Andrew N Phillips

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Increased HIV incidence in men who have sex with men despite high levels of ART-induced viral suppression: analysis of an extensively documented epidemic
    Andrew N Phillips
    Research Department of Infection and Population Health, UCL, London, United Kingdom
    PLoS ONE 8:e55312. 2013
  2. pmc Partners of people on ART - a New Evaluation of the Risks (The PARTNER study): design and methods
    Alison Rodger
    Research Department of Infection and Population Health, University College London, London, UK
    BMC Public Health 12:296. 2012
  3. doi request reprint Effect on transmission of HIV-1 resistance of timing of implementation of viral load monitoring to determine switches from first to second-line antiretroviral regimens in resource-limited settings
    Andrew N Phillips
    Department of Infection and Population Health, UCL, UK
    AIDS 25:843-50. 2011
  4. ncbi request reprint Ongoing changes in HIV RNA levels during untreated HIV infection: implications for CD4 cell count depletion
    Andrew N Phillips
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, Royal Free Campus, UCL Royal Free Campus, London, UK
    AIDS 24:1561-7. 2010
  5. doi request reprint Are previous treatment interruptions associated with higher viral rebound rates in patients with viral suppression?
    Loveleen K Bansi
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Hampstead Campus, Rowland Hill Street, London, NW3 2PF, UK
    AIDS 22:349-56. 2008
  6. ncbi request reprint Evolution of drug resistance in HIV-infected patients remaining on a virologically failing combination antiretroviral therapy regimen
    Alessandro Cozzi-Lepri
    Royal Free and University College Medical School, London, UK
    AIDS 21:721-32. 2007
  7. doi request reprint Stability of antiretroviral regimens in patients with viral suppression
    Rebecca K Lodwick
    Research Department of Infection and Population Health, Division of Population Health, Royal Free and University College Medical School, London, UK
    AIDS 22:1039-46. 2008
  8. ncbi request reprint Virological rebound after suppression on highly active antiretroviral therapy
    Amanda Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 17:1741-51. 2003
  9. ncbi request reprint Short-term clinical disease progression in HIV-1-positive patients taking combination antiretroviral therapy: the EuroSIDA risk-score
    Amanda Mocroft
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 21:1867-75. 2007
  10. doi request reprint Detection of HIV drug resistance during antiretroviral treatment and clinical progression in a large European cohort study
    Alessandro Cozzi-Lepri
    Research Department of Infection and Population Health, Royal Free and University College Medical School, London, UK
    AIDS 22:2187-98. 2008

Detail Information

Publications86

  1. pmc Increased HIV incidence in men who have sex with men despite high levels of ART-induced viral suppression: analysis of an extensively documented epidemic
    Andrew N Phillips
    Research Department of Infection and Population Health, UCL, London, United Kingdom
    PLoS ONE 8:e55312. 2013
    ....
  2. pmc Partners of people on ART - a New Evaluation of the Risks (The PARTNER study): design and methods
    Alison Rodger
    Research Department of Infection and Population Health, University College London, London, UK
    BMC Public Health 12:296. 2012
    ..There are no data on risk of transmission for anal sex in MSM when the index partner is on ART...
  3. doi request reprint Effect on transmission of HIV-1 resistance of timing of implementation of viral load monitoring to determine switches from first to second-line antiretroviral regimens in resource-limited settings
    Andrew N Phillips
    Department of Infection and Population Health, UCL, UK
    AIDS 25:843-50. 2011
    ..There is concern that antiretroviral therapy (ART) use with only clinical monitoring for failure will result in high rates of transmission of virus with resistance to drugs currently in use...
  4. ncbi request reprint Ongoing changes in HIV RNA levels during untreated HIV infection: implications for CD4 cell count depletion
    Andrew N Phillips
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, Royal Free Campus, UCL Royal Free Campus, London, UK
    AIDS 24:1561-7. 2010
    ..Understanding of the interplay between plasma HIV RNA level and CD4 cell count depletion in untreated infection remains incomplete...
  5. doi request reprint Are previous treatment interruptions associated with higher viral rebound rates in patients with viral suppression?
    Loveleen K Bansi
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Hampstead Campus, Rowland Hill Street, London, NW3 2PF, UK
    AIDS 22:349-56. 2008
    ..We investigated whether previous treatment interruptions are associated with a raised risk of viral rebound in individuals who have attained virological suppression...
