Clive J Petry

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Suckling a protein-restricted rat dam leads to diminished albuminuria in her male offspring in adult life: a longitudinal study
    Clive J Petry
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    BMC Nephrol 7:14. 2006
  2. ncbi Lack of association between common polymorphisms in the 17beta-hydroxysteroid dehydrogenase type V gene (HSD17B5) and precocious pubarche
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge CB2 2QQ, UK
    J Steroid Biochem Mol Biol 105:176-80. 2007
  3. ncbi Does the fetal genotype affect maternal physiology during pregnancy?
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK
    Trends Mol Med 13:414-21. 2007
  4. pmc Common polymorphic variation in the genetically diverse African insulin gene and its association with size at birth
    Clive J Petry
    Department of Paediatrics, Box 116, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK
    Hum Genet 126:375-84. 2009
  5. pmc Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19delta13
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, U K
    Diabetes 59:282-6. 2010
  6. doi Gestational diabetes: risk factors and recent advances in its genetics and treatment
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Br J Nutr 104:775-87. 2010
  7. pmc Diabetes in old male offspring of rat dams fed a reduced protein diet
    C J Petry
    Clinical Biochemistry Department, University of Cambridge, Addenbrooke s Hospital, UK
    Int J Exp Diabetes Res 2:139-43. 2001
  8. pmc Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrations
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Exp Diabetes Res 2011:171376. 2011
  9. doi Maternally transmitted foetal H19 variants and associations with birth weight
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Hum Genet 130:663-70. 2011
  10. ncbi Effects of early protein restriction and adult obesity on rat pancreatic hormone content and glucose tolerance
    C J Petry
    Clinical Biochemistry Dept, University of Cambridge, UK
    Horm Metab Res 32:233-9. 2000

