Pablo Pelegrin

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. doi request reprint Targeting interleukin-1 signaling in chronic inflammation: focus on P2X(7) receptor and Pannexin-1
    Pablo Pelegrin
    Faculty of Life Science, University of Manchester, Manchester, England, U K
    Drug News Perspect 21:424-33. 2008
  2. pmc Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc
    David Brough
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Eur J Immunol 39:352-8. 2009
  3. doi request reprint P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases
    Gloria Lopez-Castejon
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Immunol 185:2611-9. 2010
  4. pmc Pharmacological characterization of pannexin-1 currents expressed in mammalian cells
    Weihong Ma
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Pharmacol Exp Ther 328:409-18. 2009
  5. doi request reprint Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules
    Gloria Lopez-Castejon
    Faculty of Life Science, University of Manchester, Michael Smith Building D3315, Manchester, M13 9PT, UK
    Cell Mol Life Sci 68:3095-107. 2011
  6. doi request reprint Current status of inflammasome blockers as anti-inflammatory drugs
    Gloria Lopez-Castejon
    University of Manchester, Faculty of Life Science, AV Hill Building, 2 021, Manchester, M13 9PT, UK
    Expert Opin Investig Drugs 21:995-1007. 2012
  7. ncbi request reprint P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage
    Pablo Pelegrin
    Faculty of Life Science, University of Manchester, Manchester, United Kingdom
    J Immunol 180:7147-57. 2008
  8. doi request reprint Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding
    Sebastien Roger
    Faculty of Life Science, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 28:6393-401. 2008
  9. pmc The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release
    Pablo Pelegrin
    Faculty of Life Science, University of Manchester, Manchester, M13 9PT, UK
    Purinergic Signal 5:129-37. 2009

Detail Information

Publications9

  1. doi request reprint Targeting interleukin-1 signaling in chronic inflammation: focus on P2X(7) receptor and Pannexin-1
    Pablo Pelegrin
    Faculty of Life Science, University of Manchester, Manchester, England, U K
    Drug News Perspect 21:424-33. 2008
    ....
  2. pmc Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc
    David Brough
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Eur J Immunol 39:352-8. 2009
    ..These data provide new insights into the mechanisms of caspase-1 activation and how zinc metabolism contributes to inflammatory mechanisms...
  3. doi request reprint P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases
    Gloria Lopez-Castejon
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Immunol 185:2611-9. 2010
    ..Our results suggest P2X(7)R activation may play a novel and direct role in tissue damage through release of cathepsins independently of its proinflammatory actions via IL-1 cytokines...
  4. pmc Pharmacological characterization of pannexin-1 currents expressed in mammalian cells
    Weihong Ma
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    J Pharmacol Exp Ther 328:409-18. 2009
    ....
  5. doi request reprint Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules
    Gloria Lopez-Castejon
    Faculty of Life Science, University of Manchester, Michael Smith Building D3315, Manchester, M13 9PT, UK
    Cell Mol Life Sci 68:3095-107. 2011
    ..Therefore, our study reveals an additional level of plasticity modulating the resolution of inflammation...
  6. doi request reprint Current status of inflammasome blockers as anti-inflammatory drugs
    Gloria Lopez-Castejon
    University of Manchester, Faculty of Life Science, AV Hill Building, 2 021, Manchester, M13 9PT, UK
    Expert Opin Investig Drugs 21:995-1007. 2012
    ..Drug-like antagonists acting up- or down-stream of the inflammasome pathway have been successfully used in clinics as important therapeutics to treat different inflammatory diseases...
  7. ncbi request reprint P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage
    Pablo Pelegrin
    Faculty of Life Science, University of Manchester, Manchester, United Kingdom
    J Immunol 180:7147-57. 2008
    ..None of these release responses were associated with cell damage or cytolytic effects. This provides the first direct demonstration of a distinct signaling mechanism responsible for ATP-induced release of pro-IL-1beta...
  8. doi request reprint Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding
    Sebastien Roger
    Faculty of Life Science, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 28:6393-401. 2008
    ..This is the first example of CaM deregulating, rather than tightly controlling, calcium entry through an ion channel...
  9. pmc The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release
    Pablo Pelegrin
    Faculty of Life Science, University of Manchester, Manchester, M13 9PT, UK
    Purinergic Signal 5:129-37. 2009
    ..Thus, pannexin-1 is linked to both dye uptake and IL-1beta release but via distinct mechanisms...