Research Topics
Species | Andrew PicklesSummaryAffiliation: University of Manchester Country: UK Publications
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Detail Information
Publications
Resilience to adult psychopathology following childhood maltreatment: evidence from a community sampleStephan Collishaw
King s College London, MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, London, UK
Child Abuse Negl 31:211-29. 2007..The aims of the present study were to address the extent of resilience to adult psychopathology in a representative community sample, and to explore predictors of a good prognosis...- Variable expression of the autism broader phenotype: findings from extended pedigreesA Pickles
MRC Child Psychiatry Unit and the Institute of Psychiatry, King s College, London, UK
J Child Psychol Psychiatry 41:491-502. 2000..Patterns of expression within the families did not support a simple X-linked nor an imprinted X-linked mode of inheritance. The basis for sex differences in rates of expression is discussed... - Child psychiatric symptoms and psychosocial impairment: relationship and prognostic significanceA Pickles
School of Epidemiology and Health Science, University of Manchester, Manchester, UK
Br J Psychiatry 179:230-5. 2001..Relatively little is known about the relationships between psychiatric symptoms, diagnosis and psychosocial impairment... - Natural categories or fundamental dimensions: on carving nature at the joints and the rearticulation of psychopathologyAndrew Pickles
Biostatistics Group, School of Epidemiology and Health Science, University of Manchester, UK
Dev Psychopathol 15:529-51. 2003..We suggest replacing Meehl's analogy involving qualitatively distinct species with an alternative analogy with the "duality" of light, a phenomenon with both wave- and particle-like properties... 
Parent-mediated communication-focused treatment in children with autism (PACT): a randomised controlled trialJonathan Green
Psychiatry Research Group, University of Manchester, Manchester, UK
Lancet 375:2152-60. 2010..Results of small trials suggest that early interventions for social communication are effective for the treatment of autism in children. We therefore investigated the efficacy of such an intervention in a larger trial...
'Everyday memory' impairments in autism spectrum disordersCatherine R G Jones
Centre for Research in Autism and Education, Department of Psychology and Human Development, Institute of Education, London, WC1H 0AL, UK
J Autism Dev Disord 41:455-64. 2011..Social and communication ability was significantly associated with prospective remembering in an everyday memory context but not with the CAVLT-2. The complex nature of everyday memory and its relevance to ASD is discussed...- Validation of the social communication questionnaire in a population cohort of children with autism spectrum disordersSusie Chandler
Guy s and Thomas NHS Foundation Trust, London, UK
J Am Acad Child Adolesc Psychiatry 46:1324-32. 2007..To examine the properties of the Social Communication Questionnaire (SCQ) in a population cohort of children with autism spectrum disorders (ASDs) and in the general population... - Pathways from adolescent deliberate self-poisoning to early adult outcomes: a six-year follow-upAzza Aglan
Division of Psychiatry, University of Manchester, UK
J Child Psychol Psychiatry 49:508-15. 2008..The goal of this study was to identify pathways linking childhood risk factors to early adult outcomes of suicidal adolescents... - Reading and arithmetic in adolescents with autism spectrum disorders: peaks and dips in attainmentCatherine R G Jones
Department of Psychology and Human Development, Institute of Education, London, UK
Neuropsychology 23:718-28. 2009..The high rate of uneven academic attainment in ASD has implications for educational practice... - The Croydon Assessment of Learning Study: prevalence and educational identification of mild mental retardationEmily Simonoff
Department of Child and Adolescent Psychiatry, King s College London, Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 47:828-39. 2006..The current study estimates the prevalence of low IQ in the mental retardation range (intellectual disability) in a population sample and examines the factors that relate to educational identification... - An emerging income differential for adolescent emotional problemsEmma Gore Langton
King s College London Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 52:1081-8. 2011..Older studies reported no income differentials, while recent reports suggest that adolescents from low-income families are more likely to experience emotional difficulties than their more affluent peers... - Regression, developmental trajectory and associated problems in disorders in the autism spectrum: the SNAP studyGillian Baird
Newcomen Centre, Guy s and St Thomas NHS Foundation Trust, London, SE1 9RT, UK
J Autism Dev Disord 38:1827-36. 2008..Regression was associated with higher rates of autistic symptoms and a deviation in developmental trajectory. Regression was not associated with epilepsy or gastrointestinal problems... - Impairment in movement skills of children with autistic spectrum disordersDido Green
Newcomen Centre, Guy s and St Thomas NHS Foundation Trust, Great Maze Pond, London, UK
Dev Med Child Neurol 51:311-6. 2009..We undertook this study to explore the degree of impairment in movement skills in children with autistic spectrum disorders (ASD) and a wide IQ range... - A multimodal approach to emotion recognition ability in autism spectrum disordersCatherine R G Jones
Centre for Research in Autism and Education, Department of Psychology and Human Development, Institute of Education, London, UK
