S E Pinder

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc The value of immunohistochemistry in sentinel lymph node histopathology in breast cancer
    M B Klevesath
    Cambridge Breast Unit, Department of Surgery, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK
    Br J Cancer 92:2201-5. 2005
  2. pmc Successful management of elderly breast cancer patients treated without radiotherapy
    Kalliope Valassiadou
    Division of Breast Surgery, University of Nottingham, Nottingham, UK
    World J Surg Oncol 5:62. 2007
  3. pmc High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer
    Suet F Chin
    Breast Cancer Functional Genomics, Cancer Research UK Cambridge Research Institute and Department of Oncology University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Genome Biol 8:R215. 2007
  4. pmc An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer
    Andrew E Teschendorff
    Breast Cancer Functional Genomics Laboratory, Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK
    Genome Biol 8:R157. 2007
  5. pmc A consensus prognostic gene expression classifier for ER positive breast cancer
    Andrew E Teschendorff
    Cancer Genomics Program, Department of Oncology, University of Cambridge, Hutchison MRC Research Center, Hills Road, Cambridge CB2 2XZ, UK
    Genome Biol 7:R101. 2006
  6. ncbi request reprint Lobular in situ neoplasia and columnar cell lesions: diagnosis in breast core biopsies and implications for management
    Sarah E Pinder
    Department of Histopathology, Addenbrooke s Hospital, Cambridge, United Kingdom
    Pathology 39:208-16. 2007
  7. pmc Non-operative breast pathology: columnar cell lesions
    S E Pinder
    Department of Histopathology, Addenbrooke s Hospital, Cambridge, UK
    J Clin Pathol 60:1307-12. 2007
  8. ncbi request reprint Laboratory handling and histology reporting of breast specimens from patients who have received neoadjuvant chemotherapy
    S E Pinder
    Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Histopathology 50:409-17. 2007
  9. pmc C-erbB-3 in human breast carcinoma: expression and relation to prognosis and established prognostic indicators
    A Travis
    Department of Histopathology, City Hospital, Nottingham, UK
    Br J Cancer 74:229-33. 1996
  10. ncbi request reprint Prognostic and predictive factors in primary breast cancer and their role in patient management: The Nottingham Breast Team
    R S Rampaul
    Department of Surgery, City Hospital, Nottingham NHS Trust, Hucknall Road, Nottingham, UK
    Eur J Surg Oncol 27:229-38. 2001

Collaborators

Detail Information

Publications68

  1. pmc The value of immunohistochemistry in sentinel lymph node histopathology in breast cancer
    M B Klevesath
    Cambridge Breast Unit, Department of Surgery, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK
    Br J Cancer 92:2201-5. 2005
    ..All metastatic deposits identified by IHC were either micrometastasis or ITC. Until the prognostic significance of these deposits has been determined, IHC may be of limited value in the histopathological examination of SLNs...
  2. pmc Successful management of elderly breast cancer patients treated without radiotherapy
    Kalliope Valassiadou
    Division of Breast Surgery, University of Nottingham, Nottingham, UK
    World J Surg Oncol 5:62. 2007
    ..The addition of RT to surgery might constitute an imposition to such patients due to age-related factors. The aim of this study was to assess the efficacy of BCS without adjuvant RT in this group of patients...
  3. pmc High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer
    Suet F Chin
    Breast Cancer Functional Genomics, Cancer Research UK Cambridge Research Institute and Department of Oncology University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Genome Biol 8:R215. 2007
    ..To date, most genome-wide array comparative genomic hybridization studies have used tumor panels of relatively large tumor size and high Nottingham Prognostic Index (NPI) that are not as representative of breast cancer demographics...
  4. pmc An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer
    Andrew E Teschendorff
    Breast Cancer Functional Genomics Laboratory, Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, Robinson Way, Cambridge CB2 0RE, UK
    Genome Biol 8:R157. 2007
    ..Reliable identification of ER-negative tumors that have a good prognosis is not yet possible...
