O H Petersen

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi request reprint Ca2+ signalling and pancreatitis: effects of alcohol, bile and coffee
    Ole H Petersen
    MRC Group, Physiological Laboratory and Division of Surgery and Oncology, University of Liverpool, Liverpool L69 3BX, UK
    Trends Pharmacol Sci 27:113-20. 2006
  2. pmc Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves
    Michael C Ashby
    Medical Research Council Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    J Cell Biol 158:283-92. 2002
  3. pmc NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors
    Julia V Gerasimenko
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, England, UK
    J Cell Biol 163:271-82. 2003
  4. ncbi request reprint Local and global Ca2+ signals: physiology and pathophysiology
    Ole H Petersen
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    Biol Res 37:661-4. 2004
  5. ncbi request reprint Cation channels: homing in on the elusive CAN channels
    Ole H Petersen
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, L69 3BX, Liverpool, UK
    Curr Biol 12:R520-2. 2002
  6. ncbi request reprint Calcium signal compartmentalization
    Ole H Petersen
    MRC Secretory Control Research Group, Physiological Laboratory, University of Liiverpool, Crown Street, Liverpool L69 3BX, UK
    Biol Res 35:177-82. 2002
  7. doi request reprint Ca2+-induced pancreatic cell death: roles of the endoplasmic reticulum, zymogen granules, lysosomes and endosomes
    Ole H Petersen
    MRC Group, Physiological Laboratory, University of Liverpool, Liverpool, UK
    J Gastroenterol Hepatol 23:S31-6. 2008
  8. ncbi request reprint Polarized calcium signaling in exocrine gland cells
    Ole H Petersen
    MRC Group, The Physiological Laboratory, School of Biomedical Science, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Annu Rev Physiol 70:273-99. 2008
  9. ncbi request reprint Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells
    Ole H Petersen
    MRC Group, Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Cell Calcium 42:373-8. 2007
  10. ncbi request reprint Localization and regulation of Ca2+ entry and exit pathways in exocrine gland cells
    Ole H Petersen
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    Cell Calcium 33:337-44. 2003

Collaborators

Detail Information

Publications81

  1. ncbi request reprint Ca2+ signalling and pancreatitis: effects of alcohol, bile and coffee
    Ole H Petersen
    MRC Group, Physiological Laboratory and Division of Surgery and Oncology, University of Liverpool, Liverpool L69 3BX, UK
    Trends Pharmacol Sci 27:113-20. 2006
    ..These abnormal Ca2+ signals, which can be inhibited by caffeine, explain how excessive alcohol intake and biliary disease cause acute pancreatitis, an often-fatal human disease in which the pancreas digests itself and its surroundings...
  2. pmc Localized Ca2+ uncaging reveals polarized distribution of Ca2+-sensitive Ca2+ release sites: mechanism of unidirectional Ca2+ waves
    Michael C Ashby
    Medical Research Council Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    J Cell Biol 158:283-92. 2002
    ..CICR is the major process responsible for global Ca2+ transients, and intracellular variations in sensitivity to CICR predetermine the activation pattern of Ca2+ waves...
  3. pmc NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors
    Julia V Gerasimenko
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, England, UK
    J Cell Biol 163:271-82. 2003
    ..The nuclear envelope contains ryanodine and IP3 receptors that can be activated separately and independently; the ryanodine receptors by either NAADP or cADPR, and the IP3 receptors by IP3...
  4. ncbi request reprint Local and global Ca2+ signals: physiology and pathophysiology
    Ole H Petersen
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    Biol Res 37:661-4. 2004
    ....
  5. ncbi request reprint Cation channels: homing in on the elusive CAN channels
    Ole H Petersen
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, L69 3BX, Liverpool, UK
    Curr Biol 12:R520-2. 2002
    ..The molecular identity of Ca(2+)-activated, non-selective (CAN) cation channels has been unclear, but a member of the TRP family, TRPM4, has now been shown to be a CAN channel without significant Ca(2+) permeability...
