J M Pemberton

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. pmc Wild pedigrees: the way forward
    J M Pemberton
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Proc Biol Sci 275:613-21. 2008
  2. pmc Relationship between susceptibility of Blackface sheep to Teladorsagia circumcincta infection and an inflammatory mucosal T cell response
    Anton G Gossner
    The Roslin Institute and R D SVS, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK
    Vet Res 43:26. 2012
  3. pmc Inbreeding depression in red deer calves
    Craig A Walling
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    BMC Evol Biol 11:318. 2011
  4. doi request reprint Digital gene expression analysis of gastrointestinal helminth resistance in Scottish blackface lambs
    J M Pemberton
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Ecol 20:910-9. 2011
  5. pmc Evolution of quantitative traits in the wild: mind the ecology
    Josephine M Pemberton
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Philos Trans R Soc Lond B Biol Sci 365:2431-8. 2010
  6. pmc Environmental coupling of selection and heritability limits evolution
    A J Wilson
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 4:e216. 2006
  7. doi request reprint Natural selection on a measure of parasite resistance varies across ages and environmental conditions in a wild mammal
    A D Hayward
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    J Evol Biol 24:1664-76. 2011
  8. doi request reprint Variable extent of sex-biased dispersal in a strongly polygynous mammal
    S Perez-Espona
    School of Biological Sciences, Institute of Evolutionary Biology, The University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Ecol 19:3101-13. 2010
  9. doi request reprint Investigating temporal changes in hybridization and introgression in a predominantly bimodal hybridizing population of invasive sika (Cervus nippon) and native red deer (C. elaphus) on the Kintyre Peninsula, Scotland
    H V Senn
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Mol Ecol 19:910-24. 2010
  10. doi request reprint Metazoan-protozoan parasite co-infections and host body weight in St Kilda Soay sheep
    B H Craig
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland
    Parasitology 135:433-41. 2008

Detail Information

Publications51

  1. pmc Wild pedigrees: the way forward
    J M Pemberton
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Proc Biol Sci 275:613-21. 2008
    ..In outbred diploid populations, the pedigree approach is superior to analyses based on marker-based pairwise estimators of coancestry...
  2. pmc Relationship between susceptibility of Blackface sheep to Teladorsagia circumcincta infection and an inflammatory mucosal T cell response
    Anton G Gossner
    The Roslin Institute and R D SVS, University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK
    Vet Res 43:26. 2012
    ..These data are consistent with the hypothesis that the inability to control L3 larval colonization, adult worm infection and egg production is due to the activation of the inflammatory Th17 T cell subset...
  3. pmc Inbreeding depression in red deer calves
    Craig A Walling
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    BMC Evol Biol 11:318. 2011
    ..We also tested whether inbreeding depression varied with environmental conditions and maternal age...
  4. doi request reprint Digital gene expression analysis of gastrointestinal helminth resistance in Scottish blackface lambs
    J M Pemberton
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Ecol 20:910-9. 2011
    ..Our results are consistent with the hypothesis that both resistance and susceptibility are active responses to infection and that susceptibility is associated with dysfunction in T cell differentiation and regulation...
  5. pmc Evolution of quantitative traits in the wild: mind the ecology
    Josephine M Pemberton
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Philos Trans R Soc Lond B Biol Sci 365:2431-8. 2010
    ....
  6. pmc Environmental coupling of selection and heritability limits evolution
    A J Wilson
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom
    PLoS Biol 4:e216. 2006
    ..Assumptions of environmental constancy are likely to be violated in natural systems, and failure to acknowledge this may generate highly misleading expectations for phenotypic microevolution...
  7. doi request reprint Natural selection on a measure of parasite resistance varies across ages and environmental conditions in a wild mammal
    A D Hayward
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    J Evol Biol 24:1664-76. 2011
    ..Our findings reveal processes that may shape variation in parasite resistance in natural populations and illustrate the importance of accounting for correlated traits in selection analysis...
  8. doi request reprint Variable extent of sex-biased dispersal in a strongly polygynous mammal
    S Perez-Espona
    School of Biological Sciences, Institute of Evolutionary Biology, The University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Ecol 19:3101-13. 2010
    ..This study provides new insights on dispersal of a strongly polygynous mammal at geographical scales relevant for management and conservation...
  9. doi request reprint Investigating temporal changes in hybridization and introgression in a predominantly bimodal hybridizing population of invasive sika (Cervus nippon) and native red deer (C. elaphus) on the Kintyre Peninsula, Scotland
    H V Senn
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Mol Ecol 19:910-24. 2010
    ..Although we demonstrate that low rates of F1 hybridization can lead to substantial introgression, the progress of hybridization and introgression appears to be unpredictable over the short timescales...
