S M Pickering-Brown

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
    Zbigniew K Wszolek
    Department of Neurology, Mayo Clinic, FL, USA
    Orphanet J Rare Dis 1:30. 2006
  2. doi request reprint Review: Recent progress in frontotemporal lobar degeneration
    S M Pickering-Brown
    Clinical Neurosciences Research Group, Faculty of Human and Medical Sciences, University of Manchester, Manchester, UK
    Neuropathol Appl Neurobiol 36:4-16. 2010
  3. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
  4. ncbi request reprint The complex aetiology of frontotemporal lobar degeneration
    Stuart M Pickering-Brown
    Division of Regenerative Medicine, Stopford Building, University of Manchester, Oxford Road, Manchester, and Hope Hospital, Salford, M6 8HD, UK
    Exp Neurol 206:1-10. 2007
  5. ncbi request reprint Progranulin and frontotemporal lobar degeneration
    Stuart M Pickering-Brown
    Division of Regenerative Medicine, Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Acta Neuropathol 114:39-47. 2007
  6. doi request reprint Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations
    Stuart M Pickering-Brown
    Clinical Neuroscience Research Group, Faculty of Medical and Human Sciences, University of Manchester, Oxford Rd, Manchester M13 9PT, UK
    Brain 131:721-31. 2008
  7. ncbi request reprint A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease
    J Tian
    Clinical Neuroscience Research Group, Department of Medicine, University of Manchester, Manchester, M13 9PT, UK
    Neurosci Lett 354:103-6. 2004
  8. pmc The apolipoprotein E epsilon4 allele selectively increases the risk of frontotemporal lobar degeneration in males
    R Srinivasan
    Clinical Neurosciences Research Group, University of Manchester, UK
    J Neurol Neurosurg Psychiatry 77:154-8. 2006
  9. pmc Association between apolipoprotein E e4 allele and arteriosclerosis, cerebral amyloid angiopathy, and cerebral white matter damage in Alzheimer's disease
    J Tian
    Clinical Neuroscience Research Group, University of Manchester, Hope Hospital, Salford, Manchester M6 8HD, UK
    J Neurol Neurosurg Psychiatry 75:696-9. 2004
  10. ncbi request reprint Amyloid beta protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype
    D M Mann
    Clinical Neuroscience Research Group, Department of Medicine, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Neurosci Lett 304:161-4. 2001

