Mark B Pepys

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc C-reactive protein: a critical update
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom
    J Clin Invest 111:1805-12. 2003
  2. ncbi request reprint Amyloidosis
    Mark B Pepys
    Center for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
    Annu Rev Med 57:223-41. 2006
  3. ncbi request reprint Targeting C-reactive protein for the treatment of cardiovascular disease
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK
    Nature 440:1217-21. 2006
  4. doi request reprint A molecular correlate of clinicopathology in transthyretin amyloidosis
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, University College London Medical School, London, UK
    J Pathol 217:1-3. 2009
  5. doi request reprint C-reactive protein is neither a marker nor a mediator of atherosclerosis
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, University College London, Rowland Hill Street, London NW3 2PF, UK
    Nat Clin Pract Nephrol 4:234-5. 2008
  6. pmc Proinflammatory effects of bacterial recombinant human C-reactive protein are caused by contamination with bacterial products, not by C-reactive protein itself
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, UK
    Circ Res 97:e97-103. 2005
  7. ncbi request reprint Science and serendipity
    Mark B Pepys
    Department of Medicine, Hampstead Campus, University College London
    Clin Med 7:562-78. 2007
  8. ncbi request reprint Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE-/- mice
    Glenys A Tennent
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, UK
    Atherosclerosis 196:248-55. 2008
  9. pmc Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice
    Gideon M Hirschfield
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
    Proc Natl Acad Sci U S A 102:8309-14. 2005
  10. pmc Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?
    Julian D Gillmore
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, UK
    Immunology 112:255-64. 2004

Detail Information

Publications49

  1. pmc C-reactive protein: a critical update
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom
    J Clin Invest 111:1805-12. 2003
  2. ncbi request reprint Amyloidosis
    Mark B Pepys
    Center for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
    Annu Rev Med 57:223-41. 2006
    ..However, recent elucidation of important aspects of pathogenesis, as well as developments in diagnosis, monitoring, and treatment, have greatly improved outcomes, especially when patients are managed in specialist centers...
  3. ncbi request reprint Targeting C-reactive protein for the treatment of cardiovascular disease
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK
    Nature 440:1217-21. 2006
    ....
  4. doi request reprint A molecular correlate of clinicopathology in transthyretin amyloidosis
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, University College London Medical School, London, UK
    J Pathol 217:1-3. 2009
    ....
  5. doi request reprint C-reactive protein is neither a marker nor a mediator of atherosclerosis
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, University College London, Rowland Hill Street, London NW3 2PF, UK
    Nat Clin Pract Nephrol 4:234-5. 2008
  6. pmc Proinflammatory effects of bacterial recombinant human C-reactive protein are caused by contamination with bacterial products, not by C-reactive protein itself
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, UK
    Circ Res 97:e97-103. 2005
    ....
  7. ncbi request reprint Science and serendipity
    Mark B Pepys
    Department of Medicine, Hampstead Campus, University College London
    Clin Med 7:562-78. 2007
    ..New drugs using this mechanism are in development for amyloidosis and cardiovascular disease and potentially also Alzheimer's disease, type II diabetes and other tissue damaging conditions...
  8. ncbi request reprint Transgenic human CRP is not pro-atherogenic, pro-atherothrombotic or pro-inflammatory in apoE-/- mice
    Glenys A Tennent
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, UK
    Atherosclerosis 196:248-55. 2008
    ..Thus, there was no evidence in this 18 month study of apoE(-/-), and control apoE(+/+) mice, that transgenic human CRP was pro-atherogenic, pro-inflammatory or pro-atherothrombotic...
  9. pmc Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice
    Gideon M Hirschfield
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London NW3 2PF, United Kingdom
    Proc Natl Acad Sci U S A 102:8309-14. 2005
    ..Nevertheless, the present results do not suggest that human CRP is either proatherogenic or atheroprotective in vivo...
  10. pmc Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?
    Julian D Gillmore
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, UK
    Immunology 112:255-64. 2004
    ..Alternatively, the autoimmunity may be independent of SAP deficiency and caused by expression of 129/Sv chromosome 1 genes in the C57BL/6 background...