  6. ncbi request reprint Calcium signal compartmentalization
    Ole H Petersen
    MRC Secretory Control Research Group, Physiological Laboratory, University of Liiverpool, Crown Street, Liverpool L69 3BX, UK
    Biol Res 35:177-82. 2002
    ....
  7. doi request reprint Ca2+-induced pancreatic cell death: roles of the endoplasmic reticulum, zymogen granules, lysosomes and endosomes
    Ole H Petersen
    MRC Group, Physiological Laboratory, University of Liverpool, Liverpool, UK
    J Gastroenterol Hepatol 23:S31-6. 2008
    ....
  8. ncbi request reprint Polarized calcium signaling in exocrine gland cells
    Ole H Petersen
    MRC Group, The Physiological Laboratory, School of Biomedical Science, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Annu Rev Physiol 70:273-99. 2008
    ..The mitochondria are crucial not only for ATP generation but also for the physiologically important subcellular compartmentalization of the cytosolic Ca2+ signals...
  9. ncbi request reprint Endoplasmic reticulum calcium tunnels integrate signalling in polarised cells
    Ole H Petersen
    MRC Group, Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Cell Calcium 42:373-8. 2007
    ..Nature has evolved an elegant solution to this problem by creating operational Ca(2+) tunnels through the endoplasmic reticulum. Very recently direct evidence that such tunnelling also occurs in neurons has been provided...
  10. ncbi request reprint Localization and regulation of Ca2+ entry and exit pathways in exocrine gland cells
    Ole H Petersen
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    Cell Calcium 33:337-44. 2003
    ....
  11. ncbi request reprint Failure of calcium microdomain generation and pathological consequences
    Ole H Petersen
    MRC Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool, UK
    Cell Calcium 40:593-600. 2006
    ..Because of the abolition of ATP-dependent Ca(2+) pump activity, all intracellular Ca(2+) concentration gradients disappear and the most important part of the normal regulatory machinery is thereby destroyed. The end stage is necrosis...
  12. ncbi request reprint Ca2+ signalling and Ca2+-activated ion channels in exocrine acinar cells
    Ole H Petersen
    MRC Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Cell Calcium 38:171-200. 2005
    ..The highly polarized arrangement of the organelle systems in living acinar cells is described as well as its importance for the physiologically relevant local and polarized calcium signalling events...
  13. ncbi request reprint Ca2+ signaling in pancreatic acinar cells: physiology and pathophysiology
    O H Petersen
    MRC Group, Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    Braz J Med Biol Res 42:9-16. 2009
    ..This disease is due to toxic Ca2+ signals generated by excessive liberation of Ca2+ from both the endoplasmic reticulum and the secretory granules...
  14. doi request reprint Fatty acids, alcohol and fatty acid ethyl esters: toxic Ca2+ signal generation and pancreatitis
    O H Petersen
    MRC Secretory Control Research Group, Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    Cell Calcium 45:634-42. 2009
    ....
  15. ncbi request reprint Calcium signalling: store-operated channel found at last
    O H Petersen
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, L69 3BX, Liverpool, UK
    Curr Biol 11:R520-3. 2001
    ..This finding highlights a hitherto unrecognized link between epithelial Ca(2+) transport and Ca(2+) signalling...
  16. ncbi request reprint The endoplasmic reticulum: one continuous or several separate Ca(2+) stores?
    O H Petersen
    The MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool, UK, L69 3BX
    Trends Neurosci 24:271-6. 2001
    ..The concept of a fully connected ER network is entirely compatible with evidence indicating that the distribution of Ca2+ -release channels in the ER membrane is discontinuous with clustering in certain localities...
  17. pmc Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport
    M K Park
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, UK
    EMBO J 20:1863-74. 2001
    ..The three mitochondrial groups are activated independently by specific spatiotemporal patterns of cytosolic Ca(2+) signals and can therefore participate in the local regulation of Ca(2+) homeostasis and energy supply...
  18. doi request reprint Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells
    John A Murphy
    Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 135:632-41. 2008
    ..We tested whether CCK (CCK-8 and human CCK-58) can act directly on human pancreatic acinar cells...
