychopharmacology (Berl) 198:551-63. 2008
    ..As exogenous cannabinoid agonists impair memory formation, could it be that antagonists have opposing effects and act as memory-enhancing drugs?..
  24. ncbi request reprint Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells
    Alison J Drysdale
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Neuropharmacology 50:621-31. 2006
    ....
  25. doi request reprint EEG, activity, and sleep architecture in a transgenic AβPPswe/PSEN1A246E Alzheimer's disease mouse
    Amar Jyoti
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    J Alzheimers Dis 22:873-87. 2010
    ..Though not fully recapitulating the profile of AD patients, this suggests activity and EEG recordings as sensitive and translational biomarkers in murine models...
  26. doi request reprint Aluminum does not enhance beta-amyloid toxicity in rat hippocampal cultures
    Christiane M Nday
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, Scotland, UK
    Brain Res 1352:265-76. 2010
    ..Despite previous reports suggesting synergistic toxicity between Al and Abeta, we could not identify such a mechanism in our investigation...
  27. doi request reprint Involvement of the cholinergic system in conditioning and perceptual memory
    Lianne Robinson
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Behav Brain Res 221:443-65. 2011
    ....
  28. doi request reprint The cholinergic system and spatial learning
    Serena Deiana
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, United Kingdom
    Behav Brain Res 221:389-411. 2011
    ..Unresolved and contradictory results are highlighted and discussed...
  29. doi request reprint The cholinergic system and hippocampal plasticity
    Benjamin D Drever
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Behav Brain Res 221:505-14. 2011
    ..The present review examines these multiple roles of acetylcholine in hippocampal plasticity...
  30. doi request reprint Store-operated Ca2+ entry in hippocampal neurons: Regulation by protein tyrosine phosphatase PTP1B
    David J Koss
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Cell Calcium 53:125-38. 2013
    ..These data suggest tyrosine phosphorylation gating SOCE, and implicate PTP1B as a key regulatory enzyme. The involvement of PTP1B in SOCE and its relation to SOCC components and mechanism of regulation are discussed...
  31. pmc A comparative study of the actions of alkylpyridinium salts from a marine sponge and related synthetic compounds in rat cultured hippocampal neurones
    David J Koss
    School of Medical Sciences, College of Life Sciences and Medicine, Institute of Medical Science, The University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    BMC Pharmacol 7:1. 2007
    ..Using electrophysiology, calcium imaging and 1,6-diphenyl-1,3,5-hexatriene imaging, the pore forming properties of poly-APS and four related synthetic oligomers have been tested on primary cultured rat hippocampal neurones...
  32. pmc Presynaptic group I metabotropic glutamate receptors modulate synaptic transmission in the rat superior colliculus via 4-AP sensitive K(+) channels
    Anne Marie White
    Department of Biomedical Sciences, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, Scotland
    Br J Pharmacol 140:1421-33. 2003
    ..6. Our data indicate that group I agonists regulate transmitter release, presumably via an autoreceptor in the SC. This receptor may be involved in adaptation to repetitive stimulation via a non-PLC mediated pathway...
  33. ncbi request reprint Enhanced hippocampal long-term potentiation in rats after chronic exposure to homocysteine
    Louisa A Christie
    School of Medical Sciences, College of Life Sciences and Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Neurosci Lett 373:119-24. 2005
    ..These changes may reflect the suggested (excito-)toxicity of HCY and its putative contribution to neurodegenerative disease...
  34. ncbi request reprint Sometimes you see them, sometimes you don't: IPSCs in the rat superficial superior colliculus
    Michelle D Edwards
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, UK
    Exp Brain Res 149:331-9. 2003
    ....
  35. doi request reprint 18F-barbiturates are PET tracers with diagnostic potential in Alzheimer's disease
    Elisa Calamai
    Kosterlitz Centre for Therapeutics, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK
    Chem Commun (Camb) 49:792-4. 2013
    ..The fluorescent barbiturate 9 was able to label βA plaques in brain sections of βA mice, and co-localise with a fluorescent Zn(II) indicator...
  36. ncbi request reprint No spatial working memory deficit in beta-amyloid-exposed rats. A longitudinal study
    Eva von Linstow Roloff
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Prog Neuropsychopharmacol Biol Psychiatry 26:955-70. 2002
    ..These data suggest that intra-hippocampal beta A1-40 administration alters cholinergic transmission, but these alterations may be mild and thus do not lead to obvious working memory deficits in a DMTP task in well-trained animals...
  37. ncbi request reprint Gamma-aminobutyric acid-induced calcium signalling in rat superior collicular neurones
    Anne Marie White
    Department of Biomedical Sciences, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK
    Neurosci Lett 334:79-82. 2002
    ..This suggests that activation of GABA(A) but not GABA(C) receptors contributes to excitatory GABA responses and related calcium signals in neonatal SC neurones...