J Child Psychol Psychiatry 52:275-85. 2011..However, experimental investigations of emotion recognition ability in ASD have been equivocal, hampered by small sample sizes, narrow IQ range and over-focus on the visual modality... - A longitudinal study of behavioral, emotional and social difficulties in individuals with a history of specific language impairment (SLI)Michelle C St Clair
School of Psychological Sciences, Ellen Wilkinson Building, University of Manchester, Oxford Road, Manchester M13 9PL, UK
J Commun Disord 44:186-99. 2011.... - The persistence and stability of psychiatric problems in adolescents with autism spectrum disordersEmily Simonoff
Department of Child and Adolescent Psychiatry, King s College London, Institute of Psychiatry and NIHR Biomedical Research Centre for Mental Health, London, UK
J Child Psychol Psychiatry 54:186-94. 2013..We use a longitudinal population-representative cohort to examine for the first time the persistence of psychiatric problems and to identify risk factors for their occurrence and stability... - Precursors to social and communication difficulties in infants at-risk for autism: gaze following and attentional engagementRachael Bedford
Centre for Research in Autism and Education, Institute of Education, University of London, 25 Woburn Square, London, UK
J Autism Dev Disord 42:2208-18. 2012..The findings suggest that the subtle emergence of difficulties in JA in infancy may be related to ASD and other atypical outcomes... - Severe mood problems in adolescents with autism spectrum disorderEmily Simonoff
Department of Child and Adolescent Psychiatry, King s College London, Institute of Psychiatry and NIHR Biomedical Research Centre for Mental Health, De Crespigny Park, London, UK
J Child Psychol Psychiatry 53:1157-66. 2012..SMP in people with autism spectrum disorders (ASDs) have not previously been explored... - How far are associations between child, family and community factors and child psychopathology informant-specific and informant-general?Stephan Collishaw
King s College London Institute of Psychiatry, MRC Social, Genetic, and Developmental Psychiatry Centre, London, UK
J Child Psychol Psychiatry 50:571-80. 2009..However, few studies have systematically tested how far correlates of child psychopathology differ between informants... - Adolescent emotional and behavioural outcomes of nonparental preschool childcareHolan Liang
Institute of Psychiatry, King s College London, London, UK
Soc Psychiatry Psychiatr Epidemiol 47:399-407. 2012..This study aimed to identify whether nonparental preschool childcare was associated with adolescent mental health outcomes as measured by the strengths and difficulties questionnaire (SDQ)... - The relationship between DSM-IV oppositional defiant disorder and conduct disorder: findings from the Great Smoky Mountains StudyRichard Rowe
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK
J Child Psychol Psychiatry 43:365-73. 2002..We examine models of the relationship between oppositional defiant disorder (ODD) and conduct disorder (CD) in a community sample. Particular attention is paid to the generalisability of findings based on clinic-referred boys... - Linkage analysis of cross-sectional and longitudinally derived phenotypic measures to identify loci influencing blood pressureNeil Shephard
ARC Epidemiology Unit, University of Manchester, Manchester, United Kingdom
BMC Genet 4:S26. 2003.... - Preschoolers with autism show greater impairment in receptive compared with expressive language abilitiesKristelle Hudry
Centre for Research in Autism and Education, Department of Psychology and Human Development, Institute of Education, London, UK
Int J Lang Commun Disord 45:681-90. 2010..However, the relative degree of delay or impairment in each of these sub-domains may also be atypical and remains less well-understood... - Overgeneral autobiographical memory in women: association with childhood abuse and history of depression in a community sampleAzza Aglan
Division of Clinical Psychology, University of Manchester, UK
Br J Clin Psychol 49:359-72. 2010..No previous study has examined their joint association with overgeneral memory in a community sample, nor examined whether the associations are with both juvenile- and adult-onset depression... - Latent mixture models for multivariate and longitudinal outcomesAndrew Pickles
Biostatistics, Health Methodology Research Group, University of Manchester, University Place, Oxford Road, Manchester, M13 9PL, UK
Stat Methods Med Res 19:271-89. 2010..We review methods based on discrete random effects distributions and mixture models for application in this field... - Dimensions of respiratory symptoms in preschool children: population-based birth cohort studyJaclyn A Smith
1Respiratory Research Group, University of Manchester, Manchester M23 9LT, UK
Am J Respir Crit Care Med 177:1358-63. 2008..However, such collections or components of overall symptomatology need to be valid, and their relationship established with the known risk factors and physiologic measures... - Communication and social deficits in relatives of individuals with SLI and relatives of individuals with ASDAndrew Pickles
Biostatistics, Institute of Psychiatry, King s College London, London, UK
J Autism Dev Disord 43:156-67. 2013..There was a higher than would be expected rate (4.3 %) of ASD, particularly in siblings of SLI + ASD probands. Communication and social deficits appear to breed true in SLI and ASD... - Psychopathology in children before and after surgery for extratemporal lobe epilepsyM Chiara Colonnelli
