R G Pertwee

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. pmc Cannabinoids and the gastrointestinal tract
    R G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen Foresterhill, Aberdeen AB25 2ZD, UK
    Gut 48:859-67. 2001
  2. ncbi (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens
    Roger G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK
    Eur J Pharmacol 456:99-106. 2002
  3. ncbi Cannabinoid receptors and their ligands
    R G Pertwee
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Prostaglandins Leukot Essent Fatty Acids 66:101-21. 2002
  4. ncbi Neuropharmacology and therapeutic potential of cannabinoids
    R G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Addict Biol 5:37-46. 2000
  5. ncbi Cannabinoid receptors and pain
    R G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
    Prog Neurobiol 63:569-611. 2001
  6. ncbi Cannabinoids and multiple sclerosis
    Roger G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK
    Pharmacol Ther 95:165-74. 2002
  7. ncbi Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development
    R G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland
    Expert Opin Investig Drugs 9:1553-71. 2000
  8. ncbi Agonist-antagonist characterization of 6'-cyanohex-2'-yne-delta 8-tetrahydrocannabinol in two isolated tissue preparations
    R G Pertwee
    Department of Biomedical Sciences, Marischal College, University of Aberdeen, Scotland, UK
    Eur J Pharmacol 315:195-201. 1996
  9. pmc O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties
    R G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD
    Br J Pharmacol 129:1577-84. 2000
  10. ncbi Cannabis and cannabinoids: pharmacology and rationale for clinical use
    R G Pertwee
    Institute of Biomedical Sciences, Aberdeen, Scotland
    Forsch Komplementarmed 6:12-5. 1999

Collaborators

Detail Information

Publications59

  1. pmc Cannabinoids and the gastrointestinal tract
    R G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen Foresterhill, Aberdeen AB25 2ZD, UK
    Gut 48:859-67. 2001
    ....
  2. ncbi (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens
    Roger G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK
    Eur J Pharmacol 456:99-106. 2002
    ..We conclude that cannabidiol antagonizes R-(+)-WIN55212 and CP55940 by acting at prejunctional sites that are unlikely to be cannabinoid CB(1) or CB(2) receptors...
  3. ncbi Cannabinoid receptors and their ligands
    R G Pertwee
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Prostaglandins Leukot Essent Fatty Acids 66:101-21. 2002
    ..So too have CB(1) receptor antagonists, for example for the suppression of appetite and the management of cognitive dysfunction or schizophrenia...
  4. ncbi Neuropharmacology and therapeutic potential of cannabinoids
    R G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Addict Biol 5:37-46. 2000
    ....
  5. ncbi Cannabinoid receptors and pain
    R G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
    Prog Neurobiol 63:569-611. 2001
    ....
  6. ncbi Cannabinoids and multiple sclerosis
    Roger G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK
    Pharmacol Ther 95:165-74. 2002
    ....
  7. ncbi Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development
    R G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland
    Expert Opin Investig Drugs 9:1553-71. 2000
    ....
  8. ncbi Agonist-antagonist characterization of 6'-cyanohex-2'-yne-delta 8-tetrahydrocannabinol in two isolated tissue preparations
    R G Pertwee
    Department of Biomedical Sciences, Marischal College, University of Aberdeen, Scotland, UK
    Eur J Pharmacol 315:195-201. 1996
    ....
  9. pmc O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties
    R G Pertwee
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD
    Br J Pharmacol 129:1577-84. 2000
    ..v.). These data demonstrate the ability of the water-soluble cannabinoid, O-1057, to act as a potent agonist at CB(1) and CB(2) receptors and warrant investigation of the clinical potential of O-1057 as an analgesic...
  10. ncbi Cannabis and cannabinoids: pharmacology and rationale for clinical use
    R G Pertwee
    Institute of Biomedical Sciences, Aberdeen, Scotland
    Forsch Komplementarmed 6:12-5. 1999
    ....
  11. pmc Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens
    R A Ross
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland
    Br J Pharmacol 132:631-40. 2001
    ..In the mouse vas deferens, which seems to express vanilloid and CB(1) receptors, both receptor types appear to contribute to anandamide-induced inhibition of evoked contractions...
  12. pmc The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Br J Pharmacol 150:586-94. 2007
    ....