  5. pmc A consensus prognostic gene expression classifier for ER positive breast cancer
    Andrew E Teschendorff
    Cancer Genomics Program, Department of Oncology, University of Cambridge, Hutchison MRC Research Center, Hills Road, Cambridge CB2 2XZ, UK
    Genome Biol 7:R101. 2006
    ..A consensus prognostic gene expression classifier is still elusive in heterogeneous diseases such as breast cancer...
  6. ncbi request reprint Lobular in situ neoplasia and columnar cell lesions: diagnosis in breast core biopsies and implications for management
    Sarah E Pinder
    Department of Histopathology, Addenbrooke s Hospital, Cambridge, United Kingdom
    Pathology 39:208-16. 2007
    ..This review provides an update on the histological diagnosis of lobular neoplasia and columnar cell lesions and outlines recent clinico-pathological and molecular findings with discussion on clinical management...
  7. pmc Non-operative breast pathology: columnar cell lesions
    S E Pinder
    Department of Histopathology, Addenbrooke s Hospital, Cambridge, UK
    J Clin Pathol 60:1307-12. 2007
    ..In addition, guidelines for the management of patients with columnar cell lesions diagnosed in core needle biopsy specimens are provided...
  8. ncbi request reprint Laboratory handling and histology reporting of breast specimens from patients who have received neoadjuvant chemotherapy
    S E Pinder
    Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Histopathology 50:409-17. 2007
    ..We also present a brief review of the literature and suggest a simple method for quantifying the degree of response to neoadjuvant chemotherapy in both the primary breast carcinoma and the lymph nodes...
  9. pmc C-erbB-3 in human breast carcinoma: expression and relation to prognosis and established prognostic indicators
    A Travis
    Department of Histopathology, City Hospital, Nottingham, UK
    Br J Cancer 74:229-33. 1996
    ..It seems, however, unlikely that c-erbB-3 protein expression will emerge as a powerful enough prognostic factor to be of value in clinical practice...
  10. ncbi request reprint Prognostic and predictive factors in primary breast cancer and their role in patient management: The Nottingham Breast Team
    R S Rampaul
    Department of Surgery, City Hospital, Nottingham NHS Trust, Hucknall Road, Nottingham, UK
    Eur J Surg Oncol 27:229-38. 2001
    ..In this review we will discuss current prognostic and predictive factors with particular emphasis on those of relevance in routine histopathology, especially with respect to their clinical applications...
  11. ncbi request reprint Prognostic value of lymphovascular invasion in women with lymph node negative invasive breast carcinoma
    A H S Lee
    Department of Histopathology, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Eur J Cancer 42:357-62. 2006
    ..In conclusion, lymphovascular invasion is an independent prognostic factor in node-negative breast cancer and should be considered in decisions about adjuvant treatment in this group of women...
  12. pmc Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma
    D M Abd El-Rehim
    Department of Histopathology, The Breast Unit, Nottingham City Hospital NHS Trust and University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK
    Br J Cancer 91:1532-42. 2004
    ..These data imply that the combined profile expression patterns of the four receptor family members together provide more accurate information on the tumour behaviour than studying the expression of each receptor individually...
  13. doi request reprint Patterns of metastatic spread in early breast cancer
    M B Klevesath
    Cambridge Breast Unit, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
    Breast 22:449-54. 2013
    ..The aim of this study was to prospectively investigate metastatic pathways of spread to lymph node versus bone marrow and identify biological characteristics that determine these patterns in early invasive breast cancer...
  14. pmc Assessment of the new proliferation marker MIB1 in breast carcinoma using image analysis: associations with other prognostic factors and survival
    S E Pinder
    Department of Histopathology, City Hospital, Nottingham, UK
    Br J Cancer 71:146-9. 1995
    ..The results suggest that the tumour growth fraction, as assessed by the MIB1 labelling index, is an important predictor of survival...
  15. pmc Sections of the nipple and quadrants in mastectomy specimens for carcinoma are of limited value
    K Sikand
    Department of Histopathology, City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    J Clin Pathol 58:543-5. 2005
    ..To assess the value of nipple and quadrant sections in mastectomy specimens for carcinoma in detecting Paget's disease and multifocal carcinoma...