Collaborators

Detail Information

Publications32

  1. pmc Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
    Zbigniew K Wszolek
    Department of Neurology, Mayo Clinic, FL, USA
    Orphanet J Rare Dis 1:30. 2006
    ..The prognosis and rate of the disease's progression vary considerably among individual patients and genetic kindreds, ranging from life expectancies of several months to several years, and, in exceptional cases, as long as two decades...
  2. doi request reprint Review: Recent progress in frontotemporal lobar degeneration
    S M Pickering-Brown
    Clinical Neurosciences Research Group, Faculty of Human and Medical Sciences, University of Manchester, Manchester, UK
    Neuropathol Appl Neurobiol 36:4-16. 2010
    ..The purpose of this review is to summarize the current concepts and recent advances in our knowledge of this disease...
  3. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
    ..A new locus for amyotrophic lateral sclerosis--frontotemporal dementia (ALS-FTD) has recently been ascribed to chromosome 9p...
  4. ncbi request reprint The complex aetiology of frontotemporal lobar degeneration
    Stuart M Pickering-Brown
    Division of Regenerative Medicine, Stopford Building, University of Manchester, Oxford Road, Manchester, and Hope Hospital, Salford, M6 8HD, UK
    Exp Neurol 206:1-10. 2007
    ..Nevertheless, other genes causing FTLD remain to be identified and their biology elucidated before we have a complete understanding of the complex aetiology of this disease...
  5. ncbi request reprint Progranulin and frontotemporal lobar degeneration
    Stuart M Pickering-Brown
    Division of Regenerative Medicine, Stopford Building, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Acta Neuropathol 114:39-47. 2007
    ..These genes collectively account for 10-20% of FTLD. However, it is clear that much remains to be discovered before our knowledge of this heterogeneous condition is complete...
  6. doi request reprint Frequency and clinical characteristics of progranulin mutation carriers in the Manchester frontotemporal lobar degeneration cohort: comparison with patients with MAPT and no known mutations
    Stuart M Pickering-Brown
    Clinical Neuroscience Research Group, Faculty of Medical and Human Sciences, University of Manchester, Oxford Rd, Manchester M13 9PT, UK
    Brain 131:721-31. 2008
    ..These findings complement recent clinico-pathological findings in suggesting identifiable associations between clinical phenotype and genotype in FTLD...
  7. ncbi request reprint A polymorphism in the angiotensin 1-converting enzyme gene is associated with damage to cerebral cortical white matter in Alzheimer's disease
    J Tian
    Clinical Neuroscience Research Group, Department of Medicine, University of Manchester, Manchester, M13 9PT, UK
    Neurosci Lett 354:103-6. 2004
    ....
  8. pmc The apolipoprotein E epsilon4 allele selectively increases the risk of frontotemporal lobar degeneration in males
    R Srinivasan
    Clinical Neurosciences Research Group, University of Manchester, UK
    J Neurol Neurosurg Psychiatry 77:154-8. 2006
    ..To determine whether polymorphic variations in the apolipoprotein E gene (APOE) are associated with increased risk of frontotemporal lobar degeneration (FTLD) when mutation in tau gene is absent...
  9. pmc Association between apolipoprotein E e4 allele and arteriosclerosis, cerebral amyloid angiopathy, and cerebral white matter damage in Alzheimer's disease
    J Tian
    Clinical Neuroscience Research Group, University of Manchester, Hope Hospital, Salford, Manchester M6 8HD, UK
    J Neurol Neurosurg Psychiatry 75:696-9. 2004
    ....
  10. ncbi request reprint Amyloid beta protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype
    D M Mann
    Clinical Neuroscience Research Group, Department of Medicine, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
    Neurosci Lett 304:161-4. 2001
    ..Indeed 9/14 patients with Abeta deposits studied here had an onset of illness after 55 years of age and bore APOE epsilon4 allele...
  11. ncbi request reprint Tau load is associated with apolipoprotein E genotype and the amount of amyloid beta protein, Abeta40, in sporadic and familial Alzheimer's disease
    U Thaker
    Clinical Neuroscience Research Group, Department of Medicine, University of Manchester, Manchester, UK
    Neuropathol Appl Neurobiol 29:35-44. 2003
    ..Abeta40 plaques are rich in microglial cells and it is possible that p-tau pathology in AD is triggered by reaction of microglial cells to the presence of Abeta40 and not this peptide directly...
  12. ncbi request reprint Inherited frontotemporal dementia in nine British families associated with intronic mutations in the tau gene
    S M Pickering-Brown
    The School of Biological Sciences, Division of Neuroscience, University of Manchester, UK
    Brain 125:732-51. 2002
    ..All eight families with the +16 mutation seem to be part of a common extended pedigree, possibly originating from a founder member residing within the North Wales region of Great Britain...
  13. pmc Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease
    D M Mann
    Clinical Neuroscience Research Group, Department of Medicine, University of Manchester, Manchester, United Kingdom
    Am J Pathol 158:2165-75. 2001
    ..Finally we report that the amount of Abeta(42(43)) deposited in the brain correlated with the amount of this produced in culture by cells bearing the equivalent mutations...
  14. pmc A polymorphic variation in the interleukin 1A gene increases brain microglial cell activity in Alzheimer's disease
    A Hayes
    Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Salford M6 8HD, UK
    J Neurol Neurosurg Psychiatry 75:1475-7. 2004
    ....
  15. pmc Ubiquitin associated protein 1 is a risk factor for frontotemporal lobar degeneration
    Sara Rollinson
    Clinical Neurosciences, Faculty of Human and Medical Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Neurobiol Aging 30:656-65. 2009
    ..Our data for the first time identifies UBAP1 as a genetic risk factor for FTLD and suggests a mechanistic relationship between this protein and TDP-43...
  16. pmc Genetic associations between cathepsin D exon 2 C-->T polymorphism and Alzheimer's disease, and pathological correlations with genotype
