S P Pereira

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Photodynamic therapy of malignant biliary strictures using meso-tetrahydroxyphenylchlorin
    Stephen P Pereira
    Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, UK
    Eur J Gastroenterol Hepatol 19:479-85. 2007
  2. ncbi request reprint Autoimmune pancreatitis: clinical and radiological features and objective response to steroid therapy in a UK series
    Nicholas I Church
    Department of Gastroenterology, University College Hospital, London, United Kingdom
    Am J Gastroenterol 102:2417-25. 2007
  3. pmc MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer
    W R Matull
    The Institute of Hepatology, Division of Medicine, Royal Free and University College London Medical School, London, UK
    Br J Cancer 98:1675-81. 2008
  4. pmc A combination of serum leucine-rich α-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary strictures
    N S Sandanayake
    UCL Institute of Hepatology, University College London, 9th Floor Royal Free Hospital, London NW3 2PG, UK
    Br J Cancer 105:1370-8. 2011
  5. pmc Expansion of Anti-Mesothelin Specific CD4(+) and CD8(+) T Cell Responses in Patients with Pancreatic Carcinoma
    Yuan Chen
    The Institute for Liver and Digestive Health, University College London, London, United Kingdom Institute of Immunity and Transplantation, University College London and the Royal Free London NHS Foundation Trust, London, United Kingdom
    PLoS ONE 9:e88133. 2014
  6. ncbi request reprint Photodynamic therapy for pancreatic and biliary tract cancer: the United Kingdom experience
    Stephen Pereira
    Hepatology and Gastroenterology, UCL Institute for Liver and Digestive Health, UCL Medical School Royal Free Hospital Campus, University College London, England
    J Natl Compr Canc Netw 10:S48-51. 2012
  7. pmc Safety and long term efficacy of porfimer sodium photodynamic therapy in locally advanced biliary tract carcinoma
    Stephen P Pereira
    UCL Institute of Liver and Digestive Health, University College London, UK
    Photodiagnosis Photodyn Ther 9:287-92. 2012
  8. pmc Prospective comparison of secretin-stimulated magnetic resonance cholangiopancreatography with manometry in the diagnosis of sphincter of Oddi dysfunction types II and III
    Stephen P Pereira
    Department of Gastroenterology, University College London Hospitals NHS Trust, London, UK
    Gut 56:809-13. 2007
  9. ncbi request reprint Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K1) in severe acute liver disease
    Stephen P Pereira
    Institute of Liver Studies, King s College Hospital, London, UK
    J Hepatol 42:365-70. 2005
  10. ncbi request reprint Transdermal hormone replacement therapy improves vertebral bone density in primary biliary cirrhosis: results of a 1-year controlled trial
    S P Pereira
    Institute of Liver Studies, King s College Hospital, London, UK
    Aliment Pharmacol Ther 19:563-70. 2004

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Photodynamic therapy of malignant biliary strictures using meso-tetrahydroxyphenylchlorin
    Stephen P Pereira
    Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, UK
    Eur J Gastroenterol Hepatol 19:479-85. 2007
    ..The aim of this study was to determine the safety and efficacy of endoscopically delivered meso-tetrahydroxyphenyl chlorin photodynamic therapy in the treatment of irresectable malignant biliary strictures and recurrent stent occlusion...
  2. ncbi request reprint Autoimmune pancreatitis: clinical and radiological features and objective response to steroid therapy in a UK series
    Nicholas I Church
    Department of Gastroenterology, University College Hospital, London, United Kingdom
    Am J Gastroenterol 102:2417-25. 2007
    ..Most cases of autoimmune pancreatitis (AIP) have been reported from Japan. We present data on a UK series, including clinical and radiological features at presentation, and longitudinal response to immunosuppression...
  3. pmc MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancer
    W R Matull
    The Institute of Hepatology, Division of Medicine, Royal Free and University College London Medical School, London, UK
    Br J Cancer 98:1675-81. 2008
    ..001 for BTC vs non-BTC) and correlated negatively with BTC survival. Biliary MUC4 and serum MUC5AC are highly specific tumour-associated mucins that may be useful in the diagnosis and formulation of therapeutic strategies in BTC...
  4. pmc A combination of serum leucine-rich α-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary strictures
    N S Sandanayake
    UCL Institute of Hepatology, University College London, 9th Floor Royal Free Hospital, London NW3 2PG, UK
    Br J Cancer 105:1370-8. 2011
    ..Biliary tract cancer (BTC) and benign biliary strictures can be difficult to differentiate using standard tumour markers such as serum carbohydrate antigen 19-9 (CA19-9) as they lack diagnostic accuracy...