  10. doi request reprint Metazoan-protozoan parasite co-infections and host body weight in St Kilda Soay sheep
    B H Craig
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland
    Parasitology 135:433-41. 2008
    ..However, in adult hosts, strongyles and coccidia were independently and negatively associated with host weight. These results are consistent with the idea that strongyles and coccidia are exerting independent selection on Soay sheep...
  11. ncbi request reprint Heterozygosity, inbreeding and neonatal traits in Soay sheep on St Kilda
    A D J Overall
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT
    Mol Ecol 14:3383-93. 2005
    ..The pursuit of more detailed pedigrees offers the best prospect for identifying inbreeding depression within this study population...
  12. doi request reprint Trading offspring size for number in a variable environment: selection on reproductive investment in female Soay sheep
    A J Wilson
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK
    J Anim Ecol 78:354-64. 2009
    ....
  13. doi request reprint Maternal effects and early-life performance are associated with parasite resistance across life in free-living Soay sheep
    A D Hayward
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland
    Parasitology 137:1261-73. 2010
    ..These results add to the growing evidence that conditions experienced by individuals during development can have a profound influence on immediate and late-life performance and may even influence ageing...
  14. ncbi request reprint Epidemiology of parasitic protozoan infections in Soay sheep (Ovis aries L.) on St Kilda
    B H Craig
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, Scotland
    Parasitology 134:9-21. 2007
    ..The results of this study highlight the potential for protozoal infection to shape the evolution of parasite resistance in wild host populations harbouring diverse parasite species...
  15. ncbi request reprint Gastrointestinal nematode species burdens and host mortality in a feral sheep population
    B H Craig
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Scotland
    Parasitology 133:485-96. 2006
    ....
  16. doi request reprint Genetic diversity and population structure of Scottish Highland red deer (Cervus elaphus) populations: a mitochondrial survey
    S Perez-Espona
    Institute of Evolutionary Biology, School of Biological Sciences, The University of Edinburgh, Edinburgh, UK
    Heredity (Edinb) 102:199-210. 2009
    ....
  17. ncbi request reprint Statistical confidence for likelihood-based paternity inference in natural populations
    T C Marshall
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Mol Ecol 7:639-55. 1998
    ..CERVUS can be used to calculate allele frequencies, run simulations and perform parentage analysis using data from all types of codominant markers...
  18. ncbi request reprint Male reproductive success in a promiscuous mammal: behavioural estimates compared with genetic paternity
    D W Coltman
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Mol Ecol 8:1199-209. 1999
    ..For these reasons, census-based observations of consort associations between individuals cannot be used to accurately estimate individual male reproductive success in this population...
  19. ncbi request reprint Power to detect QTL in a free-living polygynous population
    J Slate
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, U K
    Heredity (Edinb) 83:327-36. 1999
    ..67, whereas the half-sib design has power of just 0.21. We conclude that detecting QTL may be possible in intensively studied natural populations, provided detailed life history data and good pedigree information are available...
  20. ncbi request reprint Estimating variance components in natural populations using inferred relationships
    S C Thomas
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, U K
    Heredity (Edinb) 84:427-36. 2000
    ..The modified form shows less bias in its estimates of heritability than the likelihood technique originally proposed...
  21. ncbi request reprint Maternal genetic effects set the potential for evolution in a free-living vertebrate population
    A J Wilson
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh, UK
    J Evol Biol 18:405-14. 2005
    ....
  22. ncbi request reprint A microsatellite polymorphism in the gamma interferon gene is associated with resistance to gastrointestinal nematodes in a naturally-parasitized population of Soay sheep
    D W Coltman
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    Parasitology 122:571-82. 2001
    ....
  23. doi request reprint Mapping quantitative trait loci in a wild population using linkage and linkage disequilibrium analyses
    J Hernandez-Sanchez
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, EH9 3JT, UK
    Genet Res (Camb) 92:273-81. 2010
    ..The most striking result was the confirmation of a QTL affecting birth weight that had been reported using association tests but not when using linkage-based analyses...
  24. doi request reprint Phenotypic analysis of host-parasite interactions in lambs infected with Teladorsagia circumcincta
    D Beraldi
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK
    Int J Parasitol 38:1567-77. 2008
    ..The data also suggest that genetic selection for an enhanced anti-T. circumcincta IgA response might complement selection based on a reduced FEC as a strategy to select for resistance to gastrointestinal nematodes...
