Mark S Pearce

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. doi request reprint Lifecourse predictors of adult fibrinogen levels: the Newcastle Thousand Families Study
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Int J Cardiol 155:206-11. 2012
  2. pmc Reliability and validity of ultrasound imaging of features of knee osteoarthritis in the community
    Ajay M Abraham
    Northumbria Healthcare NHS Trust, Northumberland, UK
    BMC Musculoskelet Disord 12:70. 2011
  3. pmc Temporal trends in hepatitis B and C infection in family blood donors from interior Sindh, Pakistan
    Syed Abdul Mujeeb
    Jinnah Postgraduate Medical Centre, Karachi, Pakistan
    BMC Infect Dis 8:43. 2008
  4. doi request reprint Birth weight and early socio-economic disadvantage as predictors of sex hormones and sex hormone binding globulin in men at age 49-51 years
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom
    Am J Hum Biol 23:185-9. 2011
  5. ncbi request reprint Growth in early life and childhood IQ at age 11 years: the Newcastle Thousand Families Study
    Mark S Pearce
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Int J Epidemiol 34:673-7. 2005
  6. pmc Lifecourse study of bone health at age 49-51 years: the Newcastle thousand families cohort study
    Mark S Pearce
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    J Epidemiol Community Health 59:475-80. 2005
  7. ncbi request reprint Paternal occupational exposure to electro-magnetic fields as a risk factor for cancer in children and young adults: a case-control study from the North of England
    Mark S Pearce
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, University of Newcastle upon Tyne, UK
    Pediatr Blood Cancer 49:280-6. 2007
  8. ncbi request reprint Life course determinants of insulin secretion and sensitivity at age 50 years: the Newcastle thousand families study
    Mark S Pearce
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
    Diabetes Metab Res Rev 22:118-25. 2006
  9. pmc No association between ambient particulate matter exposure during pregnancy and stillbirth risk in the north of England, 1962-1992
    M S Pearce
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Environ Res 110:118-22. 2010
  10. ncbi request reprint Self-reported smoking status and exhaled carbon monoxide: results from two population-based epidemiologic studies in the North of England
    Mark S Pearce
    Sir James Spence Institute, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Chest 128:1233-8. 2005

Detail Information

Publications104 found, 100 shown here

  1. doi request reprint Lifecourse predictors of adult fibrinogen levels: the Newcastle Thousand Families Study
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Int J Cardiol 155:206-11. 2012
    ..The aim of this study was to examine and quantify the direct and indirect associations between fetal, infancy and adult risk factors and fibrinogen levels, at age 49-51 years, using data from the Newcastle Thousand Families Study...
  2. pmc Reliability and validity of ultrasound imaging of features of knee osteoarthritis in the community
    Ajay M Abraham
    Northumbria Healthcare NHS Trust, Northumberland, UK
    BMC Musculoskelet Disord 12:70. 2011
    ..Our objective was to measure the inter-rater reliability and validity of ultrasound imaging in the detection of features of knee OA...
  3. pmc Temporal trends in hepatitis B and C infection in family blood donors from interior Sindh, Pakistan
    Syed Abdul Mujeeb
    Jinnah Postgraduate Medical Centre, Karachi, Pakistan
    BMC Infect Dis 8:43. 2008
    ..Pakistan has no active surveillance program to monitor trends of these infections. The objective of this study was to verify this trend in blood donors from the rural Sindh area of the country...
  4. doi request reprint Birth weight and early socio-economic disadvantage as predictors of sex hormones and sex hormone binding globulin in men at age 49-51 years
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom
    Am J Hum Biol 23:185-9. 2011
    ..This study investigated life-course predictors of sex hormones in men in the Newcastle Thousand Families birth cohort...
  5. ncbi request reprint Growth in early life and childhood IQ at age 11 years: the Newcastle Thousand Families Study
    Mark S Pearce
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Int J Epidemiol 34:673-7. 2005
    ..This study aimed at investigating the potential relationships between childhood IQ at age 11 years and birth weight and height at the ages of 9 and 13 years, after adjusting for the confounding factors available to this investigation...
  6. pmc Lifecourse study of bone health at age 49-51 years: the Newcastle thousand families cohort study
    Mark S Pearce
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    J Epidemiol Community Health 59:475-80. 2005
    ....
  7. ncbi request reprint Paternal occupational exposure to electro-magnetic fields as a risk factor for cancer in children and young adults: a case-control study from the North of England
    Mark S Pearce
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, University of Newcastle upon Tyne, UK
    Pediatr Blood Cancer 49:280-6. 2007
    ..We investigated whether an association exists between paternal occupations at birth involving such exposures and cancer risk in offspring, using data from the Northern Region Young Persons' Malignant Disease Registry (NRYPMDR)...