  19. ncbi request reprint Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis
    David N Criddle
    Medical Research Council Secretory Control Research Group, Physiological Laboratory, University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 130:781-93. 2006
    ..Fatty acid ethyl esters are ethanol metabolites inducing sustained, toxic elevations of the acinar cytosolic free calcium ion concentration ([Ca(2+)](C)) implicated in pancreatitis. We sought to define the mechanisms of this elevation...
  20. pmc Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca(2+) signals
    H Tinel
    Medical Research Council Secretory Control Research Group, Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    EMBO J 18:4999-5008. 1999
    ..When mitochondrial function is inhibited, this barrier disappears and the Ca(2+) signals spread all over the cytosol...
  21. ncbi request reprint Polarity in intracellular calcium signaling
    O H Petersen
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool, UK
    Bioessays 21:851-60. 1999
    ....
  22. pmc Correlation of NADH and Ca2+ signals in mouse pancreatic acinar cells
    S Voronina
    The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    J Physiol 539:41-52. 2002
    ..During the higher-frequency sinusoidal calcium oscillations induced by higher doses of ACh, NADH responses fused into a smooth rise followed by a slow decline. Supramaximal doses of ACh and CCK produced single large NADH transients...
  23. ncbi request reprint Calcium signalling and pancreatic cell death: apoptosis or necrosis?
    D N Criddle
    MRC Secretory Research Group, Department of Physiology, University of Liverpool, Liverpool, L69 3BX, UK
    Cell Death Differ 14:1285-94. 2007
    ..Apoptosis, induced by menadione or bile acids, is potentiated by inhibition of an endogenous detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1), suggesting its importance as a defence mechanism that may influence cell fate...
  24. doi request reprint Mitochondrial injury in pancreatitis
    R Mukherjee
    Division of Surgery and Oncology, University of Liverpool, Royal Liverpool University Hospital, Daulby Street, Liverpool, United Kingdom
    Cell Calcium 44:14-23. 2008
    ..The role of reactive oxygen species remains controversial. Present understanding of the part played by disordered pancreatic acinar calcium signalling and mitochondrial inhibition offers several new potential therapeutic targets...
  25. pmc Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites
    David N Criddle
    Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Proc Natl Acad Sci U S A 101:10738-43. 2004
    ....
  26. doi request reprint Dynamic changes in cytosolic and mitochondrial ATP levels in pancreatic acinar cells
    Svetlana G Voronina
    The Physiological Laboratory, School of Biomedical Sciences, The University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 138:1976-87. 2010
    ..Here we characterized the effects of these agents on ATP levels in the cytosol and mitochondria...
  27. ncbi request reprint Menadione-induced apoptosis: roles of cytosolic Ca(2+) elevations and the mitochondrial permeability transition pore
    Julia V Gerasimenko
    Medical Research Council Secretory Control Research Group, Physiological Laboratory, University of Liverpool L69 3BX, UK
    J Cell Sci 115:485-97. 2002
    ..These results suggest a twin-track model in which both intracellular release of Ca(2+) and induction of the permeability transition pore are required for initiation of apoptosis...
  28. pmc ATP depletion induces translocation of STIM1 to puncta and formation of STIM1-ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP
    Michael Chvanov
    Department of Physiology, The University of Liverpool, Crown Street, Liverpool, L69 3BX, UK
    Pflugers Arch 457:505-17. 2008
    ..We can therefore conclude that STIM1 translocation and re-translocation as well as formation of STIM1-ORAI1 clusters occur in an ATP-independent fashion and under conditions of PI(4,5)P(2) depletion...
  29. ncbi request reprint ATP depletion inhibits Ca2+ release, influx and extrusion in pancreatic acinar cells but not pathological Ca2+ responses induced by bile
    Stephanie L Barrow
    The Physiological Laboratory, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Pflugers Arch 455:1025-39. 2008
    ..Neither Ca(2+) release from internal stores nor Ca(2+) influx triggered by bile acids were inhibited by ATP depletion, emphasising the danger of these pathological mechanisms...
