Research Topics
Genomes and GenesSpecies | N D PerkinsSummaryAffiliation: University of Dundee Country: UK Publications
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Publications
NF-kappaB: tumor promoter or suppressor?Neil D Perkins
Division of Gene Regulation and Expression, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee, UK DD1 5EH
Trends Cell Biol 14:64-9. 2004..Here, I discuss this hypothesis, its implications for NF-kappaB function, and how this might influence the use of NF-kappaB-based anticancer therapies...
A novel form of the RelA nuclear factor kappaB subunit is induced by and forms a complex with the proto-oncogene c-MycNeil R Chapman
Division of Gene Expression and Regulation, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem J 366:459-69. 2002....- Regulation of NF-kappaB by atypical activators and tumour suppressorsN D Perkins
Division of Gene Regulation and Expression, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem Soc Trans 32:936-9. 2004..A better understanding of these processes and an ability to analyse RelA function in tumours could lead to improved cancer diagnosis, choice of therapy and, ultimately, development of new drugs... - SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1Toula Bouras
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Rd, Washington, DC 20057, USA
J Biol Chem 280:10264-76. 2005..Because p300 is a limiting transcriptional cofactor, deacetylation and repression of p300 by SIRT1 may serve an important integration point during metabolism and cellular differentiation... 
The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific mannerBrian J Wilson
Department of Molecular and Cellular Pathology, Ninewells Medical School, University of Dundee, DD1 9SY, UK
BMC Mol Biol 5:11. 2004..Furthermore these proteins were shown to interact with co-activators p300/CBP and the RNA polymerase II holoenzyme. Taken together these reports suggest a role for p68 and p72 in transcriptional activation...- The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitroSonia Rocha
School of Life Sciences, Division of Gene Regulation and Expression MSI WTB, Complex Dow Street University of Dundee Dundee, DD1 5EH, Scotland, United Kingdom
BMC Mol Biol 4:9. 2003..In addition, pifithrin-alpha provides a useful tool in the laboratory to investigate the function of p53 in model systems... - Transcriptional profiling of the LPS induced NF-kappaB response in macrophagesOmar Sharif
Division of Gene Regulation and Expression, College of Life Sciences, University of Dundee, MSI WTB JBC Complex, Dow Street, Dundee, DD1 5EH Scotland, UK
BMC Immunol 8:1. 2007..In this report, we have investigated and compared the LPS response in macrophage derived cell lines and peripheral blood mononuclear cell (PBMC) derived macrophages... - Differential regulation of NF-kappaB activation and function by topoisomerase II inhibitorsKirsteen J Campbell
School of Life Sciences, Division of Gene Regulation and Expression, MSI WTB, CoMPLEX, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK
BMC Cancer 6:101. 2006.... - Oncogenes, tumor suppressors and p52 NF-kappaBNeil D Perkins
Division of Gene Regulation and Expression, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, UK
Oncogene 22:7553-6. 2003..A clearer picture is now developing of the important role that p52 NF-kappaB plays during normal cell growth and how subverting its function can contribute to oncogenesis... - Good cop, bad cop: the different faces of NF-kappaBN D Perkins
Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, MSI WTB complex, Dow Street, Dundee, Scotland DD1 5EH, UK
Cell Death Differ 13:759-72. 2006.... - The Rel/NF-kappa B family: friend and foeN D Perkins
Dept of Biochemistry, Division of Gene Regulation and Expression, MSI WTB complex, Dow Street, University of Dundee, Dundee, UK DD1 5EH
Trends Biochem Sci 25:434-40. 2000..Thus, targeting NF-kappa B might lead to the development of new pharmaceutical reagents that could provide novel treatments for many inflammatory diseases and cancer... - Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathwayN D Perkins
Division of Gene Regulation and Expression, University of Dundee, Dundee, Scotland, UK
Oncogene 25:6717-30. 2006.... - Integrating cell-signalling pathways with NF-kappaB and IKK functionNeil D Perkins
College of Life Sciences, Division of Gene Regulation and Expression, James Black Centre, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, UK
Nat Rev Mol Cell Biol 8:49-62. 2007..This crosstalk constitutes a decision-making process that determines the consequences of NF-kappaB and IKK activation and, ultimately, cell fate... - Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa BKirsteen J Campbell
School of Life Sciences, Division of Gene Regulation and Expression, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
Mol Cell 13:853-65. 2004..This has important implications for the role of NF-kappa B in tumorigenesis and the use of NF-kappa B inhibitors in cancer therapy... - UV stimulation induces nuclear factor kappaB (NF-kappaB) DNA-binding activity but not transcriptional activationK J Campbell
Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem Soc Trans 29:688-91. 2001.... - Reprogramming RelAKirsteen J Campbell
School of Life Sciences, Division of Gene Regulation and Expression, MSI/WTB Complex, University of Dundee, Dundee, Scotland
Cell Cycle 3:869-72. 2004..The identification of these pathways not only allows a reinterpretation of NF-kappaB function in normal cells and during tumorigenesis but could also have implications for both traditional and NF-kappaB based cancer therapy... - p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1Sonia Rocha
School of Life Sciences, Division of Gene Expression and Regulation, University of Dundee, Scotland, United Kingdom