  16. ncbi request reprint The role of blood tumor marker measurement (using a biochemical index score and c-erbB2) in directing chemotherapy in metastatic breast cancer
    K L Cheung
    Department of Surgery, City Hospital, Nottingham, UK
    Int J Biol Markers 15:203-9. 2000
    ..003). Among the patients with positive tissue staining, sequential changes in serum c-erbB2 completely paralleled initial response...
  17. pmc Best Practice No 179. Guidelines for breast needle core biopsy handling and reporting in breast screening assessment
    I O Ellis
    Department of Histopathology, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    J Clin Pathol 57:897-902. 2004
    ..This guidance has been produced by the UK National Coordinating Committee for Breast Screening Pathology and is endorsed by the European Commission working group on breast screening pathology...
  18. ncbi request reprint The role of PTEN and its signalling pathways, including AKT, in breast cancer; an assessment of relationships with other prognostic factors and with outcome
    A R Panigrahi
    Department of Histopathology, Nottingham Breast Unit, Nottingham City Hospital, Nottingham, UK
    J Pathol 204:93-100. 2004
    ..It also suggests that, in this group of breast cancers, the most common upstream regulator of AKT may be ER rather than PTEN, EGFR or Her2...
  19. ncbi request reprint A model for predicting non-sentinel lymph node metastatic disease when the sentinel lymph node is positive
    A Pal
    Addenbrookes NHS Foundation Trust, Cambridge, UK
    Br J Surg 95:302-9. 2008
    ..The Memorial Sloan-Kettering Cancer Center (MSKCC) developed a nomogram to estimate the risk of non-SLN disease. This study critically appraised the nomogram and refined the model to improve predictive accuracy...
  20. ncbi request reprint Expression of p27kip1 in breast cancer and its prognostic significance
    A Barnes
    Department of Histopathology, Nottingham City Hospital Breast Unit, Nottingham, UK
    J Pathol 201:451-9. 2003
    ..It is concluded that the inverse relationship between p27kip1 levels and histological grade and individual grade components suggests a role for p27kip1 in both cell proliferation and differentiation, but is not clinically useful...
  21. pmc Expression of the transcription factor CTCF in invasive breast cancer: a candidate gene located at 16q22.1
    E A Rakha
    The Breast Unit, Department of Histopathology, Nottingham City Hospital NHS Trust, Hucknall Road, University of Nottingham, Nottingham NG5 1PB, UK
    Br J Cancer 91:1591-6. 2004
    ..1 loss in breast cancer and thus another gene or genes at this region remain to be identified...
  22. ncbi request reprint Spindle cell carcinoma of the breast: a case series of a rare histological subtype
    H N Khan
    Department of Surgery, Nottingham City Hospital Breast Unit, Hucknall Road, Nottingham NG5 1PB, UK
    Eur J Surg Oncol 29:600-3. 2003
    ..Spindle cell carcinoma (SpCC) represents <0.5% of breast cancers. We report the 15-year experience of SpCC at the Nottingham Breast Unit...
  23. ncbi request reprint Extent of ductal carcinoma in situ within and surrounding invasive primary breast carcinoma
    N Crombie
    Department of Histopathology, City Hospital NHS Trust, Nottingham, UK
    Br J Surg 88:1324-9. 2001
    ..This effect is restricted to the volume of DCIS in the tissue surrounding the invasive lesion rather than the intratumoral component...
  24. ncbi request reprint Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers
    S F Chin
    Cancer Genomics Program, Department of Oncology, Hutchison MRC Research Centre, University of Cambridge, Cambridge, UK
    Oncogene 26:1959-70. 2007
    ..7, 25.7 and 35.7%, respectively. These data raise the prospect of generating a molecular taxonomy of breast cancer based on copy number profiling using tumor DNA, which may be more generally applicable than expression microarray analysis...
  25. ncbi request reprint An audit of "equivocal" (C3) and "suspicious" (C4) categories in fine needle aspiration cytology of the breast
    R A Deb
    Department of Histopathology, Nottingham City Hospital NHS Trust, Hucknall Road, Nottingham NG5 1PB, UK
    Cytopathology 12:219-26. 2001
    ....