  13. ncbi Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide
    R A Ross
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
    Eur J Pharmacol 401:121-30. 2000
    ..In contrast, the inhibition by palmitoylethanolamide does not appear to be mediated by cannabinoid receptors...
  14. ncbi Evidence that cannabinoid-induced inhibition of electrically evoked contractions of the myenteric plexus--longitudinal muscle preparation of guinea-pig small intestine can be modulated by Ca2+ and cAMP
    A A Coutts
    Department of Biomedical Sciences, University of Aberdeen, Scotland
    Can J Physiol Pharmacol 76:340-6. 1998
    ..These results support the hypothesis that cannabinoid-induced inhibition in the MPLM is mediated by CB1 receptors...
  15. pmc Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestine
    A A Coutts
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD
    Br J Pharmacol 129:645-52. 2000
    ..There was no evidence of antagonism of endocannabinoids thus supporting the hypothesis that, in this tissue, SR141716A is an inverse agonist of constitutively active CB(1) receptors...
  16. pmc Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide
    R G Pertwee
    Department of Biomedical Sciences, Marischal College, University of Aberdeen
    Br J Pharmacol 110:1483-90. 1993
    ....
  17. ncbi Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception
    R A Ross
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Neuropharmacology 40:221-32. 2001
    ..These data give functional evidence for the hypothesis that the analgesic actions of cannabinoids may be mediated by presynaptic inhibition of transmitter release in sensory neurones...
  18. pmc Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist
    M G Cascio
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Br J Pharmacol 159:129-41. 2010
    ..This investigation addressed the question of whether the little-studied phytocannabinoid, cannabigerol, can activate or block any G protein-coupled receptor. Experimental..
  19. ncbi Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons
    A A Coutts
    Department of Biomedical Sciences, University of Aberdeen, Scotland, AB25 2ZD, United Kingdom
    J Neurosci 21:2425-33. 2001
    ..Agonist-induced internalization at presynaptic terminals has important implications for the modulatory effects of G-protein-coupled receptors on neurotransmitter release...
  20. pmc A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus
    S J Craib
    Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK
    Br J Pharmacol 134:30-7. 2001
    ..These data raise the possibility that the contractile action of anandamide may be due, at least in part, to lipoxygenase metabolites of this fatty acid amide that are vanilloid receptor agonists...
  21. pmc Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
    A Thomas
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Br J Pharmacol 150:613-23. 2007
    ..This study aimed to investigate whether these properties of cannabidiol extend to CB1 receptors expressed in mouse brain and to human CB2 receptors that have been transfected into CHO cells...
  22. ncbi Functional expression of cell surface cannabinoid CB(1) receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons
    A J Irving
    Department of Biomedical Sciences, University of Aberdeen, AB25 2ZD, Aberdeen, UK
    Neuroscience 98:253-62. 2000
    ..Their presence on growth cones could indicate a role in the targeting of inhibitory connections during development...
  23. pmc The synthetic cannabinoid HU210 induces spatial memory deficits and suppresses hippocampal firing rate in rats
    L Robinson
    Department of Biomedical Sciences, Institute for Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK
    Br J Pharmacol 151:688-700. 2007
    ..We therefore assessed the effects of the synthetic cannabinoid HU210 on memory and hippocampal activity...
  24. pmc International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Pharmacol Rev 62:588-631. 2010
    ....
  25. pmc Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists
    R G Pertwee
    Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK
    Curr Med Chem 17:1360-81. 2010
    ..It begins with a brief description of how each of these ligands interacts with CB(1) and/or CB(2) receptors...
  26. ncbi The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice
    A Al-Hayani
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen AB25 2ZD, Scotland, Aberdeen, UK
    Neuropharmacology 41:1000-5. 2001
    ....
  27. pmc GPR55: a new member of the cannabinoid receptor clan?
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Br J Pharmacol 152:984-6. 2007
    ..Still to be identified are the main roles played by GPR55 in health and disease and any potential therapeutic benefits of activating or blocking this receptor...
  28. pmc Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
    D Bolognini
    Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Br J Pharmacol 168:1456-70. 2013
    ..To evaluate the ability of cannabidiolic acid (CBDA) to reduce nausea and vomiting and enhance 5-HT(1A) receptor activation in animal models...
  29. ncbi The pharmacology of cannabinoid receptors and their ligands: an overview
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Int J Obes (Lond) 30:S13-8. 2006
    ....
