Affiliation: University College London
- Dopamine-dependent prediction errors underpin reward-seeking behaviour in humansMathias Pessiglione
Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
Nature 442:1042-5. 2006..We conclude that dopamine-dependent modulation of striatal activity can account for how the human brain uses reward prediction errors to improve future decisions...
- How the brain translates money into force: a neuroimaging study of subliminal motivationMathias Pessiglione
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square London WC1N 3BG, UK
Science 316:904-6. 2007..Our findings thus reveal this region as a key node in brain circuitry that enables expected rewards to energize behavior, without the need for the subjects;awareness...
- Subliminal instrumental conditioning demonstrated in the human brainMathias Pessiglione
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N3BG, UK
Neuron 59:561-7. 2008..We conclude that, even without conscious processing of contextual cues, our brain can learn their reward value and use them to provide a bias on decision making...
- Learning affective values for faces is expressed in amygdala and fusiform gyrusPredrag Petrovic
Wellcome Trust Centre for Neuroimaging, University College of London, 12 Queen Square, London, WC1N 3BG, UK
Soc Cogn Affect Neurosci 3:109-18. 2008..We conclude that amygdala and fusiform encode affective value in a manner that closely approximates a standard computational solution to learning...
- Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism. I. Effects of task complexityMathias Pessiglione
, , Paris, France
Eur J Neurosci 19:426-36. 2004..We therefore suggest that everyday cognitive difficulties may exacerbate hypokinesia (lack of initiation, abnormal slowness) and executive disorders (hesitations, freezing) in the early stages of human PD...
- Behavioral recovery in MPTP-treated monkeys: neurochemical mechanisms studied by intrastriatal microdialysisSabrina Boulet
Institut National de la Sante et de la Recherche Medicale, Unite 836, Grenoble Institut des Neurosciences, Dynamique des Réseaux Neuronaux du Mouvement, Grenoble F 38043 Cedex 09, France
J Neurosci 28:9575-84. 2008....
- Disconnecting force from money: effects of basal ganglia damage on incentive motivationLiane Schmidt
Laboratoire INSERM U610, Institut Fédératif de Recherches en Neurosciences, Universite Pierre et Marie Curie Paris 6, Site Pitié Salpêtrière, F 75013 Paris, France
Brain 131:1303-10. 2008..We conclude that bilateral striato-pallidal damage specifically disconnects motor output from affective evaluation of potential rewards...
- A new model to study compensatory mechanisms in MPTP-treated monkeys exhibiting recoveryStéphanie Mounayar
Institut National de la Sante et de la Recherche Medicale, Unité 679, Paris F 75013, France
Brain 130:2898-914. 2007..The immunohistological results suggest that both dopamine and serotonin could be implicated in the compensatory mechanisms...
- Quantitative analysis of dopaminergic loss in relation to functional territories in MPTP-treated monkeysCaroline Jan
INSERM U289, , , , 75013, Paris, France
Eur J Neurosci 18:2082-6. 2003..The preservation of dopaminergic innervation of the limbic part of cerebral structures may explain the preservation of motivational processes mediated by these limbic regions in MPTP-treated monkeys...
- An effect of dopamine depletion on decision-making: the temporal coupling of deliberation and executionMathias Pessiglione
Hopital de la Salpetriere, Paris, France
J Cogn Neurosci 17:1886-96. 2005..We suggest that such coupling may be related to the loss of dopamine-mediated functional segregation between basal ganglia circuits processing different stages of goal-directed behavior...
- Thalamic neuronal activity in dopamine-depleted primates: evidence for a loss of functional segregation within basal ganglia circuitsMathias Pessiglione
, , , 75651 Paris, France
J Neurosci 25:1523-31. 2005..Thus the major dysfunction after dopamine depletion appeared to be the loss of functional segregation within cortico-BG circuits, which could also be at the heart of parkinsonian pathophysiology...
- Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism: II. Effects of reward preferenceMathias Pessiglione
, , Paris, France
Eur J Neurosci 19:437-46. 2004..Thus, the preserved motivational processes may help to overcome executive dysfunction in the early stages of human PD...
- Impairment of context-adapted movement selection in a primate model of presymptomatic Parkinson's diseaseMathias Pessiglione
, INSERM U289, , Paris, France
Brain 126:1392-408. 2003..Similar behavioural disorders might therefore occur in the presymptomatic stage of human Parkinson's disease...