Margaret A Piggott

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Dementia with Lewy bodies
    Ian G McKeith
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    Semin Clin Neuropsychiatry 8:46-57. 2003
  2. ncbi request reprint Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia
    Margaret A Piggott
    IAH Research Laboratories, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Int J Neuropsychopharmacol 10:231-44. 2007
  3. ncbi request reprint Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution
    M A Piggott
    MRC Neurochemical Pathology Unit, Department of Neuropathology, Old Age Psychiatry, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    Brain 122:1449-68. 1999
  4. ncbi request reprint Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline
    Margaret A Piggott
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, United Kingdom
    Synapse 61:903-11. 2007
  5. ncbi request reprint Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain
    Margaret Piggott
    Newcastle General Hospital, MRC University of Newcastle Centre Development in Clinical Brain Ageing, MRC Building, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
    J Chem Neuroanat 24:211-23. 2002
  6. ncbi request reprint Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease
    Margaret A Piggott
    MRC University of Newcastle Centre in Clinical Brain Ageing, MRC Building, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
    J Chem Neuroanat 25:161-73. 2003
  7. ncbi request reprint Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies
    Thanasak Teaktong
    Institute for Ageing and Health, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE46BE, UK
    Behav Brain Res 161:299-305. 2005
  8. doi request reprint Intact coupling of M1 receptors and preserved M2 and M4 receptors in the cortex in progressive supranuclear palsy: contrast with other dementias
    Naomi M Warren
    Wolfson Research Centre, Newcastle University Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    J Chem Neuroanat 35:268-74. 2008
  9. ncbi request reprint Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy
    Naomi M Warren
    Institute for Ageing and Heath, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Mov Disord 22:1594-600. 2007
  10. ncbi request reprint In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 33:423-9. 2006

