Research Topics
Species | Elaine PerrySummaryAffiliation: University of Newcastle Country: UK Publications
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Detail Information
Publications
Absence of cholinergic deficits in "pure" vascular dementiaE Perry
Newcastle General Hospital, MRC Bldg, Westgate Rd, Newcastle upon Tyne, NE4 6BE, UK
Neurology 64:132-3. 2005..001) had greater cholinergic deficits than age-matched control subjects and patients with "pure" VaD. The absence of cholinergic deficits in "pure" VaD may be relevant to the pharmacologic treatment of these patients...- Medicinal plants and Alzheimer's disease: from ethnobotany to phytotherapyE K Perry
Medical Research Council, Newcastle General Hospital, Newcastle upon Tyne
J Pharm Pharmacol 51:527-34. 1999..Long before the current biologically-based hypothesis of cholinergic derangement in Alzheimer' s disease emerged, plants now known to contain cholinergic antagonists were recorded for their amnesia- and dementia-inducing properties... - Neurochemistry of consciousness: cholinergic pathologies in the human brainElaine K Perry
MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Prog Brain Res 145:287-99. 2004 - Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugsElaine K Perry
MRC Building, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
Ann Neurol 54:235-8. 2003..02 and 0.05, respectively). The findings, if replicated, have potential implications for the use of anticholinergic medication in elderly Parkinson's disease patients... - Butyrylcholinesterase and progression of cognitive deficits in dementia with Lewy bodiesElaine Perry
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Newcastle, UK
Neurology 60:1852-3. 2003..The authors report a highly significant association between temporal cortex butyrylcholinesterase activity and the rate of cognitive decline in a prospectively studied, autopsy-confirmed dementia with Lewy bodies series... - Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrainE K Perry
Centre Development in Clinical Brain Ageing, Newcastle General Hospital, Newcastle upon Tyne, UK
Am J Psychiatry 158:1058-66. 2001..Measures of cholinergic transmitter activity were investigated in patients with autism because of reported neuropathological abnormalities in cholinergic nuclei in the basal forebrain... - Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseasesE Perry
Department of Neuropathology, MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, Newcastle, UK
Eur J Pharmacol 393:215-22. 2000..These findings indicate an early involvement of the alpha4 subunit in beta-amyloidosis but not in nigro-striatal dopaminergic degeneration... - Involvement of alpha6/alpha3 neuronal nicotinic acetylcholine receptors in neuropsychiatric features of Dementia with Lewy bodies: [(125)I]-alpha-conotoxin MII binding in the thalamus and striatumMelissa Ray
Institute for Ageing and Health, University of Newcastle upon Tyne, MRC Building, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Neurosci Lett 372:220-5. 2004.... - Comparative distribution of binding of the muscarinic receptor ligands pirenzepine, AF-DX 384, (R,R)-I-QNB and (R,S)-I-QNB to human brainMargaret Piggott
Newcastle General Hospital, MRC University of Newcastle Centre Development in Clinical Brain Ageing, MRC Building, Westgate Road, NE4 6BE, Newcastle upon Tyne, UK
J Chem Neuroanat 24:211-23. 2002.... - Alzheimer's disease is associated with a selective increase in alpha7 nicotinic acetylcholine receptor immunoreactivity in astrocytesThanasak Teaktong
MRC Building, Centre Development in Clinical Brain Aging, Newcastle General Hospital, Newcastle upon Tyne, UK
Glia 41:207-11. 2003..Elevated alpha7 nAChRs on astrocytes in AD may contribute to alterations in calcium homeostasis and nitric oxide production, which in turn could affect beta-amyloid-mediated inflammatory processes in AD... - Commentary: botanical potentials in Alzheimer's diseaseElaine Perry
Department of Neurochemical Pathology, Wolfson Research Centre, Institute for Ageing and Health, University of Newcastle, Newcastle General Hospital, Newcastle-upon-Tyne, UK
J Altern Complement Med 13:345-6. 2007 - Altered neurogenesis in Alzheimer's diseaseIryna Ziabreva
Institute of Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Westgate Road, NE4 6BE Newcastle upon Tyne, UK
J Psychosom Res 61:311-6. 2006..Cortical cholinergic loss was strongly associated with the reduction of progenitors, with potential implications of important treatment targets... - Why people see things that are not there: a novel Perception and Attention Deficit model for recurrent complex visual hallucinationsDaniel Collerton
South of Tyne and Wearside Mental Health NHS Trust, Bensham Hospital, Gateshead NE8 4YL, United Kingdom
Behav Brain Sci 28:737-57; discussion 757-94. 2005..Several tests of the model are indicated, together with a number of treatment options that it generates... 
