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Genomes and Genes | Clive J PetrySummaryAffiliation: University of Cambridge Country: UK Publications
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Associations between paternally transmitted fetal IGF2 variants and maternal circulating glucose concentrations in pregnancyClive J Petry
Department of Paediatrics, University of Cambridge, Cambridge, UK
Diabetes 60:3090-6. 2011..To test the hypothesis that polymorphic variation in the paternally transmitted fetal IGF2 gene is associated with maternal glucose concentrations in the third trimester of pregnancy...- Suckling a protein-restricted rat dam leads to diminished albuminuria in her male offspring in adult life: a longitudinal studyClive J Petry
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
BMC Nephrol 7:14. 2006..This study monitored albuminuria longitudinally in male rats whose mothers had been protein restricted either during pregnancy or lactation... 
Lack of association between common polymorphisms in the 17beta-hydroxysteroid dehydrogenase type V gene (HSD17B5) and precocious pubarcheClive J Petry
Department of Paediatrics, University of Cambridge, Cambridge CB2 2QQ, UK
J Steroid Biochem Mol Biol 105:176-80. 2007..Precocious pubarche (PP) is a clinical entity pointing to adrenal androgen excess from mid-childhood onward and is associated with ovarian androgen excess from puberty onward. It is therefore a strong risk factor for PCOS...- Does the fetal genotype affect maternal physiology during pregnancy?Clive J Petry
Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK
Trends Mol Med 13:414-21. 2007..We propose that this mechanism is involved in the aetiology of PIH and GDM... - Common polymorphic variation in the genetically diverse African insulin gene and its association with size at birthClive J Petry
Department of Paediatrics, Box 116, Addenbrooke s Hospital, University of Cambridge, Hills Road, Cambridge, CB2 0QQ, UK
Hum Genet 126:375-84. 2009.... - Diabetes in old male offspring of rat dams fed a reduced protein dietC J Petry
Clinical Biochemistry Department, University of Cambridge, Addenbrooke s Hospital, UK
Int J Exp Diabetes Res 2:139-43. 2001..These results show that early growth retardation due to maternal protein restriction leads to the development of diabetes in old male rat offspring. The diabetes is predominantly associated with insulin resistance... - Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19delta13Clive J Petry
Department of Paediatrics, University of Cambridge, Cambridge, U K
Diabetes 59:282-6. 2010..To test this hypothesis we evaluated the effects of fetal disruption of murine H19(Delta13) on maternal glucose concentrations in pregnancy... 
Gestational diabetes: risk factors and recent advances in its genetics and treatmentClive J Petry
Department of Paediatrics, University of Cambridge, Cambridge, UK
Br J Nutr 104:775-87. 2010....- Effects of early protein restriction and adult obesity on rat pancreatic hormone content and glucose toleranceC J Petry
Clinical Biochemistry Dept, University of Cambridge, UK
Horm Metab Res 32:233-9. 2000..These results are consistent with pancreatic beta- and alpha-cells being selectively susceptible to effects associated with early dietary protein restriction... - Long-term effects on offspring of intrauterine exposure to deficits in nutritionC J Petry
Clinical Biochemistry Department, University of Cambridge, UK
Hum Reprod Update 6:578-86. 2000..This review discusses the various mechanisms by which these effects may occur, and presents the difficulties that will have to be faced if their world-wide health burdens are to be reduced... - Catecholamine levels and receptor expression in low protein rat offspringC J Petry
Clinical Biochemistry Department, University of Cambridge, UK
Diabet Med 17:848-53. 2000..The hypothesis that early growth restriction is associated with permanent alterations in catecholamine metabolism was tested... - Maternally transmitted foetal H19 variants and associations with birth weightClive J Petry
Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
Hum Genet 130:663-70. 2011..Polymorphic variation in H19 is not associated with significant changes in maternal glucose tolerance in the third trimester of pregnancy... - Increased placental glucose transport rates in pregnant mice carrying fetuses with targeted disruption of their placental-specific Igf2 transcripts are not associated with raised circulating glucose concentrationsClive J Petry
Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
Exp Diabetes Res 2011:171376. 2011..0 ± 9.1% of control values; P = .9) or e18 (91.4 ± 13.4%; P = .3), suggesting that effects on transplacental glucose transport in these mice are not mediated through changes in maternal glucose concentrations... - Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humansClive J Petry
Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital Level 8, Box 116, Cambridge CB2 2QQ, UK
BMC Genet 6:22. 2005.... - Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood heightClive J Petry
Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
Growth Horm IGF Res 15:363-8. 2005..We hypothesised that polymorphisms in the IGF2R gene could alter size at birth and childhood growth... - Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gainKen K Ong
Department of Pediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Diabetes 53:1128-33. 2004..Our results indicate that complex prenatal and postnatal gene-maternal/fetal interactions influence size at birth and childhood risk factors for adult disease... - Opposing influences of prenatal and postnatal weight gain on adrenarche in normal boys and girlsKen K Ong
Department of Pediatrics, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
J Clin Endocrinol Metab 89:2647-51. 2004..We suggest that higher adrenal androgen secretion could contribute to links between early growth and adult disease risks, possibly by enhancing insulin resistance and central fat deposition... - Depot-specific effects of early growth retardation on adipocyte insulin actionS E Ozanne
Department of Clinical Biochemistry, University of Cambridge, UK
Horm Metab Res 32:71-5. 2000..These results suggest that certain changes associated with early growth retardation are depot-specific, being enhanced in the more metabolically active intra-abdominal and epididymal tissues... - Association between a common variant near MC4R and change in body mass index develops by two weeks of ageClive J Petry
Department of Paediatrics, University of Cambridge, Cambridge, UK
Horm Res Paediatr 73:275-80. 2010..Our objective was to test the association between rs17782313 and neonatal weight gain in a contemporary population... - Early growth restriction, membrane phospholipid fatty acid composition, and insulin sensitivityC L Loizou
Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Cambridge, England
Metabolism 50:1070-7. 2001..This reduction in 22:6n-3 is similar to that observed in Pima Indians, a population with a high prevalence of type 2 diabetes... - Ghrelin receptor gene polymorphisms and body size in children and adultsEdwin A Garcia
Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
J Clin Endocrinol Metab 93:4158-61. 2008..Previous studies in U.S. families and a German population suggested GHSR to be a candidate quantitative locus for association with human obesity and growth... - Genetics of size at birthDavid B Dunger
Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Box 116, Level 8, Hills Road, Cambridge CB2 2QQ, U.K
Diabetes Care 30:S150-5. 2007 - Associations between common variation in the aromatase gene promoter region and testosterone concentrations in two young female populationsClive J Petry
Department of Paediatrics, University of Cambridge, UK
J Steroid Biochem Mol Biol 98:199-206. 2006..The variable associations with androgen-related clinical features could possibly reflect the tissue-specific promoters of the aromatase gene... - Long-term programming of blood pressure by maternal dietary iron restriction in the ratRohan M Lewis
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, CB2 2QR, UK
Br J Nutr 88:283-90. 2002..Both cardiac hypertrophy and decreased serum triacylglycerol have also been observed in Fe-restricted fetuses, suggesting that these changes may be initiated in utero... - Maternal low-protein diet programs cardiac beta-adrenergic response and signaling in 3-mo-old male offspringDenise S Fernandez-Twinn
Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge, UK
Am J Physiol Regul Integr Comp Physiol 291:R429-36. 2006..012). LP offspring have reduced beta-adrenergic responsiveness and attenuated adrenergic and insulin signaling, suggesting that intrauterine undernutrition alters heart failure risk... - Sex-discordant associations with adiponectin levels and lipid profiles in childrenKen K Ong
MRC Epidemiology Unit, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, U K
Diabetes 55:1337-41. 2006..Our data suggest a complex age- and sex-related regulation of adiponectin secretion or clearance... - Genetic variations and normal fetal growthD B Dunger
Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital, UK
Horm Res 65:34-40. 2006..This suggests that fetal genes, and in particular paternally expressed genes, may have significant effects on fetal growth during pregnancies where maternal restraint of fetal growth is less evident... - Effects of maternal iron restriction in the rat on blood pressure, glucose tolerance, and serum lipids in the 3-month-old offspringR M Lewis
Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK
Metabolism 50:562-7. 2001..It is thus speculated that the long-term effects of maternal dietary restriction may result from common fetal metabolic responses to this restriction... - Insulin sensitivity and secretion in normal children related to size at birth, postnatal growth, and plasma insulin-like growth factor-I levelsK K Ong
Department of Paediatrics, University of Cambridge, Addenbrooke's Hospital, Level 8, Box 116, Cambridge CB2 2QQ, UK
Diabetologia 47:1064-70. 2004..However, irrespective of postnatal weight gain, smaller size at birth, lower IGF-I levels and lower childhood height predicted reduced compensatory insulin secretion... - Early growth restriction leads to down regulation of protein kinase C zeta and insulin resistance in skeletal muscleS E Ozanne
Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 2QR, UK
J Endocrinol 177:235-41. 2003..These results suggest that maternal protein restriction leads to muscle insulin resistance. Reduced expression of PKC zeta may contribute to the mechanistic basis of this resistance... - Effect of maternal iron restriction during pregnancy on renal morphology in the adult rat offspringS J M Lisle
Department of Physiology, University of Cambridge, Downing Street, Cambridge CB2 3EG, UK
Br J Nutr 90:33-9. 2003..42, n 28, P<0.05) and 16 months of age (r-0.64, n 28, P<0.05). Therefore, in rats, maternal Fe restriction causes hypertension in the adult offspring that may be due, in part, to a deficit in nephron number... - Programming of intermediary metabolismC J Petry
Department of Clinical Biochemistry, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 2QR, UK
Mol Cell Endocrinol 185:81-91. 2001..Alterations in intermediary metabolism were noted in the rats with early growth restriction, which provide support for our hypothesis and clues to the mechanism... - Cell proliferation activities on skin fibroblasts from a short child with absence of one copy of the type 1 insulin-like growth factor receptor (IGF1R) gene and a tall child with three copies of the IGF1R geneYumiko Okubo
Departments of Pediatrics, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, United Kingdom
J Clin Endocrinol Metab 88:5981-8. 2003..Our data are consistent with the concept that IGF1R gene copy number is of functional and clinical importance in humans... - Association of aromatase (CYP 19) gene variation with features of hyperandrogenism in two populations of young womenC J Petry
Department of Paediatrics, University of Cambridge, Cambridge CB2 2QQ, UK
Hum Reprod 20:1837-43. 2005..Aromatase catalyses the conversion of androgens to estrogens and thus variation in the aromatase gene could contribute to female syndromes of androgen excess, such as precocious pubarche (PP) and polycystic ovarian syndrome (PCOS)... - Insulin resistance after precocious pubarche: relation to PAI-1-675 4G/5G polymorphism, and opposing influences of prenatal and postnatal weight gainAbel Lopez-Bermejo
Diabetes, Endocrinology and Nutrition Unit, Dr Josep Trueta Hospital, Girona, Spain
Clin Endocrinol (Oxf) 67:493-9. 2007..We hypothesized that this polymorphism is associated with precocious pubarche (PP), a population known to be at risk for hyperinsulinaemic hyperandrogenism... - The insulin gene variable number of tandem repeat: associations and interactions with childhood body fat mass and insulin secretion in normal childrenBarbara Heude
Medical Research Council Epidemiology Unit, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, United Kingdom
J Clin Endocrinol Metab 91:2770-5. 2006..Polymorphism at the insulin gene (INS) variable number of tandem repeat (VNTR) shows variable associations with childhood body mass index (BMI) in different populations... - The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeksAbel Lopez-Bermejo
Diabetes, Endocrinology and Nutrition Unit, Dr Josep Trueta Hospital, 17007 Girona, Spain
J Clin Endocrinol Metab 93:1501-5. 2008..Little is known about the genetic determinants of fat mass around birth. We hypothesized that the common rs9939609 single-nucleotide polymorphism (SNP) in FTO is associated with fat mass and metabolic parameters in neonates... - Fetal programming of perivenous glucose uptake reveals a regulatory mechanism governing hepatic glucose output during refeedingHelena C Murphy
Department of Diabetes and Metabolic Medicine, St. Bart's and the London School of Medicine and Dentistry, Queen Mary University of London, Mile End, London E1 4NS, U.K
Diabetes 52:1326-32. 2003..The results are pertinent to impaired regulation of hepatic glucose output in type 2 diabetes, which could arise from diminished GK-mediated glucose uptake rather than increased gluconeogenesis...