Andrew Pickles

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Resilience to adult psychopathology following childhood maltreatment: evidence from a community sample
    Stephan Collishaw
    King s College London, MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Child Abuse Negl 31:211-29. 2007
  2. ncbi request reprint Variable expression of the autism broader phenotype: findings from extended pedigrees
    A Pickles
    MRC Child Psychiatry Unit and the Institute of Psychiatry, King s College, London, UK
    J Child Psychol Psychiatry 41:491-502. 2000
  3. ncbi request reprint Child psychiatric symptoms and psychosocial impairment: relationship and prognostic significance
    A Pickles
    School of Epidemiology and Health Science, University of Manchester, Manchester, UK
    Br J Psychiatry 179:230-5. 2001
  4. ncbi request reprint Natural categories or fundamental dimensions: on carving nature at the joints and the rearticulation of psychopathology
    Andrew Pickles
    Biostatistics Group, School of Epidemiology and Health Science, University of Manchester, UK
    Dev Psychopathol 15:529-51. 2003
  5. pmc Parent-mediated communication-focused treatment in children with autism (PACT): a randomised controlled trial
    Jonathan Green
    Psychiatry Research Group, University of Manchester, Manchester, UK
    Lancet 375:2152-60. 2010
  6. ncbi request reprint Validation of the social communication questionnaire in a population cohort of children with autism spectrum disorders
    Susie Chandler
    Guy s and Thomas NHS Foundation Trust, London, UK
    J Am Acad Child Adolesc Psychiatry 46:1324-32. 2007
  7. doi request reprint 'Everyday memory' impairments in autism spectrum disorders
    Catherine R G Jones
    Centre for Research in Autism and Education, Department of Psychology and Human Development, Institute of Education, London, WC1H 0AL, UK
    J Autism Dev Disord 41:455-64. 2011
  8. doi request reprint The persistence and stability of psychiatric problems in adolescents with autism spectrum disorders
    Emily Simonoff
    Department of Child and Adolescent Psychiatry, King s College London, Institute of Psychiatry and NIHR Biomedical Research Centre for Mental Health, London, UK
    J Child Psychol Psychiatry 54:186-94. 2013
  9. doi request reprint Severe mood problems in adolescents with autism spectrum disorder
    Emily Simonoff
    Department of Child and Adolescent Psychiatry, King s College London, Institute of Psychiatry and NIHR Biomedical Research Centre for Mental Health, De Crespigny Park, London, UK
    J Child Psychol Psychiatry 53:1157-66. 2012
  10. doi request reprint Reading and arithmetic in adolescents with autism spectrum disorders: peaks and dips in attainment
    Catherine R G Jones
    Department of Psychology and Human Development, Institute of Education, London, UK
    Neuropsychology 23:718-28. 2009

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Resilience to adult psychopathology following childhood maltreatment: evidence from a community sample
    Stephan Collishaw
    King s College London, MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
    Child Abuse Negl 31:211-29. 2007
    ..The aims of the present study were to address the extent of resilience to adult psychopathology in a representative community sample, and to explore predictors of a good prognosis...
  2. ncbi request reprint Variable expression of the autism broader phenotype: findings from extended pedigrees
    A Pickles
    MRC Child Psychiatry Unit and the Institute of Psychiatry, King s College, London, UK
    J Child Psychol Psychiatry 41:491-502. 2000
    ..Patterns of expression within the families did not support a simple X-linked nor an imprinted X-linked mode of inheritance. The basis for sex differences in rates of expression is discussed...
  3. ncbi request reprint Child psychiatric symptoms and psychosocial impairment: relationship and prognostic significance
    A Pickles
    School of Epidemiology and Health Science, University of Manchester, Manchester, UK
    Br J Psychiatry 179:230-5. 2001
    ..Relatively little is known about the relationships between psychiatric symptoms, diagnosis and psychosocial impairment...
  4. ncbi request reprint Natural categories or fundamental dimensions: on carving nature at the joints and the rearticulation of psychopathology
    Andrew Pickles
    Biostatistics Group, School of Epidemiology and Health Science, University of Manchester, UK
    Dev Psychopathol 15:529-51. 2003
    ..We suggest replacing Meehl's analogy involving qualitatively distinct species with an alternative analogy with the "duality" of light, a phenomenon with both wave- and particle-like properties...