  6. ncbi request reprint Evolution of drug resistance in HIV-infected patients remaining on a virologically failing combination antiretroviral therapy regimen
    Alessandro Cozzi-Lepri
    Royal Free and University College Medical School, London, UK
    AIDS 21:721-32. 2007
    ..To estimate the extent of drug resistance accumulation in patients kept on a virologically failing regimen and its determinants in the clinical setting...
  7. doi request reprint Stability of antiretroviral regimens in patients with viral suppression
    Rebecca K Lodwick
    Research Department of Infection and Population Health, Division of Population Health, Royal Free and University College Medical School, London, UK
    AIDS 22:1039-46. 2008
    ..To study the rate of treatment change due to toxicities in patients who achieved viral suppression within 6 months of starting antiretroviral therapy and who have never experienced virological failure...
  8. ncbi request reprint Virological rebound after suppression on highly active antiretroviral therapy
    Amanda Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 17:1741-51. 2003
    ..Treatment-naive patients were at a lower risk of rebound, but among drug-experienced patients, those who added new nucleosides had a lower risk of rebound, as were patients with a good immunological response...
  9. ncbi request reprint Short-term clinical disease progression in HIV-1-positive patients taking combination antiretroviral therapy: the EuroSIDA risk-score
    Amanda Mocroft
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 21:1867-75. 2007
    ..To derive and validate a clinically applicable prognostic score for predicting short-term disease progression in HIV-infected patients taking combination antiretroviral therapy (cART)...
  10. doi request reprint Detection of HIV drug resistance during antiretroviral treatment and clinical progression in a large European cohort study
    Alessandro Cozzi-Lepri
    Research Department of Infection and Population Health, Royal Free and University College Medical School, London, UK
    AIDS 22:2187-98. 2008
    ..To investigate the relationship between detection of HIV drug resistance by 2 years from starting antiretroviral therapy and the subsequent risk of progression to AIDS and death...
  11. ncbi request reprint Causes of death in HIV infection: the key determinant to define the clinical response to anti-HIV therapy
    Amanda Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 18:2333-7. 2004
    ..Compared with homosexual individuals, IDU had an increased incidence of new AIDS/death, but only for non-HIV deaths. There is an urgent need to define and standardize causes of death in observational studies...
  12. ncbi request reprint Relationship between antiretrovirals used as part of a cART regimen and CD4 cell count increases in patients with suppressed viremia
    Amanda Mocroft
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    AIDS 20:1141-50. 2006
    ..It is unknown if the CD4 cell count response differs according to antiretroviral drugs used in combination antiretroviral therapy (cART) in patients with maximal virological suppression [viral load (VL) < 50 copies/ml]...
  13. doi request reprint Estimated glomerular filtration rate, chronic kidney disease and antiretroviral drug use in HIV-positive patients
    Amanda Mocroft
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, Division of Population Health, University College London Medical School, Royal Free Campus, London, UK
    AIDS 24:1667-78. 2010
    ..Chronic kidney disease (CKD) in HIV-positive persons might be caused by both HIV and traditional or non-HIV-related factors. Our objective was to investigate long-term exposure to specific antiretroviral drugs and CKD...
  14. ncbi request reprint HIV-1 subtypes and response to combination antiretroviral therapy in Europe
    Wendy P Bannister
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Antivir Ther 11:707-15. 2006
    ..Antiretroviral drugs have predominantly been developed in Western Europe/North America on the basis of the most prevalent subtype, B. However, non-B subtypes are increasingly spreading worldwide...
  15. doi request reprint Estimated average annual rate of change of CD4(+) T-cell counts in patients on combination antiretroviral therapy
    Amanda Mocroft
    Research Department of Infection and Population Health, University College London Medical School, London, UK
    Antivir Ther 15:563-70. 2010
    ..Patients receiving combination antiretroviral therapy (cART) might continue treatment with a virologically failing regimen. We sought to identify annual change in CD4(+) T-cell count according to levels of viraemia in patients on cART...
  16. pmc Death rates in HIV-positive antiretroviral-naive patients with CD4 count greater than 350 cells per microL in Europe and North America: a pooled cohort observational study
    Rebecca K Lodwick
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
    Lancet 376:340-5. 2010
    ..We aimed to examine this by analysis of pooled data from industrialised countries...