  8. ncbi request reprint Life course determinants of insulin secretion and sensitivity at age 50 years: the Newcastle thousand families study
    Mark S Pearce
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
    Diabetes Metab Res Rev 22:118-25. 2006
    ..This study investigated the proportion of variance in insulin secretion and resistance accounted for by factors operating at different stages of life using a cohort of all 1142 births in the city of Newcastle, UK in May and June 1947...
  9. pmc No association between ambient particulate matter exposure during pregnancy and stillbirth risk in the north of England, 1962-1992
    M S Pearce
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Environ Res 110:118-22. 2010
    ..This potential association was examined using data from the historical cohort UK Particulate Matter and Perinatal Events Research (PAMPER) study...
  10. ncbi request reprint Self-reported smoking status and exhaled carbon monoxide: results from two population-based epidemiologic studies in the North of England
    Mark S Pearce
    Sir James Spence Institute, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Chest 128:1233-8. 2005
    ..To investigate the validity of self-reported responses to questions on current smoking in two cohorts based in Northern England...
  11. ncbi request reprint Lifecourse determinants of fasting and post-challenge glucose at age 50 years: the Newcastle Thousand Families Study
    M S Pearce
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
    Eur J Epidemiol 20:915-23. 2005
    ..Any effect of birth weight on later plasma glucose levels may be compounded by additional effects of adult body composition...
  12. ncbi request reprint The relationship between birth weight and pulse pressure in children: cross-sectional study
    M S Pearce
    Paediatric and Lifecourse Epidemiology Research Group, Child Health, School of Clinical Medical Sciences, University of Newcastle upon Tyne, and Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne, UK
    J Hum Hypertens 20:207-11. 2006
    ..However, as little research has been published in this area, further investigation is required and in particular it would be important to assess whether such gender differences are apparent in other cohorts...
  13. ncbi request reprint Paternal occupational exposure to pesticides or herbicides as risk factors for cancer in children and young adults: a case-control study from the North of England
    Mark S Pearce
    School of Clinical Medical Sciences Child Health, University of Newcastle upon Tyne, England
    Arch Environ Occup Health 61:138-44. 2006
    ..Results do not support a role for preconception paternal occupational exposures to pesticides or herbicides in the etiology of childhood cancer...
  14. doi request reprint Lifecourse predictors of mammographic density: the Newcastle Thousand Families cohort Study
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Breast Cancer Res Treat 131:187-95. 2012
    ..We also confirmed associations between both BMI and menopausal status...
  15. doi request reprint CT scans in young people in Northern England: trends and patterns 1993-2002
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Pediatr Radiol 41:832-8. 2011
    ..Although CT can be greatly beneficial, its relatively high radiation doses have caused public health concerns...
  16. ncbi request reprint Tooth loss and Helicobacter pylori seropositivity: the Newcastle Thousand Families Cohort Study at age 49-51 years
    Mark S Pearce
    School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE1 4LP, UK
    Helicobacter 10:90-4. 2005
    ..It has also been suggested to be present in dental plaque. This study investigated the potential link between the number of teeth lost and H. pylori seropositivity at age 50 years...
  17. doi request reprint Sex differences in the association between infant feeding and blood cholesterol in later life: the Newcastle thousand families cohort study at age 49-51 years
    Mark S Pearce
    Institute of Health and Society, Sir James Spence Institute, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Eur J Epidemiol 24:375-80. 2009
    ..However, our findings may not reflect the situation in younger generations...
  18. ncbi request reprint Skin cancer in children and young adults: 28 years' experience from the Northern Region Young Person's Malignant Disease Registry, UK
    Mark S Pearce
    School of Clinical Medical Sciences Child Health, University of Newcastle upon Tyne, UK
    Melanoma Res 13:421-6. 2003
    ..It is important that families continue to be advised of the need for vigilance with regard to childhood sun exposure...
  19. ncbi request reprint Childhood cancer registrations in the developing world: still more boys than girls
    M S Pearce
    North of England Children s Cancer Research Unit, Department of Child Health, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    Int J Cancer 91:402-6. 2001
    ..Hence, international differences in the incidence of childhood cancer should be interpreted cautiously as they may not necessarily reflect only differences in the underlying occurrence of disease..
  20. ncbi request reprint Do circumstances in early life contribute to tooth retention in middle age?
    M S Pearce
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, Sir James Spence Institute, Royal Victoria Infirmary, University of Newcastle upon Tyne, NE1 4LP, UK
    J Dent Res 83:562-6. 2004
    ..Promotion of a healthier adult lifestyle and continued improvements in oral hygiene would appear to be the public health interventions most likely to increase tooth retention in middle age...
