Stuart N Peirson
Affiliation: University of Oxford
Tam S, Hasan S, Choi H, Brown L, Jagannath A, Hughes S, et al
. Constant Light Desynchronizes Olfactory versus Object and Visuospatial Recognition Memory Performance. J Neurosci. 2017;37:3555-3567 pubmed publisher
..Moreover, such a dispersed network of dissociable circadian clocks may provide greater flexibility when faced with conflicting environmental signals (e.g., seasonal changes in photoperiod). ..
Brown L, Fisk A, Pothecary C, Peirson S. Telling the Time with a Broken Clock: Quantifying Circadian Disruption in Animal Models. Biology (Basel). 2019;8: pubmed publisher
..Whilst there is an increasing appreciation of circadian disruption as both a risk to health and a potential therapeutic target, greater consistency in the quantification of disrupted rhythms is needed. ..
Hasan S, Foster R, Vyazovskiy V, Peirson S. Effects of circadian misalignment on sleep in mice. Sci Rep. 2018;8:15343 pubmed publisher
..Our data show that circadian misalignment results in previously uncharacterised long-term effects on sleep, which may have important consequences for behaviour. ..
Tam S, Pritchett D, Brown L, Foster R, Bannerman D, Peirson S. Sleep and circadian rhythm disruption and recognition memory in schizophrenia. Methods Enzymol. 2015;552:325-49 pubmed publisher
Hughes S, Jagannath A, Hankins M, Foster R, Peirson S. Photic regulation of clock systems. Methods Enzymol. 2015;552:125-43 pubmed publisher
..Finally, the primary assays that have been used to measure photic entrainment are described. ..
Jagannath A, Hughes S, Abdelgany A, Pothecary C, Di Pretoro S, Pires S, et al
. Isoforms of Melanopsin Mediate Different Behavioral Responses to Light. Curr Biol. 2015;25:2430-4 pubmed publisher
..These findings demonstrate that splice variants of a single receptor gene can regulate strikingly different behaviors. ..
Jagannath A, Butler R, Godinho S, Couch Y, Brown L, Vasudevan S, et al
. The CRTC1-SIK1 pathway regulates entrainment of the circadian clock. Cell. 2013;154:1100-1111 pubmed publisher
..Thus SIK1 provides negative feedback, acting to suppress the effects of light on the clock. This pathway provides a potential target for the regulation of circadian rhythms. ..
Tam S, Hasan S, Hughes S, Hankins M, Foster R, Bannerman D, et al
. Modulation of recognition memory performance by light requires both melanopsin and classical photoreceptors. Proc Biol Sci. 2016;283: pubmed publisher
..Our findings provide direct evidence that melanopsin-driven and rod/cone-driven photoresponses are integrated in order to mediate the effect of light on memory performance. ..
Peirson S, Brown L, Pothecary C, Benson L, Fisk A. Light and the laboratory mouse. J Neurosci Methods. 2018;300:26-36 pubmed publisher
..Here we provide an overview of the visual and non-visual systems before discussing practical considerations for the use of light for researchers and animal facility staff working with laboratory mice. ..