  17. ncbi request reprint Risk of extensive virological failure to the three original antiretroviral drug classes over long-term follow-up from the start of therapy in patients with HIV infection: an observational cohort study
    Andrew N Phillips
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Lancet 370:1923-8. 2007
    ..We estimated the proportion of patients who had extensive triple-class failure during long-term follow-up and examined characteristics associated with an increased rate of failure...
  18. ncbi request reprint Risk of discontinuation of nevirapine due to toxicities in antiretroviral-naive and -experienced HIV-infected patients with high and low CD4+ T-cell counts
    Amanda Mocroft
    Royal Free and University College Medical School, London, UK
    Antivir Ther 12:325-33. 2007
    ....
  19. ncbi request reprint Rate of viral rebound according to specific drugs in the regimen in 2120 patients with HIV suppression
    Andrew N Phillips
    Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 18:1795-804. 2004
    ..It is currently unclear whether the tendency for viral rebound in patients with viral load < 50 copies/ml differs according to the specific drug regimen being used...
  20. ncbi request reprint Response to efavirenz-containing regimens in previously antiretroviral-naive HIV-positive patients: the role of gender
    Colette J Smith
    HIV Biostatistics and Epidemiology Group and Department of Primary Care and Population Science, Royal Free and University College Medical School, London, United Kingdom
    J Acquir Immune Defic Syndr 46:62-7. 2007
    ..We investigated the role of gender on response to efavirenz (EFV)-containing regimens in previously antiretroviral-naive patients...
  21. doi request reprint Transmitted drug resistant HIV-1 and association with virologic and CD4 cell count response to combination antiretroviral therapy in the EuroSIDA Study
    Wendy P Bannister
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    J Acquir Immune Defic Syndr 48:324-33. 2008
    ..To investigate prevalence of transmitted drug-resistant human immunodeficiency virus (TDR) and factors associated with TDR and to compare virological and CD4 count response to combination antiretroviral therapy...
  22. ncbi request reprint Are specific antiretrovirals associated with an increased risk of discontinuation due to toxicities or patient/physician choice in patients with hepatitis C virus coinfection?
    Amanda Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Antivir Ther 10:779-90. 2005
    ..Little information to address this concern is available from clinical trials as patients with HCV are often excluded...
  23. doi request reprint Discordant responses on starting highly active antiretroviral therapy: suboptimal CD4 increases despite early viral suppression in the UK Collaborative HIV Cohort (UK CHIC) Study
    R J C Gilson
    Centre for Sexual Health and HIV Research, Research Department of Infection and Population Health, University College London, The Mortimer Market Centre, Camden Primary Care Trust, London, UK
    HIV Med 11:152-60. 2010
    ..This study was designed to determine the incidence of a discordant response at two time-points, soon after 6 months and at 12 months, and to determine the relationship with clinical outcomes...
  24. doi request reprint Outcomes in the first year after initiation of first-line HAART among heterosexual men and women in the UK CHIC Study
    Tristan J Barber
    St Stephen s AIDS Trust Clinical Trials Unit, Chelsea and Westminster NHS Foundation Trust, London, UK
    Antivir Ther 16:805-14. 2011
    ..We analysed the influence of gender on use and outcomes of first-line HAART in a UK cohort...
  25. ncbi request reprint Factors influencing increases in CD4 cell counts of HIV-positive persons receiving long-term highly active antiretroviral therapy
    Colette J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Infect Dis 190:1860-8. 2004
    ..We sought to investigate the factors associated with increases in CD4 cell count among human immunodeficiency virus (HIV)-positive antiretroviral-naive patients starting HAART...
  26. ncbi request reprint Effect of transient antiretroviral treatment during acute HIV infection: comparison of the Quest trial results with CASCADE natural history study
    Fiona C Lampe
    Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, UK
    Antivir Ther 12:189-93. 2007
    ..6 years, and 17.7% (95% confidence interval [CI]: 10.9-27.6) fulfilled the primary endpoint of VL < or =1,000 copies/ml 24 weeks after CART discontinuation...
  27. doi request reprint Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapy
    Anna Maria Geretti
    Department of Virology, Royal Free Hampstead NHS Trust, London, UK
    J Acquir Immune Defic Syndr 52:569-73. 2009
    ..There are conflicting data on the impact of low-frequency transmitted drug-resistant mutants on responses to first-line highly active antiretroviral therapy (HAART)...
