V Hugh Perry

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice
    Fabíola de Carvalho Chaves de Siqueira Mendes
    Universidade Federal do Para UFPA, Instituto de Ciencias Biologicas, Laboratório de Investigações em Neurodegeneração e Infecção, Hospital Universitário João de Barros Barreto, Rua dos Mundurucus, 4487 Guamá Belém, Para, Brasil
    BMC Neurosci 14:63. 2013
  2. pmc Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration
    V Hugh Perry
    Centre for Biological Sciences, Southampton General Hospital, University of Southampton, Mail Point 840, LD80B, South Lab and Path Block, SO16 6YD Southampton, UK
    Semin Immunopathol 35:601-12. 2013
  3. pmc Spatial memory decline after masticatory deprivation and aging is associated with altered laminar distribution of CA1 astrocytes
    Marina Negrão Frota de Almeida
    Universidade Federal do Para UFPA, Instituto de Ciencias Biologicas, Laboratório de Investigações em Neurodegeneração e Infecção, Hospital Universitário João de Barros Barreto, Belem, PA, Brazil
    BMC Neurosci 13:23. 2012
  4. doi request reprint Microglia in neurodegenerative disease
    V Hugh Perry
    School of Biological Sciences, University of Southampton, Building 62, Boldrewood Campus, Southampton SO16 7PX, UK
    Nat Rev Neurol 6:193-201. 2010
  5. ncbi request reprint Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration
    Colm Cunningham
    CNS Inflammation Group, School of Biological Sciences, Southampton, Hampshire SO16 7PX, United Kingdom
    J Neurosci 25:9275-84. 2005
  6. ncbi request reprint TGFbeta1 regulates the inflammatory response during chronic neurodegeneration
    Delphine Boche
    CNS Inflammation Group, Southampton Neurosciences Group, School of Biological Sciences, University of Southampton, Southampton, SO16 7PX Hampshire, UK
    Neurobiol Dis 22:638-50. 2006
  7. doi request reprint Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration
    Karine Palin
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Neurobiol Dis 30:19-29. 2008
  8. pmc Age related changes in microglial phenotype vary between CNS regions: grey versus white matter differences
    Adam D Hart
    Centre for Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Brain Behav Immun 26:754-65. 2012
  9. doi request reprint Immune-to-brain signalling: the role of cerebral CD163-positive macrophages
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Neurosci Lett 448:41-6. 2008
  10. ncbi request reprint Differential induction of interleukin-1beta and tumour necrosis factor-alpha may account for specific patterns of leukocyte recruitment in the brain
    Donatienne Blond
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Biomedical Sciences Building, Southampton SO16 7PX, UK
    Brain Res 958:89-99. 2002

Collaborators

Detail Information

Publications51

  1. pmc Enriched environment and masticatory activity rehabilitation recover spatial memory decline in aged mice
    Fabíola de Carvalho Chaves de Siqueira Mendes
    Universidade Federal do Para UFPA, Instituto de Ciencias Biologicas, Laboratório de Investigações em Neurodegeneração e Infecção, Hospital Universitário João de Barros Barreto, Rua dos Mundurucus, 4487 Guamá Belém, Para, Brasil
    BMC Neurosci 14:63. 2013
    ..To evaluate spatial learning, we used the Morris water maze...
  2. pmc Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration
    V Hugh Perry
    Centre for Biological Sciences, Southampton General Hospital, University of Southampton, Mail Point 840, LD80B, South Lab and Path Block, SO16 6YD Southampton, UK
    Semin Immunopathol 35:601-12. 2013
    ....
  3. pmc Spatial memory decline after masticatory deprivation and aging is associated with altered laminar distribution of CA1 astrocytes
    Marina Negrão Frota de Almeida
    Universidade Federal do Para UFPA, Instituto de Ciencias Biologicas, Laboratório de Investigações em Neurodegeneração e Infecção, Hospital Universitário João de Barros Barreto, Belem, PA, Brazil
    BMC Neurosci 13:23. 2012
    ..A soft diet (SD) was used to reduce mastication in the experimental group, whereas the control group was fed a hard diet (HD). Assays were performed in 3-, 6- and 18-month-old SD and HD mice...
