Elspeth M Payne

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Myelopoiesis and myeloid leukaemogenesis in the zebrafish
    A Michael Forrester
    Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada B3H 3J5
    Adv Hematol 2012:358518. 2012
  2. pmc Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML
    Elspeth M Payne
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 118:903-15. 2011
  3. pmc cpsf1 is required for definitive HSC survival in zebrafish
    Niccolò Bolli
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 117:3996-4007. 2011
  4. pmc Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish
    Niccolò Bolli
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 115:3329-40. 2010
  5. pmc L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway
    Elspeth M Payne
    Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 120:2214-24. 2012
  6. ncbi request reprint L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way
    Anupama Narla
    Division of Pediatric Hematology Oncology, Lucile Packard Children s Hospital, Stanford University School of Medicine, Stanford, CA, USA Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Br J Haematol 167:524-8. 2014

Collaborators

Detail Information

Publications6

  1. pmc Myelopoiesis and myeloid leukaemogenesis in the zebrafish
    A Michael Forrester
    Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada B3H 3J5
    Adv Hematol 2012:358518. 2012
    ..In this paper, we address the recent advances and future directions in the field of myelopoiesis and leukaemogenesis using the zebrafish system...
  2. pmc Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML
    Elspeth M Payne
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 118:903-15. 2011
    ....
  3. pmc cpsf1 is required for definitive HSC survival in zebrafish
    Niccolò Bolli
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 117:3996-4007. 2011
    ..These studies show that cpsf1 is essential for HSC survival and differentiation in caudal hematopoietic tissue...
  4. pmc Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish
    Niccolò Bolli
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 115:3329-40. 2010
    ..These results are likely to be relevant to human NPMc+ AML, where the observed NPMc+ multilineage expression pattern implies transformation of a multipotent stem or progenitor cell...
  5. pmc L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway
    Elspeth M Payne
    Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Blood 120:2214-24. 2012
    ..Our studies support the rationale for ongoing clinical trials of L-leucine as a therapeutic agent for DBA, and potentially for patients with del(5q) MDS...
  6. ncbi request reprint L-Leucine improves the anaemia in models of Diamond Blackfan anaemia and the 5q- syndrome in a TP53-independent way
    Anupama Narla
    Division of Pediatric Hematology Oncology, Lucile Packard Children s Hospital, Stanford University School of Medicine, Stanford, CA, USA Division of Hematology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Br J Haematol 167:524-8. 2014
    ..We confirmed this observation in human CD34+ cells. L-Leucine thus alleviates anaemia in RP-deficient cells in a TP53-independent manner. ..