  28. ncbi request reprint Increased duration of viral suppression is associated with lower viral rebound rates in patients with previous treatment failures
    Andrew A Benzie
    St Mary s Hospital, London, UK
    AIDS 21:1423-30. 2007
    ....
  29. ncbi request reprint Rate of AIDS diseases or death in HIV-infected antiretroviral therapy-naive individuals with high CD4 cell count
    Andrew N Phillips
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 21:1717-21. 2007
    ..To assess the absolute rate of AIDS and death in antiretroviral therapy (ART)-naive patients with a high CD4 cell count. Such information would be helpful in the design of a trial investigating early initiation of ART...
  30. doi request reprint Late diagnosis in the HAART era: proposed common definitions and associations with mortality
    Caroline A Sabin
    Research Department of Infection and Population Health, UCL Medical School, London, UK
    AIDS 24:723-7. 2010
    ....
  31. ncbi request reprint Associations between immune depression and cardiovascular events in HIV infection
    Caroline A Sabin
    aResearch Department of Infection and Population Health, UCL, London, UK bCopenhagen HIV Programme, University of Copenhagen, Copenhagen, Denmark cDepartment of Infectious Diseases, CHU Saint Pierre Hospital, Brussels, Belgium dDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland eHospital San Paolo, University of Milan, Milan, Italy fAcademic Medical Center, and Stichting HIV Monitoring, Amsterdam, The Netherlands gICAP Columbia University Harlem Hospital, New York, USA hDépartement de Santé Publique, Centre Hospitalier Universitaire, Nice iINSERM, Centre INSERM U897 Epidémiologie et Biostatistique jUniversité Bordeaux Segalen, Institut de Santé Publique Epidémiologie Développement ISPED, Bordeaux, France kKirby Institute, University of New South Wales, Sydney, Australia lEpidemiklinikken M5132, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark See Acknowledgements section for full listing of study group
    AIDS 27:2735-48. 2013
    ....
  32. pmc CD4 counts and the risk of systemic non-Hodgkin's lymphoma in individuals with HIV in the UK
    Mark Bower
    Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    Haematologica 94:875-80. 2009
    ..Earlier highly active anti-retroviral therapy initiation and wider access to HIV testing is advocated to reduce the risk of systemic non-Hodgkin's lymphoma...
  33. doi request reprint Haemoglobin and anaemia in the SMART study
    Amanda Mocroft
    University College Medical School, London, UK
    Antivir Ther 16:329-37. 2011
    ..Data from randomized trials on the development of anaemia after interruption of therapy are not well-described...
  34. ncbi request reprint Thymidine analogue mutation profiles: factors associated with acquiring specific profiles and their impact on the virological response to therapy
    Alessandro Cozzi-Lepri
    Royal Free and University College Medical School, London, UK
    Antivir Ther 10:791-802. 2005
    ....
  35. ncbi request reprint Deaths in the era of HAART: contribution of late presentation, treatment exposure, resistance and abnormal laboratory markers
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and UC Medical School, Pond St, London, UK
    AIDS 20:67-71. 2006
    ..To describe the characteristics of deaths that occur among HIV-positive individuals in the HAART era...
  36. doi request reprint CD4 cell count and viral load-specific rates of AIDS, non-AIDS and deaths according to current antiretroviral use
    Amanda Mocroft
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, University College London, London, UK
    AIDS 27:907-18. 2013
    ..The aim of this study was to investigate the CD4 cell count and viral load-specific rates of fatal and nonfatal AIDS and non-AIDS events according to current antiretrovirals...
  37. ncbi request reprint Viral breakthrough after suppression with highly active antiretroviral therapy: experience from 233 individuals with viral loads of less than 50 copies/ml followed for up to 4 years
    Fiona C Lampe
    Royal Free Centre for HIV Medicine, London, UK
    AIDS 17:768-70. 2003
  38. doi request reprint Antiretroviral drug resistance in HIV-1-infected patients with low-level viremia
    Nicola E Mackie
    Imperial College Healthcare National Health Service Trust, London, United Kingdom
    J Infect Dis 201:1303-7. 2010
    ..7%] of 7861 tests). We conclude that HIV-1 genotypic resistance testing is informative for patients with low viral loads...