  30. ncbi request reprint Effects of secretagogues and bile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating DeltaPsim
    Svetlana G Voronina
    Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, United Kingdom
    J Biol Chem 279:27327-38. 2004
    ..Our experiments demonstrate that physiological concentrations of secretagogues and pathologically relevant concentrations of bile acids trigger mitochondrial depolarization in pancreatic acinar cells...
  31. ncbi request reprint Bile acids induce Ca2+ release from both the endoplasmic reticulum and acidic intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors
    Julia V Gerasimenko
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool, L69 3BX United Kingdom
    J Biol Chem 281:40154-63. 2006
    ..Bile acid-elicited intracellular Ca(2+) liberation from both the ER and the apical acidic stores depends on both RyRs and IP(3)Rs...
  32. ncbi request reprint Long distance communication between muscarinic receptors and Ca2+ release channels revealed by carbachol uncaging in cell-attached patch pipette
    Michael C Ashby
    Medical Research Council Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Biol Chem 278:20860-4. 2003
    ..Our intrapipette uncaging experiments provide definitive evidence for long distance communication between basal muscarinic receptors and apical Ca2+ release channels...
  33. ncbi request reprint Calcium signalling in and around the nuclear envelope
    J Gerasimenko
    Medical Research Council Secretory Control Research Group, Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, UK
    Biochem Soc Trans 31:76-8. 2003
    ..It would appear that NAADP releases Ca(2+) from the same IP(3)- and cADPR-sensitive stores with endoplasmic reticulum characteristics...
  34. pmc Local uncaging of caged Ca(2+) reveals distribution of Ca(2+)-activated Cl(-) channels in pancreatic acinar cells
    M K Park
    Medical Research Council Secretory Control Research Group, Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Proc Natl Acad Sci U S A 98:10948-53. 2001
    ....
  35. ncbi request reprint Membrane repair: Ca(2+)-elicited lysosomal exocytosis
    J V Gerasimenko
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Curr Biol 11:R971-4. 2001
    ..Ca(2+) entry inevitably follows membrane rupture and recent studies indicate that this elicits repair via Ca(2+)-activated exocytosis of lysosomes, regulated by lysosomal synaptotagmin VII...
  36. pmc Role of phosphoinositides in STIM1 dynamics and store-operated calcium entry
    Ciara M Walsh
    The Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Biochem J 425:159-68. 2010
    ..These observations support the idea that phosphoinositides are not essential but contribute to STIM1 accumulation at ER-PM junctions with a second translocation mechanism involving direct STIM1-Orai interactions...
  37. pmc Cholecystokinin-58 and cholecystokinin-8 exhibit similar actions on calcium signaling, zymogen secretion, and cell fate in murine pancreatic acinar cells
    David N Criddle
    Department of Physiology, University of Liverpool, UK
    Am J Physiol Gastrointest Liver Physiol 297:G1085-92. 2009
    ..Our data strengthen the argument that CCK-58 is an important physiological form of this gastrointestinal hormone...
  38. ncbi request reprint The distribution of the endoplasmic reticulum in living pancreatic acinar cells
    O V Gerasimenko
    Medical Research Council Secretory Control Research Group, Physiological Laboratory, University of Liverpool, L69 3BX, Liverpool, UK
    Cell Calcium 32:261-8. 2002
    ....
  39. ncbi request reprint Role of Ca2+ in pancreatic cell death induced by alcohol metabolites
    David N Criddle
    MRC Group, Physiological Laboratory, University of Liverpool, Liverpool, UK
    J Gastroenterol Hepatol 21:S14-7. 2006
    ..The FA-induced necrosis is Ca(2+)-dependent. The destructive sustained Ca(2+) signals are due to inhibition of mitochondrial function with failure of ATP generation...
  40. doi request reprint Pancreatitis and calcium signalling: report of an international workshop
    Robert Sutton
    Division of Surgery and Oncology, MRC Group, University of Liverpool, Liverpool, UK
    Pancreas 36:e1-14. 2008
    ..The publication of these proceedings is intended to provide a platform for enhancing research and therapeutic development for acute pancreatitis...