  30. pmc The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Br J Pharmacol 153:199-215. 2008
    ....
  31. ncbi Functions of cannabinoid receptors in the hippocampus
    S N Davies
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, Scotland, UK
    Neuropharmacology 42:993-1007. 2002
    ....
  32. doi Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines
    I Brown
    Translational Medical Sciences, Division of Applied Medicine, School of Medicine and Dentistry, University of Aberdeen, Aberdeen, AB25 2ZD, UK
    Prostaglandins Leukot Essent Fatty Acids 85:305-10. 2011
    ..This could have important implications for the use of n-3 fatty acids as therapeutic agents in breast and prostate cancers expressing cannabinoid receptors...
  33. ncbi The hypothermic response of mice to delta-9-tetrahydrocannabinol is enhanced by chlorpromazine, thioxanthenes, alpha-adrenoceptor antagonists and pentolinium but not by SCH 23390 or sulpiride
    R G Pertwee
    Department of Pharmacology, University of Aberdeen, Marischal College, Scotland
    Neuropharmacology 27:149-55. 1988
    ..The present data also support the hypothesis that flupentixol and piflutixol interacted with THC not by antagonizing dopamine at D1 or D2 receptors but rather by blocking alpha-adrenoceptors...
  34. pmc Cannabinoids and glaucoma
    I Tomida
    Department of Ophthalmology, Aberdeen Royal Infirmary, University of Aberdeen, UK
    Br J Ophthalmol 88:708-13. 2004
    ..Thus, they could potentially be useful in the treatment of glaucoma. The purpose of this article is to provide the reader with an overview of the latest achievements in research into the potential use of cannabinoids for glaucoma...
  35. ncbi Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis
    J Ludovic Croxford
    Department of Neuroinflammation, Institute of Neurology, University College London, London WC1N 1PJ, United Kingdom
    J Neuroimmunol 193:120-9. 2008
    ..This further highlights the neuroprotective potential of cannabinoids to slow the progression of MS...
  36. ncbi Effects of delta9-THC and WIN-55,212-2 on place preference in the water maze in rats
    Lianne Robinson
    Department of Biomedical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Psychopharmacology (Berl) 166:40-50. 2003
    ..It therefore seems advisable to assess the reinforcing properties of the drugs in the same behavioural model used for learning experiments...
  37. ncbi Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'
    Demetris P Papahatjis
    Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vass Constantinou, Athens 116 35 Greece
    J Med Chem 46:3221-9. 2003
    ..We used molecular modeling approaches to better define the stereochemical limits of the putative subsite. In vitro pharmacological testing found 1c to be a potent CB1 agonist...
  38. ncbi 6"-Azidohex-2"-yne-cannabidiol: a potential neutral, competitive cannabinoid CB1 receptor antagonist
    Adèle Thomas
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Eur J Pharmacol 487:213-21. 2004
    ..Moreover, since it did not enhance the amplitude of electrically evoked contractions, it may be a neutral cannabinoid CB(1) receptor antagonist...
  39. ncbi Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia
    Duncan Ryan
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Neurosci Lett 408:236-41. 2006
    ....
  40. doi Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond
    Roger G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
    Addict Biol 13:147-59. 2008
    ....
  41. ncbi Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue
    Duncan Ryan
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD Scotland, UK
    Eur J Neurosci 25:2093-102. 2007
    ..Our data highlight the interaction between exogenous and endogenous cannabinoid signalling, and provide evidence for the presence of an additional pharmacological target, sensitive to endocannabinoids and to AM281...
  42. ncbi The bioassay of cannabinoids using the mouse isolated vas deferens
    Adèle Thomas
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Scotland, UK
    Methods Mol Med 123:191-207. 2006
    ....
  43. ncbi Localisation of cannabinoid CB(1) receptor immunoreactivity in the guinea pig and rat myenteric plexus
    Angela A Coutts
    Department of Biomedical Sciences, University of Aberdeen, Aberdeen, Scotland AB25 2ZD, United Kingdom
    J Comp Neurol 448:410-22. 2002
    ..In conclusion, CB(1) receptors are expressed on a variety of cholinergic sensory, interneuronal, and motor neurons in myenteric ganglia...