  39. ncbi request reprint The potential for CD4 cell increases in HIV-positive individuals who control viraemia with highly active antiretroviral therapy
    Colette J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, UK
    AIDS 17:963-9. 2003
    ..To study the long-term CD4 cell responses to highly active antiretroviral therapy (HAART) in treatment-naive patients whose viral loads remained below 500 copies/ml for prolonged periods...
  40. ncbi request reprint Rate of accumulation of thymidine analogue mutations in patients continuing to receive virologically failing regimens containing zidovudine or stavudine: implications for antiretroviral therapy programs in resource-limited settings
    Alessandro Cozzi-Lepri
    Research Department of Infection and Population Health, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 200:687-97. 2009
    ....
  41. ncbi request reprint Late presenters in the era of highly active antiretroviral therapy: uptake of and responses to antiretroviral therapy
    Caroline A Sabin
    Royal Free and University College Medical School, Royal Free NHS Trust, London, UK
    AIDS 18:2145-51. 2004
    ..To investigate the characteristics and clinical, immunological and virological outcomes for individuals presenting for care with low CD4 cell counts...
  42. ncbi request reprint Regional changes over time in initial virologic response rates to combination antiretroviral therapy across Europe
    Wendy P Bannister
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    J Acquir Immune Defic Syndr 42:229-37. 2006
    ..Regional variations may identify differences in available antiretroviral drugs or patient management...
  43. ncbi request reprint The changing pattern of Kaposi sarcoma in patients with HIV, 1994-2003: the EuroSIDA Study
    Amanda Mocroft
    Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, United Kingdom
    Cancer 100:2644-54. 2004
    ....
  44. ncbi request reprint Is there evidence for an increase in the death rate from liver-related disease in patients with HIV?
    Amanda Mocroft
    Royal Free Centre for HIV Medicine and Dept Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    AIDS 19:2117-25. 2005
    ..Increases in deaths due to liver-related disease (LRD) among HIV-infected individuals have been reported although the influence of combination antiretroviral therapy (cART) on LRD is controversial...
  45. pmc Can linear regression modeling help clinicians in the interpretation of genotypic resistance data? An application to derive a lopinavir-score
    Alessandro Cozzi-Lepri
    Department of Infection and Population Health, Division of Population Health, UCL Medical School, Royal Free Campus, London, United Kingdom
    PLoS ONE 6:e25665. 2011
    ....
  46. ncbi request reprint Limited but increasing use of treatment for hepatitis C across Europe in patients coinfected with HIV and hepatitis C
    Amanda Mocroft
    Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Scand J Infect Dis 38:1092-7. 2006
    ..6 - 6.1) to 32.6 per 1000 PYFU at/after 2004 (95% CI 22.5 - 42.7). Although prescription of HCV therapy is increasing in HIV-coinfected patients, it remains infrequent and variable across regions of Europe...
  47. pmc The 'Antiretrovirals, Sexual Transmission Risk and Attitudes' (ASTRA) study. Design, methods and participant characteristics
    Andrew Speakman
    Research Department of Infection and Population Health, UCL, London, United Kingdom
    PLoS ONE 8:e77230. 2013
    ..Future results from ASTRA will be a key resource for understanding HIV transmission within the UK, targeting prevention efforts, and informing clinical care of individuals living with HIV. ..
  48. doi request reprint Association between ALT level and the rate of cardio/cerebrovascular events in HIV-positive individuals: the D: A: D study
    Caroline A Sabin
    Research Department of Infection and Population Health, UCL, London, United Kingdom
    J Acquir Immune Defic Syndr 63:456-63. 2013
    ..We investigated associations between ALT levels and the risk of various cardiovascular and cerebrovascular outcomes in a large cohort study of HIV-positive individuals...
  49. pmc Cost-effectiveness of tenofovir instead of zidovudine for use in first-line antiretroviral therapy in settings without virological monitoring
    Viktor von Wyl
    Research Department of Infection and Population Health, University College London, London, United Kingdom
    PLoS ONE 7:e42834. 2012
    ..We conducted a cost-effectiveness analysis with emphasis on emerging patterns of drug resistance upon treatment failure and their impact on second-line therapy...
  50. doi request reprint Projected life expectancy of people with HIV according to timing of diagnosis
    Fumiyo Nakagawa
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, University College London, UK
    AIDS 26:335-43. 2012
    ..Our aims were to estimate the life expectancy of an HIV-infected MSM living in a developed country with extensive access to ART and healthcare, and to assess the effect of late diagnosis on life expectancy...