  21. ncbi request reprint Paternal employment in agriculture and childhood kidney cancer
    M S Pearce
    Department of Child Health, University of Newcastle upon Tyne, Royal Victoria Infirmary, UK
    Pediatr Hematol Oncol 17:223-30. 2000
    ..An example is given showing how a recently reported association between kidney cancer and paternal agricultural employment may have been overestimated as a result of the use of death certificate information...
  22. ncbi request reprint Childhood IQ and deaths up to middle age: The Newcastle Thousand Families Study
    M S Pearce
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Public Health 120:1020-6. 2006
    ..To test the hypothesis that an association exists between childhood IQ (at age 11) and mortality up to middle age...
  23. doi request reprint A lifecourse study of bone resorption in men ages 49-51years: the Newcastle Thousand Families cohort study
    M S Pearce
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Bone 46:952-6. 2010
    ....
  24. doi request reprint Lifecourse socio-economic mobility and oral health in middle age
    M S Pearce
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    J Dent Res 88:938-41. 2009
    ....
  25. ncbi request reprint Relationship between birth weight and blood pressure variability in children
    M S Pearce
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
    J Hum Hypertens 17:677-80. 2003
    ....
  26. pmc Particulate matter exposure during pregnancy is associated with birth weight, but not gestational age, 1962-1992: a cohort study
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, England, UK
    Environ Health 11:13. 2012
    ..Exposure to air pollutants is suggested to adversely affect fetal growth, but the evidence remains inconsistent in relation to specific outcomes and exposure windows...
  27. ncbi request reprint Does increased duration of exclusive breastfeeding protect against Helicobacter pylori Infection? The Newcastle Thousand Families Cohort Study at age 49-51 years
    Mark S Pearce
    School of Clinical Medical Sciences, Sir James Spence Institute of Child Health, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    J Pediatr Gastroenterol Nutr 41:617-20. 2005
    ....
  28. pmc Childhood growth, IQ and education as predictors of white blood cell telomere length at age 49-51 years: the Newcastle Thousand Families Study
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, England, United Kingdom
    PLoS ONE 7:e40116. 2012
    ..We investigated whether birth weight, infant growth, childhood cognition and adult height, as well as a range of lifestyle, socio-economic and educational factors, were associated with white blood cell telomere length at age 49-51 years...
  29. pmc Temporal changes in key maternal and fetal factors affecting birth outcomes: a 32-year population-based study in an industrial city
    Svetlana V Glinianaia
    Institute of Health and Society, Newcastle University, William Leech Building, The Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    BMC Pregnancy Childbirth 8:39. 2008
    ..The objective of this study was to describe temporal changes in key maternal and fetal factors affecting birth outcomes in Newcastle upon Tyne over three decades, 1961-1992...
  30. ncbi request reprint Fathers' occupational contacts and risk of childhood leukemia and non-hodgkin lymphoma
    Mark S Pearce
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
    Epidemiology 15:352-6. 2004
    ..We investigated the risk of childhood leukemia and non-Hodgkin lymphoma in relation to paternal occupational contact with other individuals, a surrogate for potential exposure to infection...
  31. doi request reprint Effect of choice of outcome measure on studies of the etiology of obesity in children
    Laura Basterfield
    Institute of Health and Society, Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK
    Ann Epidemiol 22:888-91. 2012
    ..Epidemiologic studies of the etiology of childhood obesity often use proxies for adiposity as outcomes. This study aimed to compare the ability of a range of proxy measures to detect associations with sedentary behavior...
  32. doi request reprint Physical activity, sedentary behavior, and adiposity in English children
    Laura Basterfield
    Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK
    Am J Prev Med 42:445-51. 2012
    ....
  33. doi request reprint Bioinformatic selection of putative epigenetically regulated loci associated with obesity using gene expression data
    Valérie Turcot
    Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    Gene 499:99-107. 2012
    ..The proposed workflow provides a flexible, versatile and low cost methodology for target gene prioritisation that is applicable to multiple species and disease contexts...
  34. doi request reprint Differing lifecourse associations with sport-, occupational- and household-based physical activity at age 49-51 years: the Newcastle Thousand Families Study
    Kay D Mann
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Int J Public Health 58:79-88. 2013
    ..We investigated the contributions of a range of factors from across life to variations in physical activity within the Newcastle Thousand Family's birth cohort...
  35. doi request reprint Childhood infectious disease and premature death from cancer: a prospective cohort study
    Peter W G Tennant
    Institute of Health and Society, Newcastle University, Baddiley Clark building, Richardson Road, Newcastle upon Tyne, NE2 4AX, UK
    Eur J Epidemiol 28:257-65. 2013
    ..While these results suggest some disease-specific associations between early-life infections and cancer, further studies are required to confirm the specific associations identified...
