Laura R Pearce

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi Identification of Protor as a novel Rictor-binding component of mTOR complex-2
    Laura R Pearce
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 405:513-22. 2007
  2. ncbi The nuts and bolts of AGC protein kinases
    Laura R Pearce
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Nat Rev Mol Cell Biol 11:9-22. 2010
  3. ncbi Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)
    Laura R Pearce
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland, U K
    Biochem J 431:245-55. 2010
  4. ncbi Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney
    Laura R Pearce
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 436:169-79. 2011
  5. ncbi New insights into mTOR signaling: mTORC2 and beyond
    Dario R Alessi
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD15EH, Scotland, UK
    Sci Signal 2:pe27. 2009

Detail Information

Publications5

  1. ncbi Identification of Protor as a novel Rictor-binding component of mTOR complex-2
    Laura R Pearce
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 405:513-22. 2007
    ..Protor-1 is a novel Rictor-binding subunit of mTORC2, but further work is required to establish its role...
  2. ncbi The nuts and bolts of AGC protein kinases
    Laura R Pearce
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Nat Rev Mol Cell Biol 11:9-22. 2010
    ..In addition, AGC kinases mediate diverse and important cellular functions, and their mutation and/or dysregulation contributes to the pathogenesis of many human diseases, including cancer and diabetes...
  3. ncbi Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1)
    Laura R Pearce
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland, U K
    Biochem J 431:245-55. 2010
    ..PF-4708671 is the first S6K1-specific inhibitor to be reported and will be a useful tool for delineating S6K1-specific roles downstream of mTOR...
  4. ncbi Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney
    Laura R Pearce
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 436:169-79. 2011
    ..Taken together, these results suggest that Protor-1 may play a role in enabling mTORC2 to efficiently activate SGK1, at least in the kidney...
  5. ncbi New insights into mTOR signaling: mTORC2 and beyond
    Dario R Alessi
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD15EH, Scotland, UK
    Sci Signal 2:pe27. 2009
    ..mTORC2 may control phosphorylation of the turn motif by promoting the activity of a kinase that targets the Ser/Thr-Pro sequence or by inhibiting the activity of a phosphatase...