Mol Cell Biol 23:4713-27. 2003..These results reveal a unique mechanism by which p53 regulates NF-kappaB function and cell cycle progression... - A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivationA W Snowden
Division of Gene Regulation and Expression, Department of Biochemistry, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
Mol Cell Biol 20:2676-86. 2000..We suggest that CRD1 provides a novel mechanism through which p300 and CBP can switch activities between the promoters of genes that stimulate growth and those that enhance cell cycle arrest... - Post-translational modification of RelA(p65) NF-kappaBK J Campbell
Division of Gene Regulation and Expression, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, Scotland, UK
Biochem Soc Trans 32:1087-9. 2004..These observations suggest that diagnosis and new therapies based on reprogramming NF-kappaB activity could be more efficient than total NF-kappaB inhibition... - Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunitKatie Schumm
College of Life Sciences, Division of Gene Regulation and Expression, University of Dundee, Dundee, UK
EMBO J 25:4820-32. 2006..Furthermore, they imply that in some cell types, p52 can regulate p53 function and influence p53-regulated decision-making following DNA damage and oncogene activation... - Regulation of RelA (p65) function by the large subunit of replication factor CLisa A Anderson
Division of Gene Expression and Regulation, School of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
Mol Cell Biol 23:721-32. 2003..Taken together, these observations suggest that, in addition to its previously described function in DNA replication and repair, RFC (p140) has an important role as a regulator of transcription and NF-kappaB activity... - Cell cycle regulation of the transcriptional coactivators p300 and CREB binding proteinA W Snowden
Department of Biochemistry, University of Dundee, Scotland, UK
Biochem Pharmacol 55:1947-54. 1998.... - Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-kappaB- and p53-regulated gene targetsN McTavish
Department of Surgery and Molecular Oncology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Cell Death Differ 14:1700-10. 2007.... - Regulation of cyclin D1 RNA stability by SNIP1Cameron P Bracken
College of Life Sciences, Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee, United Kingdom
Cancer Res 68:7621-8. 2008..This study shows a novel mechanism regulating Cyclin D1 expression and offers new insight into the role of SNIP1 and associated proteins as regulators of proliferation and cancer... - A cell cycle regulatory network controlling NF-kappaB subunit activity and functionBenjamin Barré
Division of Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
EMBO J 26:4841-55. 2007..These data reveal a complex regulatory network integrating NF-kappaB with the DNA-replication checkpoint and the expression of critical regulators of cell proliferation... - p21WAF1/CIP1 regulates the p300 sumoylation motif CRD1 through a C-terminal domain independently of cyclin/CDK bindingElisa Garcia-Wilson
School of Life Sciences, Division of Gene Regulation and Expression, University of Dundee, Dundee, Scotland, United Kingdom
Cell Cycle 4:1113-9. 2005..Binding of HDACs also failed to correlate with CRD1 inducibility, suggesting that p21 targets other transcriptional repression complexes to mediate this effect... - Regulation of ATR-dependent pathways by the FHA domain containing protein SNIP1K C Roche
Division of Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
Oncogene 26:4523-30. 2007..This, together with its other described functions, suggests that SNIP1 could have an important role during tumorigenesis and cancer therapy... - Cisplatin mimics ARF tumor suppressor regulation of RelA (p65) nuclear factor-kappaB transactivationKirsteen J Campbell
School of Life Sciences, Division of Gene Regulation and Expression, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom
Cancer Res 66:929-35. 2006..Moreover, our data indicate that at least with respect to RelA, cisplatin functions as an ARF mimic. Other drugs capable of mimicking this aspect of ARF function might therefore have therapeutic potential... - p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressorSonia Rocha
School of Life Sciences, Division of Gene Regulation and Expression, MSI/WTB Complex, Dow Street, University of Dundee, Dundee, DD1 5EH, Scotland, United Kingdom
Mol Cell 12:15-25. 2003..Further, we show that the response of NF-kappa B to the oncogene Bcr-Abl is determined by the ARF status of the cell. These results reveal an important function of ARF that can regulate the NF-kappa B response to oncogene activation... - Inhibition of the RelA(p65) NF-kappaB subunit by Egr-1N R Chapman
Department of Biochemistry, Division of Gene Expression and Regulation, MSI WTB complex, Dow Street, University of Dundee, Dundee, DD1 5EH Scotland, United Kingdom
J Biol Chem 275:4719-25. 2000.... - The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressorGaynor J Bates
Department of Molecular and Cellular Pathology, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
EMBO J 24:543-53. 2005..This study represents the first report of the involvement of an RNA helicase in the p53 response, and highlights a novel mechanism by which p68 may act as a tumour cosuppressor in governing p53 transcriptional activity... - DNA-dependent acetylation of p53 by the transcription coactivator p300David Dornan
Cancer Research UK Laboratories, Department of Molecular and Cellular Pathology, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
J Biol Chem 278:13431-41. 2003.... - Regulation of NF-kappaB and p53 through activation of ATR and Chk1 by the ARF tumour suppressorSonia Rocha
School of Life Sciences, Division of Gene Regulation and Expression, University of Dundee, Dundee, Scotland, UK
EMBO J 24:1157-69. 2005..Moreover, this pathway provides a mechanism through which ARF can remodel the cellular response to an oncogenic challenge and execute its function as a tumour suppressor... 