  36. doi request reprint Maternal exposure to ambient air pollutants and risk of congenital anomalies
    Judith Rankin
    Institute of Health and Society, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Environ Res 109:181-7. 2009
    ..Overall, maternal exposure to BS and SO(2) in the Northern region had limited impact on congenital anomaly risk. Studies with detailed exposure assessment are needed to further investigate this relationship...
  37. pmc No improvement in socioeconomic inequalities in birthweight and preterm birth over four decades: a population-based cohort study
    Svetlana V Glinianaia
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, England, UK
    BMC Public Health 13:345. 2013
    ..We investigated changes in the associations between socioeconomic status (SES) and birthweight and gestational age in Newcastle upon Tyne, North of England, during 1961-2000...
  38. ncbi request reprint Examination of gender effect in birth weight and miscarriage associations with childhood cancer (United Kingdom)
    M Tevfik Dorak
    Paediatric and Lifecourse Epidemiology Research Group, Sir James Spence Institute, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Cancer Causes Control 18:219-28. 2007
    ..Higher birth weight and maternal history of miscarriage has been associated with an increased risk of childhood leukemia. The possibility that this association may be sex-specific has not been explored in detail in previous studies...
  39. pmc DNA methylation patterns in cord blood DNA and body size in childhood
    Caroline L Relton
    HNRC, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 7:e31821. 2012
    ..The goal of this study was to investigate whether DNA methylation levels at birth are associated with body size later in childhood...
  40. pmc Early predictors of objectively measured physical activity and sedentary behaviour in 8-10 year old children: the Gateshead Millennium Study
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 7:e37975. 2012
    ..We used the Gateshead Millennium Study (GMS) to identify predictors of childhood PA levels...
  41. pmc Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Lancet 380:499-505. 2012
    ..We aimed to assess the excess risk of leukaemia and brain tumours after CT scans in a cohort of children and young adults...
  42. doi request reprint How the Newcastle Thousand Families birth cohort study has contributed to the understanding of the impact of birth weight and early life socioeconomic position on disease in later life
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Maturitas 72:23-8. 2012
    ....
  43. doi request reprint Stillbirth and infant mortality in singletons by cause of death, birthweight, gestational age and birthweight-for-gestation, Newcastle upon Tyne 1961-2000
    Svetlana V Glinianaia
    Institute of Health and Society, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK
    Paediatr Perinat Epidemiol 24:331-42. 2010
    ..Declines in stillbirth and infant mortality in Newcastle were associated with reductions in birthweight- and gestational age-specific mortality rates and occurred in most cause-specific groups of death...
  44. ncbi request reprint The influence of age and gender on the relationship between birth weight and blood pressure in childhood: a study using 24-hour and casual blood pressure
    John O'Sullivan
    Department of Paediatric Cardiology, Freeman Hospital, Newcastle upon Tyne NE7 7DN, UK
    Eur J Pediatr 161:423-7. 2002
    ..63, 0.88). Interaction tests demonstrated a statistically significant different relationship between birth weight and blood pressure for boys and girls ( P=0.021) and for children <11 and > or = 11 years of age ( P=0.036)...
  45. doi request reprint 20-year survival of children born with congenital anomalies: a population-based study
    Peter W G Tennant
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Lancet 375:649-56. 2010
    ..We estimated survival up to 20 years of age for a range of congenital anomaly groups and subtypes...
  46. ncbi request reprint No association between socio-economic status and white blood cell telomere length
    Jean Adams
    Institute of Health and Society, Newcastle University, 21 Claremont Place, Newcastle upon Tyne NE2 4AA, UK
    Aging Cell 6:125-8. 2007
    ..The results of this, and the previous study, suggest that there is little evidence of a strong or consistent correlation between white blood cell telomere length and markers of socio-economic status...
  47. doi request reprint Clinical outcome in children with chronic granulomatous disease managed conservatively or with hematopoietic stem cell transplantation
    Theresa Cole
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom Electronic address
    J Allergy Clin Immunol 132:1150-5. 2013
    ..In the United Kingdom and Ireland there are cohorts of children managed both conservatively and curatively...
  48. pmc CT Scans in Young People in Great Britain: Temporal and Descriptive Patterns, 1993-2002
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Radiol Res Pract 2012:594278. 2012
    ..Conclusions. In contrast to previous data from the North of England, the doubling of CT use was not accompanied by an increase in numbers of multiple examinations to the same individual...
  49. doi request reprint Predictors of survival in children born with Down syndrome: a registry-based study
    Judith Rankin
    Institute of Health and Society, Baddiley Clarke Building, Newcastle University, Richardson Rd, Newcastle upon Tyne, NE2 4AX, UK
    Pediatrics 129:e1373-81. 2012
    ..To examine the influence of fetal and maternal characteristics on the survival of children born with Down syndrome...