  25. doi request reprint Re-establishment of nematode infra-community and host survivorship in wild Soay sheep following anthelmintic treatment
    B H Craig
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, United Kingdom
    Vet Parasitol 161:47-52. 2009
    ..vitrinus. The fact that this species had higher numbers in males than females and was associated with over-winter weight loss implies it could have an important role in host mortality in high-density years...
  26. doi request reprint Sex ratio and morphological polymorphism in an isolated, endemic Teladorsagia circumcincta population
    B H Craig
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    J Helminthol 84:208-15. 2010
    ....
  27. doi request reprint Trypanosoma melophagium from the sheep ked Melophagus ovinus on the island of St Kilda
    W Gibson
    School of Biological Sciences, University of Bristol, Bristol BS81UG, UK
    Parasitology 137:1799-804. 2010
    ..The close genetic relationship of T. melophagium and T. theileri suggests that T. melophagium represents a lineage of T. theileri that adapted to transmission by sheep keds and hence became a specific parasite of sheep...
  28. ncbi request reprint Bottlenecks, drift and differentiation: the population structure and demographic history of sika deer (Cervus nippon) in the Japanese archipelago
    S J Goodman
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh, EH9 3JT, UK
    Mol Ecol 10:1357-70. 2001
    ..Habitat fragment size was not significantly associated with genetic diversity in populations but there was a significant correlation between habitat fragment size and effective population size...
  29. doi request reprint Landscape features affect gene flow of Scottish Highland red deer (Cervus elaphus)
    S Perez-Espona
    Institute of Evolutionary Biology, School of Biological Sciences, The University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Mol Ecol 17:981-96. 2008
    ..Additionally, we explored the effect of choosing arbitrary cell cost values to construct least cost-distance matrices and described a method for improving the selection of cell cost values for a particular landscape feature...
  30. doi request reprint Indirect genetics effects and evolutionary constraint: an analysis of social dominance in red deer, Cervus elaphus
    A J Wilson
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    J Evol Biol 24:772-83. 2011
    ..More generally, we argue that IGEs likely provide a widespread but poorly recognized source of evolutionary constraint for traits influenced by competition...
  31. pmc Re-mating across years and intralineage polygyny are associated with greater than expected levels of inbreeding in wild red deer
    K V Stopher
    Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, UK
    J Evol Biol 25:2457-69. 2012
    ....
  32. doi request reprint Selection and microevolution of coat pattern are cryptic in a wild population of sheep
    J Gratten
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK
    Mol Ecol 21:2977-90. 2012
    ..This highlights the importance of resolving the underlying genetic basis of phenotypic variation in explaining evolutionary dynamics...
  33. ncbi request reprint Non-invasive assessment of parasitic nematode species diversity in wild Soay sheep using molecular markers
    B Wimmer
    Institute for Animal, Cell and Population Biology, University of Edinburgh, West Mains Road, EH9 3JT Edinburgh, Scotland, UK
    Int J Parasitol 34:625-31. 2004
    ..The method was also tested for its applicability to high through-put screening of faecal samples...
  34. ncbi request reprint Population density affects sex ratio variation in red deer
    L E Kruuk
    Department of Zoology, University of Cambridge, UK
    Nature 399:459-61. 1999
    ..Comparison with other ungulate studies indicates that positive associations between maternal quality and the proportion of male offspring born have only been documented in populations below carrying capacity...
  35. pmc Heritability of fitness in a wild mammal population
    L E Kruuk
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
    Proc Natl Acad Sci U S A 97:698-703. 2000
    ..Finally, there were significant maternal effects in a range of traits, particularly for females...
  36. ncbi request reprint Fluctuating asymmetry in a secondary sexual trait: no associations with individual fitness, environmental stress or inbreeding, and no heritability
    L E B Kruuk
    Department of Zoology, University of Cambridge, Cambridge, UK
    J Evol Biol 16:101-13. 2003
    ..Given the series of null results in our other tests, it seems likely that this was a direct mechanistic effect rather than because measures of FA were indicative of individual quality or condition...
  37. pmc Estimating the prevalence of inbreeding from incomplete pedigrees
    T C Marshall
    Institute of Cell, Animal and Population Biology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
    Proc Biol Sci 269:1533-9. 2002
    ..Close and moderate inbreeding appear to be a routine part of breeding behaviour in these ruminant populations...
  38. ncbi request reprint Genetic evidence for male biased dispersal in the red-billed quelea Quelea quelea
    M Dallimer
    Institute of Cell, Animal and Population Biology, University of Edinburgh, King s Buildings, Edinburgh EH9 3JT, UK
    Mol Ecol 11:529-33. 2002
    ..There was a pattern of male-biased dispersal, the first example in a passerine, and the first time that evidence of a sex-biased pattern of dispersal has been shown for queleas...