  41. ncbi request reprint Stable Golgi-mitochondria complexes and formation of Golgi Ca(2+) gradients in pancreatic acinar cells
    Nick J Dolman
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, England, United Kingdom
    J Biol Chem 280:15794-9. 2005
    ..In addition the Golgi is ideally placed to be preferentially supplied by ATP from adjacent mitochondria...
  42. pmc Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology
    Svetlana Voronina
    The Physiological Laboratory, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    J Physiol 540:49-55. 2002
    ..The calcium releasing properties of bile acids suggest that calcium toxicity could be an important contributing factor in the bile acid-induced cellular damage...
  43. ncbi request reprint Non-uniform distribution of mitochondria in pancreatic acinar cells
    Paul R Johnson
    MRC Secretory Control Research Group, Physiological Laboratory, University of Liverpool, Liverpool, L69 3BX, UK
    Cell Tissue Res 313:37-45. 2003
    ..We conclude that in pancreatic acinar cells mitochondria are preferentially distributed to perigranular, subplasmalemmal and perinuclear regions and this distribution is not affected by isolation or fixation procedures...
  44. ncbi request reprint Attraction or repulsion by local Ca(2+) signals
    O H Petersen
    MRC Secretory Control Research Group, Department of Physiology, University of Liverpool, UK
    Curr Biol 10:R311-4. 2000
    ..The results indicate that local Ca(2+) signals may provide important directional cues for axon guidance...
  45. ncbi request reprint Calcium leak from intracellular stores--the enigma of calcium signalling
    C Camello
    The Physiological Laboratory, The University of Liverpool, Crown Street, L69 3BX, Liverpool, UK
    Cell Calcium 32:355-61. 2002
    ..In this review we will discuss the properties of the calcium leak and speculate about possible mechanisms, which could mediate this process...
  46. ncbi request reprint Generation and modulation of cytosolic Ca2+ signals in pancreatic acinar cells: techniques and mechanisms
    N J Dolman
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool, UK L69 3BX
    Biochem Soc Trans 31:947-9. 2003
    ..Here, we review recent work, using the pancreatic acinar cell as a model system, on the mechanisms employed to generate and modulate cytosolic Ca(2+) signals, and the technical advances that have made these studies possible...
  47. pmc Calcium-dependent release of NO from intracellular S-nitrosothiols
    Michael Chvanov
    The Physiological Laboratory, The University of Liverpool, Liverpool, UK
    EMBO J 25:3024-32. 2006
    ..Importantly, the source of this NO is the already available S-nitrosothiol store rather than de novo synthesis by NOS. A similar mechanism of NO release was found in dorsal root ganglia neurons...
  48. pmc Dual sensitivity of sarcoplasmic/endoplasmic Ca2+-ATPase to cytosolic and endoplasmic reticulum Ca2+ as a mechanism of modulating cytosolic Ca2+ oscillations
    Kojiro Yano
    The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Biochem J 383:353-60. 2004
    ..Our mathematical model demonstrates how luminal Ca2+, through its effect on Ca2+ uptake, can control cytosolic Ca2+ oscillations...
  49. ncbi request reprint NAADP, cADPR and IP3 all release Ca2+ from the endoplasmic reticulum and an acidic store in the secretory granule area
    Julia V Gerasimenko
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool, L69 3BX, UK
    J Cell Sci 119:226-38. 2006
    ..The endoplasmic reticulum is predominantly basal, but thin extensions penetrate into the granular area and cytosolic Ca2+ signals probably initiate at sites where endoplasmic reticulum elements and granules come close together...
  50. pmc Spatial characterisation of ryanodine-induced calcium release in mouse pancreatic acinar cells
    Michael C Ashby
    Medical Research Council Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, UK
    Biochem J 369:441-5. 2003
    ..These results suggests that co-ordinated release from co-localized RyRs and IP(3)Rs underlies the increased sensitivity of the apical region to initiation of intracellular Ca(2+) transients...
