S Pelengaris

Summary

Affiliation: University of Warwick
Country: UK

Publications

  1. ncbi request reprint c-MYC: more than just a matter of life and death
    Stella Pelengaris
    Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, UK
    Nat Rev Cancer 2:764-76. 2002
  2. ncbi request reprint Oncogenic co-operation in beta-cell tumorigenesis
    S Pelengaris
    Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Endocr Relat Cancer 8:307-14. 2001
  3. ncbi request reprint Action of Myc in vivo - proliferation and apoptosis
    S Pelengaris
    Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK
    Curr Opin Genet Dev 10:100-5. 2000
  4. ncbi request reprint Regulated beta-cell regeneration in the adult mouse pancreas
    David A Cano
    Diabetes Center, University of California San Francisco, California, USA
    Diabetes 57:958-66. 2008
  5. pmc Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis
    Stella Pelengaris
    Biomedical Research Institute, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    BMC Biol 2:26. 2004
  6. ncbi request reprint Oxidised lipoproteins may promote inflammation through the selective delay of engulfment but not binding of apoptotic cells by macrophages
    Michael Khan
    Department of Biological Sciences, Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, UK
    Atherosclerosis 171:21-9. 2003
  7. ncbi request reprint The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth
    Stella Pelengaris
    Molecular Medicine, Biomedical Research Institute, University of Warwick, Coventry, CV4 7AL, UK
    Expert Opin Ther Targets 7:623-42. 2003
  8. ncbi request reprint The many faces of c-MYC
    Stella Pelengaris
    Molecular Medicine, Biomedical Research Institute, University of Warwick, Coventry CV4 7AL, UK
    Arch Biochem Biophys 416:129-36. 2003
  9. ncbi request reprint Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    Stella Pelengaris
    Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    Cell 109:321-34. 2002
  10. doi request reprint Effects of c-MYC activation on glucose stimulus-secretion coupling events in mouse pancreatic islets
    Séverine M A Pascal
    Unit of Endocrinology and Metabolism, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Endocrinol Metab 295:E92-102. 2008

Collaborators

  • J A Bluestone
  • D J Betteridge
  • Gerard I Evan
  • Michael Khan
  • Séverine M A Pascal
  • David A Cano
  • Sam Robson
  • Ingrid C Rulifson
  • Mike German
  • Matthias Hebrok
  • Lamorna B Swigart
  • Yves Guiot
  • Jean Christophe Jonas
  • Patrick W Heiser
  • John Betteridge
  • Chris Smith
  • Michael Cooper

Detail Information

Publications11

  1. ncbi request reprint c-MYC: more than just a matter of life and death
    Stella Pelengaris
    Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, UK
    Nat Rev Cancer 2:764-76. 2002
    ..Regulatable transgenic mouse models of oncogenesis have shed light on these issues and provide hope for effective cancer therapies...
  2. ncbi request reprint Oncogenic co-operation in beta-cell tumorigenesis
    S Pelengaris
    Molecular Medicine Research Centre, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Endocr Relat Cancer 8:307-14. 2001
    ..These results suggest that, in the pancreatic beta-cells, early suppression of apoptosis is essential for the survival of Myc-activated beta-cells and islet neoplasia...
  3. ncbi request reprint Action of Myc in vivo - proliferation and apoptosis
    S Pelengaris
    Biological Sciences, University of Warwick, Coventry, CV4 7AL, UK
    Curr Opin Genet Dev 10:100-5. 2000
    ..An outstanding feature of these experiments is the demonstration that the balance between oncogene-induced proliferation and apoptosis in a given tissue can be a critical determinant in the initiation and maintenance of the tumor...
  4. ncbi request reprint Regulated beta-cell regeneration in the adult mouse pancreas
    David A Cano
    Diabetes Center, University of California San Francisco, California, USA
    Diabetes 57:958-66. 2008
    ..Our results also suggest the regeneration of beta-cells is mediated by replication of beta-cells rather than neogenesis from pancreatic ducts...
  5. pmc Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis
    Stella Pelengaris
    Biomedical Research Institute, Department of Biological Sciences, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK
    BMC Biol 2:26. 2004
    ..But would this apply to other tumours?..
  6. ncbi request reprint Oxidised lipoproteins may promote inflammation through the selective delay of engulfment but not binding of apoptotic cells by macrophages
    Michael Khan
    Department of Biological Sciences, Molecular Medicine Research Centre, University of Warwick, Coventry CV4 7AL, UK
    Atherosclerosis 171:21-9. 2003
    ..This mechanism may contribute to chronic persisting inflammation in the atherosclerotic artery and rheumatoid joint...
  7. ncbi request reprint The c-MYC oncoprotein as a treatment target in cancer and other disorders of cell growth
    Stella Pelengaris
    Molecular Medicine, Biomedical Research Institute, University of Warwick, Coventry, CV4 7AL, UK
    Expert Opin Ther Targets 7:623-42. 2003
    ..Although still in its infancy, encouraging results have been reported using antisense oligodeoxynucleotide-based methods, as well as other approaches to interfere with MYC expression both in vitro and in vivo...
  8. ncbi request reprint The many faces of c-MYC
    Stella Pelengaris
    Molecular Medicine, Biomedical Research Institute, University of Warwick, Coventry CV4 7AL, UK
    Arch Biochem Biophys 416:129-36. 2003
    ..Although still in its infancy, encouraging results have been reported for several approaches using gene targeting to interfere with c-MYC expression or activity both in vitro and in vivo...
  9. ncbi request reprint Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression
    Stella Pelengaris
    Molecular Medicine Research Center, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, United Kingdom
    Cell 109:321-34. 2002
    ..Our data indicate that highly complex neoplastic lesions can be both induced and maintained in vivo by a simple combination of two interlocking molecular lesions...
  10. doi request reprint Effects of c-MYC activation on glucose stimulus-secretion coupling events in mouse pancreatic islets
    Séverine M A Pascal
    Unit of Endocrinology and Metabolism, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    Am J Physiol Endocrinol Metab 295:E92-102. 2008
    ....
  11. ncbi request reprint c-Myc and downstream targets in the pathogenesis and treatment of cancer
    Sam Robson
    Biological Sciences, Biomedical Research Institute, University of Warwick, Coventry, CV4 7AL, UK
    Recent Pat Anticancer Drug Discov 1:305-26. 2006
    ..This review will discuss what is known about the role of c-Myc in growth deregulation and cancer and will conclude with a discussion of the most promising recent developments in Myc-targeted therapeutics...