  4. doi request reprint Microglia in neurodegenerative disease
    V Hugh Perry
    School of Biological Sciences, University of Southampton, Building 62, Boldrewood Campus, Southampton SO16 7PX, UK
    Nat Rev Neurol 6:193-201. 2010
    ..The fact that diseases with a chronic systemic inflammatory component are risk factors for Alzheimer disease implies that crosstalk occurs between systemic inflammation and microglia in the CNS...
  5. ncbi request reprint Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration
    Colm Cunningham
    CNS Inflammation Group, School of Biological Sciences, Southampton, Hampshire SO16 7PX, United Kingdom
    J Neurosci 25:9275-84. 2005
    ..The finding that a single acute systemic inflammatory event can induce neuronal death in the CNS has implications for therapy in neurodegenerative diseases...
  6. ncbi request reprint TGFbeta1 regulates the inflammatory response during chronic neurodegeneration
    Delphine Boche
    CNS Inflammation Group, Southampton Neurosciences Group, School of Biological Sciences, University of Southampton, Southampton, SO16 7PX Hampshire, UK
    Neurobiol Dis 22:638-50. 2006
    ..These data suggest that TGFbeta1 plays a critical role in the downregulation of microglial responses minimizing brain inflammation and thus avoiding exacerbation of brain damage...
  7. doi request reprint Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration
    Karine Palin
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Neurobiol Dis 30:19-29. 2008
    ....
  8. pmc Age related changes in microglial phenotype vary between CNS regions: grey versus white matter differences
    Adam D Hart
    Centre for Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Brain Behav Immun 26:754-65. 2012
    ..Taken together, these findings show that the effects of age on microglial phenotype and functional integrity vary significantly between CNS compartments, as do, albeit to a lesser extent, the effects of systemic LPS...
  9. doi request reprint Immune-to-brain signalling: the role of cerebral CD163-positive macrophages
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Neurosci Lett 448:41-6. 2008
    ..Cerebral endothelial cells outnumber CD163-positive macrophages and are arguably better situated to signal circulating inflammatory stimuli to the brain...
  10. ncbi request reprint Differential induction of interleukin-1beta and tumour necrosis factor-alpha may account for specific patterns of leukocyte recruitment in the brain
    Donatienne Blond
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Biomedical Sciences Building, Southampton SO16 7PX, UK
    Brain Res 958:89-99. 2002
    ....
  11. pmc Comparison of inflammatory and acute-phase responses in the brain and peripheral organs of the ME7 model of prion disease
    Colm Cunningham
    CNS Inflammation Group, School of Biological Sciences, Bassett Crescent East, Southampton, Hampshire SO16 7PX, United Kingdom
    J Virol 79:5174-84. 2005
    ..We also propose that serum cytokine and APP measurements are not useful during preclinical disease. Possible consequences of the clear chronic elevation of APPs in the CNS are discussed...
  12. doi request reprint Systemic inflammation induces axon injury during brain inflammation
    Beatriz Moreno
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton, UK
    Ann Neurol 70:932-42. 2011
    ..We hypothesize that systemic inflammation leads to enhanced axonal damage in MS as a consequence of innate immune system activation...
  13. doi request reprint Reactive hypertrophy of synaptic varicosities within the hippocampus of prion-infected mice
    Zuzana Siskova
    CNS Inflammation Group, Basset Crescent East, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Biochem Soc Trans 38:471-5. 2010
    ....
  14. ncbi request reprint The systemic and local acute phase response following acute brain injury
    David C Wilcockson
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton, Hampshire, UK
    J Cereb Blood Flow Metab 22:318-26. 2002
    ..These results suggest that the local APR may play a role as an antiinflammatory mechanism. These findings indicate a potentially pivotal role for peripheral and local APP production on outcome after brain injury...
  15. ncbi request reprint Systemic infections and inflammation affect chronic neurodegeneration
    V Hugh Perry
    Southampton Neuroscience Group, School of Biological Sciences and School of Medicine, University of Southampton, Southampton SO16 7PX, UK
    Nat Rev Immunol 7:161-7. 2007
    ....
