R A Pearson

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Restoration of vision after transplantation of photoreceptors
    R A Pearson
    Department of Genetics, UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Nature 485:99-103. 2012
  2. ncbi Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina
    R A Pearson
    Department of Genetics, University College London Institute of Ophthalmology, London, UK
    Cell Transplant 19:487-503. 2010
  3. ncbi Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival
    E L West
    Department of Genetics, University College London Institute of Ophthalmology, London, UK
    Cell Transplant 21:871-87. 2012
  4. ncbi Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors
    E L West
    Division of Molecular Therapy, University College London, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Exp Eye Res 86:601-11. 2008
  5. ncbi Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression
    J Lakowski
    UCL Institute of Child Health, UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Stem Cells 29:1391-404. 2011
  6. ncbi Cell transplantation strategies for retinal repair
    E L West
    Department of Genetics, UCL Institute of Ophthalmology, London, UK
    Prog Brain Res 175:3-21. 2009
  7. ncbi Retinal repair by transplantation of photoreceptor precursors
    R E MacLaren
    Division of Molecular Therapy, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK
    Nature 444:203-7. 2006
  8. ncbi Stem cell therapy and the retina
    R E MacLaren
    Vitreoretinal Service, Moorfields Eye Hospital, London, UK
    Eye (Lond) 21:1352-9. 2007
  9. ncbi Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells
    J Lakowski
    Developmental Biology Unit, UCL Institute of Child Health, University College London, 30 Guilford Street, London, UK
    Hum Mol Genet 19:4545-59. 2010
  10. ncbi EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV
    K S Balaggan
    Division of Molecular Therapy, Institute of Ophthalmology, London, UK
    Gene Ther 13:1153-65. 2006

Collaborators

Detail Information

Publications10

  1. ncbi Restoration of vision after transplantation of photoreceptors
    R A Pearson
    Department of Genetics, UCL Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    Nature 485:99-103. 2012
    ..Together, these results demonstrate the feasibility of photoreceptor transplantation as a therapeutic strategy for restoring vision after retinal degeneration...
  2. ncbi Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina
    R A Pearson
    Department of Genetics, University College London Institute of Ophthalmology, London, UK
    Cell Transplant 19:487-503. 2010
    ..This study shows that targeted disruption of OLM junctional proteins enhances integration in the wild-type and degenerating retina and may be a useful approach for developing photoreceptor transplantation strategies...
  3. ncbi Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival
    E L West
    Department of Genetics, University College London Institute of Ophthalmology, London, UK
    Cell Transplant 21:871-87. 2012
    ....
  4. ncbi Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors
    E L West
    Division of Molecular Therapy, University College London, Institute of Ophthalmology, 11 43 Bath Street, London EC1V 9EL, UK
    Exp Eye Res 86:601-11. 2008
    ..Reversible disruption of the OLM may provide a strategy for increasing cell integration in future therapeutic applications...
  5. ncbi Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression
    J Lakowski
    UCL Institute of Child Health, UCL Institute of Ophthalmology, University College London, London, United Kingdom
    Stem Cells 29:1391-404. 2011
    ..Refinement of the selection of donorphotoreceptor precursor cells can increase the number of integrated photoreceptor cells,which is a prerequisite for the restoration of sight...
  6. ncbi Cell transplantation strategies for retinal repair
    E L West
    Department of Genetics, UCL Institute of Ophthalmology, London, UK
    Prog Brain Res 175:3-21. 2009
    ..Finally, we consider the future translation of retinal cell therapy as a therapeutic strategy to treat retinal degeneration...
  7. ncbi Retinal repair by transplantation of photoreceptor precursors
    R E MacLaren
    Division of Molecular Therapy, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK
    Nature 444:203-7. 2006
    ..These findings define the ontogenetic stage of donor cells for successful rod photoreceptor transplantation...
  8. ncbi Stem cell therapy and the retina
    R E MacLaren
    Vitreoretinal Service, Moorfields Eye Hospital, London, UK
    Eye (Lond) 21:1352-9. 2007
    ....
  9. ncbi Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells
    J Lakowski
    Developmental Biology Unit, UCL Institute of Child Health, University College London, 30 Guilford Street, London, UK
    Hum Mol Genet 19:4545-59. 2010
    ..We conclude that flow-sorted embryonic-stage Crx-positive donor cells have the potential to replace lost cones, as well as rods, an important requirement for retinal disease therapy...
  10. ncbi EIAV vector-mediated delivery of endostatin or angiostatin inhibits angiogenesis and vascular hyperpermeability in experimental CNV
    K S Balaggan
    Division of Molecular Therapy, Institute of Ophthalmology, London, UK
    Gene Ther 13:1153-65. 2006
    ....