  26. ncbi request reprint Identification of carcinoma cells in peripheral blood samples of patients with advanced breast carcinoma using RT-PCR amplification of CK7 and MUC1
    T Felton
    Department of Histopathology, The City Hospital NHS Trust, Nottingham, UK
    Breast 13:35-41. 2004
    ..However a high proportion of false-positive results was seen in the control population. More extensive investigation is required before the technique is likely to be of benefit clinically...
  27. pmc Impact of a national external quality assessment scheme for breast pathology in the UK
    I O Ellis
    Department of Histopathology, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    J Clin Pathol 59:138-45. 2006
    ..This article presents the results and observed effects of the UK National Health Service Breast Screening Programme (NHSBSP) external quality assurance scheme in breast histopathology...
  28. pmc Preoperative assessment of prognostic factors in breast cancer
    H Denley
    Department of Histopathology, Nottingham City Hospital NHS Trust, Hucknall Road, Nottingham NG5 1PB, UK
    J Clin Pathol 54:20-4. 2001
    ..In the future, other molecular markers such as C-erbB-2 might also prove beneficial in predicting response to newly developed treatments...
  29. doi request reprint Experts and performance in histopathology--a study in breast pathology
    D M Parham
    Department of Histopathology, Royal Bournemouth Hospital, Castle Lane East, Bournemouth BH7 7DW, UK
    Pathol Res Pract 206:749-52. 2010
    ..The study shows that the CWS ratio is potentially a very useful tool in the assessment of pathologists with regard to assessing their progress through training...
  30. ncbi request reprint Excision biopsy findings of patients with breast needle core biopsies reported as suspicious of malignancy (B4) or lesion of uncertain malignant potential (B3)
    A H S Lee
    Department of Histopathology, City Hospital, Nottingham, UK
    Histopathology 42:331-6. 2003
    ..The majority of cores are reported as benign (B1), normal (B2) or malignant (B5). The predictive value of the two borderline categories suspicious of malignancy (B4) and lesion of uncertain malignant potential (B3) was studied...
  31. ncbi request reprint "Inflammatory" breast cancer
    M Cariati
    Cambridge Breast Unit, Addenbrooke s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge CB2 2QQ, UK
    Surg Oncol 14:133-43. 2005
    ..quot;Inflammatory" breast cancer is a rare and very aggressive form of the disease characterised by rapid onset and dismal outcome...
  32. ncbi request reprint A gene-expression signature to predict survival in breast cancer across independent data sets
    A Naderi
    Cancer Genomics Program, Department of Oncology, Hutchison MRC Research Center, University of Cambridge, Cambridge, UK
    Oncogene 26:1507-16. 2007
    ..In spite of these results, further studies that profile larger cohorts using a single microarray platform, will be needed before prospective clinical use of molecular classifiers can be contemplated...
  33. pmc Best Practice No 176: Updated recommendations for HER2 testing in the UK
    I O Ellis
    Department of Histopathology, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    J Clin Pathol 57:233-7. 2004
    ..To ensure maintenance of expertise, an annual caseload volume of at least 250 cases is recommended for laboratories providing a testing service...
  34. ncbi request reprint Prognostic significance of BRCA1 expression in sporadic breast carcinomas
    H Lambie
    Department of Histopathology, Nottingham City Hospital, Nottingham, UK
    J Pathol 200:207-13. 2003
    ..Loss of BRCA1 expression associated with high-grade breast tumours suggests that BRCA1 may play an important role in the pathogenesis of sporadic breast cancer...
  35. ncbi request reprint HER-2 in breast cancer--methods of detection, clinical significance and future prospects for treatment
    R S Rampaul
    Department of Surgery, Nottingham City Hospital, Nottingham, UK
    Crit Rev Oncol Hematol 43:231-44. 2002
    ..However, it is prudent that whichever methods employed are standardized, especially those that possess may have a degree of subjectivity in their assesment...
  36. ncbi request reprint Neuroendocrine differentiation and prognosis in breast adenocarcinoma
    A Miremadi
    Department of Histopathology, Nottingham City Hospital, Nottingham, UK
    Histopathology 40:215-22. 2002
    ..To date there are few detailed studies examining its relevance in breast carcinoma. In this study we evaluate the frequency and prognostic importance of neuroendocrine differentiation in breast adenocarcinoma...