  16. doi request reprint Systemic inflammation modulates Fc receptor expression on microglia during chronic neurodegeneration
    Katie Lunnon
    Central Nervous System Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 6YD, United Kingdom
    J Immunol 186:7215-24. 2011
    ..At the same time, IgG influx into the brain could provide a cross-linking ligand resulting in excessive microglia activation that is detrimental to neurons already under threat by misfolded protein...
  17. doi request reprint Unaltered SNARE complex formation in an in vivo model of prion disease
    Ayodeji A Asuni
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
    Brain Res 1233:1-7. 2008
    ..Thus the accumulation of PrP(Sc) although deleterious to synaptic function in vivo, does not exert its synaptic effects by disrupting the formation of SNARE complexes that are core to transmitter release...
  18. doi request reprint Selective presynaptic degeneration in the synaptopathy associated with ME7-induced hippocampal pathology
    Bryony C Gray
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, Hants, UK
    Neurobiol Dis 35:63-74. 2009
    ..This synaptic pathology or "synaptopathy" may represent the earliest neuronal dysfunction in this and other protein misfolding induced neurodegenerative diseases...
  19. pmc The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective
    V Hugh Perry
    School of Biological Sciences, University of Southampton, Southampton, U K
    ASN Neuro 2:e00047. 2010
    ..We highlight here some of the gaps in our understanding of synapse degeneration in chronic neurodegenerative disease...
  20. doi request reprint Change in tau phosphorylation associated with neurodegeneration in the ME7 model of prion disease
    Ayodeji A Asuni
    CNS Inflammation Group, University of Southampton, Southampton SO16 7PX, UK
    Biochem Soc Trans 38:545-51. 2010
    ..These data suggest that the changes in tau phosphorylation recorded here and observed by others relate to end-stage prion pathology when early dysfunctions have progressed to overt neuronal loss...
  21. doi request reprint Contribution of systemic inflammation to chronic neurodegeneration
    V Hugh Perry
    School of Biological Sciences, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Acta Neuropathol 120:277-86. 2010
    ....
  22. ncbi request reprint Blood-derived dendritic cells in an acute brain injury
    Tracey A Newman
    CNS Inflammation Group, University of Southampton, UK
    J Neuroimmunol 166:167-72. 2005
    ..We conclude that DC are recruited to an excitotoxic lesion from a blood-derived cell population. This may have implications for neuropathologies involving DC recruitment...
  23. ncbi request reprint Differential regulation of type I and type II interleukin-1 receptors in focal brain inflammation
    Fabian Docagne
    Molecular Neuropathology Laboratory, School of Biological Sciences, University of Southampton, UK
    Eur J Neurosci 21:1205-14. 2005
    ..The lesion-specific expression of IL-1 receptors suggests that the receptors are differentially regulated in a manner not directly related to the endogenous level of IL-1 in the CNS...
  24. ncbi request reprint The influence of systemic inflammation on inflammation in the brain: implications for chronic neurodegenerative disease
    V Hugh Perry
    CNS Inflammation Group, University of Southampton, Biomedical Sciences Building, Southampton SO16 7PX, UK
    Brain Behav Immun 18:407-13. 2004
    ..These interactions suggest that systemic infections, or indeed any systemic challenge that promotes a systemic inflammatory response, may contribute to the outcome or progression of chronic neurodegenerative disease...
  25. pmc Innate inflammation in Parkinson's disease
    V Hugh Perry
    School of Biological Sciences, University of Southampton, Southampton, UK
    Cold Spring Harb Perspect Med 2:a009373. 2012
    ....
  26. pmc Brain region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease
    Zuzana Siskova
    Centre for Biological Sciences, University of Southampton, Southampton, United Kingdom
    PLoS ONE 8:e55004. 2013
    ..These observations demonstrate that neuronal vulnerability to pathological protein misfolding is strongly dependent on the structure and function of the target neurons...