  5. pmc Parent-mediated communication-focused treatment in children with autism (PACT): a randomised controlled trial
    Jonathan Green
    Psychiatry Research Group, University of Manchester, Manchester, UK
    Lancet 375:2152-60. 2010
    ..Results of small trials suggest that early interventions for social communication are effective for the treatment of autism in children. We therefore investigated the efficacy of such an intervention in a larger trial...
  6. ncbi request reprint Validation of the social communication questionnaire in a population cohort of children with autism spectrum disorders
    Susie Chandler
    Guy s and Thomas NHS Foundation Trust, London, UK
    J Am Acad Child Adolesc Psychiatry 46:1324-32. 2007
    ..To examine the properties of the Social Communication Questionnaire (SCQ) in a population cohort of children with autism spectrum disorders (ASDs) and in the general population...
  7. doi request reprint 'Everyday memory' impairments in autism spectrum disorders
    Catherine R G Jones
    Centre for Research in Autism and Education, Department of Psychology and Human Development, Institute of Education, London, WC1H 0AL, UK
    J Autism Dev Disord 41:455-64. 2011
    ..Social and communication ability was significantly associated with prospective remembering in an everyday memory context but not with the CAVLT-2. The complex nature of everyday memory and its relevance to ASD is discussed...
  8. doi request reprint The persistence and stability of psychiatric problems in adolescents with autism spectrum disorders
    Emily Simonoff
    Department of Child and Adolescent Psychiatry, King s College London, Institute of Psychiatry and NIHR Biomedical Research Centre for Mental Health, London, UK
    J Child Psychol Psychiatry 54:186-94. 2013
    ..We use a longitudinal population-representative cohort to examine for the first time the persistence of psychiatric problems and to identify risk factors for their occurrence and stability...
  9. doi request reprint Severe mood problems in adolescents with autism spectrum disorder
    Emily Simonoff
    Department of Child and Adolescent Psychiatry, King s College London, Institute of Psychiatry and NIHR Biomedical Research Centre for Mental Health, De Crespigny Park, London, UK
    J Child Psychol Psychiatry 53:1157-66. 2012
    ..SMP in people with autism spectrum disorders (ASDs) have not previously been explored...
  10. doi request reprint Reading and arithmetic in adolescents with autism spectrum disorders: peaks and dips in attainment
    Catherine R G Jones
    Department of Psychology and Human Development, Institute of Education, London, UK
    Neuropsychology 23:718-28. 2009
    ..The high rate of uneven academic attainment in ASD has implications for educational practice...
  11. doi request reprint Pathways from adolescent deliberate self-poisoning to early adult outcomes: a six-year follow-up
    Azza Aglan
    Division of Psychiatry, University of Manchester, UK
    J Child Psychol Psychiatry 49:508-15. 2008
    ..The goal of this study was to identify pathways linking childhood risk factors to early adult outcomes of suicidal adolescents...
  12. ncbi request reprint The Croydon Assessment of Learning Study: prevalence and educational identification of mild mental retardation
    Emily Simonoff
    Department of Child and Adolescent Psychiatry, King s College London, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 47:828-39. 2006
    ..The current study estimates the prevalence of low IQ in the mental retardation range (intellectual disability) in a population sample and examines the factors that relate to educational identification...
  13. doi request reprint Parent-reported gastro-intestinal symptoms in children with autism spectrum disorders
    Susie Chandler
    Children s Neurosciences Department, Newcomen Child Development Centre, Guy s and St Thomas NHS Foundation Trust, Staircase D, St Thomas Hospital, Westminster Bridge Road, London, SE1 7EH, UK
    J Autism Dev Disord 43:2737-47. 2013
    ..Parents report more GI symptoms in children with ASD than children with either SEN or TD children but the frequency of reported symptoms is greater in the past than currently in all groups. ..
  14. doi request reprint An emerging income differential for adolescent emotional problems
    Emma Gore Langton
    King s College London Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 52:1081-8. 2011
    ..Older studies reported no income differentials, while recent reports suggest that adolescents from low-income families are more likely to experience emotional difficulties than their more affluent peers...
