Matthew D W Piper

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Diet, metabolism and lifespan in Drosophila
    Matthew D W Piper
    UCL Centre for Research on Ageing, Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Exp Gerontol 40:857-62. 2005
  2. pmc Calories do not explain extension of life span by dietary restriction in Drosophila
    William Mair
    Department of Biology, Centre for Research on Ageing, University College London, London, United Kingdom
    PLoS Biol 3:e223. 2005
  3. pmc Evolutionary conservation of regulated longevity assurance mechanisms
    Joshua J McElwee
    Department of Biology, University College London, London WC1E 6BT, UK
    Genome Biol 8:R132. 2007
  4. doi request reprint Dietary restriction and aging: a unifying perspective
    Matthew D W Piper
    Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK
    Cell Metab 14:154-60. 2011
  5. doi request reprint Diet and aging
    Matthew D W Piper
    UCL Institute of Healthy Ageing, University College London, London, WC1E 6BT, UK
    Cell Metab 8:99-104. 2008
  6. pmc Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster
    Richard C Grandison
    UCL Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK
    PLoS ONE 4:e4067. 2009
  7. ncbi request reprint Counting the calories: the role of specific nutrients in extension of life span by food restriction
    Matthew D W Piper
    Department of Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK
    J Gerontol A Biol Sci Med Sci 60:549-55. 2005
  8. ncbi request reprint Optimization of dietary restriction protocols in Drosophila
    Timothy M Bass
    UCL Centre for Research on Ageing, Department of Biology, University College London, Gower St, London, WC1E 6BT, UK
    J Gerontol A Biol Sci Med Sci 62:1071-81. 2007
  9. doi request reprint Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster
    Richard Wong
    Institute for Healthy Ageing, Darwin Building, University College London, Gower St, London, WC1E 6BT, UK
    Nat Methods 5:214-5; author reply 215. 2008
  10. ncbi request reprint Dietary restriction in Drosophila
    Linda Partridge
    UCL Centre for Research on Ageing, Department of Biology, University College London, London WC1E 6BT, UK
    Mech Ageing Dev 126:938-50. 2005

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Diet, metabolism and lifespan in Drosophila
    Matthew D W Piper
    UCL Centre for Research on Ageing, Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Exp Gerontol 40:857-62. 2005
    ..Current data indicate lifespan-extension by DR is likely to involve both enhancement of various defense and detoxification mechanisms and a complex range of metabolic alterations that make energy available for these processes...
  2. pmc Calories do not explain extension of life span by dietary restriction in Drosophila
    William Mair
    Department of Biology, Centre for Research on Ageing, University College London, London, United Kingdom
    PLoS Biol 3:e223. 2005
    ..Calorie intake is therefore not the key factor in the reduction of mortality rate by DR in this species...
  3. pmc Evolutionary conservation of regulated longevity assurance mechanisms
    Joshua J McElwee
    Department of Biology, University College London, London WC1E 6BT, UK
    Genome Biol 8:R132. 2007
    ..To address this, we have applied a novel, multi-level cross-species comparative analysis to compare gene expression changes accompanying increased longevity in mutant nematodes, fruitflies and mice with reduced IIS...
  4. doi request reprint Dietary restriction and aging: a unifying perspective
    Matthew D W Piper
    Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK
    Cell Metab 14:154-60. 2011
    ..We provide examples showing that it is more informative to analyze DR in terms of dietary balance and that dietary optimization for life span is critical for studies examining the biology of aging and other traits...
  5. doi request reprint Diet and aging
    Matthew D W Piper
    UCL Institute of Healthy Ageing, University College London, London, WC1E 6BT, UK
    Cell Metab 8:99-104. 2008
    ..Here we discuss examples of diet/genotype interactions that show a more complex mechanistic view is required and that mild dietary modifications can dramatically change the interpretation of model organism aging studies...
  6. pmc Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster
    Richard C Grandison
    UCL Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK
    PLoS ONE 4:e4067. 2009
    ..Outcomes of lifespan studies in model organisms are particularly susceptible to variations in technical procedures. This is especially true of dietary restriction, which is implemented in many different ways among laboratories...
  7. ncbi request reprint Counting the calories: the role of specific nutrients in extension of life span by food restriction
    Matthew D W Piper
    Department of Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK
    J Gerontol A Biol Sci Med Sci 60:549-55. 2005
    ..Delineation of the nutritional components that are critical for life-span extension will help to reveal the mechanisms by which it operates...
  8. ncbi request reprint Optimization of dietary restriction protocols in Drosophila
    Timothy M Bass
    UCL Centre for Research on Ageing, Department of Biology, University College London, Gower St, London, WC1E 6BT, UK
    J Gerontol A Biol Sci Med Sci 62:1071-81. 2007
    ..We propose procedures to ensure that diets are suitable for the study of DR in Drosophila...
  9. doi request reprint Pitfalls of measuring feeding rate in the fruit fly Drosophila melanogaster
    Richard Wong
    Institute for Healthy Ageing, Darwin Building, University College London, Gower St, London, WC1E 6BT, UK
    Nat Methods 5:214-5; author reply 215. 2008
  10. ncbi request reprint Dietary restriction in Drosophila
    Linda Partridge
    UCL Centre for Research on Ageing, Department of Biology, University College London, London WC1E 6BT, UK
    Mech Ageing Dev 126:938-50. 2005
    ..This rapid mortality rate recovery provides a powerful framework within which to further investigate the mechanisms by which DR extends lifespan...
