Simon Hs Pearce

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Clinical disorders of extracellular calcium-sensing and the molecular biology of the calcium-sensing receptor
    Simon H S Pearce
    School of Clinical Medical Sciences, Institute of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    Ann Med 34:201-6. 2002
  2. pmc Study of Optimal Replacement of Thyroxine in the ElDerly (SORTED): protocol for a mixed methods feasibility study to assess the clinical utility of lower dose thyroxine in elderly hypothyroid patients: study protocol for a randomized controlled trial
    Scott Wilkes
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne NE2 4AX, UK
    Trials 14:83. 2013
  3. pmc Adrenal steroidogenesis after B lymphocyte depletion therapy in new-onset Addison's disease
    Simon H S Pearce
    Newcastle University, Newccastle upon Tyne Hospitals National Health Service Foundation Trust, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, United Kingdom
    J Clin Endocrinol Metab 97:E1927-32. 2012
  4. pmc Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity
    David O McDonald
    Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
    J Mol Med (Berl) 87:971-80. 2009
  5. pmc Trends in thyroid hormone prescribing and consumption in the UK
    Anna L Mitchell
    Endocrine Unit, Royal Victoria Infirmary and Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK
    BMC Public Health 9:132. 2009
  6. ncbi request reprint Spontaneous reporting of adverse reactions to carbimazole and propylthiouracil in the UK
    Simon H S Pearce
    School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Clin Endocrinol (Oxf) 61:589-94. 2004
  7. ncbi request reprint Genetic progress towards the molecular basis of autoimmunity
    Simon H S Pearce
    Institute of Human Genetics, International Centre for Life, Central Parkway, University of Newcastle, Newcastle upon Tyne, NE1 3BZ, UK
    Trends Mol Med 12:90-8. 2006
  8. doi request reprint Genetics of type 1 diabetes and autoimmune thyroid disease
    Simon H S Pearce
    Institute of Human Genetics, University of Newcastle, International Centre for Life, Newcastle upon Tyne, UK
    Endocrinol Metab Clin North Am 38:289-301, vii-viii. 2009
  9. ncbi request reprint No association of the codon 55 methionine to valine polymorphism in the SUMO4 gene with Graves' disease
    Claire E Jennings
    Institute of Human Genetics and School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Clin Endocrinol (Oxf) 62:362-5. 2005
  10. ncbi request reprint Genetic association studies of the FOXP3 gene in Graves' disease and autoimmune Addison's disease in the United Kingdom population
    Catherine J Owen
    Institute of Human Genetics, International Centre for Life, University of Newcastle, Central Parkway, Newcastle upon Tyne, UK
    J Mol Endocrinol 37:97-104. 2006

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Clinical disorders of extracellular calcium-sensing and the molecular biology of the calcium-sensing receptor
    Simon H S Pearce
    School of Clinical Medical Sciences, Institute of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    Ann Med 34:201-6. 2002
    ..In the future, therapeutic compounds that modulate calcium-sensing receptor function may have a role in the medical management of hyperparathyroidism (calcimimetic drugs) and osteoporosis (calcilytic drugs)...
  2. pmc Study of Optimal Replacement of Thyroxine in the ElDerly (SORTED): protocol for a mixed methods feasibility study to assess the clinical utility of lower dose thyroxine in elderly hypothyroid patients: study protocol for a randomized controlled trial
    Scott Wilkes
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne NE2 4AX, UK
    Trials 14:83. 2013
    ..We report the protocol of a feasibility study working towards a full-scale randomized controlled trial to test whether lower dose levothyroxine has beneficial cardiovascular outcomes in the oldest old...
  3. pmc Adrenal steroidogenesis after B lymphocyte depletion therapy in new-onset Addison's disease
    Simon H S Pearce
    Newcastle University, Newccastle upon Tyne Hospitals National Health Service Foundation Trust, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, United Kingdom
    J Clin Endocrinol Metab 97:E1927-32. 2012
    ..A diagnosis of Addison's disease means lifelong dependence on daily glucocorticoid and mineralocorticoid therapy and is associated with increased morbidity and mortality as well as a risk of unexpected adrenal crisis...
  4. pmc Thyroid peroxidase forms thionamide-sensitive homodimers: relevance for immunomodulation of thyroid autoimmunity
    David O McDonald
    Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, UK
    J Mol Med (Berl) 87:971-80. 2009
    ..This suggests a structural correlate to the effect of thionamides on TPO enzymatic activity and opens up a novel potential mechanism for thionamide immunomodulation of autoimmune thyroid disease...
  5. pmc Trends in thyroid hormone prescribing and consumption in the UK
    Anna L Mitchell
    Endocrine Unit, Royal Victoria Infirmary and Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK
    BMC Public Health 9:132. 2009
    ..This study aimed to provide a picture of thyroid hormone usage in the UK and to survey patient opinion about current community prescribing policies for levothyroxine...
  6. ncbi request reprint Spontaneous reporting of adverse reactions to carbimazole and propylthiouracil in the UK
    Simon H S Pearce
    School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Clin Endocrinol (Oxf) 61:589-94. 2004
    ..To determine the frequency and spectrum of serious adverse drug reactions (ADRs) to thionamide antithyroid drugs...
  7. ncbi request reprint Genetic progress towards the molecular basis of autoimmunity
    Simon H S Pearce
    Institute of Human Genetics, International Centre for Life, Central Parkway, University of Newcastle, Newcastle upon Tyne, NE1 3BZ, UK
    Trends Mol Med 12:90-8. 2006
    ..However, much basic genetic, molecular and clinical research is still needed to help us fully understand the underlying mechanisms of autoimmunity and how these translate into prognosis or therapy...