  37. pmc Pathological validation and significance of micrometastasis in sentinel nodes in primary breast cancer
    R S Rampaul
    Department of Pathology, Nottingham City Hospital, Nottingham, UK
    Breast Cancer Res 3:113-6. 2001
    ..In this review, we address the pathological validation and significance of micrometastasis in sentinel node biopsy in primary breast cancer...
  38. ncbi request reprint Predicting invasion in mammographically detected microcalcification
    M J Bagnall
    International Breast Screening Education Centre, Nottingham City Hospital, UK
    Clin Radiol 56:828-32. 2001
    ..It would seem reasonable to consider staging the axilla at therapeutic surgery in these patients...
  39. pmc Diagnosis of axillary nodal metastases by ultrasound-guided core biopsy in primary operable breast cancer
    A Damera
    Department of Radiology, Helen Garrod Breast Screening Unit, Nottingham International Breast Education Centre, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Br J Cancer 89:1310-3. 2003
    ..In conclusion, US can identify abnormal nodes in patients presenting with primary operable breast cancer. In all, 65% of these nodes are malignant and this can often be confirmed with US-guided core biopsy...
  40. ncbi request reprint Breast pathology practice: most common problems in a consultation service
    T C Putti
    Department of Pathology, National University of Singapore, Singapore, and Department of Histopathology, The Breast Unit, Nottingham City Hospital NHS Trust, UK
    Histopathology 47:445-57. 2005
    ..The use of common immunohistochemical stains such as various cytokeratin and myoepithelial markers, E-cadherin and hormone receptors is helpful in solving most of these diagnostic dilemmas...
  41. ncbi request reprint Randomized clinical trial comparing radioisotope occult lesion localization and wire-guided excision for biopsy of occult breast lesions
    R S Rampaul
    Nottingham Breast Institute, City Hospital, Nottingham NG1 5PB, UK
    Br J Surg 91:1575-7. 2004
    ..Accurate localization of impalpable breast lesions that require biopsy is important. This randomized trial compared radioisotope occult lesion localization (ROLL) with the standard hooked-wire technique...
  42. ncbi request reprint Basal phenotype: a powerful prognostic factor in small screen-detected invasive breast cancer with long-term follow-up
    A J Evans
    Radiology, Breast Institute, Nottingham City Hospital, Nottingham, UK
    J Med Screen 14:210-4. 2007
    ..To assess the frequency and prognostic significance of a basal phenotype in a group of women with screen-detected invasive breast cancers with long-term follow-up and to focus particularly on women with small ( < 15 mm) breast cancers...
  43. pmc Growth pattern of ductal carcinoma in situ (DCIS): a retrospective analysis based on mammographic findings
    J Z Thomson
    Departments of Radiology and Pathology, City Hospital, Nottingham, UK
    Br J Cancer 85:225-7. 2001
    ..Additionally, the results suggest that increased importance should be placed on identifying the 'nipple' and 'anti-nipple' margins of DCIS represented by calcifications for both surgical excision and pathological scrutiny...
  44. doi request reprint Proliferation markers and survival in early breast cancer: a systematic review and meta-analysis of 85 studies in 32,825 patients
    R Stuart-Harris
    Cancer Research UK Cambridge Research Institute, Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK
    Breast 17:323-34. 2008
    ..Ki-67, MI, PCNA and LI are associated with worse survival outcomes in early breast cancer. However, whether these proliferation markers provide additional prognostic information to commonly used prognostic indices remains unclear...
  45. ncbi request reprint Accuracy of mammography in predicting histological extent of ductal carcinoma in situ (DCIS)
    J Chakrabarti
    Department of Breast Surgery, Nottingham Breast Institute, Nottingham City Hospital, University of Nottingham, Hucknall Road, Nottingham NG5 1PB, UK
    Eur J Surg Oncol 32:1089-92. 2006
    ..Accuracy of mammography in predicting pathological extent of ductal carcinoma in situ (DCIS)...