  51. ncbi request reprint CD4 cell count changes in individuals with counts above 500 cells/mm and viral loads below 50 copies/ml on antiretroviral therapy
    Andrew N Phillips
    Royal Free Centre for HIV Medicine, London, UK
    AIDS 16:1073-5. 2002
  52. ncbi request reprint Decline in esophageal candidiasis and use of antimycotics in European patients with HIV
    Amanda Mocroft
    Royal Free Centre for HIV Medicine and Dept Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    Am J Gastroenterol 100:1446-54. 2005
    ....
  53. ncbi request reprint Changes in viral load in people with virological failure who remain on the same HAART regimen
    Alessandro Cozzi-Lepri
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, UK
    Antivir Ther 8:127-36. 2003
    ..To assess the rate of change in viral load and CD4 count over time in HIV-infected patients experiencing virological failure on a HAART regimen...
  54. doi request reprint Long-term trends in adherence to antiretroviral therapy from start of HAART
    Valentina Cambiano
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
    AIDS 24:1153-62. 2010
    ..We aimed to investigate long-term trends in highly active antiretroviral therapy (HAART) adherence to identify the main predictors and to evaluate whether participants experience periods of low adherence (<or=60%)...
  55. doi request reprint HIV-associated central nervous system diseases in the recent combination antiretroviral therapy era
    Lucy Garvey
    Clinical Trials Centre, Winston Churchill Wing, St Mary s Hospital, London, W2 1NY, UK
    Eur J Neurol 18:527-34. 2011
    ..Data describing the incidence and survival of HIV-related central nervous system diseases (CNS-D) in recent years are sparse...
  56. ncbi request reprint The relationship between CD4 cell count nadirs and the toxicity profiles of antiretroviral regimens
    J Smith Colette
    Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Hospital, London, UK
    Antivir Ther 10:459-67. 2005
    ..We investigated the relationship between the pre-HAART CD4 count nadir, HAART and the occurrence of laboratory-defined toxicities...
  57. ncbi request reprint Markers of HIV-1 disease progression in individuals with haemophilia coinfected with hepatitis C virus: a longitudinal study
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, UK
    Lancet 360:1546-51. 2002
    ..We aimed to assess the relation between markers of liver function and progression to AIDS and death in individuals with haemophilia infected with HIV-1 and hepatitis C virus...
  58. ncbi request reprint The rate of viral rebound after attainment of an HIV load <50 copies/mL according to specific antiretroviral drugs in use: results from a multicenter cohort study
    Colette J Smith
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 192:1387-97. 2005
    ....
  59. ncbi request reprint Impact of therapeutic immunization on HIV-1 viremia after discontinuation of antiretroviral therapy initiated during acute infection
    Sabine Kinloch-de Loes
    Department of Medicine, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 192:607-17. 2005
    ..Our trial design appears to be feasible and safe for testing future immune-boosting strategies...
  60. ncbi request reprint Use of viral load measured after 4 weeks of highly active antiretroviral therapy to predict virologic outcome at 24 weeks for HIV-1-positive individuals
    Colette J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Acquir Immune Defic Syndr 37:1155-9. 2004
    ..We suggest that this group of patients should be particularly closely monitored...
  61. ncbi request reprint Physical and psychological symptoms and risk of virologic rebound among patients with virologic suppression on antiretroviral therapy
    Fiona C Lampe
    Department of Infection and Population Health, University College London Medical School, London, UK
    J Acquir Immune Defic Syndr 54:500-5. 2010
    ..We examined the association of self-reported physical and psychological symptoms with subsequent virologic rebound among patients with viral suppression on combination antiretroviral therapy (cART)...
  62. doi request reprint Outcomes from monitoring of patients on antiretroviral therapy in resource-limited settings with viral load, CD4 cell count, or clinical observation alone: a computer simulation model
    Andrew N Phillips
    HIV Epidemiology and Biostatistics Group, Department of Primary Care and Population Sciences, and Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, University College London, London, UK
    Lancet 371:1443-51. 2008
    ..Our aim was to study the potential consequences of such monitoring strategies, especially in terms of survival and resistance development...