  50. pmc Global LINE-1 DNA methylation is associated with blood glycaemic and lipid profiles
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Int J Epidemiol 41:210-7. 2012
    ..The hypothesis that Long Interspersed Nucleotide Element 1 (LINE-1) DNA methylation (an index of global DNA methylation) is associated with biomarkers of metabolic health was investigated in this study...
  51. pmc Socio-economic variation in CT scanning in Northern England, 1990-2002
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    BMC Health Serv Res 12:24. 2012
    ..This study aimed to assess socio-economic variation among young people having CT scans in Northern England between 1990 and 2002 inclusive...
  52. pmc The influence of childhood IQ and education on social mobility in the Newcastle Thousand Families birth cohort
    Lynne F Forrest
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    BMC Public Health 11:895. 2011
    ..This study examined the association of such factors with intra-generational and inter-generational social mobility within the Newcastle Thousand Families 1947 birth cohort...
  53. ncbi request reprint Cancer in adolescents and young adults aged 15-24 years: a report from the North of England young person's malignant disease registry, UK
    Mark S Pearce
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, UK
    Pediatr Blood Cancer 45:687-93. 2005
    ..Descriptions of population-based data have rarely been published specifically for adolescents and young adults with cancer...
  54. doi request reprint Space-time clustering of elevated thyroid stimulating hormone levels
    Mark S Pearce
    Institute of Health and Society, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle University, Newcastle upon Tyne, UK
    Eur J Epidemiol 26:405-11. 2011
    ..Further research is required to a) validate these results in other populations and b) to assess in more detail the potential environmental determinants of increased CHT risk...
  55. ncbi request reprint The influence of erythrocyte folate and serum vitamin B12 status on birth weight
    Caroline L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Br J Nutr 93:593-9. 2005
    ..08, 0.42), P=0.005; n 145). These findings suggest that maternal folate status is an important determinant of infant birth weight. The combined effects of smoking and reduced RBC status on birth weight require further investigation...
  56. ncbi request reprint Temporal changes in the distribution of population risk factors attenuate the reduction in perinatal mortality
    Svetlana V Glinianaia
    Public Health Research Group, School of Population and Health Sciences, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    J Clin Epidemiol 58:1299-307. 2005
    ..To examine and quantify the changing contribution of some risk factors to the perinatal mortality rate...
  57. doi request reprint Cognitive ability in children with chronic granulomatous disease: a comparison of those managed conservatively with those who have undergone hematopoietic stem cell transplant
    Theresa S Cole
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    Neuropediatrics 44:230-2. 2013
    ..Studies have shown people with CGD and those transplanted for primary immunodeficiencies have lower than average cognitive ability. In this study, IQ in children with CGD and those transplanted for it was within the normal range. ..
  58. pmc Early life influences kidney function at age 63-64 years, but so does adult body size: results from the newcastle thousand families birth cohort
    Stephanie L Harrison
    School of Biomedical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 8:e66660. 2013
    ..The aim of this study was to investigate early life variables in relation to adult kidney function, and compare these to the influence of later life variables...
  59. doi request reprint Measuring physical activity in pregnancy: a comparison of accelerometry and self-completion questionnaires in overweight and obese women
    Ruth Bell
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK Electronic address
    Eur J Obstet Gynecol Reprod Biol 170:90-5. 2013
    ..This study compares self-reported physical activity using two questionnaire methods with objectively recorded physical activity using accelerometry in overweight and obese pregnant women...
  60. pmc The epidemiology of bone cancer in 0 - 39 year olds in northern England, 1981 - 2002
    Rachel Eyre
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, England, UK
    BMC Cancer 10:357. 2010
    ..There is a paucity of recent epidemiological data on bone cancers. The aim of this study was to describe incidence and survival patterns for bone cancers diagnosed during 1981 - 2002...
  61. ncbi request reprint An investigation of folate-related genetic factors in the determination of birthweight
    Caroline L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, Newcastle Univisersity, Newcastle upon Tyne, UK
    Paediatr Perinat Epidemiol 19:360-7. 2005
    ..However, when placed on a background of deficient maternal nutritional status, they may detrimentally affect fetal growth...
  62. pmc Life course measures of socioeconomic position and self reported health at age 50: prospective cohort study
    Jean Adams
    School of Population and Health Sciences, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, UK
    J Epidemiol Community Health 58:1028-9. 2004
  63. pmc Social mobility over the lifecourse and self reported mental health at age 50: prospective cohort study
    Paul A Tiffin
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, Sir James Spence Institute, Royal Victoria Infirmary, University of Newcastle upon Tyne NE1 4LP, UK
    J Epidemiol Community Health 59:870-2. 2005
    ..To investigate the effect of socioeconomic status throughout the lifecourse on self reported mental health at age 50 years...