  11. doi request reprint Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C-reactive protein, for clinical use
    Mark B Pepys
    Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, Rowland Hill Street, London NW3 2PF, UK
    J Immunol Methods 384:92-102. 2012
    ..Furthermore neither of our preparations was pro-inflammatory in mice in vivo...
  12. pmc Pathogenetic mechanisms of amyloid A amyloidosis
    J Paul Simons
    Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom
    Proc Natl Acad Sci U S A 110:16115-20. 2013
    ....
  13. ncbi request reprint Human C-reactive protein does not protect against acute lipopolysaccharide challenge in mice
    Gideon M Hirschfield
    Center for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom
    J Immunol 171:6046-51. 2003
    ..Rather than being protective in this situation, human CRP may thus have pathogenic proinflammatory effects in vivo...
  14. doi request reprint Sustained pharmacological depletion of serum amyloid P component in patients with systemic amyloidosis
    Julian D Gillmore
    Centre for Amyloidosis and Acute Phase Proteins and the National Amyloidosis Centre, University College London Medical School, London, UK
    Br J Haematol 148:760-7. 2010
    ..These promising clinical observations merit further study...
  15. pmc Antibodies to human serum amyloid P component eliminate visceral amyloid deposits
    Karl Bodin
    Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    Nature 468:93-7. 2010
    ..The unprecedented capacity of this novel combined therapy to eliminate amyloid deposits should be applicable to all forms of systemic and local amyloidosis...
  16. ncbi request reprint Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy
    Helen J Lachmann
    The National Amyloidosis Centre and Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, UK
    Br J Haematol 122:78-84. 2003
    ..Clinical improvement following chemotherapy in AL amyloidosis is delayed, but treatment strategies can be guided by their early effect on serum FLC concentration...
  17. ncbi request reprint Normal circulating serum amyloid P component concentration in systemic sclerosis
    Glenys A Tennent
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, London, UK
    Arthritis Rheum 56:2013-7. 2007
    ..Because neither sustained SAP depletion in humans nor SAP deficiency in mice is associated with fibrosis, we sought to establish rigorously the serum SAP concentration in well-characterized patients with SSc...
  18. pmc Trapping of palindromic ligands within native transthyretin prevents amyloid formation
    Simon E Kolstoe
    Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Royal Free Campus, University College London Medical School, London NW3 2PF, United Kingdom
    Proc Natl Acad Sci U S A 107:20483-8. 2010
    ..These superstabilizers are orally bioavailable and exhibit low inhibitory activity against cyclooxygenase (COX). They offer a promising platform for development of drugs to treat and prevent TTR amyloidosis...
  19. doi request reprint Immunoradiometric assay for human serum amyloid P component
    David J Millar
    Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, Rowland Hill Street, London NW3 2PF, UK
    J Immunol Methods 371:18-24. 2011
    ....
  20. pmc Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritis
    Francesco Carlucci
    Imperial College London, London, UK
    Arthritis Rheum 62:245-9. 2010
    ..This study was undertaken to attempt to replicate these observations using a highly purified and fully characterized human CRP preparation...
  21. ncbi request reprint Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability
    Brian R Clapp
    Centre for Clinical Pharmacology and Therapeutics, BHF Laboratories, University College London, London, United Kingdom
    Circulation 111:1530-6. 2005
    ..We therefore investigated the direct effect of CRP on vascular reactivity...
  22. doi request reprint Monitoring systemic amyloidosis using MRI measurements of the extracellular volume fraction
    Adrienne E Campbell-Washburn
    Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, UK
    Amyloid 20:93-8. 2013
    ..01). MRI measurement of ECV is a sensitive marker of amyloid deposits with potential application for early detection and monitoring therapies promoting their clearance...
  23. pmc Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component
    Simon E Kolstoe
    Centre for Amyloidosis and Acute Phase Proteins and National Amyloidosis Centre, Division of Medicine Royal Free Campus, University College London Medical School, London NW3 2PF, United Kingdom
    Proc Natl Acad Sci U S A 106:7619-23. 2009
    ..These results support further clinical study of SAP depletion in Alzheimer's disease and potentially other neurodegenerative diseases...
  24. pmc Classical and alternative pathway complement activation are not required for reactive systemic AA amyloid deposition in mice
    Winston L Hutchinson
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, UK
    Immunology 112:250-4. 2004
    ..Complement activation by either the classical or alternative pathways is thus not apparently necessary for the experimental induction of systemic AA amyloid in mice...
