Benjamin S Pickard

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Speeding disease gene discovery by sequence based candidate prioritization
    Euan A Adie
    Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Edinburgh, UK
    BMC Bioinformatics 6:55. 2005
  2. ncbi The PDE4B gene confers sex-specific protection against schizophrenia
    Benjamin S Pickard
    Medical Genetics Section, School of Clinical and Molecular Medicine, Molecular Medicine Centre, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Psychiatr Genet 17:129-33. 2007
  3. doi Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder
    B S Pickard
    Department of Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Mol Psychiatry 14:874-84. 2009
  4. ncbi Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability
    Ben S Pickard
    Department of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, UK
    Am J Med Genet B Neuropsychiatr Genet 136:26-32. 2005
  5. ncbi Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder
    B S Pickard
    Medical Genetics Section, School of Clinical and Molecular Medicine, Molecular Medicine Centre, University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 11:847-57. 2006
  6. ncbi Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18
    Ben S Pickard
    Department of Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Psychiatr Genet 15:37-44. 2005
  7. ncbi Cytogenetics and gene discovery in psychiatric disorders
    B S Pickard
    Medical Genetics, School of Molecular and Clinical Medicine, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Pharmacogenomics J 5:81-8. 2005
  8. pmc A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder
    B S Pickard
    Medical Genetics, School of Clinical and Molecular Medicine, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 105:14940-5. 2008
  9. pmc A 4q35.2 subtelomeric deletion identified in a screen of patients with co-morbid psychiatric illness and mental retardation
    Ben S Pickard
    Medical Genetics, Molecular Medicine Centre, Univ, of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    BMC Med Genet 5:21. 2004
  10. ncbi The NPAS3 gene--emerging evidence for a role in psychiatric illness
    Benjamin S Pickard
    Medical Genetics Section, School of Clinical and Molecular Medicine, Molecular Medicine Centre, University of Edinburgh, Edinburgh, UK
    Ann Med 38:439-48. 2006

