Affiliation: University of Bristol
- Childhood abuse is associated with methylation of multiple loci in adult DNAMatthew Suderman
Sackler Program for Epigenetics and Developmental Psychobiology, McGill University, 3655 Promenade Sir William Osler, Montreal H3G 1Y6, QC, Canada
BMC Med Genomics 7:13. 2014..DNA methylation is a critical mechanism in epigenetic regulation. We aimed to establish whether childhood abuse was associated with adult DNA methylation profiles...
- Change in paternal grandmothers' early food supply influenced cardiovascular mortality of the female grandchildrenLars Olov Bygren
Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden
BMC Genet 15:12. 2014..We have now studied transgenerational responses (TGR) to sharp differences of harvest between two consecutive years' for ancestors of 317 people in Överkalix, Sweden...
- Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humansClive J Petry
Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital Level 8, Box 116, Cambridge CB2 2QQ, UK
BMC Genet 6:22. 2005....
- Male-line transgenerational responses in humansMarcus E Pembrey
Clinical and Molecular Genetics Unit, Institute of Child Health, University College, London, UK
Hum Fertil (Camb) 13:268-71. 2010..Whilst the mediating molecular mechanism(s) is unknown, the sex-specific transmission patterns and exposure-sensitive periods suggest a pre-evolved transgenerational response mechanism...
- The Avon Longitudinal Study of Parents and Children (ALSPAC): a resource for genetic epidemiologyMarcus Pembrey
Institute of Child Health, University College London, London, UK
Eur J Endocrinol 151:U125-9. 2004....
- Sex-specific, male-line transgenerational responses in humansMarcus E Pembrey
Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, England, UK
Eur J Hum Genet 14:159-66. 2006..Such responses add an entirely new dimension to the study of gene-environment interactions in development and health...
- Prepubertal start of father's smoking and increased body fat in his sons: further characterisation of paternal transgenerational responsesKate Northstone
School of Social and Community Medicine, University of Bristol, London, UK
Eur J Hum Genet 22:1382-6. 2014..Smoking by boys in mid childhood may contribute to obesity in adolescent boys of the next generation. ..
- Differences between blood donors and a population sample: implications for case-control studiesJean Golding
School of Social and Community Medicine, University of Bristol, Bristol, UK, MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK, and Institute of Child Health, University College London, London, UK
Int J Epidemiol 42:1145-56. 2013..Selecting appropriate controls for studies of genetic variation in case series is important. The two major candidates involve the use of blood donors or a random sample of the population...
- Parental and grandparental ages in the autistic spectrum disorders: a birth cohort studyJean Golding
Department of Community Based Medicine, University of Bristol, Centre for Child and Adolescent Health, Bristol, United Kingdom
PLoS ONE 5:e9939. 2010..A number of studies have assessed ages of parents of children with autistic spectrum disorders (ASD), and reported both maternal and paternal age effects. Here we assess relationships with grandparental ages...
- The search for genenotype/phenotype associations and the phenome scanRichard Jones
ALSPAC, Department of Community Based Medicine, University of Bristol, Bristol, UK
Paediatr Perinat Epidemiol 19:264-75. 2005..We believe that this approach can generate data that will be useful in answering generic questions about genotype/phenotype associations as well as in discovering novel ones...
- Is the growth of the child of a smoking mother influenced by the father's prenatal exposure to tobacco? A hypothesis generating longitudinal studyMarcus Pembrey
School of Social and Community Medicine, University of Bristol, Bristol, UK Centre for Child and Adolescent Health, University of Bristol, Bristol, UK Institute of Child Health, University College London, London, UK
BMJ Open 4:e005030. 2014..The aim of this study was to determine whether the prenatal smoke exposure of either parent influenced the growth of the fetus of a smoking woman, and whether any effects were dependent on the fetal sex...
- Genetic epidemiology: some special contributions of birth cohortsMarcus Pembrey
Institute of Child Health, University College London, and Avon Longitudinal Study of Parents and Children, University of Bristol, Bristol, UK
Paediatr Perinat Epidemiol 18:3-7. 2004....
- Human transgenerational responses to early-life experience: potential impact on development, health and biomedical researchMarcus Pembrey
School of Social and Community Medicine, University of Bristol, Bristol, UK UCL Institute of Child Health, London, UK
J Med Genet 51:563-72. 2014..This review was developed initially as a position paper by the multidisciplinary Network in Epigenetic Epidemiology to encourage transgenerational research in human cohorts. ..
- Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gainKen K Ong
Department of Pediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Diabetes 53:1128-33. 2004..Our results indicate that complex prenatal and postnatal gene-maternal/fetal interactions influence size at birth and childhood risk factors for adult disease...
- Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individualsRachel M Freathy
Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
Am J Hum Genet 80:1150-61. 2007..In conclusion, we have identified the first type 2 diabetes-susceptibility allele to be reproducibly associated with birth weight. Common gene variants can substantially influence normal birth-weight variation...
- Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association studyIan P Hall
Division of Therapeutics and Molecular Medicine, University of Nottingham, UK
Lancet 368:771-9. 2006..We aimed to relate the long-term prevalence of asthma or wheeze to functional coding region polymorphisms in the ADRB2 gene...
- Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood heightClive J Petry
Department of Paediatrics, University of Cambridge, Box 116, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
Growth Horm IGF Res 15:363-8. 2005..We hypothesised that polymorphisms in the IGF2R gene could alter size at birth and childhood growth...
- Investigation of UBE3A and MECP2 in Angelman syndrome (AS) and patients with features of ASMegan P Hitchins
Molecular Embryology Unit, Institute of Child Health and Great Ormond Street Hospital, University College London, London, United Kingdom
Am J Med Genet A 125:167-72. 2004..While MECP2 mutations can cause a phenotype reminiscent of AS in rare cases, they fail to account for the excess of sporadic patients with a definitive clinical diagnosis of AS...
- A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analysesMichael N Weedon
Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, EX1 2LU, UK
Am J Hum Genet 79:991-1001. 2006..In conclusion, a comprehensive analysis of common variation of the glucokinase gene shows that this is the first gene to be reproducibly associated with fasting glucose and fetal growth...