  25. ncbi request reprint C-reactive protein and cardiovascular disease: weighing the evidence
    Gordon D O Lowe
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, University College London, Rowland Hill Street, London NW3 2PF, United Kingdom
    Curr Atheroscler Rep 8:421-8. 2006
    ..Future clinical trials of specific CRP inhibitors now in development could directly test the contribution of CRP to pathogenesis of cardiovascular disease...
  26. ncbi request reprint Sequential heart and autologous stem cell transplantation for systemic AL amyloidosis
    Julian D Gillmore
    National Amyloidosis Centre, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom
    Blood 107:1227-9. 2006
    ..Heart transplantation followed by SCT is feasible in selected patients with cardiac AL amyloidosis and may confer substantial survival benefit...
  27. doi request reprint Structural basis of ligand specificity in the human pentraxins, C-reactive protein and serum amyloid P component
    Halina Mikolajek
    Laboratory of Protein Crystallography, Acute Phase Proteins, Division of Medicine, Royal Free Campus, University College London Medical School, Rowland Hill Street, London NW3 2PF, UK
    J Mol Recognit 24:371-7. 2011
    ..These fundamental observations on structure-activity relationships will aid the design of improved pentraxin targeting drugs...
  28. doi request reprint Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis
    P Patrizia Mangione
    Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, Laboratory of Protein Crystallography, Centre for Amyloidosis and Acute Phase Proteins, and Electron Microscopy Unit, University College London, London NW3 2PF, United Kingdom
    Proc Natl Acad Sci U S A 111:1539-44. 2014
    ..However, binding of RBP, but not thyroxine, inhibited subsequent fibrillogenesis. ..
  29. ncbi request reprint Production of granulocyte colony-stimulating factor in the nonspecific acute phase response enhances host resistance to bacterial infection
    Mahdad Noursadeghi
    Center for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom
    J Immunol 169:913-9. 2002
    ....
  30. ncbi request reprint Human plasma fibrinogen is synthesized in the liver
    Glenys A Tennent
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, London, United Kingdom
    Blood 109:1971-4. 2007
    ..After transplantation, only the wild-type sequence was detected, and the liver is thus the source of at least 98% of the circulation fibrinogen...
  31. doi request reprint Infusion of pharmaceutical-grade natural human C-reactive protein is not proinflammatory in healthy adult human volunteers
    Thirusha Lane
    From the Wolfson Drug Discovery Unit, and the National Amyloidosis Centre, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London, United Kingdom M B P, T L, H J L, J d G, P N H Department of Clinical Biochemistry, Royal Free Hospital, London, United Kingdom N W and the National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom S P, Y M
    Circ Res 114:672-6. 2014
    ..None of the in vitro or animal findings have been reproduced with pure natural human CRP. Nevertheless, the strong proinflammatory effects of infusing recombinant bacterial CRP into humans have still been inappropriately ascribed to CRP...
  32. ncbi request reprint Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis
    Helen J Lachmann
    National Amyloidosis Centre, Department of Medicine, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    N Engl J Med 346:1786-91. 2002
    ....
  33. pmc Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin
    P Patrizia Mangione
    From the Wolfson Drug Discovery Unit, Centre for Amyloidosis and Acute Phase Proteins, Division of Medicine, University College London, London NW3 2PF, United Kingdom
    J Biol Chem 288:30917-30. 2013
    ..Elucidation of this crucial causative event in clinical amyloidosis should also help to explain the hitherto mysterious timing and location of amyloid deposition. ..
  34. doi request reprint Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay
    Reecha Sofat
    Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Building, 5 University Street, London, WC1E 6JJ, UK
    J Immunol Methods 390:63-73. 2013
    ..Research on complement factor H (fH) in human disease is hampered by lack of an assay suitable for use in large-scale epidemiological studies. We describe the development and validation of a high throughput nephelometric assay for fH...
  35. ncbi request reprint MHC typing in variant Creutzfeldt-Jakob disease
    Mark B Pepys
    Centre for Amyloidosis and Acute Phase Proteins, Department of Medicine, Royal Free and University College Medical School, Rowland Hill Street, NW3 2PF, London, UK
    Lancet 361:487-9. 2003
    ..Our results do not support the idea of an association between MHC types and either susceptibility to, or expression of, vCJD...