  63. ncbi request reprint Interruption of antiretroviral therapy and risk of cardiovascular disease in persons with HIV-1 infection: exploratory analyses from the SMART trial
    Andrew N Phillips
    Department of Primary Care and Population Sciences, Royal Free University College Medical School, London, UK
    Antivir Ther 13:177-87. 2008
    ..Exploratory analyses were performed to better understand the reasons for this observation...
  64. doi request reprint The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapy
    C A Sabin
    Department of Primary Care and Population Science, Royal Free and UC Medical School, London, UK
    HIV Med 10:35-43. 2009
    ....
  65. ncbi request reprint Virologic, immunologic, and clinical response to highly active antiretroviral therapy: the gender issue revisited
    Antonia L Moore
    Department of Primary Care and Population Sciences, Royal free and University College School fo Medicine, Hampstead, London, UK
    J Acquir Immune Defic Syndr 32:452-61. 2003
    ..Highly active antiretroviral therapy (HAART) has dramatically improved the prognosis for patients with HIV. There is ongoing debate over a potential gender effect on patient outcome after HAART...
  66. doi request reprint Plasma HIV-1 RNA detection below 50 copies/ml and risk of virologic rebound in patients receiving highly active antiretroviral therapy
    Tomas Doyle
    Department of Virology, Royal Free Hampstead NHS Trust, and Department of Virology, UCL Medical School, London, United Kingdom
    Clin Infect Dis 54:724-32. 2012
    ..Current viral load (VL) assays show increased sensitivity, but the significance of RNA detection <50 copies/mL is unclear...
  67. pmc HIV treatment as prevention: systematic comparison of mathematical models of the potential impact of antiretroviral therapy on HIV incidence in South Africa
    Jeffrey W Eaton
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS Med 9:e1001245. 2012
    ..This study compares the predictions of several mathematical models simulating the same ART intervention programmes to determine the extent to which models agree about the epidemiological impact of expanded ART...
  68. ncbi request reprint Gender and clinical outcomes after starting highly active antiretroviral treatment: a cohort study
    Antonia L Moore
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Hampstead, London, UK
    J Acquir Immune Defic Syndr 29:197-202. 2002
    ..To examine gender differences in clinical response to highly active antiretroviral treatment (HAART)...
  69. ncbi request reprint Should HIV therapy be started at a CD4 cell count above 350 cells/microl in asymptomatic HIV-1-infected patients?
    Caroline A Sabin
    Research Department of Infection and Population Health, Division of Population Health, UCL Medical School, University College London, Royal Free Campus, Rowland Hill Street, London, UK
    Curr Opin Infect Dis 22:191-7. 2009
    ..The aim is to review the available data that contribute to the debate on the optimal time to initiate highly active antiretroviral therapy (HAART) in HIV-infected individuals with a CD4 cell count more than 350 cells/microl...
  70. pmc Changes in lipids and lipoprotein particle concentrations after interruption of antiretroviral therapy
    Fiona C Lampe
    Research Department of Infection and Population Health, University College London, London, United Kingdom
    J Acquir Immune Defic Syndr 54:275-84. 2010
    ..We examined short-term changes in lipids and lipoprotein particles among 332 HIV-infected individuals randomized to interrupt or continue ART in the "Strategies for Management of Antiretroviral Therapy" trial...
  71. doi request reprint 'Test-and-treat': the end of the HIV epidemic?
    Valentina Cambiano
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, London, UK
    Curr Opin Infect Dis 24:19-26. 2011
    ..Antiretroviral therapy (ART) has been shown to dramatically reduce viral load which is strongly associated with the risk of transmission, therefore there is the potential to reduce HIV transmissions with ART...
  72. ncbi request reprint Virologic and immunologic response to regimens containing nevirapine or efavirenz in combination with 2 nucleoside analogues in the Italian Cohort Naive Antiretrovirals (I.Co.N.A.) study
    Alessandro Cozzi-Lepri
    Royal Free Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    J Infect Dis 185:1062-9. 2002
    ..The findings of this study are in agreement with those of other observational studies...
  73. pmc Twenty five years of HIV infection in haemophilic men in Britain: an observational study
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and UC Medical School, London NW3 2PF
    BMJ 331:997-8. 2005
  74. ncbi request reprint Success of clinical care for human immunodeficiency virus infection according to demographic group among sexually infected patients in a routine clinic population, 1999 to 2004
    Fiona C Lampe
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Hospital, Rowland Hill Street, London, England
    Arch Intern Med 167:692-700. 2007
    ..The success of clinical care for human immunodeficiency virus infection may vary across demographic groups, because of patient- and health care-related factors...