Detail Information

Publications23

  1. pmc Speeding disease gene discovery by sequence based candidate prioritization
    Euan A Adie
    Medical Genetics Section, Department of Medical Sciences, The University of Edinburgh, Edinburgh, UK
    BMC Bioinformatics 6:55. 2005
    ..However, here we show that disease genes share patterns of sequence-based features that can provide a good basis for automatic prioritization of candidates by machine learning...
  2. ncbi The PDE4B gene confers sex-specific protection against schizophrenia
    Benjamin S Pickard
    Medical Genetics Section, School of Clinical and Molecular Medicine, Molecular Medicine Centre, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Psychiatr Genet 17:129-33. 2007
    ....
  3. doi Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder
    B S Pickard
    Department of Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK
    Mol Psychiatry 14:874-84. 2009
    ....
  4. ncbi Disruption of a brain transcription factor, NPAS3, is associated with schizophrenia and learning disability
    Ben S Pickard
    Department of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, UK
    Am J Med Genet B Neuropsychiatr Genet 136:26-32. 2005
    ..Sequencing of the gene in a third patient diagnosed with IBGC, schizophrenia, and mild learning disability did not reveal functional mutations...
  5. ncbi Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder
    B S Pickard
    Medical Genetics Section, School of Clinical and Molecular Medicine, Molecular Medicine Centre, University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 11:847-57. 2006
    ..We propose that these convergent cytogenetic and genetic findings provide molecular evidence for common aetiologies for different psychiatric conditions and further support the 'glutamate hypothesis' of psychotic illness...
  6. ncbi Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18
    Ben S Pickard
    Department of Medical Genetics, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Psychiatr Genet 15:37-44. 2005
    ....
  7. ncbi Cytogenetics and gene discovery in psychiatric disorders
    B S Pickard
    Medical Genetics, School of Molecular and Clinical Medicine, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Pharmacogenomics J 5:81-8. 2005
    ..Cytogenetic events may provide important insights into neurochemical pathways and cellular processes critical for the development of complex psychiatric phenotypes in the population at large...
  8. pmc A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder
    B S Pickard
    Medical Genetics, School of Clinical and Molecular Medicine, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 105:14940-5. 2008
    ..These data suggest a mechanism whereby the genetic protective effect is mediated through increased kainate receptor expression...
  9. pmc A 4q35.2 subtelomeric deletion identified in a screen of patients with co-morbid psychiatric illness and mental retardation
    Ben S Pickard
    Medical Genetics, Molecular Medicine Centre, Univ, of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    BMC Med Genet 5:21. 2004
    ..We describe here a screen for telomeric abnormalities in a cohort of 69 patients in which mental retardation co-exists with severe psychiatric illness...
  10. ncbi The NPAS3 gene--emerging evidence for a role in psychiatric illness
    Benjamin S Pickard
    Medical Genetics Section, School of Clinical and Molecular Medicine, Molecular Medicine Centre, University of Edinburgh, Edinburgh, UK
    Ann Med 38:439-48. 2006
    ..In addition, we speculate on the physiological regulation of NPAS3 and whether NPAS3 gene variation contributes to psychiatric illness at the population level...
  11. ncbi Disrupted-in-Schizophrenia-1
    Walter J Muir
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland EH10 5HF, United Kingdom
    Curr Psychiatry Rep 10:140-7. 2008
    ..We also discuss the latest findings on the neuronal functions of the protein DISC1 encoded by the gene...
  12. pmc A cytogenetic abnormality and rare coding variants identify ABCA13 as a candidate gene in schizophrenia, bipolar disorder, and depression
    Helen M Knight
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Am J Hum Genet 85:833-46. 2009
    ..These data identify a candidate gene, highlight the genetic overlap between schizophrenia, bipolar disorder, and depression, and suggest that rare coding variants may contribute significantly to risk of these disorders...
  13. doi GRIK4/KA1 protein expression in human brain and correlation with bipolar disorder risk variant status
    Helen M Knight
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Am J Med Genet B Neuropsychiatr Genet 159:21-9. 2012
    ..Biological mechanisms which may contribute to this protective effect include KA1 involvement in adult hippocampal neurogenesis, HPA axis activation, or plasticity processes affecting neuronal circuitry...
  14. ncbi Genetics of schizophrenia and bipolar affective disorder: strategies to identify candidate genes
    D J Porteous
    Medical Genetics Section, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, EH4 2XU
    Cold Spring Harb Symp Quant Biol 68:383-94. 2003
  15. doi Homozygosity mapping in a family presenting with schizophrenia, epilepsy and hearing impairment
    Helen M Knight
    Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK
    Eur J Hum Genet 16:750-8. 2008
    ..3 and 22q12.3-q13.3 may lead to the discovery of causative variants, and consequent disrupted molecular pathways associated with this rare phenotype...
  16. ncbi DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling
    J Kirsty Millar
    Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Edinburgh EH4 2XU, UK
    Science 310:1187-91. 2005
    ..We propose a mechanistic model whereby DISC1 sequesters PDE4B in resting cells and releases it in an activated state in response to elevated cAMP...
  17. ncbi Chromosome abnormalities, mental retardation and the search for genes in bipolar disorder and schizophrenia
    D H R Blackwood
    Division of Psychiatry, School of Molecular and Clinical Medicine, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK
    Neurotox Res 14:113-20. 2008
    ....
  18. ncbi Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population
    P A Thomson
    Department of Medical Sciences, Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Western General Hospital, Edinburgh, UK
    Mol Psychiatry 12:94-104. 2007
    ..Our study identifies a new of NRG1 region involved in schizophrenia and bipolar disorder in the Scottish population...
  19. ncbi SUSPECTS: enabling fast and effective prioritization of positional candidates
    E A Adie
    Medical Genetics Section, School of Molecular and Clinical Medicine, University of Edinburgh EH4 2XU UK
    Bioinformatics 22:773-4. 2006
    ..It uses multiple lines of evidence to rank genes quickly and effectively while limiting the effect of annotation bias to significantly improve performance...
  20. ncbi Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia
    A Christoforou
    Medical Genetics Section, Molecular Medicine Centre, Western General Hospital, University of Edinburgh, Edinburgh, UK
    Mol Psychiatry 12:1011-25. 2007
    ..This study has identified significant associations between BP and SCZ within the chromosome 4p linkage region, resulting in candidate regions worthy of further investigation...
  21. ncbi Chromosomal abnormalities and mental illness
    D J MacIntyre
    Department of Psychiatry, University of Edinburgh, Scotland, UK
    Mol Psychiatry 8:275-87. 2003
    ..Full karyotyping of individuals with psychotic illness especially where this coexists with mild learning disability, dysmorphism or a strong family history of mental disorder is encouraged...
  22. ncbi Serine proteases in rodent hippocampus
    B J Davies
    Center for Genome Research, University of Edinburgh, King s Buildings, West Mains Road, Edinburgh EH9 3JQ, United Kingdom
    J Biol Chem 273:23004-11. 1998
    ..In contrast, and despite robust expression of t-PA, the usual t-PA substrate plasminogen was not expressed at detectable levels...
  23. ncbi Chromosomal abnormalities and psychosis
    Walter J Muir
    Br J Psychiatry 188:501-3. 2006
    ..One such gene is DISCI and there is increasing evidence that it may be an important modulator of risk of psychosis...