  46. pmc The NHS breast screening programme (pathology) EQA: experience in recent years relating to issues involved in individual performance appraisal
    D M Parham
    Department of Pathology, Royal Bournemouth Hospital, Bournemouth, Dorset BH7 7DW, UK
    J Clin Pathol 59:130-7. 2006
    ....
  47. ncbi request reprint Survival of invasive breast cancer according to the Nottingham Prognostic Index in cases diagnosed in 1990-1999
    R W Blamey
    The Breast Institute, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Eur J Cancer 43:1548-55. 2007
    ..The Nottingham Prognostic Index (NPI) is a well established and widely used method of predicting survival of operable primary breast cancer...
  48. ncbi request reprint Reading the prognosis of the individual with breast cancer
    R W Blamey
    The Breast Institute, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Eur J Cancer 43:1545-7. 2007
    ..To obtain better survival estimates for the individual than is provided by placement in an NPI group...
  49. ncbi request reprint The pathological and radiological features of screen-detected breast cancers diagnosed following arbitration of discordant double reading opinions
    E J Cornford
    The Nottingham Breast Institute, Nottingham City Hospital, Nottingham, UK
    Clin Radiol 60:1182-7. 2005
    ....
  50. pmc Bone metastases from breast carcinoma: histopathological - radiological correlations and prognostic features
    J J James
    Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Br J Cancer 89:660-5. 2003
    ....
  51. ncbi request reprint Loss of CD59 expression in breast tumours correlates with poor survival
    Z Madjd
    CRC Academic Unit of Clinical Oncology, University of Nottingham, City Hospital, Hucknall Road, Nottingham, NG5 1PB, UK
    J Pathol 200:633-9. 2003
    ..These findings indicate that loss of CD59 may offer a selective advantage for breast cancers, resulting in more aggressive tumours and conferring a poor prognosis for patients...
  52. pmc Prognostic factors for patients with hepatic metastases from breast cancer
    L Wyld
    Department of Surgical and Anaesthetic Sciences, University of Sheffield, Sheffield S10 2JF, UK
    Br J Cancer 89:284-90. 2003
    ..Awareness of the prognostic implications of the above factors may assist in selecting the most appropriate treatment for these patients.British Journal of Cancer (2003) 89, 284-290. doi:10.1038/sj.bjc.6601038 www.bjcancer.com..
  53. ncbi request reprint Expert opinion: Reporting needle core biopsies of breast carcinomas
    S A Hoda
    The Department of Pathology, Weill Medical College of Cornell University and New York Presbyterian Hospital Weill Cornell Medical Center, New York, NY, USA
    Histopathology 43:84-90. 2003
    ....
  54. ncbi request reprint Correlation between immunohistochemistry (HercepTest) and fluorescence in situ hybridization (FISH) for HER-2 in 426 breast carcinomas from 37 centres
    M Dowsett
    Academic Department of Biochemistry, Royal Marsden NHS Trust, London, UK
    J Pathol 199:418-23. 2003
    ..These data support an algorithm in which FISH testing is restricted to IHC 2+ tumours in reference centres. The results may not extrapolate to laboratories with less experience or using different methodologies...
  55. ncbi request reprint Is the presence of mammographic comedo calcification really a prognostic factor for small screen-detected invasive breast cancers?
    J J James
    Nottingham City Hospital, Nottingham, U K
    Clin Radiol 58:54-62. 2003
    ..We have determined prognostic factors for small screen-detected cancers in a univariate and multivariate fashion...
  56. pmc E-cadherin as a prognostic indicator in primary breast cancer
    C Parker
    Department of Histopathology, University of Nottingham, City Hospital, Hucknall Road, Nottingham NHS Trust
    Br J Cancer 85:1958-63. 2001
    ..Thus E-CD expression in human breast cancer appears to have minimal prognostic value, but may have a role as a phenotypic marker...
  57. ncbi request reprint False-negative breast screening assessment: what lessons can we learn?
    H C Burrell
    Nottingham Breast Screening Unit, City Hospital NHS Trust, Nottingham NG5 1PG, U K
    Clin Radiol 56:385-8. 2001
    ..To review women who have had breast cancer diagnosed following previous assessment of a screen-detected mammographic abnormality in order to ascertain the frequency and characteristics of false-negative assessment...