Detail Information

Publications17

  1. ncbi request reprint Dementia with Lewy bodies
    Ian G McKeith
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
    Semin Clin Neuropsychiatry 8:46-57. 2003
    ..Dementia developing late in the course of PD shares many of the same clinical and pathological characteristics...
  2. ncbi request reprint Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia
    Margaret A Piggott
    IAH Research Laboratories, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Int J Neuropsychopharmacol 10:231-44. 2007
    ..D2 receptor binding did not vary with cognitive decline (MMSE) or visual hallucinations, but was significantly higher with increased extrapyramidal symptoms...
  3. ncbi request reprint Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution
    M A Piggott
    MRC Neurochemical Pathology Unit, Department of Neuropathology, Old Age Psychiatry, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    Brain 122:1449-68. 1999
    ..The distinct changes in the rostrocaudal pattern of expression of dopaminergic parameters are relevant to the interpretation of the in vivo imaging and diagnosis of DLB...
  4. ncbi request reprint Selective loss of dopamine D2 receptors in temporal cortex in dementia with Lewy bodies, association with cognitive decline
    Margaret A Piggott
    Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, United Kingdom
    Synapse 61:903-11. 2007
    ..That the reduction of D2 receptors correlated with cognitive decline suggests that neuroleptics, as dopamine D2 receptor antagonists, may have a deleterious effect on cognition in DLB...
  5. ncbi request reprint Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brain
    Margaret Piggott
    Newcastle General Hospital, MRC University of Newcastle Centre Development in Clinical Brain Ageing, MRC Building, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
    J Chem Neuroanat 24:211-23. 2002
    ....
  6. ncbi request reprint Muscarinic receptors in basal ganglia in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease
    Margaret A Piggott
    MRC University of Newcastle Centre in Clinical Brain Ageing, MRC Building, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
    J Chem Neuroanat 25:161-73. 2003
    ..Low density of striatal M1 receptors may relate to the extent of movement disorder in DLB, and to a reduced risk of parkinsonism with acetylcholinesterase inhibition...
  7. ncbi request reprint Muscarinic M2 and M4 receptors in anterior cingulate cortex: relation to neuropsychiatric symptoms in dementia with Lewy bodies
    Thanasak Teaktong
    Institute for Ageing and Health, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE46BE, UK
    Behav Brain Res 161:299-305. 2005
    ..Upregulation of M2 and M4 muscarinic receptors in cingulate and adjacent cortex may thus contribute to the development of psychosis in DLB, with potential implications for treatments with drugs acting on these receptors...
  8. doi request reprint Intact coupling of M1 receptors and preserved M2 and M4 receptors in the cortex in progressive supranuclear palsy: contrast with other dementias
    Naomi M Warren
    Wolfson Research Centre, Newcastle University Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    J Chem Neuroanat 35:268-74. 2008
    ..We conclude from this first systematic study of cortical muscarinic receptors in PSP that functioning cortical muscarinic receptors are preserved. A further, larger trial of cholinergic therapy, such as an M1 agonist, may be warranted...
  9. ncbi request reprint Basal ganglia cholinergic and dopaminergic function in progressive supranuclear palsy
    Naomi M Warren
    Institute for Ageing and Heath, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Mov Disord 22:1594-600. 2007
    ..These results do not account for the poor response to dopaminergic and cholinergic replacement therapies in PSP, and suggest relative preservation of postsynaptic striatal projection neurones bearing D2/M1 receptors...
  10. ncbi request reprint In vivo SPECT imaging of muscarinic acetylcholine receptors using (R,R) 123I-QNB in dementia with Lewy bodies and Parkinson's disease dementia
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Neuroimage 33:423-9. 2006
    ..123I-QNB binding was also compared to the corresponding cerebral perfusion changes in the same subjects...
  11. ncbi request reprint Muscarinic receptors in the thalamus in progressive supranuclear palsy and other neurodegenerative disorders
    Naomi M Warren
    From the Institute for Ageing and Heath, Newcastle General Hospital, London, UK
    J Neuropathol Exp Neurol 66:399-404. 2007
    ..There were no significant changes in the ventrolateral nucleus (motor). Cholinergic dysfunction within the AP and MD nuclei of the thalamus may contribute to behavioral and cognitive disturbances associated with PSP...
  12. ncbi request reprint Cholinergic systems in progressive supranuclear palsy
    N M Warren
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Brain 128:239-49. 2005
    ..Cholinergic deficits based on clinical and neurochemical parameters are then discussed, before concluding with suggested future directions for cholinergic treatments...
  13. ncbi request reprint Cholinergic nicotinic receptor involvement in movement disorders associated with Lewy body diseases. An autoradiography study using [(125)I]alpha-conotoxinMII in the striatum and thalamus
    I J Bohr
    Institute for Ageing and Health, Newcastle General Hospital, Centre Development in Clinical Brain Ageing, MRC Building, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Exp Neurol 191:292-300. 2005
    ..In DLB + EPF and PD patients, there was decreased binding in the ventral lateral nucleus. This study demonstrates alterations of alpha6 and/or alpha3 nAChRs binding in DLB and PD, which are likely to relate to extra-pyramidal symptoms...
  14. ncbi request reprint Visual hallucinations are associated with lower alpha bungarotoxin binding in dementia with Lewy bodies
    J A Court
    Joint MRC University of Newcastle Centre Development in Clinical Brain Ageing, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
    Pharmacol Biochem Behav 70:571-9. 2001
    ..001). Loss of cortical alpha 7 nicotinic receptors may contribute to hallucinations and delusional misidentification in DLB, with implications for treatment and understanding the mechanisms of psychotic symptoms in dementia...
  15. ncbi request reprint Nicotine binding in human striatum: elevation in schizophrenia and reductions in dementia with Lewy bodies, Parkinson's disease and Alzheimer's disease and in relation to neuroleptic medication
    J A Court
    MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
    Neuroscience 98:79-87. 2000
    ..Further study is warranted to explore which nicotinic receptor subunits and which neuronal compartments are involved in the changes in [3H]nicotine binding reported, to aid development of potential nicotinic receptor therapy...
  16. ncbi request reprint Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington's and Parkinson's disease cases
    R E Goodchild
    MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne, UK
    Eur J Neurosci 11:449-56. 1999
    ..These data suggest that H3-receptors are present upon striatonigral projection neurons of the direct and indirect movement pathways thus providing histaminergic control over the activity of both these circuits...
  17. pmc The basal ganglia cholinergic neurochemistry of progressive supranuclear palsy and other neurodegenerative diseases
    N M Warren
    Institute for Ageing and Health, Newcastle University, New Castle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 78:571-5. 2007
    ..This relates, in part, to a lack of knowledge of the underlying neurochemical abnormalities, including cholinergic receptor status in the basal ganglia...