  51. ncbi request reprint Basal and physiological Ca(2+) leak from the endoplasmic reticulum of pancreatic acinar cells. Second messenger-activated channels and translocons
    Richard B Lomax
    Medical Research Council Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Biol Chem 277:26479-85. 2002
    ..1-1 mm) to remove nascent polypeptides from ribosomes increases Ca(2+) leak from the endoplasmic reticulum by a mechanism independent of the endoplasmic reticulum Ca(2+) pumps and of the receptors for IP(3) or ryanodine...
  52. pmc Activation of trypsinogen in large endocytic vacuoles of pancreatic acinar cells
    Mark W Sherwood
    Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Proc Natl Acad Sci U S A 104:5674-9. 2007
    ..We propose that the initiation of acute pancreatitis depends on endocytic vacuole formation and trypsinogen activation in this compartment...
  53. ncbi request reprint Signal transduction, calcium and acute pancreatitis
    Robert Sutton
    Department of Surgery, University of Liverpool, 5th Floor UCD Block, Royal Liverpool University Hospital, Daulby Street, Liverpool L69 3GA, UK
    Pancreatology 3:497-505. 2003
    ..This review outlines current understanding of signal transduction in the pancreas, and its application to the pathophysiology of acute pancreatitis...
  54. pmc Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening
    Heidi K Baumgartner
    Physiological Laboratory, School of Biomedical Sciences, Liverpool University, Liverpool L69 3BX, United Kingdom
    J Biol Chem 284:20796-803. 2009
    ..We conclude that elevated Ca2+ in mitochondria is the crucial factor in determining whether cells undergo oxidative stress-induced apoptosis...
  55. ncbi request reprint Bile acids induce a cationic current, depolarizing pancreatic acinar cells and increasing the intracellular Na+ concentration
    Svetlana G Voronina
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Biol Chem 280:1764-70. 2005
    ..Bile-induced depolarization of acinar cells should have a profound effect on acinar fluid secretion and, consequently, on transport of secreted zymogens...
  56. pmc Free radicals and the pancreatic acinar cells: role in physiology and pathology
    M Chvanov
    The University of Liverpool The Physiological Laboratory Crown Street, Liverpool L69 3BX, UK
    Philos Trans R Soc Lond B Biol Sci 360:2273-84. 2005
    ..ROS are implicated in the early events within the acinar cells, leading to the development of acute pancreatitis. The available data on ROS/RNS involvement in the apoptotic and necrotic death of pancreatic acinar cells will be discussed...
  57. ncbi request reprint The specificity of Ca2+ signalling
    O H Petersen
    MRC Secretory Control Research Group, The Physiological Laboratory, University of Liverpool, Liverpool, UK
    Acta Physiol Hung 89:439-50. 2002
    ..Recent technical advances have shown that different patterns of Ca2+ signals can be created, in space and time, which allow specific cellular responses to be elicited...
  58. ncbi request reprint Calcium signalling: past, present and future
    Ole H Petersen
    Physiological Laboratory, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Cell Calcium 38:161-9. 2005
    ..The future of the Ca2+ signalling field lies with detailed investigations of the integrative function in vivo and clarification of the pathology associated with malfunctions of Ca2+ signalling cascades...
  59. pmc Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors
    Julia V Gerasimenko
    Medical Research Council Group, Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Proc Natl Acad Sci U S A 106:10758-63. 2009
    ....
  60. ncbi request reprint Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins
    Heidi K Baumgartner
    The Physiological Laboratory, Biomedical Sciences, Liverpool University, Crown Street, Liverpool, UK
    Am J Physiol Gastrointest Liver Physiol 293:G296-307. 2007
    ....
  61. doi request reprint Modulation of calcium signalling by mitochondria
    Ciara Walsh
    Department of Physiology, School of Biomedical Sciences, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Biochim Biophys Acta 1787:1374-82. 2009
    ....