  5. pmc Expansion of Anti-Mesothelin Specific CD4(+) and CD8(+) T Cell Responses in Patients with Pancreatic Carcinoma
    Yuan Chen
    The Institute for Liver and Digestive Health, University College London, London, United Kingdom Institute of Immunity and Transplantation, University College London and the Royal Free London NHS Foundation Trust, London, United Kingdom
    PLoS ONE 9:e88133. 2014
    ..c) Mesothelin-specific CD4+ T cell response is directly inhibited by elevated IL-10 in cancer patients. These data provides evidence for the use of Mesothelin as an immunogen for tumour-specific T cell response. ..
  6. ncbi request reprint Photodynamic therapy for pancreatic and biliary tract cancer: the United Kingdom experience
    Stephen Pereira
    Hepatology and Gastroenterology, UCL Institute for Liver and Digestive Health, UCL Medical School Royal Free Hospital Campus, University College London, England
    J Natl Compr Canc Netw 10:S48-51. 2012
    ....
  7. pmc Safety and long term efficacy of porfimer sodium photodynamic therapy in locally advanced biliary tract carcinoma
    Stephen P Pereira
    UCL Institute of Liver and Digestive Health, University College London, UK
    Photodiagnosis Photodyn Ther 9:287-92. 2012
    ..In patients with unresectable cholangiocarcinoma, photodynamic therapy (PDT) with porfimer sodium promotes biliary drainage and may improve survival and quality of life...
  8. pmc Prospective comparison of secretin-stimulated magnetic resonance cholangiopancreatography with manometry in the diagnosis of sphincter of Oddi dysfunction types II and III
    Stephen P Pereira
    Department of Gastroenterology, University College London Hospitals NHS Trust, London, UK
    Gut 56:809-13. 2007
    ..In sphincter of Oddi dysfunction (SOD), sphincter of Oddi manometry (SOM) predicts the response to sphincterotomy, but is invasive and associated with complications...
  9. ncbi request reprint Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K1) in severe acute liver disease
    Stephen P Pereira
    Institute of Liver Studies, King s College Hospital, London, UK
    J Hepatol 42:365-70. 2005
    ..However, there have been no studies of the pharmacokinetics or efficacy of i.v. or oral K1 in such patients...
  10. ncbi request reprint Transdermal hormone replacement therapy improves vertebral bone density in primary biliary cirrhosis: results of a 1-year controlled trial
    S P Pereira
    Institute of Liver Studies, King s College Hospital, London, UK
    Aliment Pharmacol Ther 19:563-70. 2004
    ..Retrospective studies have suggested that hormone replacement therapy may reduce the rate of bone loss in primary biliary cirrhosis, but no controlled data are available...
  11. pmc The pharmacokinetics and safety of porfimer after repeated administration 30-45 days apart to patients undergoing photodynamic therapy
    S P Pereira
    UCL Division of Surgery and Interventional Science, London, UK
    Aliment Pharmacol Ther 32:821-7. 2010
    ..Porfimer is an intravenous (i.v.) injectable photosensitizing agent used in the photodynamic treatment of tumours and of high-grade dysplasia in Barrett's oesophagus...
  12. pmc Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspirates
    L Ayaru
    The Institute of Hepatology, University College London, London, UK
    Br J Cancer 98:1548-54. 2008
    ..In this study, we demonstrate that Mcm5 in bile detected by a simple automated test is a more sensitive indicator of pancreaticobiliary malignancy than routine brush cytology...
  13. pmc Biochemical markers of acute pancreatitis
    W R Matull
    Institute of Hepatology, University College London Medical School, London, UK
    J Clin Pathol 59:340-4. 2006
    ..For obscure aetiologies, serum calcium and triglycerides should be measured. Genetic polymorphisms may play an important role in "idiopathic" acute recurrent pancreatitis...
  14. ncbi request reprint Octreotide increases the proportions of arachidonic acid-rich phospholipids in gall-bladder bile
    S P Pereira
    Gastroenterology Unit, Division of Medicine, Guy s Hospital Campus, GKT School of Medicine, King s College London, UK
    Aliment Pharmacol Ther 15:1435-43. 2001
    ..However, there are few data on the effect of octreotide on biliary arachidonic acid-rich phospholipids or mucin glycoprotein, factors which also influence cholesterol gallstone formation...