  64. ncbi request reprint How do factors at different stages of the lifecourse contribute to oral-health-related quality of life in middle age for men and women?
    J Mason
    School of Dental Sciences, University of Newcastle upon Tyne, UK
    J Dent Res 85:257-61. 2006
    ..Lifecourse influences on oral-health-related quality of life appear different for men and women, which may have implications for the effectiveness of public health interventions and health promotion...
  65. pmc Creation of an adiposity index for children aged 6-8 years: the Gateshead Millennium Study
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Biomed Res Int 2013:431825. 2013
    ..A number of measures of childhood adiposity are in use, but all are relatively imprecise and prone to bias. We constructed an adiposity index (AI) using a number of different measures...
  66. ncbi request reprint Stability of habitual physical activity and sedentary behavior monitoring by accelerometry in 6- to 8-year-olds
    Laura Basterfield
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom
    J Phys Act Health 8:543-7. 2011
    ....
  67. pmc Postnatal growth and DNA methylation are associated with differential gene expression of the TACSTD2 gene and childhood fat mass
    Alexandra Groom
    Institute of Genetic Medicine and Human Nutrition Research Centre, Newcastle University, Newcastle upon Tyne, UK
    Diabetes 61:391-400. 2012
    ..Noncausal methylation patterns may still be useful predictors of later adiposity...
  68. pmc Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities? A cross-sectional study
    Louise Hayes
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    BMC Public Health 10:723. 2010
    ..The aim of this study was to determine to what extent differences in metabolic health in very obese women are explained by differences in body fat distribution, insulin resistance and level of physical activity...
  69. ncbi request reprint Intrauterine growth and cerebral palsy in twins: a European multicenter study
    Svetlana V Glinianaia
    School of Population and Health Sciences, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne, UK
    Twin Res Hum Genet 9:460-6. 2006
    ..For twins born at less than 32 weeks' gestation, this pattern is only demonstrable for babies weighing below the optimum weight-for-gestation...
  70. ncbi request reprint Incidence and survival for testicular germ cell tumor in young males: a report from the Northern Region Young Person's Malignant Disease Registry, United Kingdom
    Qi Xu
    Paediatric and Lifecourse Epidemiology Research Group, Child Health School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Urol Oncol 25:32-7. 2007
    ....
  71. ncbi request reprint Self-report overestimates true height loss: implications for diagnosis of osteoporosis
    Fraser Birrell
    Department of Rheumatology, University of Newcastle upon Tyne, 4th Floor, Cookson Building, UK
    Clin Rheumatol 24:590-2. 2005
    ..In clinical practice, objective confirmation of reported height loss should be undertaken, wherever possible, prior to further investigation...
  72. ncbi request reprint Causes of death in patients with rheumatoid arthritis: comparison with siblings and matched osteoarthritis controls
    Namita Kumar
    Musculoskeletal Unit, Freeman Hospital, Newcastle upon Tyne, UK
    J Rheumatol 34:1695-8. 2007
    ..We assessed differences in causes and age of death between patients with RA and their siblings. Comparisons were also made with a control group of subjects with lower limb osteoarthritis (OA)...
  73. doi request reprint The relatively small contribution of birth weight to blood pressure at age 49-51 years in the Newcastle Thousand Families Study
    Kay D Mann
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    J Hypertens 29:1077-84. 2011
    ..The aim of this study was to investigate the relative contributions of a range of factors from across life to variations in SBP and DBP in the Newcastle Thousand Families Study...
  74. ncbi request reprint Stature of young people with malignant bone tumors
    Simon J Cotterill
    Department of Child Health, University of Newcastle upon Tyne, UK
    Pediatr Blood Cancer 42:59-63. 2004
    ..Little is known about the aetiology of primary bone tumours. There have been conflicting reports relating to stature in young people with bone cancer...
  75. doi request reprint Childhood respiratory illness and lung function at ages 14 and 50 years: childhood respiratory illness and lung function
    Peter W G Tennant
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, NE1 4LP, United Kingdom
    Chest 137:146-55. 2010
    ..We used data from the Newcastle Thousand Families Study to examine how these and other factors influenced FEV(1) at age 14 years and between 14 and 49 to 51 years...
  76. ncbi request reprint Lifecourse predictors of normal metabolic parameters in overweight and obese adults
    L Hayes
    Paediatric and Lifecourse Epidemiology Research Group, Schools of Population and Health Sciences and Clinical Medical Sciences, Sir James Spence Institute, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Int J Obes (Lond) 30:970-6. 2006
    ..We sought to examine the effect of factors from different stages of life on risk of metabolic abnormalities at age 50 years in overweight and obese adults...