  62. ncbi request reprint The pancreas misled: signals to pancreatitis
    David N Criddle
    MRC Group, Physiological Laboratory, University of Liverpool, Liverpool, UK
    Pancreatology 7:436-46. 2007
    ..While recent discoveries have increased insight and suggest prophylaxis or treatment targets, more work is required to define the mechanisms and interactions of cell signalling pathways in the pathogenesis of pancreatitis...
  63. ncbi request reprint An N-terminal truncated form of Orp150 is a cytoplasmic ligand for the anti-proliferative mushroom Agaricus bisporus lectin and is required for nuclear localization sequence-dependent nuclear protein import
    Lu Gang Yu
    Department of Medicine, The Henry Wellcome Laboratory of Molecular and Cellular Gastroenterology, University of Liverpool, Liverpool L69, United Kingdom
    J Biol Chem 277:24538-45. 2002
    ..This cytoplasmic form of Orp150 expresses the lectin carbohydrate ligand (sialyl-2,3-galactosyl-beta1,3-N-acetylgalactosamine-alpha) and is shown to be essential for nuclear localization sequence-dependent nuclear protein import...
  64. pmc Ribosome-free terminals of rough ER allow formation of STIM1 puncta and segregation of STIM1 from IP(3) receptors
    Gyorgy Lur
    Department of Physiology, School of Biomedical Sciences, University of Liverpool, Liverpool L69 3BX, UK
    Curr Biol 19:1648-53. 2009
    ....
  65. ncbi request reprint Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells
    David N Criddle
    MRC Secretory Research Group, Department of Physiology and Division of Surgery and Oncology, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Biol Chem 281:40485-92. 2006
    ..Two-electron detoxifying enzymes such as NAD(P)H:quinone oxidoreductase, which are elevated in pancreatitis, may provide protection against excessive ROS and exert an important role in determining acinar cell fate...
  66. ncbi request reprint The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death
    Alexej Verkhratsky
    School of Biological Sciences, The University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Eur J Pharmacol 447:141-54. 2002
    ..In pathological conditions, fluctuations in [Ca(2+)](L) may initiate either adaptive or fatal stress responses...
  67. pmc Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers
    Jose M Cancela
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, Unité CNRS UPR 9040, 1 Avenue de la Terrasse, 91 198 Gif sur Yvette, France
    EMBO J 21:909-19. 2002
    ..Different combinations of Ca2+ releasing messengers can shape the spatio-temporal patterns of cytosolic Ca2+ signals. NAADP and cADPR are emerging as key messengers in the globalization of Ca2+ signals...
  68. ncbi request reprint Twenty years of calcium imaging: cell physiology to dye for
    Harm J Knot
    Department of Pharmacology and Therapeutics and Division of Cardiology College of Medicine, University of Florida, Gainesville, FL, USA
    Mol Interv 5:112-27. 2005
    ....
  69. ncbi request reprint Regulation of intracellular Ca2+ stores by multiple Ca2+-releasing messengers
    Jose M Cancela
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, Unité Centre National de la Recherche Scientifique, Gif sur Yvette, France
    Diabetes 51:S349-57. 2002
    ..Here we focus on the possible combinatorial roles of inositol 1,4,5-trisphosphate, cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate in beta-cell function...
  70. ncbi request reprint Co-ordination of Ca(2+) signalling in mammalian cells by the new Ca(2+)-releasing messenger NAADP
    Jose M Cancela
    Laboratoire de Neurobiologie Cellulaire et Moleculaire, CNRS UPR 9040, 1 Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Pflugers Arch 446:322-7. 2003
    ..NAADP acts at a very low concentration and seems to have a key role in sensitising cyclic ADP-ribose and inositol trisphosphate receptors. These points will be discussed in the present review...
  71. ncbi request reprint The endoplasmic reticulum as an integrator of multiple dendritic events
    Myoung Kyu Park
    Department of Physiliogy, Sungkyunkwan University School of Medicine and Center For Molecular Medicine, Samsung Biomedical Resarch Institute, Suwon, Korea
    Neuroscientist 14:68-77. 2008
    ..Therefore, the ER network in neurons is emerging as a conveyor and integrator of signals. In this article, we will discuss the various roles of the ER and the functional and structural organization of the ER network in neurons...