  27. ncbi request reprint Mannose receptor expression specifically reveals perivascular macrophages in normal, injured, and diseased mouse brain
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    Glia 49:375-84. 2005
    ....
  28. pmc An antigen-specific pathway for CD8 T cells across the blood-brain barrier
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton, UK
    J Exp Med 204:2023-30. 2007
    ..This has implications for a variety of diseases in which antigen-specific CD8 T cell traffic into the brain is a beneficial or deleterious feature...
  29. pmc Intracerebral immune complex formation induces inflammation in the brain that depends on Fc receptor interaction
    Jessica L Teeling
    Centre for of Biological Sciences, University of Southampton, Southampton General Hospital, UK
    Acta Neuropathol 124:479-90. 2012
    ..These observations may have important implications for the development of therapeutic antibodies directed against neuronal antigens used for therapeutic intervention in neurological diseases...
  30. pmc Mouse maternal systemic inflammation at the zygote stage causes blunted cytokine responsiveness in lipopolysaccharide-challenged adult offspring
    Charlotte L Williams
    School of Biological Sciences, University of Southampton, Mailpoint 840, Level D Laboratories and Pathology Block, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    BMC Biol 9:49. 2011
    ....
  31. ncbi request reprint CINC-1 is an acute-phase protein induced by focal brain injury causing leukocyte mobilization and liver injury
    Sandra J Campbell
    Molecular Neuropathology Laboratory, School of Biological Sciences, University of Southampton, Biomedical Sciences Building, Southampton S016 7PX, UK
    FASEB J 17:1168-70. 2003
    ..Hepatic CINC-1 synthesis following injury presents a novel focus for treatment of inflammation...
  32. ncbi request reprint Atypical inflammation in the central nervous system in prion disease
    V Hugh Perry
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Curr Opin Neurol 15:349-54. 2002
    ..There is also now evidence to suggest that a peripheral infection, and its consequent systemic cytokine expression, may drive central nervous system cytokine expression and perhaps exacerbate disease...
  33. ncbi request reprint Altered chemokine expression in the spinal cord and brain contributes to differential interleukin-1beta-induced neutrophil recruitment
    Sandra J Campbell
    Molecular Neuropathology Laboratory and CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton, UK
    J Neurochem 83:432-41. 2002
    ..No expression of CINC-2beta mRNA was detected. Thus differential chemokine induction may contribute to variations in neutrophil recruitment in during development and between the different CNS compartments...
  34. ncbi request reprint The impact of systemic infection on the progression of neurodegenerative disease
    V Hugh Perry
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Nat Rev Neurosci 4:103-12. 2003
  35. doi request reprint Regulation of microglial proliferation during chronic neurodegeneration
    Diego Gómez-Nicola
    Centre for Biological Sciences, University of Southampton, SO16 6YD, Southampton, United Kingdom
    J Neurosci 33:2481-93. 2013
    ....
  36. pmc Soluble axoplasm enriched from injured CNS axons reveals the early modulation of the actin cytoskeleton
    Patrick Garland
    Centre for Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    PLoS ONE 7:e47552. 2012
    ..These findings highlight a previously unexplored area of axon biology, which may open novel avenues to prevent axon degeneration. Our method for isolating CNS axoplasm also represents a new tool to study axon biology...
  37. ncbi request reprint Selective effects of upper respiratory tract infection on cognition, mood and emotion processing: a prospective study
    Romola S Bucks
    University of Southampton, UK
    Brain Behav Immun 22:399-407. 2008
    ..URTIs also affect mood. Future studies need to examine the role of inflammatory molecules and the brain regions implicated in mediating these findings...
  38. pmc Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia
    Ursula Püntener
    Centre for Biological Sciences, University of Southampton, South Lab and Path Block, MP840, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    J Neuroinflammation 9:146. 2012
    ..In this study, we investigated the immune adaptation of microglia and brain vascular endothelial cells in response to systemic inflammation or bacterial infection...