Medicinal plants and dementia therapy: herbal hopes for brain aging?Elaine Perry
Institute of Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 6BE, UK
CNS Neurosci Ther 17:683-98. 2011....- Dreaming and hallucinations - continuity or discontinuity? Perspectives from dementia with Lewy bodiesDaniel Collerton
Institute for Ageing and Health, Newcastle University, UK
Conscious Cogn 20:1016-20. 2011..A similar analysis of other psychotic features in Lewy body dementia and other disorders suggests that, in contrast to hallucinations, there may be more convincing parallels between dreaming and delusional states... - Hallucinations predict attentional improvements with rivastigmine in dementia with lewy bodiesIan G McKeith
Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
Dement Geriatr Cogn Disord 18:94-100. 2004..This may reflect the greater cholinergic deficits in areas of the brain responsible for visual hallucinations, offering greater potential for attentional improvement... - A positive association between 5HT re-uptake binding sites and depression in dementia with Lewy bodiesClive Ballard
Institute for the Health of the Elderly, University of Newcastle, Newcastle, UK
J Affect Disord 69:219-23. 2002..The neurochemical basis for depression in DLB has not been investigated... - Proteasomal abnormalities in cortical Lewy body disease and the impact of proteasomal inhibition within cortical and cholinergic systemsNicholas Macinnes
Wolfson Centre for Age Related Disease, King s College London, London, UK
J Neural Transm 115:869-78. 2008..These findings suggest that proteasomal abnormalities are present within cortical Lewy body disease and the experimental inhibition of proteasomal function mirrors the neuropathological changes seen within the disorder... - Chronic nicotine treatment reduces beta-amyloidosis in the brain of a mouse model of Alzheimer's disease (APPsw)Agneta Nordberg
Karolinska Institutet, Neurotec, Division of Molecular Neuropharmacology, Huddinge University Hospital, Stockholm, Sweden
J Neurochem 81:655-8. 2002..These results indicate that nicotine may effectively reduce amyloid beta peptide aggregation in brain and that nicotinic drug treatment may be a novel protective therapy in Alzheimer's disease... - The distribution pattern of pathology and cholinergic deficits in amygdaloid complex in Alzheimer's disease and dementia with Lewy bodiesHuseyin A Sahin
Department of Neurology, Ondokuz Mayis University, Faculty of Medicine, Kurupelit, 55139, Samsun, Turkey
Acta Neuropathol 111:115-25. 2006.... - Selective nicotinic receptor consequences in APP(SWE) transgenic miceIvan Bednar
Divisions of Molecular Neuropharmacology, Occupational Therapy and Elderly Care Research NEUROTEC, S 141 86 Stockholm, Sweden
Mol Cell Neurosci 20:354-65. 2002..The upregulation of the nAChRs probably reflects compensatory mechanisms in response to Abeta burden in the brains of Tg+ mice... - The k variant of the butyrylcholinesterase gene is associated with reduced phosphorylation of tau in dementia patientsClive Ballard
Wolfson Centre for Age Related Diseases, Guys Campus, Kings College London, London, UK
Dement Geriatr Cogn Disord 19:357-60. 2005..2, p = 0.039), but no difference in the extent of Abeta(1-42) deposition. BuChE may play this role in the phosphorylation of tau, relevant to therapeutic inhibition of the enzyme... - Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesteraseMarie M Svedberg
Karolinska Institutet, Neurotec, Division of Molecular Neuropharmacology, Huddinge University Hospital, Stockholm, Sweden
J Mol Neurosci 18:211-22. 2002.... - Thalamic nicotinic receptors implicated in disturbed consciousness in dementia with Lewy bodiesSally L Pimlott
West of Scotland Radionuclide Dispensary, Western Infirmary, Dumbarton Road, Glasgow G11 6NT, UK
Neurobiol Dis 21:50-6. 2006..These findings, together with previous neocortical data, implicate nicotinic modulation of thalamo-cortical circuitry as a key component in the control of conscious awareness in DLB... - Nicotine reduces A beta in the brain and cerebral vessels of APPsw miceEwa Hellström-Lindahl
Karolinska Institutet, Neurotec Department, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge B84, S 141 86 Stockholm, Sweden
Eur J Neurosci 19:2703-10. 2004..Further studies are required to identify potential mechanisms of the nicotine's amyloid-reducing effect...