  8. doi request reprint Genetics of type 1 diabetes and autoimmune thyroid disease
    Simon H S Pearce
    Institute of Human Genetics, University of Newcastle, International Centre for Life, Newcastle upon Tyne, UK
    Endocrinol Metab Clin North Am 38:289-301, vii-viii. 2009
    ....
  9. ncbi request reprint No association of the codon 55 methionine to valine polymorphism in the SUMO4 gene with Graves' disease
    Claire E Jennings
    Institute of Human Genetics and School of Clinical Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Clin Endocrinol (Oxf) 62:362-5. 2005
    ..We aimed to establish whether this locus also contributes towards the genetic susceptibility to Graves' disease (GD) and autoimmune Addison's disease...
  10. ncbi request reprint Genetic association studies of the FOXP3 gene in Graves' disease and autoimmune Addison's disease in the United Kingdom population
    Catherine J Owen
    Institute of Human Genetics, International Centre for Life, University of Newcastle, Central Parkway, Newcastle upon Tyne, UK
    J Mol Endocrinol 37:97-104. 2006
    ..This study has found no robust evidence that FOXP3 gene polymorphism contributes to the susceptibility to GD or AAD in the UK population...
  11. ncbi request reprint Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association
    Catherine J Owen
    Institute of Human Genetics, University of Newcastle, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    J Clin Endocrinol Metab 92:1106-11. 2007
    ..These findings raise the possibility that this locus may influence autoimmune disease susceptibility across many populations...
  12. ncbi request reprint Disordered calcium crystal handling in antisense CLC-5-treated collecting duct cells
    John A Sayer
    Department of Medicine, University of Newcastle upon Tyne, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Biochem Biophys Res Commun 300:305-10. 2003
    ..We conclude that expression of CLC-5 in mIMCD-3 cells allows acidification of endosomes and endocytosis, and that disruption of CLC-5 expression causes abnormal crystal agglomeration...
  13. ncbi request reprint Extracellular calcium-sensing receptor dysfunction is associated with two new phenotypes
    John A Sayer
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle, UK
    Clin Endocrinol (Oxf) 59:419-21. 2003
  14. ncbi request reprint Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome
    Catherine J Owen
    Institute of Human Genetics and Department of Child Health, University of Newcastle upon Tyne, United Kingdom
    J Clin Endocrinol Metab 88:6034-9. 2003
    ..Our analysis has elucidated the molecular basis of IPEX in one family and has, for the first time, provided evidence for an autosomal locus, suggesting genetic heterogeneity in this syndrome...
  15. ncbi request reprint What is the evidence behind the evidence-base? The premature death of block-replace antithyroid drug regimens for Graves' disease
    Salman Razvi
    Department of Endocrinology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Eur J Endocrinol 154:783-6. 2006
    ....
  16. doi request reprint Discordance for X-linked hypophosphataemic rickets in identical twin girls
    Catherine J Owen
    Institute of Human Genetics, Centre for Life, Newcastle University, Sir James Spence Institute for Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Horm Res 71:237-44. 2009
    ..One twin had a skeletal and biochemical phenotype consistent with XLH, whilst the second twin appeared normal. Complete non-penetrance in XLH has not been previously reported and our aim was to explore potential reasons for this...
  17. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  18. ncbi request reprint Genomic polymorphism at the interferon-induced helicase (IFIH1) locus contributes to Graves' disease susceptibility
    Alison Sutherland
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne NE1 3BZ, United Kingdom
    J Clin Endocrinol Metab 92:3338-41. 2007
    ..Previous investigations have also demonstrated that an intronic polymorphism (termed PD1.3; SNP ID rs11568821) in the programmed cell death (PDCD1) gene was associated with systemic lupus erythematosus and rheumatoid arthritis...
  19. pmc FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity
    Manuela Fanciulli
    Physiological Genomics and Medicine Group, UK Medical Research Council MRC Clinical Sciences Centre, Imperial College, London W12 0NN, UK
    Nat Genet 39:721-3. 2007
    ..Our findings suggest that low FCGR3B copy number, and in particular complete FCGR3B deficiency, has a key role in the development of systemic autoimmunity...
  20. ncbi request reprint Role of the CD40 locus in Graves' disease
    Fiona A Houston
    Institute of Human Genetics, University of Newcastle upon Tyne, United Kingdom
    Thyroid 14:506-9. 2004
    ..We are unable to confirm a role for CD40 in Graves' disease pathogenesis in our U.K. population, however, further studies involving larger patient cohorts and a saturated SNP marker map are required to resolve this issue...
  21. ncbi request reprint The genetics of autoimmune thyroid disease
    Bijayeswar Vaidya
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 3BZ, United Kingdom
    J Clin Endocrinol Metab 87:5385-97. 2002
  22. pmc Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice
    John Falardeau
    Harvard Center for Reproductive Endocrine Sciences and Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital MGH, Boston, Massachusetts 02114, USA
    J Clin Invest 118:2822-31. 2008
    ..In conclusion, we identified FGF8 as a gene implicated in GnRH deficiency in both humans and mice and demonstrated an exquisite sensitivity of GnRH neuron development to reductions in FGF8 signaling...
  23. ncbi request reprint Toward precise forecasting of autoimmune endocrinopathy
    Simon H S Pearce
    J Clin Endocrinol Metab 89:544-7. 2004