Simon Hs Pearce
Affiliation: University of Newcastle
- Clinical disorders of extracellular calcium-sensing and the molecular biology of the calcium-sensing receptorSimon H S Pearce
School of Clinical Medical Sciences, Institute of Human Genetics, University of Newcastle upon Tyne, United Kingdom
Ann Med 34:201-6. 2002..In the future, therapeutic compounds that modulate calcium-sensing receptor function may have a role in the medical management of hyperparathyroidism (calcimimetic drugs) and osteoporosis (calcilytic drugs)...
- Study of Optimal Replacement of Thyroxine in the ElDerly (SORTED): protocol for a mixed methods feasibility study to assess the clinical utility of lower dose thyroxine in elderly hypothyroid patients: study protocol for a randomized controlled trialScott Wilkes
Institute of Health and Society, Newcastle University, Newcastle upon Tyne NE2 4AX, UK
Trials 14:83. 2013..We report the protocol of a feasibility study working towards a full-scale randomized controlled trial to test whether lower dose levothyroxine has beneficial cardiovascular outcomes in the oldest old...
- Adrenal steroidogenesis after B lymphocyte depletion therapy in new-onset Addison's diseaseSimon H S Pearce
Newcastle University, Newccastle upon Tyne Hospitals National Health Service Foundation Trust, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, United Kingdom
J Clin Endocrinol Metab 97:E1927-32. 2012..A diagnosis of Addison's disease means lifelong dependence on daily glucocorticoid and mineralocorticoid therapy and is associated with increased morbidity and mortality as well as a risk of unexpected adrenal crisis...
- Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunityDavid O McDonald
Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
J Mol Med (Berl) 87:971-80. 2009..This suggests a structural correlate to the effect of thionamides on TPO enzymatic activity and opens up a novel potential mechanism for thionamide immunomodulation of autoimmune thyroid disease...
- Trends in thyroid hormone prescribing and consumption in the UKAnna L Mitchell
Endocrine Unit, Royal Victoria Infirmary and Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK
BMC Public Health 9:132. 2009..This study aimed to provide a picture of thyroid hormone usage in the UK and to survey patient opinion about current community prescribing policies for levothyroxine...
- Spontaneous reporting of adverse reactions to carbimazole and propylthiouracil in the UKSimon H S Pearce
School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
Clin Endocrinol (Oxf) 61:589-94. 2004..To determine the frequency and spectrum of serious adverse drug reactions (ADRs) to thionamide antithyroid drugs...
- Genetic progress towards the molecular basis of autoimmunitySimon H S Pearce
Institute of Human Genetics, International Centre for Life, Central Parkway, University of Newcastle, Newcastle upon Tyne, NE1 3BZ, UK
Trends Mol Med 12:90-8. 2006..However, much basic genetic, molecular and clinical research is still needed to help us fully understand the underlying mechanisms of autoimmunity and how these translate into prognosis or therapy...
- Genetics of type 1 diabetes and autoimmune thyroid diseaseSimon H S Pearce
Institute of Human Genetics, University of Newcastle, International Centre for Life, Newcastle upon Tyne, UK
Endocrinol Metab Clin North Am 38:289-301, vii-viii. 2009....
- No association of the codon 55 methionine to valine polymorphism in the SUMO4 gene with Graves' diseaseClaire E Jennings
Institute of Human Genetics and School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
Clin Endocrinol (Oxf) 62:362-5. 2005..We aimed to establish whether this locus also contributes towards the genetic susceptibility to Graves' disease (GD) and autoimmune Addison's disease...
- Genetic association studies of the FOXP3 gene in Graves' disease and autoimmune Addison's disease in the United Kingdom populationCatherine J Owen
Institute of Human Genetics, International Centre for Life, University of Newcastle, Central Parkway, Newcastle upon Tyne, UK
J Mol Endocrinol 37:97-104. 2006..This study has found no robust evidence that FOXP3 gene polymorphism contributes to the susceptibility to GD or AAD in the UK population...
- Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease associationCatherine J Owen
Institute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
J Clin Endocrinol Metab 92:1106-11. 2007..These findings raise the possibility that this locus may influence autoimmune disease susceptibility across many populations...
- Disordered calcium crystal handling in antisense CLC-5-treated collecting duct cellsJohn A Sayer
Department of Medicine, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
Biochem Biophys Res Commun 300:305-10. 2003..We conclude that expression of CLC-5 in mIMCD-3 cells allows acidification of endosomes and endocytosis, and that disruption of CLC-5 expression causes abnormal crystal agglomeration...
- Extracellular calcium-sensing receptor dysfunction is associated with two new phenotypesJohn A Sayer
School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle, UK
Clin Endocrinol (Oxf) 59:419-21. 2003
- Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndromeCatherine J Owen
Institute of Human Genetics and Department of Child Health, University of Newcastle upon Tyne, United Kingdom
J Clin Endocrinol Metab 88:6034-9. 2003..Our analysis has elucidated the molecular basis of IPEX in one family and has, for the first time, provided evidence for an autosomal locus, suggesting genetic heterogeneity in this syndrome...
- What is the evidence behind the evidence-base? The premature death of block-replace antithyroid drug regimens for Graves' diseaseSalman Razvi
Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Eur J Endocrinol 154:783-6. 2006....
- Discordance for X-linked hypophosphataemic rickets in identical twin girlsCatherine J Owen
Institute of Human Genetics, Centre for Life, Newcastle University, Sir James Spence Institute for Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK
Horm Res 71:237-44. 2009..One twin had a skeletal and biochemical phenotype consistent with XLH, whilst the second twin appeared normal. Complete non-penetrance in XLH has not been previously reported and our aim was to explore potential reasons for this...
- Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variantsPaul R Burton
Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
Nat Genet 39:1329-37. 2007....
- Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibilityAlison Sutherland
Institute of Human Genetics, Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom
J Clin Endocrinol Metab 92:3338-41. 2007..Previous investigations have also demonstrated that an intronic polymorphism (termed PD1.3; SNP ID rs11568821) in the programmed cell death (PDCD1) gene was associated with systemic lupus erythematosus and rheumatoid arthritis...
- FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunityManuela Fanciulli
Physiological Genomics and Medicine Group, UK Medical Research Council MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
Nat Genet 39:721-3. 2007..Our findings suggest that low FCGR3B copy number, and in particular complete FCGR3B deficiency, has a key role in the development of systemic autoimmunity...
- Role of the CD40 locus in Graves' diseaseFiona A Houston
Institute of Human Genetics, University of Newcastle upon Tyne, United Kingdom
Thyroid 14:506-9. 2004..We are unable to confirm a role for CD40 in Graves' disease pathogenesis in our U.K. population, however, further studies involving larger patient cohorts and a saturated SNP marker map are required to resolve this issue...
- The genetics of autoimmune thyroid diseaseBijayeswar Vaidya
School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 3BZ, United Kingdom
J Clin Endocrinol Metab 87:5385-97. 2002
- Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and miceJohn Falardeau
Harvard Center for Reproductive Endocrine Sciences and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital MGH, Boston, Massachusetts 02114, USA
J Clin Invest 118:2822-31. 2008..In conclusion, we identified FGF8 as a gene implicated in GnRH deficiency in both humans and mice and demonstrated an exquisite sensitivity of GnRH neuron development to reductions in FGF8 signaling...
- Toward precise forecasting of autoimmune endocrinopathySimon H S Pearce
J Clin Endocrinol Metab 89:544-7. 2004