  39. ncbi request reprint Reduction of excitotoxicity and associated leukocyte recruitment by a broad-spectrum matrix metalloproteinase inhibitor
    Sandra J Campbell
    Molecular Neuropathology Laboratory, School of Biological Sciences, University of Southampton, Biomedical Sciences Building, Southampton SO16 7PX, UK
    J Neurochem 89:1378-86. 2004
    ..These studies suggest that MMP inhibitors have therapeutic potential for use in stroke, and support the increasing evidence that microglial activation may contribute to neuronal cell death...
  40. pmc Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK
    J Physiol 586:2231-44. 2008
    ..Similar and distinct postnatal outcomes were observed here compared with maternal LPD treatment during post-fertilization preimplantation development which may reflect the relative contribution of the paternal genome...
  41. ncbi request reprint Transforming growth factor-beta 1-mediated neuroprotection against excitotoxic injury in vivo
    Delphine Boche
    CNS Inflammation Group, Southampton Neuroscience Group, School of Biological Sciences, University of Southampton, Southampton, Hampshire, UK
    J Cereb Blood Flow Metab 23:1174-82. 2003
    ..We have demonstrated in vivo that the cerebral tolerance phenomenon induced by LPS pretreatment is mediated by TGF-beta 1 cytokine...
  42. pmc Fcγ receptor upregulation is associated with immune complex inflammation in the mouse retina and early age-related macular degeneration
    Salome Murinello
    Centre for Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Invest Ophthalmol Vis Sci 55:247-58. 2014
    ..To examine this further, we developed a novel experimental mouse model of retinal inflammation and evaluated whether inflammation associated with immune complex formation was present in eyes of AMD donors...
  43. ncbi request reprint What is immune privilege (not)?
    Ian Galea
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, SO16 7PX, UK
    Trends Immunol 28:12-8. 2007
    ..It is now increasingly recognized how immune privilege is maintained actively as a result of the immunoregulatory characteristics of the CNS-resident cells and their microenvironment...
  44. ncbi request reprint Stress primes microglia to the presence of systemic inflammation: implications for environmental influences on the brain
    V Hugh Perry
    CNS Inflammation Group, School of Biological Sciences, University of Southampton, Southampton SO16 7PX, UK
    Brain Behav Immun 21:45-6. 2007
  45. doi request reprint Integration of a macro/micro architectured compartmentalised neuronal culture device using a rapid prototyping moulding process
    Martin Arundell
    School of Biological Sciences, University of Southampton, Southampton, UK
    Lab Chip 11:3001-5. 2011
    ..The compartmentalised device has several advantages including good experimental accessibility and versatility with a variety of end user applications...
  46. doi request reprint C1q: the perfect complement for a synaptic feast?
    V Hugh Perry
    School of Biological Sciences, University of Southampton, Southampton, SO16 7PX, UK
    Nat Rev Neurosci 9:807-11. 2008
    ....
  47. ncbi request reprint Self-destruct programs in the processes of developing neurons
    David Shepherd
    School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
    Curr Top Dev Biol 65:149-67. 2005
  48. doi request reprint Microglial priming in neurodegenerative disease
    V Hugh Perry
    Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Tremona Road, Southampton SO16 6YD, UK
    Nat Rev Neurol 10:217-24. 2014
    ..Both lifestyle changes and pharmacological therapies could, therefore, provide efficient means to slow down or halt neurodegeneration. ..
  49. ncbi request reprint Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1
    Holly Bowen
    Division of Biochemistry and Molecular Biology, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
    J Biol Chem 278:36017-26. 2003
    ....
  50. ncbi request reprint Adaptive responses by mouse early embryos to maternal diet protect fetal growth but predispose to adult onset disease
    Adam J Watkins
    School of Biological Sciences, University of Southampton, Southampton SO16 7PX, United Kingdom
    Biol Reprod 78:299-306. 2008
    ..However, activation of such responses may also lead to adult excess growth and cardiovascular and behavioral diseases...
  51. ncbi request reprint Association between dementia and infectious disease: evidence from a case-control study
    Nicholas Dunn
    University of Southampton, UK
    Alzheimer Dis Assoc Disord 19:91-4. 2005
    ..Smoking and diabetes mellitus are associated with onset of dementia in the elderly. The evidence from this study may represent cause and effect, since there is a credible biologic explanation...