Mathias Pessiglione

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans
    Mathias Pessiglione
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nature 442:1042-5. 2006
  2. pmc How the brain translates money into force: a neuroimaging study of subliminal motivation
    Mathias Pessiglione
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square London WC1N 3BG, UK
    Science 316:904-6. 2007
  3. pmc Subliminal instrumental conditioning demonstrated in the human brain
    Mathias Pessiglione
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N3BG, UK
    Neuron 59:561-7. 2008
  4. pmc Learning affective values for faces is expressed in amygdala and fusiform gyrus
    Predrag Petrovic
    Wellcome Trust Centre for Neuroimaging, University College of London, 12 Queen Square, London, WC1N 3BG, UK
    Soc Cogn Affect Neurosci 3:109-18. 2008
  5. ncbi request reprint Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism. I. Effects of task complexity
    Mathias Pessiglione
    Neurologie et Thérapeutique expérimentale INSERM U289, Hopital de la Salpetriere, Paris, France
    Eur J Neurosci 19:426-36. 2004
  6. doi request reprint Behavioral recovery in MPTP-treated monkeys: neurochemical mechanisms studied by intrastriatal microdialysis
    Sabrina Boulet
    Institut National de la Sante et de la Recherche Medicale, Unite 836, Grenoble Institut des Neurosciences, Dynamique des Réseaux Neuronaux du Mouvement, Grenoble F 38043 Cedex 09, France
    J Neurosci 28:9575-84. 2008
  7. doi request reprint Disconnecting force from money: effects of basal ganglia damage on incentive motivation
    Liane Schmidt
    Laboratoire INSERM U610, Institut Fédératif de Recherches en Neurosciences, Universite Pierre et Marie Curie Paris 6, Site Pitié Salpêtrière, F 75013 Paris, France
    Brain 131:1303-10. 2008
  8. ncbi request reprint A new model to study compensatory mechanisms in MPTP-treated monkeys exhibiting recovery
    Stéphanie Mounayar
    Institut National de la Sante et de la Recherche Medicale, Unité 679, Paris F 75013, France
    Brain 130:2898-914. 2007
  9. ncbi request reprint Quantitative analysis of dopaminergic loss in relation to functional territories in MPTP-treated monkeys
    Caroline Jan
    INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75013, Paris, France
    Eur J Neurosci 18:2082-6. 2003
  10. ncbi request reprint An effect of dopamine depletion on decision-making: the temporal coupling of deliberation and execution
    Mathias Pessiglione
    Hopital de la Salpetriere, Paris, France
    J Cogn Neurosci 17:1886-96. 2005