    Y Davidson
    Clinical Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Stott Lane, Salford M6 8HD, Manchester, UK
    J Neurol Neurosurg Psychiatry 77:515-7. 2006
    ....
  17. doi request reprint Progressive anomia revisited: focal degeneration associated with progranulin gene mutation
    Julie S Snowden
    School of Translational Medicine, University of Manchester, Hope Hospital, Salford, UK
    Neurocase 13:366-77. 2007
    ..The case exemplifies the heterogeneity of clinical expression of FTLD and contributes to understanding of primary progressive aphasia...
  18. ncbi request reprint Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia
    J S Snowden
    Clinical Neuroscience Research Group, University of Manchester Salford, Manchester, UK
    Brain 129:3091-102. 2006
    ..The findings provide compelling evidence for the link between FTD and PNFA, while raising the possibility of identifiable clinical differences between FTLD patients with MAPT and PGRN mutations...
  19. ncbi request reprint Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease
    A M Shiarli
    Clinical Neuroscience Research Group, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Salford, UK
    Neuropathol Appl Neurobiol 32:374-87. 2006
    ....
  20. ncbi request reprint TDP-43 gene analysis in frontotemporal lobar degeneration
    Sara Rollinson
    Division of Regenerative Medicine, Department of Medicine, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Neurosci Lett 419:1-4. 2007
    ..We found no evidence of TDP-43 variation increasing risk for FTLD in this cohort. These data suggest that TDP-43 accumulation is a consequence of the disease process underlying FTLD...
  21. ncbi request reprint The genetics of frontotemporal lobar degeneration
    Stephen Sikkink
    Clinical Neurosciences, University of Manchester, Manchester, UK
    Curr Opin Neurol 20:693-8. 2007
    ..Up to 40% of patients with frontotemporal lobar degeneration have a family history of a similar disorder in a first-degree relative, highlighting a significant genetic contribution to the aetiology of this disorder...
  22. ncbi request reprint Apolipoprotein E epsilon4 allele frequency and age at onset of Alzheimer's disease
    Yvonne Davidson
    Clinical Neuroscience Research Group, Division of Medicine and Neuroscience, University of Manchester, Greater Manchester Neurosciences Centre, Hope Hospital, Salford, UK
    Dement Geriatr Cogn Disord 23:60-6. 2007
    ..44, was highest in the 60-69 years age class, progressively decreasing either side of this age group. APOE epsilon4 allele therefore has its maximum impact between onset ages of between 60 and 70 years...
  23. ncbi request reprint Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
    Matt Baker
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Nature 442:916-9. 2006
    ..Our results identify mutations in PGRN as a cause of neurodegenerative disease and indicate the importance of PGRN function for neuronal survival...
  24. pmc Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the progranulin gene
    Jonathan D Rohrer
    Dementia Research Centre, Institute of Neurology, University College London, London, England
    Arch Neurol 65:506-13. 2008
    ..To describe the clinical, neuropsychologic, and radiologic features of a family with a C31LfsX35 mutation in the progranulin gene CCDS11483.1)...
  25. ncbi request reprint A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17
    Ian R Mackenzie
    Department of Pathology, University of British Columbia, Vancouver, Canada
    Brain 129:853-67. 2006
    ....
  26. ncbi request reprint Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative
    Rosa Rademakers
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Lancet Neurol 6:857-68. 2007
    ..The most common mutation in GRN is Arg493X. We aimed to establish the contribution of this mutation to FTLD and related disorders...
  27. ncbi request reprint Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration
    Jennifer Gass
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Hum Mol Genet 15:2988-3001. 2006
    ..Neuropathological examination showed FTLD with ubiquitin-positive cytoplasmic and intranuclear inclusions in all PGRN mutation carriers...
  28. ncbi request reprint Mutations in progranulin explain atypical phenotypes with variants in MAPT
    Stuart M Pickering-Brown
    Brain 129:3124-6. 2006
    ..Here, we demonstrate that the MAPT variants are almost certainly rare benign polymorphisms as all of these cases harbour mutations in Progranulin (PGRN). Mutations in PGRN were recently shown to cause ubiquitin-positive FTDP-17...
  29. ncbi request reprint Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study
    Bradley F Boeve
    Department of Neurology, Mayo Clinic Rochester, MN 55905, USA
    Brain 129:3103-14. 2006
    ..These findings suggest that the insR352 PSEN1 is not pathogenic, and the IVS1+1G-->A mutation in PGRN causes FTDP associated with FTLD-U pathology and represents a new class of neurodegenerative disease--the 'hypoprogranulinopathies'...
  30. ncbi request reprint CHMP2B mutations are not a common cause of frontotemporal lobar degeneration
    Ashley Cannon
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Neurosci Lett 398:83-4. 2006
    ..Polymorphisms were detected but were present in control samples. We conclude that mutations in CHMP2B are a rare cause of familial FTLD and may be specific to the Danish pedigree...
  31. pmc TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration
    Penelope Foulds
    Division of Biomedical and Life Sciences, School of Health and Medicine, University of Lancaster, Lancaster, UK
    Acta Neuropathol 116:141-6. 2008
    ..As a predictive test, plasma TDP-43 level may have great practical value in directing therapeutic strategies aimed at preventing or removing tau or TDP-43 pathological changes from the brain in FTLD and AD...
  32. ncbi request reprint An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies
    Rohan de Silva
    Reta Lila Weston Institute of Neurological Studies, University College London, Windeyer Building, 46 Cleveland St, W1T 4JF, London, UK
    Acta Neuropathol 111:329-40. 2006
    ..The use of such tau isoform specific antibodies may refine pathological criteria underpinning FTLD...