Laura R Pearce

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. Pearce L, Alton G, Richter D, Kath J, Lingardo L, Chapman J, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem J. 2010;431:245-55 pubmed publisher
    ..PF-4708671 is the first S6K1-specific inhibitor to be reported and will be a useful tool for delineating S6K1-specific roles downstream of mTOR. ..
  2. Pearce L, Huang X, Boudeau J, Pawłowski R, Wullschleger S, Deak M, et al. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J. 2007;405:513-22 pubmed
    ..Protor-1 is a novel Rictor-binding subunit of mTORC2, but further work is required to establish its role. ..
  3. Pearce L, Komander D, Alessi D. The nuts and bolts of AGC protein kinases. Nat Rev Mol Cell Biol. 2010;11:9-22 pubmed publisher
    ..In addition, AGC kinases mediate diverse and important cellular functions, and their mutation and/or dysregulation contributes to the pathogenesis of many human diseases, including cancer and diabetes. ..