Kirsten P Perrett
Affiliation: University of Oxford
- Towards an improved serogroup B Neisseria meningitidis vaccineKirsten P Perrett
Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Headington, Oxford, OX3 7LJ, UK
Expert Opin Biol Ther 5:1611-25. 2005..Investment by the pharmaceutical industry in preclinical research and development provides hope that an efficacious serogroup B meningococcal vaccine can be developed...
- Immunogenicity and immune memory of a nonadjuvanted quadrivalent meningococcal glycoconjugate vaccine in infantsKirsten P Perrett
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
Pediatr Infect Dis J 28:186-93. 2009..We evaluated the immunogenicity and reactogenicity of a novel quadrivalent nonadjuvanted meningococcal glycoconjugate vaccine (MenACWY-CRM) in healthy infants...
- Immunogenicity of a tetravalent meningococcal glycoconjugate vaccine in infants: a randomized controlled trialMatthew D Snape
Oxford Vaccine Group, University of Oxford, England
JAMA 299:173-84. 2008..However, the currently licensed vaccine is poorly immunogenic in infancy, when the highest rates of disease are observed...
- Plasma and memory B-cell kinetics in infants following a primary schedule of CRM 197-conjugated serogroup C meningococcal polysaccharide vaccineDominic F Kelly
Oxford Vaccine Group, Department of Paediatrics, Oxford University, Oxford, UK
Immunology 127:134-43. 2009..This study provides data on B-cell kinetics following a primary schedule of immunization in young infants upon which to base further studies of the underlying cellular mechanism of humoral immunity...
- B cell memory to a serogroup C meningococcal conjugate vaccine in childhood and response to booster: little association with serum IgG antibodyKirsten P Perrett
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford OX3 7LE, United Kingdom
J Immunol 189:2673-81. 2012..Measurement of B cell memory in peripheral blood does not predict steady state Ab levels nor the capacity to respond to a booster dose of MenC Ag...
- Maintaining protection against invasive bacteria with protein-polysaccharide conjugate vaccinesAndrew J Pollard
Department of Paediatrics, University of Oxford, Level 2, Children s Hospital, Oxford, UK
Nat Rev Immunol 9:213-20. 2009..In this Science and Society article, we describe how vaccine-induced immunity wanes rapidly after vaccination in early childhood and argue that strategies that sustain protection in the population must be considered...
- Single nucleotide polymorphisms in the Toll-like receptor 3 and CD44 genes are associated with persistence of vaccine-induced immunity to the serogroup C meningococcal conjugate vaccineCatrin E Moore
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, United Kingdom
Clin Vaccine Immunol 19:295-303. 2012..These results suggest that genetic polymorphisms in the TLR3 and CD44 genes are associated with the persistence of the immune response to MenC vaccines 1 to 6 years after vaccination...