Marcus Pembrey

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. pmc Childhood abuse is associated with methylation of multiple loci in adult DNA
    Matthew Suderman
    Sackler Program for Epigenetics and Developmental Psychobiology, McGill University, 3655 Promenade Sir William Osler, Montreal H3G 1Y6, QC, Canada
    BMC Med Genomics 7:13. 2014
  2. pmc Change in paternal grandmothers' early food supply influenced cardiovascular mortality of the female grandchildren
    Lars Olov Bygren
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    BMC Genet 15:12. 2014
  3. pmc Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital Level 8, Box 116, Cambridge CB2 2QQ, UK
    BMC Genet 6:22. 2005
  4. doi request reprint Male-line transgenerational responses in humans
    Marcus E Pembrey
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College, London, UK
    Hum Fertil (Camb) 13:268-71. 2010
  5. ncbi request reprint The Avon Longitudinal Study of Parents and Children (ALSPAC): a resource for genetic epidemiology
    Marcus Pembrey
    Institute of Child Health, University College London, London, UK
    Eur J Endocrinol 151:U125-9. 2004
  6. ncbi request reprint Sex-specific, male-line transgenerational responses in humans
    Marcus E Pembrey
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, England, UK
    Eur J Hum Genet 14:159-66. 2006
  7. doi request reprint Prepubertal start of father's smoking and increased body fat in his sons: further characterisation of paternal transgenerational responses
    Kate Northstone
    School of Social and Community Medicine, University of Bristol, London, UK
    Eur J Hum Genet 22:1382-6. 2014
  8. pmc Differences between blood donors and a population sample: implications for case-control studies
    Jean Golding
    School of Social and Community Medicine, University of Bristol, Bristol, UK, MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK, and Institute of Child Health, University College London, London, UK
    Int J Epidemiol 42:1145-56. 2013
  9. pmc Parental and grandparental ages in the autistic spectrum disorders: a birth cohort study
    Jean Golding
    Department of Community Based Medicine, University of Bristol, Centre for Child and Adolescent Health, Bristol, United Kingdom
    PLoS ONE 5:e9939. 2010
  10. ncbi request reprint The search for genenotype/phenotype associations and the phenome scan
    Richard Jones
    ALSPAC, Department of Community Based Medicine, University of Bristol, Bristol, UK
    Paediatr Perinat Epidemiol 19:264-75. 2005