  15. doi request reprint A longitudinal study of behavioral, emotional and social difficulties in individuals with a history of specific language impairment (SLI)
    Michelle C St Clair
    School of Psychological Sciences, Ellen Wilkinson Building, University of Manchester, Oxford Road, Manchester M13 9PL, UK
    J Commun Disord 44:186-99. 2011
    ....
  16. doi request reprint A multimodal approach to emotion recognition ability in autism spectrum disorders
    Catherine R G Jones
    Centre for Research in Autism and Education, Department of Psychology and Human Development, Institute of Education, London, UK
    J Child Psychol Psychiatry 52:275-85. 2011
    ..However, experimental investigations of emotion recognition ability in ASD have been equivocal, hampered by small sample sizes, narrow IQ range and over-focus on the visual modality...
  17. doi request reprint Regression, developmental trajectory and associated problems in disorders in the autism spectrum: the SNAP study
    Gillian Baird
    Newcomen Centre, Guy s and St Thomas NHS Foundation Trust, London, SE1 9RT, UK
    J Autism Dev Disord 38:1827-36. 2008
    ..Regression was associated with higher rates of autistic symptoms and a deviation in developmental trajectory. Regression was not associated with epilepsy or gastrointestinal problems...
  18. doi request reprint Impairment in movement skills of children with autistic spectrum disorders
    Dido Green
    Newcomen Centre, Guy s and St Thomas NHS Foundation Trust, Great Maze Pond, London, UK
    Dev Med Child Neurol 51:311-6. 2009
    ..We undertook this study to explore the degree of impairment in movement skills in children with autistic spectrum disorders (ASD) and a wide IQ range...
  19. pmc Communication and social deficits in relatives of individuals with SLI and relatives of individuals with ASD
    Andrew Pickles
    Biostatistics, Institute of Psychiatry, King s College London, London, UK
    J Autism Dev Disord 43:156-67. 2013
    ..There was a higher than would be expected rate (4.3 %) of ASD, particularly in siblings of SLI + ASD probands. Communication and social deficits appear to breed true in SLI and ASD...
  20. ncbi request reprint Precursors to social and communication difficulties in infants at-risk for autism: gaze following and attentional engagement
    Rachael Bedford
    Centre for Research in Autism and Education, Institute of Education, University of London, 25 Woburn Square, London, UK
    J Autism Dev Disord 42:2208-18. 2012
    ..The findings suggest that the subtle emergence of difficulties in JA in infancy may be related to ASD and other atypical outcomes...
  21. doi request reprint How far are associations between child, family and community factors and child psychopathology informant-specific and informant-general?
    Stephan Collishaw
    King s College London Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry Centre, London, UK
    J Child Psychol Psychiatry 50:571-80. 2009
    ..However, few studies have systematically tested how far correlates of child psychopathology differ between informants...
  22. doi request reprint Intervention for infants at risk of developing autism: a case series
    Jonathan Green
    Institute of Brain, Behaviour and Mental Health, University of Manchester, Room 4 308, Jean McFarlane Building, Oxford Rd, Manchester, M13 9PL, UK
    J Autism Dev Disord 43:2502-14. 2013
    ..Measurement across domains was successful and on larger samples promise to be an effective test of whether such an intervention in infancy will modify emergent atypical developmental trajectories in infants at risk for autism. ..
  23. doi request reprint Adolescent emotional and behavioural outcomes of nonparental preschool childcare
    Holan Liang
    Institute of Psychiatry, King s College London, London, UK
    Soc Psychiatry Psychiatr Epidemiol 47:399-407. 2012
    ..This study aimed to identify whether nonparental preschool childcare was associated with adolescent mental health outcomes as measured by the strengths and difficulties questionnaire (SDQ)...
  24. doi request reprint Overgeneral autobiographical memory in women: association with childhood abuse and history of depression in a community sample
    Azza Aglan
    Division of Clinical Psychology, University of Manchester, UK
    Br J Clin Psychol 49:359-72. 2010
    ..No previous study has examined their joint association with overgeneral memory in a community sample, nor examined whether the associations are with both juvenile- and adult-onset depression...