  72. ncbi request reprint The NAADP receptor: new receptors or new regulation?
    Antony Galione
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK
    Mol Interv 5:73-9. 2005
    ..However, others have suggested that it acts in a novel way to regulate a known calcium release channel, the ryanodine receptor...
  73. ncbi request reprint Morphological and functional changes of dissociated single pancreatic acinar cells: testing the suitability of the single cell as a model for exocytosis and calcium signaling
    Myoung Kyu Park
    Medical Research Center for Regulation of Neuronal Cell Excitability and Department of Physiology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Jangan ku, Suwon, 440 746, South Korea
    Cell Calcium 35:367-79. 2004
    ..These findings suggest that the dissociated single pancreatic acinar cells preserve an intact Ca(2+) signaling machinery but alter in shape and have impaired exocytotic functions and resting membrane potentials...
  74. ncbi request reprint The FEPS Inaugural Lecture--Bristol 2005
    Ole H Petersen
    Acta Physiol (Oxf) 187:353. 2006
  75. ncbi request reprint Intraluminal calcium as a primary regulator of endoplasmic reticulum function
    Denis Burdakov
    Faculty of Life Sciences, The University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Cell Calcium 38:303-10. 2005
    ..Direct monitoring of [Ca2+](ER) under conditions where the cytosolic [Ca2+] is known may also help to capture elusive biophysical information about the ER, such as the potential difference across the ER membrane...
  76. ncbi request reprint Generation of specific Ca(2+) signals from Ca(2+) stores and endocytosis by differential coupling to messengers
    Alexis Menteyne
    Centre National de la Recherche Scientifique, Institut de Neurobiologie Alfred Fessard FRC2118, Laboratoire de Neurobiologie Cellulaire et Moléculaire UPR9040, Gif sur Yvette F 91198, France
    Curr Biol 16:1931-7. 2006
    ..We propose that multiple Ca(2+)-releasing messengers determine specific agonist-elicited Ca(2+) signatures by controlling the balance among different acidic Ca(2+) stores, endocytosis, and the ER...
  77. ncbi request reprint From Galvani to patch clamp: the development of electrophysiology
    Alexei Verkhratsky
    Faculty of Life Sciences, The University of Manchester, Manchester, M13 9PT, UK
    Pflugers Arch 453:233-47. 2006
    ....
  78. ncbi request reprint Decoding of short-lived Ca2+ influx signals into long term substrate phosphorylation through activation of two distinct classes of protein kinase C
    Hideo Mogami
    Department of Physiology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu 431 3192, Japan
    J Biol Chem 278:9896-904. 2003
    ..Thus, Ca(2+) influx alone via voltage-dependent Ca(2+) channels can generate DAG, thereby activating cPKC and nPKC, whose activation is structurally independent of Ca(2+)...
  79. ncbi request reprint Visualizing formation and dynamics of vacuoles in living cells using contrasting dextran-bound indicator: endocytic and nonendocytic vacuoles
    Svetlana G Voronina
    The Physiological Laboratory, The Univ of Liverpool, Crown St, Liverpool L69 3BX UK
    Am J Physiol Gastrointest Liver Physiol 293:G1333-8. 2007
    ..We expect that the new technique will also be applicable and useful for studies of vacuole dynamics in other cell types...
  80. ncbi request reprint What can we learn about cell signalling by combining optical imaging and patch clamp techniques?
    Myoung Kyu Park
    Department of Physiology, Sungkyunkwan University School of Medicine, 300 Chunchun dong, Changan Ku, Suwon, 440 746, Korea
    Pflugers Arch 444:305-16. 2002
    ..This paper describes the advantages of combining patch-clamp and optical imaging methods as well as some of the recent achievements using this approach...
  81. ncbi request reprint The endoplasmic reticulum is a focal point for co-ordination of cellular activity
    Martin D Bootman
    Laboratory of Molecular Signalling, The Babraham Institute, Babraham, CB2 4AT, Cambridge, UK
    Cell Calcium 32:231-4. 2002