  39. ncbi request reprint Lack of genetic and plumage differentiation in the red-billed quelea Quelea quelea across a migratory divide in southern Africa
    M Dallimer
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Kings Buildings, Edinburgh EH9 3JT, UK
    Mol Ecol 12:345-53. 2003
    ..This is perhaps because the migratory divide does not act to separate individuals into populations within which genetic and plumage differentiation can be maintained...
  40. ncbi request reprint Reproductive isolation in a threespine stickleback hybrid zone
    F C Jones
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    J Evol Biol 19:1531-44. 2006
    ..We discuss the potential contribution of temporal, spatial, and sexual prezygotic barriers to the observed reproductive isolation as well as postzygotic selection against hybrid zygotes or fry...
  41. pmc Male mate choice influences female promiscuity in Soay sheep
    B T Preston
    Institute of Biological Sciences, University of Stirling, Stirling FK9 4LA, UK
    Proc Biol Sci 272:365-73. 2005
    ....
  42. pmc A genome scan for quantitative trait loci in a wild population of red deer (Cervus elaphus)
    J Slate
    AgResearch, Invermay Agricultural Centre, Mosgiel, New Zealand
    Genetics 162:1863-73. 2002
    ..To our knowledge this is the first time that a QTL for any trait has been mapped in a wild mammal population. It is hoped that this study will stimulate further investigations of the genetic architecture of fitness traits in the wild...
  43. ncbi request reprint Admixture and patterns of linkage disequilibrium in a free-living vertebrate population
    J Slate
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK
    J Evol Biol 20:1415-27. 2007
    ..Association mapping may be possible in this population, although a high 'baseline' level of LD could lead to false positive associations between marker loci and a trait of interest...
  44. ncbi request reprint Fine-scale genetic structure in a free-living ungulate population
    D W Coltman
    Department of Animal and Plant Sciences, University of Sheffield, Western Bank, UK
    Mol Ecol 12:733-42. 2003
    ..However, genetic substructure can lead to allelic associations and generate environmental effects within lineages that have the potential to confound heritability analyses and allelic association studies...
  45. ncbi request reprint Estimating the functional form for the density dependence from life history data
    T Coulson
    Department of Life Sciences, Imperial College London, Silwood Park, Ascot, Berkshire, United Kingdom
    Ecology 89:1661-74. 2008
    ..The simple method we develop has potential to provide substantial insight into the relative contributions of population and individual-level processes to the dynamics of populations in stochastic environments...
  46. doi request reprint A localized negative genetic correlation constrains microevolution of coat color in wild sheep
    J Gratten
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield S10 2TN, UK
    Science 319:318-20. 2008
    ..This result demonstrates the importance of understanding the genetic basis of fitness variation when making predictions about the microevolutionary consequences of selection...
  47. ncbi request reprint Estimating selection on neonatal traits in red deer using elasticity path analysis
    T Coulson
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
    Evolution 57:2879-92. 2003
    ....
  48. pmc Overt and covert competition in a promiscuous mammal: the importance of weaponry and testes size to male reproductive success
    B T Preston
    Institute of Biological Sciences, University of Stirling, Stirling FK9 4LA, UK
    Proc Biol Sci 270:633-40. 2003
    ..Our results thus provide direct quantitative evidence that male reproductive success in wild populations of mammals is dependent upon the relative magnitude of both overt contest competition and covert sperm competition...
  49. ncbi request reprint Why large-scale climate indices seem to predict ecological processes better than local weather
    T B Hallett
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nature 430:71-5. 2004
    ....
  50. pmc Compelling evidence that a single nucleotide substitution in TYRP1 is responsible for coat-colour polymorphism in a free-living population of Soay sheep
    J Gratten
    Department of Animal and Plant Sciences, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Proc Biol Sci 274:619-26. 2007
    ..0001, LOD=110.20), and very tight linkage between Coat colour and TYRP1 (LOD=29.50)...
  51. ncbi request reprint A framework for power and sensitivity analyses for quantitative genetic studies of natural populations, and case studies in Soay sheep (Ovis aries)
    M B Morrissey
    Department of Integrative Biology, University of Guelph, Guelph, ON, Canada
    J Evol Biol 20:2309-21. 2007
    ..09. Given this range of results, we suggest that such power and sensitivity analyses could greatly complement empirical studies, and we provide the computer program PEDANTICS to aid in their application...