  15. pmc Phase I/II study of verteporfin photodynamic therapy in locally advanced pancreatic cancer
    M T Huggett
    UCL Institute for Liver and Digestive Health, University College London, UCL Medical School Royal Free Hospital Campus, U3 Floor, Pond Street, London NW3 2QG, UK
    Br J Cancer 110:1698-704. 2014
    ..This study assessed a shorter acting photosensitiser, verteporfin...
  16. pmc Apical MUC1 expression revealed on the foveolar epithelium in H. pylori gastritis
    M Rashid
    Department of Oncology, UCL Cancer Institute, London WCIE 6BT, UK
    Br J Cancer 108:1113-8. 2013
    ..Here we investigate the basis for the loss of apical staining of the gastric foveolar epithelium in H. pylori gastritis...
  17. pmc Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding
    S P Pereira
    Department of Gastroenterology, The Middlesex Hospital, University College London Hospitals NHS Trust, London, UK
    Arch Dis Child Fetal Neonatal Ed 88:F113-8. 2003
    ..To compare the pharmacokinetics and efficacy of oral versus intravenous mixed micellar vitamin K prophylaxis in infants with cholestatic liver disease, a known risk factor for vitamin K deficiency bleeding...
  18. doi request reprint Serum bilirubin and risk of respiratory disease and death
    Laura J Horsfall
    Research Department of Primary Care and Population Health, University College London, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, England
    JAMA 305:691-7. 2011
    ..Serum total bilirubin levels in healthy patients reflect genetic and environmental factors that could influence the risk of developing respiratory disease...
  19. ncbi request reprint Quality of life after liver transplantation for alcoholic liver disease
    S P Pereira
    Institute of Liver Studies, King s College School of Medicine and Dentistry, London, UK
    Liver Transpl 6:762-8. 2000
    ..Overall, the quality of life after liver transplantation for ALD is high and broadly similar to the levels expected in the normal population...
  20. ncbi request reprint Systematic review: sphincter of Oddi dysfunction--non-invasive diagnostic methods and long-term outcome after endoscopic sphincterotomy
    S N Sgouros
    Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, UK
    Aliment Pharmacol Ther 24:237-46. 2006
    ..Sphincter of Oddi dysfunction is a benign, functional gastrointestinal disorder for which invasive endoscopic therapy with potential complications is often recommended...
  21. ncbi request reprint Cross-sectional imaging of gastric neoplasia
    R Hargunani
    Department of Radiology, Royal Free Hampstead NHS Trust, London, NW3 2QG, UK
    Clin Radiol 64:420-9. 2009
    ..We also describe the optimal techniques for up-to-date and accurate gastric imaging, outlining the role of MDCT and EUS...
  22. ncbi request reprint A controlled trial of ondansetron in the pruritus of cholestasis
    J W O'Donohue
    Institute of Liver Studies, King s College Hospital, London, UK
    Aliment Pharmacol Ther 21:1041-5. 2005
    ..The 5-hydroxytryptamine(3) receptor antagonist, ondansetron, has been used in the treatment of pruritus of cholestasis, but there are few controlled data...
  23. ncbi request reprint Photodynamic therapy using verteporfin photosensitization in the pancreas and surrounding tissues in the Syrian golden hamster
    Lakshmana Ayaru
    The UCL Institute of Hepatology, Department of Medicine, Royal Free and University College London Medical School, University College London, London, UK
    Pancreatology 7:20-7. 2007
    ....
  24. ncbi request reprint Bile composition in inflammatory bowel disease: ileal disease and colectomy, but not colitis, induce lithogenic bile
    S P Pereira
    Gastroenterology Unit, Guy s Hospital Campus, GKT School of Medicine, London, UK
    Aliment Pharmacol Ther 17:923-33. 2003
    ..Inflammatory bowel disease is a risk factor for gall-bladder stones, but there is controversy about the composition of these stones and whether such patients develop lithogenic bile...
  25. ncbi request reprint Endoscopic ultrasound-guided tissue sampling by combined fine needle aspiration and trucut needle biopsy: a prospective study
    J Wittmann
    Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, UK
    Cytopathology 17:27-33. 2006
    ..We prospectively evaluated the safety and accuracy of EUS-FNA alone versus combined EUS-FNA and trucut needle biopsy (TNB) in patients referred to our Unit over a 3-year period...
  26. pmc Review article: surgical, neo-adjuvant and adjuvant management strategies in biliary tract cancer
    J R A Skipworth
    Department of Surgery and Interventional Science, University College London, UK
    Aliment Pharmacol Ther 34:1063-78. 2011
    ..The incidence and mortality rates associated with cholangiocarcinoma continue to rise, mandating the development of novel strategies for early detection, improved resection and treatment of residual lesions...
