R A Pearson

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Advances in repairing the degenerate retina by rod photoreceptor transplantation
    Rachael A Pearson
    Department of Genetics, UCL Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK Electronic address
    Biotechnol Adv 32:485-91. 2014
  2. pmc Restoration of vision after transplantation of photoreceptors
    R A Pearson
    Department of Genetics, UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Nature 485:99-103. 2012
  3. pmc Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina
    R A Pearson
    Department of Genetics, University College London Institute of Ophthalmology, London, UK
    Cell Transplant 19:487-503. 2010
  4. pmc Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival
    E L West
    Department of Genetics, University College London Institute of Ophthalmology, London, UK
    Cell Transplant 21:871-87. 2012
  5. pmc Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors
    E L West
    Division of Molecular Therapy, University College London, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Exp Eye Res 86:601-11. 2008
  6. pmc Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression
    J Lakowski
    UCL Institute of Child Health, UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Stem Cells 29:1391-404. 2011
  7. pmc Cell transplantation strategies for retinal repair
    E L West
    Department of Genetics, UCL Institute of Ophthalmology, London, UK
    Prog Brain Res 175:3-21. 2009
  8. ncbi request reprint Retinal repair by transplantation of photoreceptor precursors
    R E MacLaren
    Division of Molecular Therapy, University College London Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Nature 444:203-7. 2006
  9. ncbi request reprint Stem cell therapy and the retina
    R E MacLaren
    Vitreoretinal Service, Moorfields Eye Hospital, London, UK
    Eye (Lond) 21:1352-9. 2007
  10. pmc Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells
    J Lakowski
    Developmental Biology Unit, UCL Institute of Child Health, University College London, 30 Guilford Street, London, UK
    Hum Mol Genet 19:4545-59. 2010

Collaborators

Detail Information

Publications11

  1. pmc Advances in repairing the degenerate retina by rod photoreceptor transplantation
    Rachael A Pearson
    Department of Genetics, UCL Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK Electronic address
    Biotechnol Adv 32:485-91. 2014
    ..However, there are still challenges presented by the degenerating recipient retinal environment that must be addressed as we move to translating these technologies towards clinical application. ..
  2. pmc Restoration of vision after transplantation of photoreceptors
    R A Pearson
    Department of Genetics, UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Nature 485:99-103. 2012
    ..Together, these results demonstrate the feasibility of photoreceptor transplantation as a therapeutic strategy for restoring vision after retinal degeneration...
  3. pmc Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina
    R A Pearson
    Department of Genetics, University College London Institute of Ophthalmology, London, UK
    Cell Transplant 19:487-503. 2010
    ..This study shows that targeted disruption of OLM junctional proteins enhances integration in the wild-type and degenerating retina and may be a useful approach for developing photoreceptor transplantation strategies...
  4. pmc Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival
    E L West
    Department of Genetics, University College London Institute of Ophthalmology, London, UK
    Cell Transplant 21:871-87. 2012
    ....
  5. pmc Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors
    E L West
    Division of Molecular Therapy, University College London, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Exp Eye Res 86:601-11. 2008
    ..Reversible disruption of the OLM may provide a strategy for increasing cell integration in future therapeutic applications...
  6. pmc Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression
    J Lakowski
    UCL Institute of Child Health, UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Stem Cells 29:1391-404. 2011
    ..Refinement of the selection of donorphotoreceptor precursor cells can increase the number of integrated photoreceptor cells,which is a prerequisite for the restoration of sight...
  7. pmc Cell transplantation strategies for retinal repair
    E L West
    Department of Genetics, UCL Institute of Ophthalmology, London, UK
    Prog Brain Res 175:3-21. 2009
    ..Finally, we consider the future translation of retinal cell therapy as a therapeutic strategy to treat retinal degeneration...
  8. ncbi request reprint Retinal repair by transplantation of photoreceptor precursors
    R E MacLaren
    Division of Molecular Therapy, University College London Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Nature 444:203-7. 2006
    ..These findings define the ontogenetic stage of donor cells for successful rod photoreceptor transplantation...
  9. ncbi request reprint Stem cell therapy and the retina
    R E MacLaren
    Vitreoretinal Service, Moorfields Eye Hospital, London, UK
    Eye (Lond) 21:1352-9. 2007
    ....
  10. pmc Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells
    J Lakowski
    Developmental Biology Unit, UCL Institute of Child Health, University College London, 30 Guilford Street, London, UK
    Hum Mol Genet 19:4545-59. 2010
    ..We conclude that flow-sorted embryonic-stage Crx-positive donor cells have the potential to replace lost cones, as well as rods, an important requirement for retinal disease therapy...
  11. ncbi request reprint EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV
    K S Balaggan
    Division of Molecular Therapy, Institute of Ophthalmology, London, UK
    Gene Ther 13:1153-65. 2006
    ....