  36. pmc Influenza virus infection is not affected by serum amyloid P component
    Jeff Herbert
    Department of Medicine, Royal Free and University College Medical School, London, UK
    Mol Med 8:9-15. 2002
    ..We therefore investigated a possible role of SAP in either host resistance or viral virulence during influenza infection in vivo...
  37. ncbi request reprint C-reactive protein risk prediction: low specificity, high sensitivity
    Wolfgang Koenig
    Ann Intern Med 136:550-2. 2002
  38. ncbi request reprint Markers of inflammation in women on different hormone replacement therapies
    Margit Fröhlich
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Ann Med 35:353-61. 2003
    ..To measure inflammatory markers in postmenopausal women on different forms of hormone replacement therapy (HRT)...
  39. ncbi request reprint Obesity is an important determinant of baseline serum C-reactive protein concentration in monozygotic twins, independent of genetic influences
    Jerry R Greenfield
    Department of Endocrinology, St Vincent s Hospital, Sydney, Australia
    Circulation 109:3022-8. 2004
    ..The aim of this study was to examine the relationship between CRP and accurately measured body fat, lipids, apolipoproteins, blood pressure, and environmental and behavioral factors, independent of genetic influences...
  40. ncbi request reprint Lack of seasonal variation in C-reactive protein
    Margit Fröhlich
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, D 89081 Ulm, Germany
    Clin Chem 48:575-7. 2002
  41. ncbi request reprint C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease
    John Danesh
    Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom
    N Engl J Med 350:1387-97. 2004
    ..We report data from a large study of C-reactive protein and other circulating inflammatory markers, as well as updated meta-analyses, to evaluate their relevance to the prediction of coronary heart disease...
  42. ncbi request reprint Refinement of the association of serum C-reactive protein concentration and coronary heart disease risk by correction for within-subject variation over time: the MONICA Augsburg studies, 1984 and 1987
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Am J Epidemiol 158:357-64. 2003
    ..The results suggest that the true association between C-reactive protein and cardiovascular risk is underestimated by a single C-reactive protein determination, and that several serial C-reactive protein measurements should be taken...
  43. ncbi request reprint Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats
    Ramanjit Gill
    F Hoffman La Roche Ltd, Preclinical CNS Research, Pharmaceuticals Division, Basel, Switzerland
    J Cereb Blood Flow Metab 24:1214-8. 2004
    ....
  44. ncbi request reprint Is leptin an important physiological regulator of CRP?
    Winston L Hutchinson
    Nat Med 13:17-8; author reply 19-21. 2007
  45. ncbi request reprint Beta-edge interactions in a pentadecameric human antibody V kappa domain
    Leo C James
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 367:603-8. 2007
    ..We suggest that the exposure of this beta-edge in V kappa domains may explain why light-chain deposition disease is mediated predominantly by kappa antibodies...
  46. ncbi request reprint Human serum amyloid P component protects against Escherichia coli O157:H7 Shiga toxin 2 in vivo: therapeutic implications for hemolytic-uremic syndrome
    Glen D Armstrong
    Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Canada
    J Infect Dis 193:1120-4. 2006
    ..However, the potent protection conferred by human SAP in the mouse model suggests that infusion of supplemental SAP may be a useful novel therapeutic approach to the treatment of this devastating condition...
  47. ncbi request reprint Genetic effects on baseline values of C-reactive protein and serum amyloid a protein: a comparison of monozygotic and dizygotic twins
    Alex J MacGregor
    Twin Research and Genetic Epidemiology Unit, St Thomas Hospital, London SE1 7EH, UK
    Clin Chem 50:130-4. 2004
    ..These values, especially of CRP, are associated with future atherothrombotic events, and the determinants of baseline CRP and SAA concentration are therefore of considerable interest...
  48. ncbi request reprint Determination of C-reactive protein: comparison of three high-sensitivity immunoassays
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Clin Chem 49:1691-5. 2003
  49. ncbi request reprint CRP or not CRP? That is the question
    Mark B Pepys
    Arterioscler Thromb Vasc Biol 25:1091-4. 2005