  44. pmc Cannabinoid pharmacology: the first 66 years
    Roger G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD
    Br J Pharmacol 147:S163-71. 2006
    ..Some goals for future research are identified...
  45. ncbi Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor antagonist N-(piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716)
    Maria Elena Y Francisco
    Chemistry and Life Sciences, Research Triangle Institute, Research Triangle Park, NC 27709, USA
    J Med Chem 45:2708-19. 2002
    ....
  46. pmc Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist
    Adèle Thomas
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Br J Pharmacol 146:917-26. 2005
    ..The bases of these agonist- and tissue-dependent effects remain to be established...
  47. ncbi Cannabinoids and multiple sclerosis
    Roger G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Mol Neurobiol 36:45-59. 2007
    ..Evidence that the endocannabinoid system plays a protective role in multiple sclerosis is also discussed as are potential pharmacological strategies for enhancing such protection in the clinic...
  48. ncbi Inverse agonism and neutral antagonism at cannabinoid CB1 receptors
    Roger G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    Life Sci 76:1307-24. 2005
    ..So too are possible clinical consequences of the production of inverse cannabimimetic effects, there being convincing evidence that released endocannabinoids can have "autoprotective" roles...
  49. ncbi Pharmacological characterization of the anandamide cyclooxygenase metabolite: prostaglandin E2 ethanolamide
    Ruth A Ross
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK AB25 2ZD
    J Pharmacol Exp Ther 301:900-7. 2002
    ..We conclude that this compound is pharmacologically active, however its physiological relevance has yet to be established...
  50. ncbi Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2
    Douglas McHugh
    Institute of Medical Sciences, University of Aberdeen, Aberdeen, AB25 2ZD, Scotland, UK
    Mol Pharmacol 73:441-50. 2008
    ..Furthermore, our findings have implications for the potential pharmacological manipulation of elements of the endocannabinoid system for the treatment of various inflammatory conditions...
  51. ncbi Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis
    Heping Xu
    Department of Ophthalmology, School of Medicine, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK
    J Leukoc Biol 82:532-41. 2007
    ....
  52. ncbi Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats
    Paola Fadda
    Department of Biomedical Science, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Neuropharmacology 47:1170-9. 2004
    ..It appears that spatial working/short-term memory is not sensitive to CBD-rich extracts and that potentiation and antagonism of Delta(9)-THC-induced spatial memory deficits is dependent on the ratio between CBD and Delta(9)-THC...
  53. ncbi Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study
    Ileana Tomida
    Department of Ophthalmology, Aberdeen Royal Infirmary, Institute of Medical Sciences, University of Aberdeen, UK
    J Glaucoma 15:349-53. 2006
    ..The purpose of this study was to assess the effect on intraocular pressure (IOP) and the safety and tolerability of oromucosal administration of a low dose of delta-9-tetrahydrocannabinol (Delta-9-THC) and cannabidiol (CBD)...
  54. ncbi Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts
    Paola Fadda
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, UK
    Behav Brain Res 168:307-11. 2006
    ..These data suggest that reversal of working memory deficits by CBD-rich extracts are specific to the cannabinoid system and do not compensate for acutely induced cholinergic or glutamatergic receptor hypoactivity...
  55. ncbi Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells
    Alison J Drysdale
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Neuropharmacology 50:621-31. 2006
    ....
  56. pmc The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids
    Roger G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland, UK
    AAPS J 7:E625-54. 2005
    ....
  57. ncbi Allosteric modulation of the cannabinoid CB1 receptor
    Martin R Price
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, Scotland
    Mol Pharmacol 68:1484-95. 2005
    ..The data presented clearly demonstrate, for the first time, that the cannabinoid CB1 receptor contains an allosteric binding site that can be recognized by synthetic small molecule ligands...
  58. ncbi Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities
    Brian F Thomas
    Science and Engineering Group, Research Triangle Institute, Research Triangle Park, NC 27709, USA
    Bioorg Med Chem 13:5463-74. 2005
    ..Furthermore, the selectivity of these compounds appears to impart unique pharmacological properties when tested in a mouse vas deferens assay for CB1 receptor antagonism...
  59. ncbi Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats
    Lianne Robinson
    School of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Psychopharmacology (Berl) 198:551-63. 2008
    ..As exogenous cannabinoid agonists impair memory formation, could it be that antagonists have opposing effects and act as memory-enhancing drugs?..