  38. doi request reprint Sleep and hippocampus: do we search for the right things?
    Jurij Brankack
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK
    Prog Neuropsychopharmacol Biol Psychiatry 33:806-12. 2009
    ..In this review, we attempt to reconcile some of the seemingly antagonistic theories of sleep function in a succinct and unbiased manner and develop an eclectic view of its role in learning and memory...
  39. ncbi request reprint Postnatal alterations of GABA receptor profiles in the rat superior colliculus
    S E Clark
    Department of Biomedical Sciences, Aberdeen University, Foresterhill, AB25 2ZD, Aberdeen, UK
    Neuroscience 104:441-54. 2001
    ..Together, this points towards a contribution of the GABAergic system to processes of postnatal maturation in the superficial superior colliculus...
  40. ncbi request reprint Ionic mechanisms of GABA-induced long-term potentiation in the rat superior colliculus
    A M White
    Department of Biomedical Sciences, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, AB25 2ZD, UK
    Exp Brain Res 140:486-94. 2001
    ....
  41. doi request reprint Scopolamine-induced deficits in social memory in mice: reversal by donepezil
    G Riedel
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Behav Brain Res 204:217-25. 2009
    ....
  42. ncbi request reprint Fear conditioning-induced time- and subregion-specific increase in expression of mGlu5 receptor protein in rat hippocampus
    G Riedel
    Department of Biomedical Sciences, Institute for Medical Sciences, Aberdeen University, Foresterhill, Aberdeen AB25 2ZD, UK
    Neuropharmacology 39:1943-51. 2000
    ..They support the notion that mGluRs in CA3 may play a part in short-term, and those in CA1 may play a part in long-term consolidation of memory...
  43. ncbi request reprint Characterisation of rat superficial superior colliculus neurones: firing properties and sensitivity to GABA
    M D Edwards
    Department of Biomedical Sciences, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
    Neuroscience 110:93-104. 2002
    ..In line with evidence provided by previous in vivo investigations, identification of visual stimuli and orientation responses appears to be realised via the network properties of the receptive fields that form topographic maps...
  44. doi request reprint Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behavi
    Serena Deiana
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Psychopharmacology (Berl) 219:859-73. 2012
    ..Other constituents of Cannabis sativa, the hemp plant, however, remain relatively unexplored in vivo. These include cannabidiol (CBD), cannabidivarine (CBDV), Δ(9)-tetrahydrocannabivarin (Δ(9)-THCV) and cannabigerol (CBG)...
  45. ncbi request reprint Glutamate receptor function in learning and memory
    Gernot Riedel
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, UK
    Behav Brain Res 140:1-47. 2003
    ..However, memory formation appears to require mGluRs, through the modulation of consolidation and/or recall. Overall, mGluR functions seem variable and dependent on brain structure and learning task...
  46. doi request reprint CRMP2 hyperphosphorylation is characteristic of Alzheimer's disease and not a feature common to other neurodegenerative diseases
    Ritchie Williamson
    Biomedical Research Institute, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK
    J Alzheimers Dis 27:615-25. 2011
    ....
  47. ncbi request reprint Long-term homocysteine exposure induces alterations in spatial learning, hippocampal signalling and synaptic plasticity
    S A Algaidi
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Exp Neurol 197:8-21. 2006
    ..Overall, it is concluded that healthy adult rats are able to cope with continuous exposure to HCY. While HCY affects growth and neuronal excitability, this does not precipitate into an immediate impairment of cognitive function...
  48. ncbi request reprint Dissociation of cholinergic function in spatial and procedural learning in rats
    E von Linstow Roloff
    School of Medical Sciences, College of Life Science and Medicine, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    Neuroscience 146:875-89. 2007
    ..Apart from the well-known contribution to sensorimotor and procedural learning, our findings provide compelling evidence for an important role of muscarinic acetylcholine receptor signaling in spatial episodic-like memory...
  49. ncbi request reprint Long-term study of chronic oral aluminum exposure and spatial working memory in rats
    Eva von Linstow Roloff
    Department of Biomedical Sciences, Institute for Medical Sciences, University of Aberdeen, Fostererhill, Scotland
    Behav Neurosci 116:351-6. 2002
    ..This testing protocol may enable between- and within-subject long-term assessment of spatial working memory before and after drug treatment and may prove useful in animal models of progressive cognitive decline...
  50. doi request reprint Synthesis, SAR, and X-ray structure of human BACE-1 inhibitors with cyclic urea derivatives
    Heuisul Park
    Drug Discovery, Research and Development, LG Life Sciences, 104 1 Munji dong, Yuseong Gu, Daejon 305 380, Republic of Korea
    Bioorg Med Chem Lett 18:2900-4. 2008
    ..Modification of P3, P1, and P2' and combination of SAR display a >100-fold increase in potency with good cellular activity (IC(50)=0.15microM) relative to the previously reported compound 3...