  25. doi request reprint Latent mixture models for multivariate and longitudinal outcomes
    Andrew Pickles
    Biostatistics, Health Methodology Research Group, University of Manchester, University Place, Oxford Road, Manchester, M13 9PL, UK
    Stat Methods Med Res 19:271-89. 2010
    ..We review methods based on discrete random effects distributions and mixture models for application in this field...
  26. doi request reprint Preschoolers with autism show greater impairment in receptive compared with expressive language abilities
    Kristelle Hudry
    Centre for Research in Autism and Education, Department of Psychology and Human Development, Institute of Education, London, UK
    Int J Lang Commun Disord 45:681-90. 2010
    ..However, the relative degree of delay or impairment in each of these sub-domains may also be atypical and remains less well-understood...
  27. pmc Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressure
    Neil Shephard
    ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom
    BMC Genet 4:S26. 2003
    ....
  28. ncbi request reprint The relationship between DSM-IV oppositional defiant disorder and conduct disorder: findings from the Great Smoky Mountains Study
    Richard Rowe
    Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK
    J Child Psychol Psychiatry 43:365-73. 2002
    ..We examine models of the relationship between oppositional defiant disorder (ODD) and conduct disorder (CD) in a community sample. Particular attention is paid to the generalisability of findings based on clinic-referred boys...
  29. doi request reprint Dimensions of respiratory symptoms in preschool children: population-based birth cohort study
    Jaclyn A Smith
    1Respiratory Research Group, University of Manchester, Manchester M23 9LT, UK
    Am J Respir Crit Care Med 177:1358-63. 2008
    ..However, such collections or components of overall symptomatology need to be valid, and their relationship established with the known risk factors and physiologic measures...
  30. ncbi request reprint Longitudinal trajectories of peer relations in children with specific language impairment
    Pearl L H Mok
    The University of Manchester, Manchester, UK
    J Child Psychol Psychiatry 55:516-27. 2014
    ..Peer relations is a vulnerable area of functioning in children with specific language impairment (SLI), but little is known about the developmental trajectories of individuals...
  31. doi request reprint Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing
    Danielle C M Belgrave
    Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, University of Manchester, United Kingdom
    J Allergy Clin Immunol 132:575-583.e12. 2013
    ..Previous studies have suggested the presence of different childhood wheeze phenotypes through statistical modeling based on parentally reported wheezing...
  32. doi request reprint Psychopathology in children before and after surgery for extratemporal lobe epilepsy
    M Chiara Colonnelli
    Neuroscience Department, UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
    Dev Med Child Neurol 54:521-6. 2012
    ..To establish the rates and types of psychiatric disorder in children before and after surgery for extratemporal epilepsy. Relationships between psychiatric morbidity and demographic/clinical variables were examined...
  33. ncbi request reprint Institutional care: associations between overactivity and lack of selectivity in social relationships
    Penny Roy
    Department of Language and Communication Science, City University, London, UK
    J Child Psychol Psychiatry 45:866-73. 2004
    ....
  34. ncbi request reprint Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)
    Gillian Baird
    Newcomen Centre, Guy s and St Thomas NHS Foundation Trust, London, UK
    Lancet 368:210-5. 2006
    ..Recent reports have suggested that the prevalence of autism and related spectrum disorders (ASDs) is substantially higher than previously recognised. We sought to quantify prevalence of ASDs in children in South Thames, UK...
  35. ncbi request reprint A flexible model for multivariate interval-censored survival times with complex correlation structure
    Milena Falcaro
    Biostatistics Group, Division of Epidemiology and Health Sciences, The University of Manchester, UK
    Stat Med 26:663-80. 2007
    ..The proposed model allows estimation of the genetic and environmental effects that are shared by both of these risk behaviours as well as those that are specific...
  36. ncbi request reprint Early adult outcomes of adolescents who deliberately poisoned themselves
    Richard Harrington
    Royal Manchester Children s Hospital, Manchester, UK
    J Am Acad Child Adolesc Psychiatry 45:337-45. 2006
    ..To describe the early adult psychopathological and social outcomes of adolescents who deliberately poisoned themselves...
  37. pmc Estimating intervention effects in a complex multi-level smoking prevention study
    Milena Falcaro
    Biostatistics Group, School of Community Based Medicine, University of Manchester, UK
    Int J Environ Res Public Health 6:463-77. 2009
    ....