Collaborators

Detail Information

Publications39

  1. pmc Suckling a protein-restricted rat dam leads to diminished albuminuria in her male offspring in adult life: a longitudinal study
    Clive J Petry
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    BMC Nephrol 7:14. 2006
    ..This study monitored albuminuria longitudinally in male rats whose mothers had been protein restricted either during pregnancy or lactation...
  2. ncbi Lack of association between common polymorphisms in the 17beta-hydroxysteroid dehydrogenase type V gene (HSD17B5) and precocious pubarche
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge CB2 2QQ, UK
    J Steroid Biochem Mol Biol 105:176-80. 2007
    ..Precocious pubarche (PP) is a clinical entity pointing to adrenal androgen excess from mid-childhood onward and is associated with ovarian androgen excess from puberty onward. It is therefore a strong risk factor for PCOS...
  3. ncbi Does the fetal genotype affect maternal physiology during pregnancy?
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK
    Trends Mol Med 13:414-21. 2007
    ..We propose that this mechanism is involved in the aetiology of PIH and GDM...
  4. pmc Common polymorphic variation in the genetically diverse African insulin gene and its association with size at birth
    Clive J Petry
    Department of Paediatrics, Box 116, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK
    Hum Genet 126:375-84. 2009
    ....
  5. pmc Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19delta13
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, U K
    Diabetes 59:282-6. 2010
    ..To test this hypothesis we evaluated the effects of fetal disruption of murine H19(Delta13) on maternal glucose concentrations in pregnancy...
  6. doi Gestational diabetes: risk factors and recent advances in its genetics and treatment
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Br J Nutr 104:775-87. 2010
    ....
  7. pmc Diabetes in old male offspring of rat dams fed a reduced protein diet
    C J Petry
    Clinical Biochemistry Department, University of Cambridge, Addenbrooke s Hospital, UK
    Int J Exp Diabetes Res 2:139-43. 2001
    ..These results show that early growth retardation due to maternal protein restriction leads to the development of diabetes in old male rat offspring. The diabetes is predominantly associated with insulin resistance...
  8. pmc Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrations
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Exp Diabetes Res 2011:171376. 2011
    ..0 ± 9.1% of control values; P = .9) or e18 (91.4 ± 13.4%; P = .3), suggesting that effects on transplacental glucose transport in these mice are not mediated through changes in maternal glucose concentrations...
  9. doi Maternally transmitted foetal H19 variants and associations with birth weight
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Hum Genet 130:663-70. 2011
    ..Polymorphic variation in H19 is not associated with significant changes in maternal glucose tolerance in the third trimester of pregnancy...
  10. ncbi Effects of early protein restriction and adult obesity on rat pancreatic hormone content and glucose tolerance
    C J Petry
    Clinical Biochemistry Dept, University of Cambridge, UK
    Horm Metab Res 32:233-9. 2000
    ..These results are consistent with pancreatic beta- and alpha-cells being selectively susceptible to effects associated with early dietary protein restriction...
  11. pmc Associations between paternally transmitted fetal IGF2 variants and maternal circulating glucose concentrations in pregnancy
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Diabetes 60:3090-6. 2011
    ..To test the hypothesis that polymorphic variation in the paternally transmitted fetal IGF2 gene is associated with maternal glucose concentrations in the third trimester of pregnancy...
  12. ncbi Catecholamine levels and receptor expression in low protein rat offspring
    C J Petry
    Clinical Biochemistry Department, University of Cambridge, UK
    Diabet Med 17:848-53. 2000
    ..The hypothesis that early growth restriction is associated with permanent alterations in catecholamine metabolism was tested...
  13. ncbi Long-term effects on offspring of intrauterine exposure to deficits in nutrition
    C J Petry
    Clinical Biochemistry Department, University of Cambridge, UK
    Hum Reprod Update 6:578-86. 2000
    ..This review discusses the various mechanisms by which these effects may occur, and presents the difficulties that will have to be faced if their world-wide health burdens are to be reduced...
  14. pmc Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital Level 8, Box 116, Cambridge CB2 2QQ, UK
    BMC Genet 6:22. 2005
    ....
  15. ncbi Opposing influences of prenatal and postnatal weight gain on adrenarche in normal boys and girls
    Ken K Ong
    Department of Pediatrics, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    J Clin Endocrinol Metab 89:2647-51. 2004
    ..We suggest that higher adrenal androgen secretion could contribute to links between early growth and adult disease risks, possibly by enhancing insulin resistance and central fat deposition...
  16. ncbi Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood height
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Growth Horm IGF Res 15:363-8. 2005
    ..We hypothesised that polymorphisms in the IGF2R gene could alter size at birth and childhood growth...
  17. ncbi Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain
    Ken K Ong
    Department of Pediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 53:1128-33. 2004
    ..Our results indicate that complex prenatal and postnatal gene-maternal/fetal interactions influence size at birth and childhood risk factors for adult disease...
  18. ncbi Depot-specific effects of early growth retardation on adipocyte insulin action
    S E Ozanne
    Department of Clinical Biochemistry, University of Cambridge, UK
    Horm Metab Res 32:71-5. 2000
    ..These results suggest that certain changes associated with early growth retardation are depot-specific, being enhanced in the more metabolically active intra-abdominal and epididymal tissues...
  19. doi Association between a common variant near MC4R and change in body mass index develops by two weeks of age
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Cambridge, UK
    Horm Res Paediatr 73:275-80. 2010
    ..Our objective was to test the association between rs17782313 and neonatal weight gain in a contemporary population...
  20. ncbi Early growth restriction, membrane phospholipid fatty acid composition, and insulin sensitivity
    C L Loizou
    Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Cambridge, England
    Metabolism 50:1070-7. 2001
    ..This reduction in 22:6n-3 is similar to that observed in Pima Indians, a population with a high prevalence of type 2 diabetes...
  21. pmc Ghrelin receptor gene polymorphisms and body size in children and adults
    Edwin A Garcia
    Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    J Clin Endocrinol Metab 93:4158-61. 2008
    ..Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth...
  22. doi Genetics of size at birth
    David B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Box 116, Level 8, Hills Road, Cambridge CB2 2QQ, U K