Regulation of the RelA (p65) transactivation domainJohn M O'Shea
College of Life Sciences, Wellcome Centre for Gene Regulation and Expression, MSI WTB complex, Dow Street, University of Dundee, Dundee, Scotland, UK
Biochem Soc Trans 36:603-8. 2008..Moreover, we discuss how analysis of its evolutionary conservation reveals distinct subdomains and conserved residues that might give insights into its regulation and function...- ARF the integrator: linking NF-kappaB, p53 and checkpoint kinasesSonia Rocha
Division of Gene Regulation and Expression, Dow Street, University of Dundee, School of Life Sciences, Dundee, Scotland, United Kingdom
Cell Cycle 4:756-9. 2005..Therefore, through this mechanism, ARF can integrate the cellular response to an oncogene, thus maximising the effectiveness of the p53 tumor suppressor pathway... - The large subunit of replication factor C interacts with the histone deacetylase, HDAC1Lisa A Anderson
Division of Gene Regulation and Expression, School of Life Sciences, University of Dundee, Medical Sciences Institute Wellcome Trust Biocentre Complex, Dow Street, Dundee DD1 5EH, United Kingdom
J Biol Chem 277:29550-4. 2002..Further analysis revealed that RFC (p140) contains two distinct transcriptional repression domains. Moreover, both of these domains interact separately with HDAC1... - Not just a CDK inhibitor: regulation of transcription by p21(WAF1/CIP1/SDI1)Neil D Perkins
Cell Cycle 1:39-41. 2002 - Differential regulation of c-Jun-dependent transcription by SUMO-specific proteasesJinke Cheng
Department of Cardiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
J Biol Chem 280:14492-8. 2005..Thus, two SUMO-specific proteases regulate c-Jun-dependent transcription through entirely different mechanisms... - IEX-1 directly interferes with RelA/p65 dependent transactivation and regulation of apoptosisAlexander Arlt
Laboratory of Molecular Gastroenterology and Hepatology, 1st Department of Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
Biochim Biophys Acta 1783:941-52. 2008..Finally, ChIP-assays revealed that IEX-1 associates with the promoter of these genes. Altogether, our findings suggest a critical role of IEX-1 in the NF-kappaB dependent regulation of apoptotic responses... - A238L inhibits NF-ATc2, NF-kappa B, and c-Jun activation through a novel mechanism involving protein kinase C-theta-mediated up-regulation of the amino-terminal transactivation domain of p300Aitor G Granja
Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
J Immunol 180:2429-42. 2008..These findings provide new strategies to develop therapies potentially useful in the control of disorders related to p300 deregulation... - p53 and NF-kappaB crosstalk: IKKalpha tips the balanceVinay Tergaonkar
Institute of Molecular and Cell Biology, Proteos 61, Singapore
Mol Cell 26:158-9. 2007..2007) show that IkappaB kinase alpha (IKKalpha) can determine which pathway is dominant... - The ETS domain transcription factor Elk-1 contains a novel class of repression domainShen Hsi Yang
School of Biological Sciences, University of Manchester, 2205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
Mol Cell Biol 22:5036-46. 2002..Thus, the Elk-1 R motif and the p300 CRD1 motif represent a new class of repression domains that are regulated in a context-dependent manner... - Induction of transcription by p21Waf1/Cip1/Sdi1: role of NFkappaB and effect of non-steroidal anti-inflammatory drugsJason C Poole
Department of Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, USA
Cell Cycle 3:931-40. 2004..These findings suggest the feasibility of developing agents that will counteract p21-mediated induction of disease-associated genes... - P300 transcriptional repression is mediated by SUMO modificationDavid Girdwood
Institute of Biomolecular Sciences, University of Street Andrews, North Haugh, United Kingdom
Mol Cell 11:1043-54. 2003..These results reveal a mechanism controlling p300 function and suggest that SUMO-dependent repression is mediated by recruitment of HDAC6... - SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genesMakiko Fujii
Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, Maryland 20892, USA
Mol Cell 24:771-83. 2006....