Catherine J Pears

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+
    Amanda J Unsworth
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 286:21073-82. 2011
  2. pmc Control of cyclin C levels during development of Dictyostelium
    David M Greene
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e10543. 2010
  3. pmc Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis
    A J Unsworth
    Department of Biochemistry, University of Oxford, UK
    J Thromb Haemost 10:1887-94. 2012
  4. pmc Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets
    Catherine J Pears
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 3:e3793. 2008
  5. pmc Targets downstream of Cdk8 in Dictyostelium development
    David M Greene
    Biochemistry Department, Oxford University, South Parks Road, Oxford OX1 3QU UK
    BMC Dev Biol 11:2. 2011
  6. ncbi request reprint DNA damage signaling and repair in Dictyostelium discoideum
    Duen Wei Hsu
    Department of Biochemistry, University of Oxford, Oxford, UK
    Cell Cycle 5:702-8. 2006
  7. pmc The role of ADP-ribosylation in regulating DNA double-strand break repair
    Catherine J Pears
    Department of Biochemistry, University of Oxford, Oxford, UK
    Cell Cycle 11:48-56. 2012
  8. pmc PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks
    C Anne Marie Couto
    Department of Biochemistry, University of Oxford, England, UK
    J Cell Biol 194:367-75. 2011
  9. ncbi request reprint PKD: a new protein kinase C-dependent pathway in platelets
    Margaret J Stafford
    Department of Biochemistry, University of Oxford, United Kingdom
    Blood 101:1392-9. 2003
  10. doi request reprint DNA double-strand break repair pathway choice in Dictyostelium
    Duen Wei Hsu
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    J Cell Sci 124:1655-63. 2011

Collaborators

Detail Information

Publications17

  1. pmc Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+
    Amanda J Unsworth
    Department of Biochemistry, University of Oxford, Oxford OX1 3QU, United Kingdom
    J Biol Chem 286:21073-82. 2011
    ..These results also demonstrate isoform-specific inhibitory effects of PKC in platelets...
  2. pmc Control of cyclin C levels during development of Dictyostelium
    David M Greene
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e10543. 2010
    ..Cells in which the gene encoding Cdk8 has been deleted fail to enter aggregates due to a failure of early gene expression...
  3. pmc Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis
    A J Unsworth
    Department of Biochemistry, University of Oxford, UK
    J Thromb Haemost 10:1887-94. 2012
    ..In comparison to the classical isoforms of protein kinase C (PKC), the novel isoforms are thought to play minor or inhibitory roles in the regulation of platelet activation and thrombosis...
  4. pmc Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets
    Catherine J Pears
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 3:e3793. 2008
    ..Increasing evidence suggests that individual isoforms of protein kinase C (PKC) play distinct roles in regulating platelet activation...
  5. pmc Targets downstream of Cdk8 in Dictyostelium development
    David M Greene
    Biochemistry Department, Oxford University, South Parks Road, Oxford OX1 3QU UK
    BMC Dev Biol 11:2. 2011
    ..Strains in which the gene encoding Cdk8 have been disrupted fail to form multicellular aggregates unless supplied with exogenous pulses of cAMP and later in development, cdk8- cells show a defect in spore production...
  6. ncbi request reprint DNA damage signaling and repair in Dictyostelium discoideum
    Duen Wei Hsu
    Department of Biochemistry, University of Oxford, Oxford, UK
    Cell Cycle 5:702-8. 2006
    ....
  7. pmc The role of ADP-ribosylation in regulating DNA double-strand break repair
    Catherine J Pears
    Department of Biochemistry, University of Oxford, Oxford, UK
    Cell Cycle 11:48-56. 2012
    ..The implications of these data with regards to how ADP-ribosylation regulates DNA repair and genome stability are discussed...
  8. pmc PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks
    C Anne Marie Couto
    Department of Biochemistry, University of Oxford, England, UK
    J Cell Biol 194:367-75. 2011
    ..Furthermore, a PAR interaction motif in Ku70 was required for this regulation and efficient NHEJ. These data illustrate that PARylation at DSBs promotes NHEJ through recruitment or retention of repair factors at sites of DNA damage...
  9. ncbi request reprint PKD: a new protein kinase C-dependent pathway in platelets
    Margaret J Stafford
    Department of Biochemistry, University of Oxford, United Kingdom
    Blood 101:1392-9. 2003
    ..This study shows that PKD is rapidly activated by a wide variety of platelet agonists through a PKC-dependent pathway. Activation of PKD enables phosphorylation of a distinct set of substrates to those targeted by PKC in platelets...
  10. doi request reprint DNA double-strand break repair pathway choice in Dictyostelium
    Duen Wei Hsu
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    J Cell Sci 124:1655-63. 2011
    ..These data illustrate a functional NHEJ pathway in vegetative Dictyostelium and the importance of Ku in regulating DSB repair choice during this phase of the life cycle...
  11. ncbi request reprint Distinct but critical roles for integrin alphaIIbbeta3 in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin
    Kelly Thornber
    Department of Biochemistry, University of Oxford, UK
    FEBS J 273:5032-43. 2006
    ..These results suggest that integrins may play an important role in lamellipodia formation triggered by nonintegrin ligands in platelets and possibly in other cell types...
  12. ncbi request reprint Nonhomologous end-joining promotes resistance to DNA damage in the absence of an ADP-ribosyltransferase that signals DNA single strand breaks
    C Anne Marie Couto
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    J Cell Sci 126:3452-61. 2013
    ..Taken together, these data indicate overlapping functions of different ARTs in signalling DNA damage, and illustrate a critical requirement for NHEJ in maintaining cell viability in the absence of an effective SSB response. ..
  13. ncbi request reprint DNA-PKcs-dependent signaling of DNA damage in Dictyostelium discoideum
    Jessica J R Hudson
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom
    Curr Biol 15:1880-5. 2005
    ..These data illustrate a cell cycle-dependent requirement for Dictyostelium DNA-PK in signaling and combating DNA DSBs and represent the first experimental verification of DNA-PKcs in a nonvertebrate organism...
  14. ncbi request reprint Developmental decisions in Dictyostelium discoideum
    Lana Strmecki
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Dev Biol 284:25-36. 2005
    ....
  15. pmc Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote
    Duen Wei Hsu
    Nuclear Signalling Laboratory, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Nucleic Acids Res 40:7247-56. 2012
    ..These studies confirm that dynamic acetylation targeted to H3K4me3 arose early in evolution and reveal a very high level of specificity of histone variant utilization in a simple multicellular eukaryote...
  16. doi request reprint Investigation of DNA repair pathway activity
    Anne Marie C Couto
    Department of Biochemistry, University of Oxford, Oxford, UK
    Methods Mol Biol 983:295-310. 2013
    ..Finally, we also describe more direct assays to assess repair of DNA double-strand breaks by either homologous recombination or non-homologous end joining...
  17. ncbi request reprint Emerging models for DNA repair: Dictyostelium discoideum as a model for nonhomologous end-joining
    Catherine J Pears
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    DNA Repair (Amst) 17:121-31. 2014
    ..Here we discuss the use of this organism as an additional model to study DNA repair, with specific reference to NHEJ. ..