  75. ncbi request reprint Raised viral load in patients with viral suppression on highly active antiretroviral therapy: transient increase or treatment failure?
    Antonia L Moore
    Department of Primary Care and Population Sciences and Centre for HIV Medicine, Royal Free and University College School of Medicine, Hampstead, London NW3 2PF, UK
    AIDS 16:615-8. 2002
    ....
  76. ncbi request reprint Predictors of CD4 count change over 8 months of follow up in HIV-1-infected patients with a CD4 count>or=300 cells/microL who were assigned to 7.5 MIU interleukin-2
    Zoe Fox
    Hvidovre University Hospital, DK 2650 Hvidovre, Denmark
    HIV Med 8:112-23. 2007
    ..The IL-2 induction phase consists of three dosing cycles over 6-8 months (7.5 MIU twice a day, for 5 days every 8 weeks)...
  77. ncbi request reprint Theoretical rationale for the use of sequential single-drug antiretroviral therapy for treatment of HIV infection
    Andrew N Phillips
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    AIDS 17:1009-16. 2003
    ..We aimed to explore the use of sequential monotherapy regimens using a mathematical model of quasi-species dynamics, to see if these could take advantage of the poor replicative capacity of highly resistant virus...
  78. ncbi request reprint Changes over time in risk of initial virological failure of combination antiretroviral therapy: a multicohort analysis, 1996 to 2002
    Fiona C Lampe
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, England
    Arch Intern Med 166:521-8. 2006
    ..We examined risk of initial virological failure of CART according to the year of starting therapy...
  79. pmc Treatment exhaustion of highly active antiretroviral therapy (HAART) among individuals infected with HIV in the United Kingdom: multicentre cohort study
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and UC Medical School, London NW3 2PF
    BMJ 330:695. 2005
    ....
  80. ncbi request reprint A comparison between abacavir and efavirenz as the third drug used in combination with a background therapy regimen of 2 nucleoside reverse-transcriptase inhibitors in patients with initially suppressed viral loads
    Alessandro Cozzi-Lepri
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, University College London, United Kingdom
    J Infect Dis 194:20-8. 2006
    ....
  81. ncbi request reprint The ability of four genotypic interpretation systems to predict virological response to ritonavir-boosted protease inhibitors
    Zoe V Fox
    Copenhagen HIV Programme, Medical Faculty at University of Copenhagen, Denmark
    AIDS 21:2033-42. 2007
    ..We compared PI/r resistance levels ascribed by four GIS and examined their abilities to predict HIV-RNA reductions after starting a PI/r-based regimen (baseline)...
  82. ncbi request reprint Human immunodeficiency virus rebound after suppression to <400 copies/mL during initial highly active antiretroviral therapy regimens, according to prior nucleoside experience and duration of suppression
    Andrew N Phillips
    Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, United Kingdom
    J Infect Dis 186:1086-91. 2002
    ..95; P=.009). It appears that only a small period of pre-HAART nucleoside therapy is sufficient to confer a disadvantage, in terms of risk of virus rebound, that persists for several years...
  83. pmc When should antiretroviral therapy for HIV be started?
    Andrew N Phillips
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London NW3 2PF
    BMJ 334:76-8. 2007
  84. pmc Activation and coagulation biomarkers are independent predictors of the development of opportunistic disease in patients with HIV infection
    Alison J Rodger
    HIV Epidemiology and Biostatistics Group, Research Dept of Infection and Population Health, UCL Medical School, University College London, London, UK
    J Infect Dis 200:973-83. 2009
    ..Their associations with opportunistic disease (OD) in human immunodeficiency virus (HIV)-positive patients were examined...
  85. doi request reprint Modelling the impact of treatment with individual antiretrovirals
    Valentina Cambiano
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, London, UK
    Curr Opin HIV AIDS 6:124-30. 2011
    ..The focus of our attention is models which explicitly model specific effects of individual antiretroviral drugs...
  86. ncbi request reprint Virological suppression at 6 months is related to choice of initial regimen in antiretroviral-naive patients: a cohort study
    Gail V Matthews
    Department of HIV Medicine, Chelsea Hospital, London, UK
    AIDS 16:53-61. 2002
    ....