Stella Pelengaris

Summary

Affiliation: University of Warwick
Country: UK

Publications

  1. ncbi request reprint The many faces of c-MYC
    Stella Pelengaris
    Molecular Medicine, Biomedical Research Institute, University of Warwick, Coventry CV4 7AL, UK
    Arch Biochem Biophys 416:129-36. 2003
  2. ncbi request reprint The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth
    Stella Pelengaris
    Molecular Medicine, Biomedical Research Institute, University of Warwick, Coventry, CV4 7AL, UK
    Expert Opin Ther Targets 7:623-42. 2003
  3. pmc Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis
    Stella Pelengaris
    Biomedical Research Institute, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    BMC Biol 2:26. 2004
  4. ncbi request reprint c-MYC: more than just a matter of life and death
    Stella Pelengaris
    Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, UK
    Nat Rev Cancer 2:764-76. 2002
  5. ncbi request reprint Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    Stella Pelengaris
    Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    Cell 109:321-34. 2002
  6. pmc Re-expression of IGF-II is important for beta cell regeneration in adult mice
    Luxian Zhou
    School of Life Sciences, University of Warwick, Coventry, United Kingdom
    PLoS ONE 7:e43623. 2012
  7. pmc Non-β-cell progenitors of β-cells in pregnant mice
    Sylvie Abouna
    Department of Biological Sciences, University of Warwick, Coventry, UK
    Organogenesis 6:125-33. 2010
  8. ncbi request reprint c-Myc and downstream targets in the pathogenesis and treatment of cancer
    Sam Robson
    Biological Sciences, Biomedical Research Institute, University of Warwick, Coventry, CV4 7AL, UK
    Recent Pat Anticancer Drug Discov 1:305-26. 2006
  9. ncbi request reprint Oxidised lipoproteins may promote inflammation through the selective delay of engulfment but not binding of apoptotic cells by macrophages
    Michael Khan
    Department of Biological Sciences, Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, UK
    Atherosclerosis 171:21-9. 2003
  10. pmc A simple matter of life and death-the trials of postnatal Beta-cell mass regulation
    Elena Tarabra
    School of Life Sciences, Warwick University, Gibbet Hill Road, Coventry CV4 7AL, UK
    Int J Endocrinol 2012:516718. 2012

Collaborators

  • Michael Khan
  • James Young
  • Gerard I Evan
  • J A Bluestone
  • D J Betteridge
  • Sylvie Abouna
  • Luxian Zhou
  • Elena Tarabra
  • David Epstein
  • David A Cano
  • Séverine M A Pascal
  • Sam Robson
  • Tim Wilhelm Nattkemper
  • Hassan Nakhai
  • Julia Herold
  • Ian Sweeney
  • Vasiliki Ifandi
  • Robert W Old
  • Lamorna B Swigart
  • Yves Guiot
  • Matthias Hebrok
  • Jean Christophe Jonas
  • Mike German
  • Patrick W Heiser
  • Ingrid C Rulifson

Detail Information

Publications12

  1. ncbi request reprint The many faces of c-MYC
    Stella Pelengaris
    Molecular Medicine, Biomedical Research Institute, University of Warwick, Coventry CV4 7AL, UK
    Arch Biochem Biophys 416:129-36. 2003
    ..Although still in its infancy, encouraging results have been reported for several approaches using gene targeting to interfere with c-MYC expression or activity both in vitro and in vivo...
  2. ncbi request reprint The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth
    Stella Pelengaris
    Molecular Medicine, Biomedical Research Institute, University of Warwick, Coventry, CV4 7AL, UK
    Expert Opin Ther Targets 7:623-42. 2003
    ..Although still in its infancy, encouraging results have been reported using antisense oligodeoxynucleotide-based methods, as well as other approaches to interfere with MYC expression both in vitro and in vivo...
  3. pmc Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis
    Stella Pelengaris
    Biomedical Research Institute, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    BMC Biol 2:26. 2004
    ..But would this apply to other tumours?..
  4. ncbi request reprint c-MYC: more than just a matter of life and death
    Stella Pelengaris
    Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, UK
    Nat Rev Cancer 2:764-76. 2002
    ..Regulatable transgenic mouse models of oncogenesis have shed light on these issues and provide hope for effective cancer therapies...
  5. ncbi request reprint Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    Stella Pelengaris
    Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    Cell 109:321-34. 2002
    ..Our data indicate that highly complex neoplastic lesions can be both induced and maintained in vivo by a simple combination of two interlocking molecular lesions...
  6. pmc Re-expression of IGF-II is important for beta cell regeneration in adult mice
    Luxian Zhou
    School of Life Sciences, University of Warwick, Coventry, United Kingdom
    PLoS ONE 7:e43623. 2012
    ..In this study we investigated the effect of IGF-II on beta cell regeneration...
  7. pmc Non-β-cell progenitors of β-cells in pregnant mice
    Sylvie Abouna
    Department of Biological Sciences, University of Warwick, Coventry, UK
    Organogenesis 6:125-33. 2010
    ..Further, there was no transdifferentiation of β-cells to other cell types in a two and half month period following labeling, including the period of pregnancy...
  8. ncbi request reprint c-Myc and downstream targets in the pathogenesis and treatment of cancer
    Sam Robson
    Biological Sciences, Biomedical Research Institute, University of Warwick, Coventry, CV4 7AL, UK
    Recent Pat Anticancer Drug Discov 1:305-26. 2006
    ..This review will discuss what is known about the role of c-Myc in growth deregulation and cancer and will conclude with a discussion of the most promising recent developments in Myc-targeted therapeutics...
  9. ncbi request reprint Oxidised lipoproteins may promote inflammation through the selective delay of engulfment but not binding of apoptotic cells by macrophages
    Michael Khan
    Department of Biological Sciences, Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, UK
    Atherosclerosis 171:21-9. 2003
    ..This mechanism may contribute to chronic persisting inflammation in the atherosclerotic artery and rheumatoid joint...
  10. pmc A simple matter of life and death-the trials of postnatal Beta-cell mass regulation
    Elena Tarabra
    School of Life Sciences, Warwick University, Gibbet Hill Road, Coventry CV4 7AL, UK
    Int J Endocrinol 2012:516718. 2012
    ..Furthermore, we will also address more recently appreciated regulators of beta-cell mass, such as microRNAs...
  11. doi request reprint Effects of c-MYC activation on glucose stimulus-secretion coupling events in mouse pancreatic islets
    Séverine M A Pascal
    Unit of Endocrinology and Metabolism, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Endocrinol Metab 295:E92-102. 2008
    ....
  12. ncbi request reprint Regulated beta-cell regeneration in the adult mouse pancreas
    David A Cano
    Diabetes Center, University of California San Francisco, California, USA
    Diabetes 57:958-66. 2008
    ..Our results also suggest the regeneration of beta-cells is mediated by replication of beta-cells rather than neogenesis from pancreatic ducts...