Research Topics
| S P PereiraSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Photodynamic therapy of malignant biliary strictures using meso-tetrahydroxyphenylchlorinStephen P Pereira
Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, UK
Eur J Gastroenterol Hepatol 19:479-85. 2007..The aim of this study was to determine the safety and efficacy of endoscopically delivered meso-tetrahydroxyphenyl chlorin photodynamic therapy in the treatment of irresectable malignant biliary strictures and recurrent stent occlusion...- Autoimmune pancreatitis: clinical and radiological features and objective response to steroid therapy in a UK seriesNicholas I Church
Department of Gastroenterology, University College Hospital, London, United Kingdom
Am J Gastroenterol 102:2417-25. 2007..Most cases of autoimmune pancreatitis (AIP) have been reported from Japan. We present data on a UK series, including clinical and radiological features at presentation, and longitudinal response to immunosuppression... 
Safety and long term efficacy of porfimer sodium photodynamic therapy in locally advanced biliary tract carcinomaStephen P Pereira
UCL Institute of Liver and Digestive Health, University College London, UK Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, UK Electronic address
Photodiagnosis Photodyn Ther 9:287-92. 2012..In patients with unresectable cholangiocarcinoma, photodynamic therapy (PDT) with porfimer sodium promotes biliary drainage and may improve survival and quality of life...- Transdermal hormone replacement therapy improves vertebral bone density in primary biliary cirrhosis: results of a 1-year controlled trialS P Pereira
Institute of Liver Studies, King s College Hospital, London, UK
Aliment Pharmacol Ther 19:563-70. 2004..Retrospective studies have suggested that hormone replacement therapy may reduce the rate of bone loss in primary biliary cirrhosis, but no controlled data are available... - Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K1) in severe acute liver diseaseStephen P Pereira
Institute of Liver Studies, King s College Hospital, London, UK
J Hepatol 42:365-70. 2005..However, there have been no studies of the pharmacokinetics or efficacy of i.v. or oral K1 in such patients... 
The pharmacokinetics and safety of porfimer after repeated administration 30-45 days apart to patients undergoing photodynamic therapyS P Pereira
UCL Division of Surgery and Interventional Science, London, UK
Aliment Pharmacol Ther 32:821-7. 2010..Porfimer is an intravenous (i.v.) injectable photosensitizing agent used in the photodynamic treatment of tumours and of high-grade dysplasia in Barrett's oesophagus...- Prospective comparison of secretin-stimulated magnetic resonance cholangiopancreatography with manometry in the diagnosis of sphincter of Oddi dysfunction types II and IIIStephen P Pereira
Department of Gastroenterology, University College London Hospitals NHS Trust, London, UK
Gut 56:809-13. 2007..In sphincter of Oddi dysfunction (SOD), sphincter of Oddi manometry (SOM) predicts the response to sphincterotomy, but is invasive and associated with complications... - MUC4 and MUC5AC are highly specific tumour-associated mucins in biliary tract cancerW R Matull
The Institute of Hepatology, Division of Medicine, Royal Free and University College London Medical School, London, UK
Br J Cancer 98:1675-81. 2008..001 for BTC vs non-BTC) and correlated negatively with BTC survival. Biliary MUC4 and serum MUC5AC are highly specific tumour-associated mucins that may be useful in the diagnosis and formulation of therapeutic strategies in BTC... - Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleedingS P Pereira
Department of Gastroenterology, The Middlesex Hospital, University College London Hospitals NHS Trust, London, UK
Arch Dis Child Fetal Neonatal Ed 88:F113-8. 2003..To compare the pharmacokinetics and efficacy of oral versus intravenous mixed micellar vitamin K prophylaxis in infants with cholestatic liver disease, a known risk factor for vitamin K deficiency bleeding... - Serum bilirubin and risk of respiratory disease and deathLaura J Horsfall
Research Department of Primary Care and Population Health, University College London, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, England
JAMA 305:691-7. 2011..Serum total bilirubin levels in healthy patients reflect genetic and environmental factors that could influence the risk of developing respiratory disease... - A controlled trial of ondansetron in the pruritus of cholestasisJ W O'Donohue
Institute of Liver Studies, King s College Hospital, London, UK
Aliment Pharmacol Ther 21:1041-5. 2005..The 5-hydroxytryptamine(3) receptor antagonist, ondansetron, has been used in the treatment of pruritus of cholestasis, but there are few controlled data... - Photodynamic therapy using verteporfin photosensitization in the pancreas and surrounding tissues in the Syrian golden hamsterLakshmana Ayaru
The UCL Institute of Hepatology, Department of Medicine, Royal Free and University College London Medical School, University College London, London, UK
Pancreatology 7:20-7. 2007.... - A combination of serum leucine-rich α-2-glycoprotein 1, CA19-9 and interleukin-6 differentiate biliary tract cancer from benign biliary stricturesN S Sandanayake
UCL Institute of Hepatology, University College London, 9th Floor Royal Free Hospital, London NW3 2PG, UK
Br J Cancer 105:1370-8. 2011..Biliary tract cancer (BTC) and benign biliary strictures can be difficult to differentiate using standard tumour markers such as serum carbohydrate antigen 19-9 (CA19-9) as they lack diagnostic accuracy... - Cross-sectional imaging of gastric neoplasiaR Hargunani
Department of Radiology, Royal Free Hampstead NHS Trust, London, NW3 2QG, UK
Clin Radiol 64:420-9. 2009..We also describe the optimal techniques for up-to-date and accurate gastric imaging, outlining the role of MDCT and EUS... - Systematic review: sphincter of Oddi dysfunction--non-invasive diagnostic methods and long-term outcome after endoscopic sphincterotomyS N Sgouros
Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, London, UK
Aliment Pharmacol Ther 24:237-46. 2006..Further controlled trials are needed to justify the invasive management of patients with biliary Type III and pancreatic sphincter of Oddi dysfunction... - Biochemical markers of acute pancreatitisW R Matull
Institute of Hepatology, University College London Medical School, London, UK
J Clin Pathol 59:340-4. 2006..For obscure aetiologies, serum calcium and triglycerides should be measured. Genetic polymorphisms may play an important role in "idiopathic" acute recurrent pancreatitis... - Drainage and bypass procedures for palliation of malignant diseases of the upper gastrointestinal tractM T Huggett
UCL Institute of Hepatology, University College London, London, UK
Clin Oncol (R Coll Radiol) 22:755-63. 2010..Here we discuss the available treatments for the palliation of gastric outlet and biliary tract obstruction and the evidence for the respective approaches... - Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspiratesL Ayaru
The Institute of Hepatology, University College London, London, UK
Br J Cancer 98:1548-54. 2008..In this study, we demonstrate that Mcm5 in bile detected by a simple automated test is a more sensitive indicator of pancreaticobiliary malignancy than routine brush cytology... - Review article: surgical, neo-adjuvant and adjuvant management strategies in biliary tract cancerJ R A Skipworth
Department of Surgery and Interventional Science, University College London, UK
Aliment Pharmacol Ther 34:1063-78. 2011..The incidence and mortality rates associated with cholangiocarcinoma continue to rise, mandating the development of novel strategies for early detection, improved resection and treatment of residual lesions... - Systematic review: endoscopic and imaging-based techniques in the assessment of portal haemodynamics and the risk of variceal bleedingS N Sgouros
Department of Gastroenterology, University College London Hospitals NHS Foundation Trust, UK
Aliment Pharmacol Ther 30:965-76. 2009..Invasive measurement of the hepatic venous pressure gradient (HVPG) is regarded as the gold standard for risk stratification and the evaluation of pharmaceutical agents in patients with portal hypertension... - Genetic regulation of MUC1 alternative splicing in human tissuesW Ng
Research Department of Genetics, Evolution and Environment University College London, Wolfson House, 4 Stephenson Way, London, UK
Br J Cancer 99:978-85. 2008..In conclusion, over-representation of certain transcripts in tumour material cannot be evaluated without information on the SNP genotype as well... - Quality of life after liver transplantation for alcoholic liver diseaseS P Pereira
Institute of Liver Studies, King s College School of Medicine and Dentistry, London, UK
Liver Transpl 6:762-8. 2000..Overall, the quality of life after liver transplantation for ALD is high and broadly similar to the levels expected in the normal population... - Complications and diagnostic difficulties arising from biliary self-expanding metal stent insertion before definitive histological diagnosisLakshmana Ayaru
Department of Gastroenterology, University College Hospital, University College London Hospitals NHS Foundation Trust, London, UK
J Gastroenterol Hepatol 23:315-20. 2008..However, problems may arise if metal stents are inserted before definitive histological diagnosis. The aim of this study was to evaluate the outcome of such patients... - Acute pancreatitisJames R A Skipworth
Department of Surgery, University College London Hospitals NHS Foundation Trust, London, UK
Curr Opin Crit Care 14:172-8. 2008..To review advances over the last year in the prevention, diagnosis and management of acute pancreatitis... - Autoimmune pancreatitis/IgG4-associated cholangitis and primary sclerosing cholangitis--overlapping or separate diseases?George J M Webster
Department of Gastroenterology, University College Hospital, 235 Euston Road, London NW1, UK
J Hepatol 51:398-402. 2009..Improvements in understanding the relationship between these conditions might lead to an enhanced understanding of the aetiopathogenesis, and improved treatment of both conditions... - Presentation and management of post-treatment relapse in autoimmune pancreatitis/immunoglobulin G4-associated cholangitisNeomal S Sandanayake
Department of Gastroenterology, University College Hospital, London, United Kingdom Institute of Hepatology, University College London, London NW1 2BU, United Kingdom
Clin Gastroenterol Hepatol 7:1089-96. 2009..Patients respond rapidly to steroids but can relapse after therapy. We assessed the clinical management of relapse in a group of patients with AIP/IAC... - Re: Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on incidence of intra- and extrahepatic cholangiocarcinoma in the United StatesWolf-Rudiger Matull
J Natl Cancer Inst 99:407; author reply 407-8. 2007 - Endoscopic ultrasound of the upper gastrointestinal tract and mediastinum: diagnosis and therapyPriyajit Prasad
Digestive Disease Center, Medical University of South Carolina, Charleston, SC, USA
Cardiovasc Intervent Radiol 29:947-57. 2006..Emerging investigational techniques include EUS-guided enteric anastomosis formation and fine-needle injection therapy for malignant disease... - Photodynamic therapy for pancreatic and biliary tract carcinomaLakshmana Ayaru
Institute of Hepatology, Department of Medicine, Royal Free and University College London Medical School, London, United Kingdom
Int J Gastrointest Cancer 35:1-13. 2005.... - The use of immunoglobulin g4 immunostaining in diagnosing pancreatic and extrapancreatic involvement in autoimmune pancreatitisMaesha G Deheragoda
Department of Histopathology, University College Hospital, London, United Kingdom
Clin Gastroenterol Hepatol 5:1229-34. 2007..Autoimmune pancreatitis (AIP) is recognized increasingly as a multisystem disorder. We evaluated the use of immunoglobulin (Ig)G4 immunostaining of pancreatic and extrapancreatic biopsy specimens to make a definitive diagnosis of AIP...