  38. doi request reprint Evidence for interplay between genes and parenting on infant temperament in the first year of life: monoamine oxidase A polymorphism moderates effects of maternal sensitivity on infant anger proneness
    Andrew Pickles
    Institute of Psychiatry, King s College London, London, UK
    J Child Psychol Psychiatry 54:1308-17. 2013
    ..In contrast to previous studies, we examined MAOA G × E prospectively using an observational measure of a key aspect of the infant environment, maternal sensitivity, at a specified developmental time point...
  39. ncbi request reprint Predictors of antisocial personality. Continuities from childhood to adult life
    Emily Simonoff
    Department of Child and Adolescent Psychiatry, Guy s, King s and St Thomas Medical School and Institute of Psychiatry, London, UK
    Br J Psychiatry 184:118-27. 2004
    ..Antisocial behaviour in adult life has its roots in childhood...
  40. ncbi request reprint Seemingly minor changes to a questionnaire can make a big difference to mean scores: a cautionary tale
    Robert Goodman
    King s College London, Institute of Psychiatry, London, UK
    Soc Psychiatry Psychiatr Epidemiol 42:322-7. 2007
    ..It is not unusual for researchers to make apparently minor modifications to existing instruments without checking if this alters psychometric properties...
  41. doi request reprint Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive decline
    Antony Payton
    Centre for Integrated Genomic Medical Research, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Neurobiol Aging 31:351-2. 2010
    ..We observed a nominal significant association between this polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities...
  42. ncbi request reprint Major depression and associated impairment: same or different genetic and environmental risk factors?
    Debra L Foley
    Virginia Institute for Psychiatric and Behavioral Genetics, Departments of Human Genetics and Psychiatry, Virginia Commonwealth University, USA
    Am J Psychiatry 160:2128-33. 2003
    ..Impairment was added as a diagnostic criterion for many psychiatric disorders in DSM-IV. Does the addition of impairment influence only prevalence rates, or does it also introduce new etiological factors into psychiatric diagnoses?..
  43. ncbi request reprint The relationship between separation anxiety and impairment
    Debra L Foley
    Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia Commonwealth University, USA
    J Anxiety Disord 22:635-41. 2008
    ..The results indicate that impairment may index current treatment need but symptom levels provide the best information about severity and prognosis...
  44. ncbi request reprint Course and short-term outcomes of separation anxiety disorder in a community sample of twins
    Debra L Foley
    Human Genetics Department, Virginia Commonwealth University, Richmond 23298 0003, USA
    J Am Acad Child Adolesc Psychiatry 43:1107-14. 2004
    ..To assess the course and short-term outcomes associated with separation anxiety disorder (SAD) in a community setting...
  45. ncbi request reprint Modelling the contribution of changes in family life to time trends in adolescent conduct problems
    Stephan Collishaw
    MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    Soc Sci Med 65:2576-87. 2007
    ....
  46. ncbi request reprint An association analysis of microsatellite markers across the Prader-Willi/Angelman critical region on chromosome 15 (q11-13) and autism spectrum disorder
    Sarah Curran
    MRC Social, Genetic and Developmental Pyschiatry Centre, Institute of Pyschiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 137:25-8. 2005
    ..Further more systematic work in larger samples is required and confirmation that GABRB3 is imprinted is desirable...
  47. ncbi request reprint Using the autism diagnostic interview--revised to increase phenotypic homogeneity in genetic studies of autism
    Vanessa Hus
    University of Michigan Autism and Communication Disorders Center, Ann Arbor, Michigan, USA
    Biol Psychiatry 61:438-48. 2007
    ..Group differences in age, gender, IQ, and measures of autism severity are examined as related to Autism Diagnostic Interview-Revised (ADI-R) domains previously used for subsetting or Quantitative Trait Analysis (QTL)...
  48. ncbi request reprint Juvenile- versus adult-onset depression: multiple differences imply different pathways
    Jonathan Hill
    Department of Psychiatry, University of Liverpool, UK
    Psychol Med 34:1483-93. 2004
    ..These include age of onset, presence of co-morbid disorders, and history of childhood sexual abuse. This study examined these factors in the context of the contrast between onset of depression in young women before and after age 16...