  77. pmc Objectively measured physical activity during pregnancy: a study in obese and overweight women
    Catherine McParlin
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    BMC Pregnancy Childbirth 10:76. 2010
    ..Obese and overweight women may benefit from increased physical activity (PA) during pregnancy. There is limited published data describing objectively measured PA in such women...
  78. ncbi request reprint Carotid sinus hypersensitivity in asymptomatic older persons: implications for diagnosis of syncope and falls
    Simon R J Kerr
    Institute for Ageing and Health, University of Newcastle upon Tyne, England
    Arch Intern Med 166:515-20. 2006
    ....
  79. doi request reprint Congenital anomaly and childhood cancer: A population-based, record linkage study
    Judith Rankin
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    Pediatr Blood Cancer 51:608-12. 2008
    ..Association with the presence of congenital anomalies has been noted in some studies. In this study, we describe and quantify the association between congenital anomalies and childhood cancer...
  80. ncbi request reprint IgG subclass responses in childhood Helicobacter pylori duodenal ulcer: evidence of T-helper cell type 2 responses
    David I Campbell
    Paediatric and Life Course Epidemiology Research Group, School of Clinical and Medical Sciences Child Health, University of Newcastle upon Tyne, Royal Victoria Infirmary, UK
    Helicobacter 9:289-92. 2004
    ..It has been suggested that children colonized by H. pylori also produce a mucosal Th1 response, but there are few studies that have measured IgG subclass responses in children with duodenal ulcer...
  81. ncbi request reprint Perinatal mortality rates: adjusting for risk factor profile is essential
    Judith Rankin
    School of Population and Health Sciences Epidemiology and Public Health, University of Newcastle, Newcastle, UK
    Paediatr Perinat Epidemiol 19:56-8. 2005
    ..We recommend the construction of a 'standard birth population' for calculating standardised perinatal mortality rates that would improve direct comparisons between populations...
  82. ncbi request reprint Stillbirths among offspring of male radiation workers at Sellafield nuclear reprocessing plant
    L Parker
    Department of Child Health, University of Newcastle upon Tyne, UK
    Lancet 354:1407-14. 1999
    ....
  83. pmc Changing patterns of perinatal death, 1982-2000: a retrospective cohort study
    R Bell
    School of Population and Health Sciences, Faculty of Medical Sciences, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Arch Dis Child Fetal Neonatal Ed 89:F531-6. 2004
    ..To describe trends in cause specific stillbirth and neonatal mortality...
  84. ncbi request reprint Space-time clustering analyses of testicular cancer amongst 15-24-year-olds in Northern England
    R J Q McNally
    School of Clinical Medical Sciences Child Health, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    Eur J Epidemiol 21:139-44. 2006
    ..The very limited finding of space-time clustering may provide tentative evidence for an environmental, or infectious component to aetiology. However, it may well be a chance finding. A larger study based on national data is required...
  85. ncbi request reprint No consistent association between birthweight and parental risk of diabetes and cardiovascular disease
    J Adams
    School of Population and Health Sciences, The Medical School, University of Newcastle upon Tyne, UK
    Diabet Med 22:950-3. 2005
    ..It has been proposed that an inverse relationship between birthweight and parental risk of diabetes and cardiovascular disease is evidence in support of this hypothesis...
  86. pmc Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population
    C L Relton
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences, Newcastle University, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    J Med Genet 41:256-60. 2004
    ..To investigate the contribution of polymorphic variation in genes involved in the folate-dependent homocysteine pathway in the aetiology of neural tube defects (NTD)...
  87. ncbi request reprint Thyroid cancer in children and young adults in the North of England. Is increasing incidence related to the Chernobyl accident?
    S J Cotterill
    Sir James Spence Institute of Child Health, University of Newcastle upon Tyne, Queen Victoria Road, NE1 4LP, Newcastle, UK
    Eur J Cancer 37:1020-6. 2001
    ..Further collaborative international studies are needed to investigate changes in the incidence of thyroid cancer in children and young adults...
  88. ncbi request reprint A lifecourse study of risk for hyperinsulinaemia, dyslipidaemia and obesity (the central metabolic syndrome) at age 49-51 years
    L Parker
    Paediatric and Lifecourse Epidemiology Research Group, University of Newcastle upon Tyne, Sir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Diabet Med 20:406-15. 2003
    ..A central metabolic syndrome (CMS) has been identified comprising obesity, dyslipidaemia and insulin resistance. This study was designed to investigate determinants of risk for CMS...
  89. doi request reprint The relationship between gestational age, systolic blood pressure and pulse pressure in children
    C L Relton
    Institute of Health and Society, School of Clinical Medical Sciences Child Health, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    J Hum Hypertens 22:352-7. 2008
    ....
  90. pmc Parental recall of birth weight: how accurate is it?