Neuroscience Department, UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Dev Med Child Neurol 54:521-6. 2012..To establish the rates and types of psychiatric disorder in children before and after surgery for extratemporal epilepsy. Relationships between psychiatric morbidity and demographic/clinical variables were examined... - Institutional care: associations between overactivity and lack of selectivity in social relationshipsPenny Roy
Department of Language and Communication Science, City University, London, UK
J Child Psychol Psychiatry 45:866-73. 2004.... - A flexible model for multivariate interval-censored survival times with complex correlation structureMilena Falcaro
Biostatistics Group, Division of Epidemiology and Health Sciences, The University of Manchester, UK
Stat Med 26:663-80. 2007..The proposed model allows estimation of the genetic and environmental effects that are shared by both of these risk behaviours as well as those that are specific... - Early adult outcomes of adolescents who deliberately poisoned themselvesRichard Harrington
Royal Manchester Children's Hospital, Manchester, UK
J Am Acad Child Adolesc Psychiatry 45:337-45. 2006.... - Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: the Special Needs and Autism Project (SNAP)Gillian Baird
Newcomen Centre, Guy s and St Thomas NHS Foundation Trust, London, UK
Lancet 368:210-5. 2006..Recent reports have suggested that the prevalence of autism and related spectrum disorders (ASDs) is substantially higher than previously recognised. We sought to quantify prevalence of ASDs in children in South Thames, UK... - Estimating intervention effects in a complex multi-level smoking prevention studyMilena Falcaro
Biostatistics Group, School of Community Based Medicine, University of Manchester, UK
Int J Environ Res Public Health 6:463-77. 2009.... - Investigation of a functional quinine oxidoreductase (NQO2) polymorphism and cognitive declineAntony Payton
Centre for Integrated Genomic Medical Research, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
Neurobiol Aging 31:351-2. 2010..We observed a nominal significant association between this polymorphism and the trajectory of delayed memory recall over time (p=0.029). No other associations were seen with the decline of other cognitive abilities... - Seemingly minor changes to a questionnaire can make a big difference to mean scores: a cautionary taleRobert Goodman
King s College London, Institute of Psychiatry, London, UK
Soc Psychiatry Psychiatr Epidemiol 42:322-7. 2007..It is not unusual for researchers to make apparently minor modifications to existing instruments without checking if this alters psychometric properties... - Predictors of antisocial personality. Continuities from childhood to adult lifeEmily Simonoff
Department of Child and Adolescent Psychiatry, Guy s, King s and St Thomas Medical School and Institute of Psychiatry, London, UK
Br J Psychiatry 184:118-27. 2004..Antisocial behaviour in adult life has its roots in childhood... - Major depression and associated impairment: same or different genetic and environmental risk factors?Debra L Foley
Virginia Institute for Psychiatric and Behavioral Genetics, Departments of Human Genetics and Psychiatry, Virginia Commonwealth University, USA
Am J Psychiatry 160:2128-33. 2003..Impairment was added as a diagnostic criterion for many psychiatric disorders in DSM-IV. Does the addition of impairment influence only prevalence rates, or does it also introduce new etiological factors into psychiatric diagnoses?.. - The relationship between separation anxiety and impairmentDebra L Foley
Virginia Institute for Psychiatric and Behavioral Genetics, Medical College of Virginia Commonwealth University, USA
J Anxiety Disord 22:635-41. 2008..The results indicate that impairment may index current treatment need but symptom levels provide the best information about severity and prognosis... - Using the autism diagnostic interview--revised to increase phenotypic homogeneity in genetic studies of autismVanessa Hus
University of Michigan Autism and Communication Disorders Center, Ann Arbor, Michigan, USA
Biol Psychiatry 61:438-48. 2007..Group differences in age, gender, IQ, and measures of autism severity are examined as related to Autism Diagnostic Interview-Revised (ADI-R) domains previously used for subsetting or Quantitative Trait Analysis (QTL)... - Course and short-term outcomes of separation anxiety disorder in a community sample of twinsDebra L Foley
Human Genetics Department, Virginia Commonwealth University, Richmond 23298 0003, USA
J Am Acad Child Adolesc Psychiatry 43:1107-14. 2004..To assess the course and short-term outcomes associated with separation anxiety disorder (SAD) in a community setting... - Juvenile- versus adult-onset depression: multiple differences imply different pathwaysJonathan Hill
Department of Psychiatry, University of Liverpool, UK
Psychol Med 34:1483-93. 2004..These include age of onset, presence of co-morbid disorders, and history of childhood sexual abuse. This study examined these factors in the context of the contrast between onset of depression in young women before and after age 16... - An association analysis of microsatellite markers across the Prader-Willi/Angelman critical region on chromosome 15 (q11-13) and autism spectrum disorderSarah Curran
MRC Social, Genetic and Developmental Pyschiatry Centre, Institute of Pyschiatry, De Crespigny Park, London SE5 8AF, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 137:25-8. 2005..Further more systematic work in larger samples is required and confirmation that GABRB3 is imprinted is desirable... - Modelling the contribution of changes in family life to time trends in adolescent conduct problemsStephan Collishaw
MRC Social, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
Soc Sci Med 65:2576-87. 2007....