  11. pmc Quantification of food intake in Drosophila
    Richard Wong
    Institute of Healthy Ageing, and GEE, University College London, London, UK
    PLoS ONE 4:e6063. 2009
    ..This approach provides a practical and reliable method for quantification of food intake in Drosophila under normal, undisturbed culture conditions...
  12. pmc Dietary restriction in Drosophila: delayed aging or experimental artefact?
    Matthew D W Piper
    University College London Centre for Research on Ageing, Department of Biology, University College London, London, United Kingdom
    PLoS Genet 3:e57. 2007
    ..We also indicate some experiments that could be performed to determine if DR in Drosophila operates through similar mechanisms to the process in rodents...
  13. pmc Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila
    Richard C Grandison
    Institute of Healthy Ageing, Department of Genetics Evolution and Environment, University College London, UK
    Nature 462:1061-4. 2009
    ..In other organisms, including mammals, it may be possible to obtain the benefits to lifespan of dietary restriction without incurring a reduction in fecundity, through a suitable balance of nutrients in the diet...
  14. ncbi request reprint Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice
    Colin Selman
    Centre for Diabetes and Endocrinology, Department of Medicine, University College London, Rayne Institute, London, United Kingdom
    Physiol Genomics 27:187-200. 2006
    ..Mice undergoing acute CR rapidly adopt many transcriptional and metabolic changes of long-term CR, suggesting that the beneficial effects of CR may require only a short-term reduction in caloric intake...
  15. pmc A holidic medium for Drosophila melanogaster
    Matthew D W Piper
    Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, London, UK
    Nat Methods 11:100-5. 2014
    ..We used this holidic medium to investigate amino acid-specific effects on food-choice behavior and report that folic acid from the microbiota is sufficient for Drosophila development. ..
  16. pmc Detrimental effects of RNAi: a cautionary note on its use in Drosophila ageing studies
    Nazif Alic
    Institute of Healthy Ageing, and GEE, University College London, London, United Kingdom
    PLoS ONE 7:e45367. 2012
    ..However, we also show that RNAi restricted to certain tissues may not be detrimental to lifespan...
  17. pmc Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
    Susan J Broughton
    Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:3105-10. 2005
    ..However, the ablated flies show an extension of median and maximal lifespan and increased resistance to oxidative stress and starvation...
  18. ncbi request reprint Transcriptional responses of Saccharomyces cerevisiae to preferred and nonpreferred nitrogen sources in glucose-limited chemostat cultures
    Viktor M Boer
    Department of Biotechnology, Delft University of Technology, Julianalaan, Delft, The Netherlands
    FEMS Yeast Res 7:604-20. 2007
    ..By this criterion, leucine, proline and methionine were 'poor' nitrogen sources, and phenylalanine showed an 'intermediate' NCR response...
  19. pmc Prolonged maltose-limited cultivation of Saccharomyces cerevisiae selects for cells with improved maltose affinity and hypersensitivity
    Mickel L A Jansen
    Department of Biotechnology, Delft University of Technology, 2628 BC Delft, The Netherlands
    Appl Environ Microbiol 70:1956-63. 2004
    ..The observed trade-off between substrate affinity and substrate tolerance may be relevant for metabolic engineering and strain selection for utilization of substrates that are taken up by proton symport...
  20. pmc Directed evolution of pyruvate decarboxylase-negative Saccharomyces cerevisiae, yielding a C2-independent, glucose-tolerant, and pyruvate-hyperproducing yeast
    Antonius J A van Maris
    Department of Biotechnology, Delft University of Technology, NL 2628 BC Delft BIRD Engineering B V, NL 3044 CK Rotterdam, The Netherlands
    Appl Environ Microbiol 70:159-66. 2004
    ..54 g of pyruvate g of glucose(-1)...
  21. ncbi request reprint Identification of a novel one-carbon metabolism regulon in Saccharomyces cerevisiae
    Cristy L Gelling
    Ramaciotti Centre for Gene Function Analysis and School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia
    J Biol Chem 279:7072-81. 2004
    ..The one-carbon response is distinct from the Bas1p purine biosynthesis regulon and thus represents the first example of transcriptional regulation in response to activated one-carbon status...
  22. pmc Identification and characterization of phenylpyruvate decarboxylase genes in Saccharomyces cerevisiae
    Zeynep Vuralhan
    Kluyver Laboratory of Biotechnology, Delft University of Technology, 2628 BC Delft, The Netherlands
    Appl Environ Microbiol 69:4534-41. 2003
    ..Modifications to this gene could therefore be important for metabolic engineering of the Ehrlich pathway...
  23. ncbi request reprint The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur
    Viktor M Boer
    Kluyver Laboratory of Biotechnology, Technical University of Delft, Julianalaan 67, 2628BC Delft, The Netherlands
    J Biol Chem 278:3265-74. 2003
    ..The transcription of these genes can be used as indicators for the characterization of nutrient-limited growth conditions and provide information for metabolic engineering strategies...
  24. ncbi request reprint Reproducibility of oligonucleotide microarray transcriptome analyses. An interlaboratory comparison using chemostat cultures of Saccharomyces cerevisiae
    Matthew D W Piper
    Kluyver Laboratory of Biotechnology, Technical University of Delft, Julianalaan 26, Delft 2628BC, The Netherlands
    J Biol Chem 277:37001-8. 2002
    ....