Collaborators

Detail Information

Publications19

  1. pmc Childhood abuse is associated with methylation of multiple loci in adult DNA
    Matthew Suderman
    Sackler Program for Epigenetics and Developmental Psychobiology, McGill University, 3655 Promenade Sir William Osler, Montreal H3G 1Y6, QC, Canada
    BMC Med Genomics 7:13. 2014
    ..DNA methylation is a critical mechanism in epigenetic regulation. We aimed to establish whether childhood abuse was associated with adult DNA methylation profiles...
  2. pmc Change in paternal grandmothers' early food supply influenced cardiovascular mortality of the female grandchildren
    Lars Olov Bygren
    Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
    BMC Genet 15:12. 2014
    ..We have now studied transgenerational responses (TGR) to sharp differences of harvest between two consecutive years' for ancestors of 317 people in Överkalix, Sweden...
  3. pmc Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital Level 8, Box 116, Cambridge CB2 2QQ, UK
    BMC Genet 6:22. 2005
    ....
  4. doi request reprint Male-line transgenerational responses in humans
    Marcus E Pembrey
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College, London, UK
    Hum Fertil (Camb) 13:268-71. 2010
    ..Whilst the mediating molecular mechanism(s) is unknown, the sex-specific transmission patterns and exposure-sensitive periods suggest a pre-evolved transgenerational response mechanism...
  5. ncbi request reprint The Avon Longitudinal Study of Parents and Children (ALSPAC): a resource for genetic epidemiology
    Marcus Pembrey
    Institute of Child Health, University College London, London, UK
    Eur J Endocrinol 151:U125-9. 2004
    ....
  6. ncbi request reprint Sex-specific, male-line transgenerational responses in humans
    Marcus E Pembrey
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, England, UK
    Eur J Hum Genet 14:159-66. 2006
    ..Such responses add an entirely new dimension to the study of gene-environment interactions in development and health...
  7. doi request reprint Prepubertal start of father's smoking and increased body fat in his sons: further characterisation of paternal transgenerational responses
    Kate Northstone
    School of Social and Community Medicine, University of Bristol, London, UK
    Eur J Hum Genet 22:1382-6. 2014
    ..Smoking by boys in mid childhood may contribute to obesity in adolescent boys of the next generation. ..
  8. pmc Differences between blood donors and a population sample: implications for case-control studies
    Jean Golding
    School of Social and Community Medicine, University of Bristol, Bristol, UK, MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK, and Institute of Child Health, University College London, London, UK
    Int J Epidemiol 42:1145-56. 2013
    ..Selecting appropriate controls for studies of genetic variation in case series is important. The two major candidates involve the use of blood donors or a random sample of the population...
  9. pmc Parental and grandparental ages in the autistic spectrum disorders: a birth cohort study
    Jean Golding
    Department of Community Based Medicine, University of Bristol, Centre for Child and Adolescent Health, Bristol, United Kingdom
    PLoS ONE 5:e9939. 2010
    ..A number of studies have assessed ages of parents of children with autistic spectrum disorders (ASD), and reported both maternal and paternal age effects. Here we assess relationships with grandparental ages...
  10. ncbi request reprint The search for genenotype/phenotype associations and the phenome scan
    Richard Jones
    ALSPAC, Department of Community Based Medicine, University of Bristol, Bristol, UK
    Paediatr Perinat Epidemiol 19:264-75. 2005
    ..We believe that this approach can generate data that will be useful in answering generic questions about genotype/phenotype associations as well as in discovering novel ones...
  11. pmc Is the growth of the child of a smoking mother influenced by the father's prenatal exposure to tobacco? A hypothesis generating longitudinal study
    Marcus Pembrey
    School of Social and Community Medicine, University of Bristol, Bristol, UK Centre for Child and Adolescent Health, University of Bristol, Bristol, UK Institute of Child Health, University College London, London, UK
    BMJ Open 4:e005030. 2014
    ..The aim of this study was to determine whether the prenatal smoke exposure of either parent influenced the growth of the fetus of a smoking woman, and whether any effects were dependent on the fetal sex...
  12. ncbi request reprint Genetic epidemiology: some special contributions of birth cohorts
    Marcus Pembrey
    Institute of Child Health, University College London, and Avon Longitudinal Study of Parents and Children, University of Bristol, Bristol, UK
    Paediatr Perinat Epidemiol 18:3-7. 2004
    ....
  13. doi request reprint Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research
    Marcus Pembrey
    School of Social and Community Medicine, University of Bristol, Bristol, UK UCL Institute of Child Health, London, UK
    J Med Genet 51:563-72. 2014
    ..This review was developed initially as a position paper by the multidisciplinary Network in Epigenetic Epidemiology to encourage transgenerational research in human cohorts. ..
  14. ncbi request reprint Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain
    Ken K Ong
    Department of Pediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 53:1128-33. 2004
    ..Our results indicate that complex prenatal and postnatal gene-maternal/fetal interactions influence size at birth and childhood risk factors for adult disease...
  15. pmc Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals
    Rachel M Freathy
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Am J Hum Genet 80:1150-61. 2007
    ..In conclusion, we have identified the first type 2 diabetes-susceptibility allele to be reproducibly associated with birth weight. Common gene variants can substantially influence normal birth-weight variation...
  16. ncbi request reprint Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study
    Ian P Hall
    Division of Therapeutics and Molecular Medicine, University of Nottingham, UK
    Lancet 368:771-9. 2006
    ..We aimed to relate the long-term prevalence of asthma or wheeze to functional coding region polymorphisms in the ADRB2 gene...
  17. ncbi request reprint Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood height
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Growth Horm IGF Res 15:363-8. 2005
    ..We hypothesised that polymorphisms in the IGF2R gene could alter size at birth and childhood growth...
  18. ncbi request reprint Investigation of UBE3A and MECP2 in Angelman syndrome (AS) and patients with features of AS
    Megan P Hitchins
    Molecular Embryology Unit, Institute of Child Health and Great Ormond Street Hospital, University College London, London, United Kingdom
    Am J Med Genet A 125:167-72. 2004
    ..While MECP2 mutations can cause a phenotype reminiscent of AS in rare cases, they fail to account for the excess of sporadic patients with a definitive clinical diagnosis of AS...
  19. pmc A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses
    Michael N Weedon
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, EX1 2LU, UK
    Am J Hum Genet 79:991-1001. 2006
    ..In conclusion, a comprehensive analysis of common variation of the glucokinase gene shows that this is the first gene to be reproducibly associated with fasting glucose and fetal growth...