    J J O'Sullivan
    The Department of Child Health, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Arch Dis Child 82:202-3. 2000
    ..To assess the accuracy of parental recall of birth weight in a British population and to investigate whether social class and age of the child significantly influence the accuracy of recalled birth weight...
  91. doi request reprint Incidence and clinical features of Langerhans cell histiocytosis in the UK and Ireland
    J A Salotti
    Newcastle University, Newcastle upon Tyne, UK
    Arch Dis Child 94:376-80. 2009
    ..There are few published studies on the epidemiology of Langerhans cell histiocytosis (LCH). We undertook a survey to ascertain all newly diagnosed cases aged 0-16 years in the UK and Republic of Ireland...
  92. doi request reprint Lifecourse predictors of adult respiratory function: results from the Newcastle Thousand Families Study
    P W G Tennant
    Sir James Spence Institute, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
    Thorax 63:823-30. 2008
    ..We have used detailed longitudinal data from the Newcastle Thousand Families cohort to assess the impact of birth weight, and various other factors acting throughout the lifecourse, on predicting forced expiratory volume in 1 s (FEV(1))...
  93. pmc Increasing Incidence, but Lack of Seasonality, of Elevated TSH Levels, on Newborn Screening, in the North of England
    Mark S Pearce
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne NE1 4LP, UK
    J Thyroid Res 2010:101948. 2010
    ..There was no evidence of seasonal variation in incidence. The reasons for the increasing incidence are unclear, but do not appear to involve increasing exposure to seasonally varying factors or changes in measurements methods...
  94. doi request reprint Longitudinal study of physical activity and sedentary behavior in children
    Laura Basterfield
    Institute of Health and Society, Human Nutrition Research Centre, Newcastle University, M1 151 Leech Building Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, United Kingdom
    Pediatrics 127:e24-30. 2011
    ....
  95. pmc Incidence and survival of childhood bone cancer in northern England and the West Midlands, 1981-2002
    R Eyre
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne NE1 4LP, UK
    Br J Cancer 100:188-93. 2009
    ..98-1.05; P=0.35) over this time period. Reasons for failure to improve survival including potential delays in diagnosis, accrual to trials, adherence to therapy and lack of improvement in treatment strategies all need to be considered...
  96. doi request reprint TSH levels in relation to gestation, birth weight and sex
    Murthy Korada
    Department of Paediatrics, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Horm Res 72:120-3. 2009
    ..Low birth weight is associated with hypothyroidism and an adverse metabolic profile in later life. Our aim was to examine the relationship between neonatal TSH and birth weight, gestational age and sex...
  97. ncbi request reprint Evidence of an environmental contribution to the aetiology of cryptorchidism and hypospadias?
    N A Abdullah
    School of Clinical Medical Sciences Child Health, Sir James Spence Institute, Newcastle University, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK
    Eur J Epidemiol 22:615-20. 2007
    ..The aim was to determine if there is evidence of spatial heterogeneity in the prevalence of these conditions and to test the hypothesis that environmental factors may contribute to aetiology...
  98. doi request reprint Repeat testing for congenital hypothyroidism in preterm infants is unnecessary with an appropriate thyroid stimulating hormone threshold
    M Korada
    School of Clinical Medical Sciences Child Health, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Arch Dis Child Fetal Neonatal Ed 93:F286-8. 2008
    ..Revised UK neonatal screening guidelines recommend that a second blood sample for assay of thyroid stimulating hormone (TSH) be taken when preterm infants reach a postmenstrual age of 36 weeks...
  99. ncbi request reprint Differences in bone mineral density and geometry in men and women: the Newcastle Thousand Families Study at 50 years old
    S P Tuck
    Department of Rheumatology, Musculoskeletal Unit, Freeman Hospital, Freeman Road, Newcastle upon Tyne NE7 7DN, UK
    Br J Radiol 78:493-8. 2005
    ..We conclude that there are gender differences in BMD, skeletal size and geometry in middle aged men and women, which together with the subsequent rate of bone loss, may influence fracture risk in later life...
  100. pmc Birth prevalence of cryptorchidism and hypospadias in northern England, 1993-2000
    N A Abdullah
    Paediatric and Lifecourse Epidemiology Research Group, School of Clinical Medical Sciences Child Health, Newcastle University, Newcastle upon Tyne, UK
    Arch Dis Child 92:576-9. 2007
    ..To address this issue we investigated the birth prevalence of cryptorchidism and hypospadias in the northern region of England during the period 1993-2000...
  101. doi request reprint Predictors of age at menarche in the newcastle thousand families study
    Mwenza Blell
    Department of Anthropology, Durham University, UK
    J Biosoc Sci 40:563-75. 2008
    ..It is suggested that future work should focus on illuminating the mechanisms underlying these statistical relationships...