  58. ncbi request reprint Metastatic carcinoma of the breast with tubular features: differences compared with metastatic ductal carcinoma of no specific type
    L J Hamilton
    Nottingham Breast Institute, Nottingham City Hospital, Nottingham, UK
    Clin Oncol (R Coll Radiol) 16:119-24. 2004
    ....
  59. pmc Grade of recurrent in situ and invasive carcinoma following treatment of pure ductal carcinoma in situ of the breast
    R R Millis
    Hedley Atkins Cancer Research UK Breast Pathology Laboratory, Guy s Hospital, London SE1 9RT, UK
    Br J Cancer 90:1538-42. 2004
    ..This is in agreement with immunohistochemical and molecular data indicating that low-grade and high-grade mammary carcinomas are quite different lesions...
  60. ncbi request reprint Clinical value of epidermal growth factor receptor expression in primary breast cancer
    R S Rampaul
    Nottingham Breast Institute, University of Nottingham, Nottingham City Hospital, NHS Trust, Nottingham, UK
    Adv Anat Pathol 12:271-3. 2005
    ..The impetus to standardize such studies is much needed as there are now several tyrosine kinase inhibitors directed against the EGF receptor and phase II trials are showing significant promise...
  61. ncbi request reprint Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer
    J M Gee
    Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Redwood Building, Cardiff University, Cardiff, UK
    Endocr Relat Cancer 12:S99-S111. 2005
    ..IGF-1R inhibitors may also prove valuable in ER- patients, since considerable IGF-1R signalling activity was apparent within approximately 50% of such tumours...
  62. ncbi request reprint Size of invasive breast cancer and risk of local recurrence after breast-conservation therapy
    K S Asgeirsson
    The Nottingham Breast Unit, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, UK
    Eur J Cancer 39:2462-9. 2003
    ..A registration study of patients with cancers larger than 3 cm treated by breast conservation with or without partial breast reconstruction is proposed...
  63. ncbi request reprint E-cadherin expression in invasive non-lobular carcinoma of the breast and its prognostic significance
    E A Rakha
    The Breast Unit, Department of Histopathology and Division of Respiratory Medicine, Nottingham City Hospital NHS Trust, University of Nottingham, Nottingham, UK
    Histopathology 46:685-93. 2005
    ..However, the clinicopathological and prognostic value of E-cadherin in the more frequent non-lobular types of breast carcinoma is unclear...
  64. ncbi request reprint Patterns of metastatic breast carcinoma: influence of tumour histological grade
    G J R Porter
    Helen Garrod Breast Unit, Nottingham City Hospitals NHS Trust, Nottingham, UK
    Clin Radiol 59:1094-8. 2004
    ..To assess if the pattern of metastatic spread of carcinoma of the breast varies according to tumour histological grade...
  65. ncbi request reprint Breast imaging findings in women with BRCA1- and BRCA2-associated breast carcinoma
    L J Hamilton
    Nottingham Breast Institute, Nottingham City Hospital, Nottingham, UK
    Clin Radiol 59:895-902. 2004
    ..To document the breast imaging findings of women with BRCA1 and BRCA2-associated breast carcinoma...
  66. ncbi request reprint Brain metastases from breast cancer: identification of a high-risk group
    A J Evans
    Nottingham Breast Institute, City Hospital, Nottingham, UK
    Clin Oncol (R Coll Radiol) 16:345-9. 2004
    ....
  67. ncbi request reprint Phenotypic similarities in bilateral breast cancer
    J Kollias
    Nottingham City Hospital, Nottingham, UK
    Breast Cancer Res Treat 85:255-61. 2004
    ..It is likely that this is related to similar tumourogenic pathways occurring at equivalent exposure times to various environmental and hormonal influences, although, in a proportion of cases, inherited genetic factors may play a role...
  68. ncbi request reprint Change in expression of ER, bcl-2 and MIB1 on primary tamoxifen and relation to response in ER positive breast cancer
    F S Kenny
    Professorial Unit of Surgery, Nottingham City Hospital, UK
    Breast Cancer Res Treat 65:135-44. 2001
    ....