Collaborators

Detail Information

Publications13

  1. pmc Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans
    Mathias Pessiglione
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nature 442:1042-5. 2006
    ..We conclude that dopamine-dependent modulation of striatal activity can account for how the human brain uses reward prediction errors to improve future decisions...
  2. pmc How the brain translates money into force: a neuroimaging study of subliminal motivation
    Mathias Pessiglione
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square London WC1N 3BG, UK
    Science 316:904-6. 2007
    ..Our findings thus reveal this region as a key node in brain circuitry that enables expected rewards to energize behavior, without the need for the subjects;awareness...
  3. pmc Subliminal instrumental conditioning demonstrated in the human brain
    Mathias Pessiglione
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N3BG, UK
    Neuron 59:561-7. 2008
    ..We conclude that, even without conscious processing of contextual cues, our brain can learn their reward value and use them to provide a bias on decision making...
  4. pmc Learning affective values for faces is expressed in amygdala and fusiform gyrus
    Predrag Petrovic
    Wellcome Trust Centre for Neuroimaging, University College of London, 12 Queen Square, London, WC1N 3BG, UK
    Soc Cogn Affect Neurosci 3:109-18. 2008
    ..We conclude that amygdala and fusiform encode affective value in a manner that closely approximates a standard computational solution to learning...
  5. ncbi request reprint Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism. I. Effects of task complexity
    Mathias Pessiglione
    Neurologie et Thérapeutique expérimentale INSERM U289, Hopital de la Salpetriere, Paris, France
    Eur J Neurosci 19:426-36. 2004
    ..We therefore suggest that everyday cognitive difficulties may exacerbate hypokinesia (lack of initiation, abnormal slowness) and executive disorders (hesitations, freezing) in the early stages of human PD...
  6. doi request reprint Behavioral recovery in MPTP-treated monkeys: neurochemical mechanisms studied by intrastriatal microdialysis
    Sabrina Boulet
    Institut National de la Sante et de la Recherche Medicale, Unite 836, Grenoble Institut des Neurosciences, Dynamique des Réseaux Neuronaux du Mouvement, Grenoble F 38043 Cedex 09, France
    J Neurosci 28:9575-84. 2008
    ....
  7. doi request reprint Disconnecting force from money: effects of basal ganglia damage on incentive motivation
    Liane Schmidt
    Laboratoire INSERM U610, Institut Fédératif de Recherches en Neurosciences, Universite Pierre et Marie Curie Paris 6, Site Pitié Salpêtrière, F 75013 Paris, France
    Brain 131:1303-10. 2008
    ..We conclude that bilateral striato-pallidal damage specifically disconnects motor output from affective evaluation of potential rewards...
  8. ncbi request reprint A new model to study compensatory mechanisms in MPTP-treated monkeys exhibiting recovery
    Stéphanie Mounayar
    Institut National de la Sante et de la Recherche Medicale, Unité 679, Paris F 75013, France
    Brain 130:2898-914. 2007
    ..The immunohistological results suggest that both dopamine and serotonin could be implicated in the compensatory mechanisms...
  9. ncbi request reprint Quantitative analysis of dopaminergic loss in relation to functional territories in MPTP-treated monkeys
    Caroline Jan
    INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 47 Boulevard de l Hopital, 75013, Paris, France
    Eur J Neurosci 18:2082-6. 2003
    ..The preservation of dopaminergic innervation of the limbic part of cerebral structures may explain the preservation of motivational processes mediated by these limbic regions in MPTP-treated monkeys...
  10. ncbi request reprint An effect of dopamine depletion on decision-making: the temporal coupling of deliberation and execution
    Mathias Pessiglione
    Hopital de la Salpetriere, Paris, France
    J Cogn Neurosci 17:1886-96. 2005
    ..We suggest that such coupling may be related to the loss of dopamine-mediated functional segregation between basal ganglia circuits processing different stages of goal-directed behavior...
  11. ncbi request reprint Thalamic neuronal activity in dopamine-depleted primates: evidence for a loss of functional segregation within basal ganglia circuits
    Mathias Pessiglione
    Laboratoire de neurologie et thérapeutique expérimentale, Institut National de la Santé et de la Recherche Médicale Unité 679, Hopital de la Salpetriere, 75651 Paris, France
    J Neurosci 25:1523-31. 2005
    ..Thus the major dysfunction after dopamine depletion appeared to be the loss of functional segregation within cortico-BG circuits, which could also be at the heart of parkinsonian pathophysiology...
  12. ncbi request reprint Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism: II. Effects of reward preference
    Mathias Pessiglione
    Neurologie et Thérapeutique expérimentale INSERM U289, Hopital de la Salpetriere, Paris, France
    Eur J Neurosci 19:437-46. 2004
    ..Thus, the preserved motivational processes may help to overcome executive dysfunction in the early stages of human PD...
  13. ncbi request reprint Impairment of context-adapted movement selection in a primate model of presymptomatic Parkinson's disease
    Mathias Pessiglione
    Neurologie et Thérapeutique Expérimentale, INSERM U289, Hopital de la Salpetriere, Paris, France
    Brain 126:1392-408. 2003
    ..Similar behavioural disorders might therefore occur in the presymptomatic stage of human Parkinson's disease...