    Diabetes Care 30:S150-5. 2007
  23. ncbi Long-term programming of blood pressure by maternal dietary iron restriction in the rat
    Rohan M Lewis
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, CB2 2QR, UK
    Br J Nutr 88:283-90. 2002
    ..Both cardiac hypertrophy and decreased serum triacylglycerol have also been observed in Fe-restricted fetuses, suggesting that these changes may be initiated in utero...
  24. ncbi Associations between common variation in the aromatase gene promoter region and testosterone concentrations in two young female populations
    Clive J Petry
    Department of Paediatrics, University of Cambridge, UK
    J Steroid Biochem Mol Biol 98:199-206. 2006
    ..The variable associations with androgen-related clinical features could possibly reflect the tissue-specific promoters of the aromatase gene...
  25. ncbi Maternal low-protein diet programs cardiac beta-adrenergic response and signaling in 3-mo-old male offspring
    Denise S Fernandez-Twinn
    Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge, UK
    Am J Physiol Regul Integr Comp Physiol 291:R429-36. 2006
    ..012). LP offspring have reduced beta-adrenergic responsiveness and attenuated adrenergic and insulin signaling, suggesting that intrauterine undernutrition alters heart failure risk...
  26. ncbi Sex-discordant associations with adiponectin levels and lipid profiles in children
    Ken K Ong
    MRC Epidemiology Unit, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, U K
    Diabetes 55:1337-41. 2006
    ..Our data suggest a complex age- and sex-related regulation of adiponectin secretion or clearance...
  27. ncbi Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspring
    R M Lewis
    Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
    Metabolism 50:562-7. 2001
    ..It is thus speculated that the long-term effects of maternal dietary restriction may result from common fetal metabolic responses to this restriction...
  28. ncbi Early growth restriction leads to down regulation of protein kinase C zeta and insulin resistance in skeletal muscle
    S E Ozanne
    Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 2QR, UK
    J Endocrinol 177:235-41. 2003
    ..These results suggest that maternal protein restriction leads to muscle insulin resistance. Reduced expression of PKC zeta may contribute to the mechanistic basis of this resistance...
  29. ncbi Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levels
    K K Ong
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, Level 8, Box 116, Cambridge CB2 2QQ, UK
    Diabetologia 47:1064-70. 2004
    ..The largest variations in growth rates occur during the first postnatal years. We hypothesised that early postnatal variations in height and weight gain and IGF-I levels may be associated with risk markers for adult disease...
  30. ncbi Genetic variations and normal fetal growth
    D B Dunger
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, UK
    Horm Res 65:34-40. 2006
    ..This suggests that fetal genes, and in particular paternally expressed genes, may have significant effects on fetal growth during pregnancies where maternal restraint of fetal growth is less evident...
  31. ncbi Effect of maternal iron restriction during pregnancy on renal morphology in the adult rat offspring
    S J M Lisle
    Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
    Br J Nutr 90:33-9. 2003
    ..42, n 28, P<0.05) and 16 months of age (r-0.64, n 28, P<0.05). Therefore, in rats, maternal Fe restriction causes hypertension in the adult offspring that may be due, in part, to a deficit in nephron number...
  32. ncbi Programming of intermediary metabolism
    C J Petry
    Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 2QR, UK
    Mol Cell Endocrinol 185:81-91. 2001
    ..Alterations in intermediary metabolism were noted in the rats with early growth restriction, which provide support for our hypothesis and clues to the mechanism...
  33. ncbi The potential impact of the fetal genotype on maternal blood pressure during pregnancy
    Clive J Petry
    aDepartment of Paediatrics, University of Cambridge bNeonatal Unit, Cambridge University Hospitals NHS Foundation Trust cMedical Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK
    J Hypertens 32:1553-61. 2014
    ..This article reviews the current state of knowledge linking the fetal genotype with maternal blood pressure in pregnancy. ..
  34. ncbi Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R gene
    Yumiko Okubo
    Departments of Pediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Clin Endocrinol Metab 88:5981-8. 2003
    ..Our data are consistent with the concept that IGF1R gene copy number is of functional and clinical importance in humans...
  35. ncbi Association of aromatase (CYP 19) gene variation with features of hyperandrogenism in two populations of young women
    C J Petry
    Department of Paediatrics, University of Cambridge, Cambridge CB2 2QQ, UK
    Hum Reprod 20:1837-43. 2005
    ..Aromatase catalyses the conversion of androgens to estrogens and thus variation in the aromatase gene could contribute to female syndromes of androgen excess, such as precocious pubarche (PP) and polycystic ovarian syndrome (PCOS)...
  36. ncbi Insulin resistance after precocious pubarche: relation to PAI-1-675 4G/5G polymorphism, and opposing influences of prenatal and postnatal weight gain
    Abel Lopez-Bermejo
    Diabetes, Endocrinology and Nutrition Unit, Dr Josep Trueta Hospital, Girona, Spain
    Clin Endocrinol (Oxf) 67:493-9. 2007
    ..We hypothesized that this polymorphism is associated with precocious pubarche (PP), a population known to be at risk for hyperinsulinaemic hyperandrogenism...
  37. ncbi The insulin gene variable number of tandem repeat: associations and interactions with childhood body fat mass and insulin secretion in normal children
    Barbara Heude
    Medical Research Council Epidemiology Unit, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, United Kingdom
    J Clin Endocrinol Metab 91:2770-5. 2006
    ..Polymorphism at the insulin gene (INS) variable number of tandem repeat (VNTR) shows variable associations with childhood body mass index (BMI) in different populations...
  38. ncbi Fetal programming of perivenous glucose uptake reveals a regulatory mechanism governing hepatic glucose output during refeeding
    Helena C Murphy
    Department of Diabetes and Metabolic Medicine, St Bart s and the London School of Medicine and Dentistry, Queen Mary University of London, Mile End, London E1 4NS, U K
    Diabetes 52:1326-32. 2003
    ..The results are pertinent to impaired regulation of hepatic glucose output in type 2 diabetes, which could arise from diminished GK-mediated glucose uptake rather than increased gluconeogenesis...
  39. doi The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks
    Abel Lopez-Bermejo
    Diabetes, Endocrinology and Nutrition Unit, Dr Josep Trueta Hospital, 17007 Girona, Spain
    J Clin Endocrinol Metab 93:1501-5. 2008
    ..Little is known about the genetic determinants of fat mass around birth. We hypothesized that the common rs9939609 single-nucleotide polymorphism (SNP) in FTO is associated with fat mass and metabolic parameters in neonates...