  27. pmc Drainage and bypass procedures for palliation of malignant diseases of the upper gastrointestinal tract
    M T Huggett
    UCL Institute of Hepatology, University College London, London, UK
    Clin Oncol (R Coll Radiol) 22:755-63. 2010
    ..Here we discuss the available treatments for the palliation of gastric outlet and biliary tract obstruction and the evidence for the respective approaches...
  28. pmc Genetic regulation of MUC1 alternative splicing in human tissues
    W Ng
    Research Department of Genetics, Evolution and Environment University College London, Wolfson House, 4 Stephenson Way, London, UK
    Br J Cancer 99:978-85. 2008
    ..In conclusion, over-representation of certain transcripts in tumour material cannot be evaluated without information on the SNP genotype as well...
  29. doi request reprint Systematic review: endoscopic and imaging-based techniques in the assessment of portal haemodynamics and the risk of variceal bleeding
    S N Sgouros
    Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, UK
    Aliment Pharmacol Ther 30:965-76. 2009
    ..Invasive measurement of the hepatic venous pressure gradient (HVPG) is regarded as the gold standard for risk stratification and the evaluation of pharmaceutical agents in patients with portal hypertension...
  30. doi request reprint Complications and diagnostic difficulties arising from biliary self-expanding metal stent insertion before definitive histological diagnosis
    Lakshmana Ayaru
    Department of Gastroenterology, University College Hospital, University College London Hospitals NHS Foundation Trust, London, UK
    J Gastroenterol Hepatol 23:315-20. 2008
    ..However, problems may arise if metal stents are inserted before definitive histological diagnosis. The aim of this study was to evaluate the outcome of such patients...
  31. ncbi request reprint Autoimmune pancreatitis/IgG4-associated cholangitis and primary sclerosing cholangitis--overlapping or separate diseases?
    George J M Webster
    Department of Gastroenterology, University College Hospital, 235 Euston Road, London NW1, UK
    J Hepatol 51:398-402. 2009
    ..Improvements in understanding the relationship between these conditions might lead to an enhanced understanding of the aetiopathogenesis, and improved treatment of both conditions...
  32. doi request reprint Presentation and management of post-treatment relapse in autoimmune pancreatitis/immunoglobulin G4-associated cholangitis
    Neomal S Sandanayake
    Department of Gastroenterology, University College Hospital, London, United Kingdom Institute of Hepatology, University College London, London NW1 2BU, United Kingdom
    Clin Gastroenterol Hepatol 7:1089-96. 2009
    ..Patients respond rapidly to steroids but can relapse after therapy. We assessed the clinical management of relapse in a group of patients with AIP/IAC...
  33. doi request reprint Acute pancreatitis
    James R A Skipworth
    Department of Surgery, University College London Hospitals NHS Foundation Trust, London, UK
    Curr Opin Crit Care 14:172-8. 2008
    ..To review advances over the last year in the prevention, diagnosis and management of acute pancreatitis...
  34. ncbi request reprint Re: Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on incidence of intra- and extrahepatic cholangiocarcinoma in the United States
    Wolf Rudiger Matull
    J Natl Cancer Inst 99:407; author reply 407-8. 2007
  35. ncbi request reprint Endoscopic ultrasound of the upper gastrointestinal tract and mediastinum: diagnosis and therapy
    Priyajit Prasad
    Digestive Disease Center, Medical University of South Carolina, Charleston, SC, USA
    Cardiovasc Intervent Radiol 29:947-57. 2006
    ..Emerging investigational techniques include EUS-guided enteric anastomosis formation and fine-needle injection therapy for malignant disease...
  36. ncbi request reprint The use of immunoglobulin g4 immunostaining in diagnosing pancreatic and extrapancreatic involvement in autoimmune pancreatitis
    Maesha G Deheragoda
    Department of Histopathology, University College Hospital, London, United Kingdom
    Clin Gastroenterol Hepatol 5:1229-34. 2007
    ..Autoimmune pancreatitis (AIP) is recognized increasingly as a multisystem disorder. We evaluated the use of immunoglobulin (Ig)G4 immunostaining of pancreatic and extrapancreatic biopsy specimens to make a definitive diagnosis of AIP...
  37. ncbi request reprint Photodynamic therapy for pancreatic and biliary tract carcinoma
    Lakshmana Ayaru
    Institute of Hepatology, Department of Medicine, Royal Free and University College London Medical School, London, United Kingdom
    Int J Gastrointest Cancer 35:1-13. 2005
    ....